Bioconductor Affymetrix Probe Listing

Probe Symbol Description Chromosome Chromosome Location GenBank Gene PubMed Gene Ontology Pathway
TC0500002755.mm.2 Cxcl9 chemokine (C-X-C motif) ligand 9 5 -92321330 NM_008599, BC003343 NM_008599, BC003343 118

cytokine activity

extracellular region

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

immune response

chemokine activity

response to bacterium

external side of plasma membrane

neutrophil chemotaxis

CXCR chemokine receptor binding

positive regulation of myoblast differentiation

defense response to virus

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

positive regulation of myoblast fusion

04060

04062

04620

TC0500003731.mm.2 Gbp4 guanylate binding protein 4 5 -105115766 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 NM_001256005, NM_008620, BC141364, BC147434 11

negative regulation of transcription by RNA polymerase II

negative regulation of protein phosphorylation

GTPase activity

protein binding

GTP binding

negative regulation of protein ubiquitination

cytoplasmic vesicle

negative regulation of interferon-alpha production

negative regulation of protein import into nucleus

defense response to protozoan

regulation of defense response to virus

defense response to Gram-positive bacterium

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC1100000119.mm.2 Upp1 uridine phosphorylase 1 11 9118007, 9118102, 9118506 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 NM_001159401, NM_001159402, NM_009477, BC036559 43

catalytic activity

uridine phosphorylase activity

uridine phosphorylase activity

nucleoplasm

cytoplasm

cytosol

uridine catabolic process

uridine catabolic process

pyrimidine nucleotide metabolic process

CMP catabolic process

dCMP catabolic process

dCMP catabolic process

thymidine phosphorylase activity

nucleoside metabolic process

nucleotide catabolic process

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring pentosyl groups

identical protein binding

UMP catabolic process

dTMP catabolic process

dUMP catabolic process

uridine metabolic process

deoxyuridine phosphorylase activity

00240

00983

01100

TC0200004396.mm.2 Rasgrp1 RAS guanyl releasing protein 1 2 -117279983 NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 NM_011246, BC057120, BC057341 77

cytokine production

positive regulation of protein phosphorylation

inflammatory response to antigenic stimulus

guanyl-nucleotide exchange factor activity

calcium ion binding

intracellular anatomical structure

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

cytosol

plasma membrane

plasma membrane

small GTPase mediated signal transduction

zinc ion binding

regulation of phosphatidylinositol 3-kinase signaling

membrane

diacylglycerol binding

natural killer cell activation

cell differentiation

phosphatidylcholine binding

secretory granule localization

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-gamma production

positive regulation of tumor necrosis factor production

positive regulation of natural killer cell activation

positive regulation of natural killer cell differentiation

positive regulation of T cell differentiation in thymus

intracellular signal transduction

T cell proliferation

B cell proliferation

T cell activation

B cell activation

identical protein binding

mast cell degranulation

positive regulation of MAP kinase activity

positive regulation of GTPase activity

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of JNK cascade

positive regulation of Ras protein signal transduction

metal ion binding

vesicle transport along microtubule

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

activation of GTPase activity

activation of GTPase activity

04010

04660

TC0200002374.mm.2 Procr protein C receptor, endothelial 2 155751216 NM_011171, BC028755 NM_011171, BC028755 78

extracellular space

extracellular space

centrosome

blood coagulation

hemostasis

protein C-terminus binding

membrane

integral component of membrane

signaling receptor activity

perinuclear region of cytoplasm

negative regulation of coagulation

negative regulation of coagulation

negative regulation of coagulation

 
TC1000001994.mm.2 Calhm6 calcium homeostasis modulator family member 6 10 -34126066 NM_175449, BC095946 NM_175449, BC095946 16

cation channel activity

integral component of plasma membrane

ion transport

membrane

integral component of membrane

 
TC1100001171.mm.2 Nos2 nitric oxide synthase 2, inducible 11 78925290, 78920786, 78924739 NM_010927, BC062378 NM_010927, BC062378 1387

response to hypoxia

actin binding

nitric-oxide synthase activity

nitric-oxide synthase activity

nitric-oxide synthase activity

protein binding

calmodulin binding

extracellular space

nucleus

nucleus

cytoplasm

cytoplasm

peroxisome

cytosol

cytosol

cytosol

plasma membrane

arginine catabolic process

arginine catabolic process

arginine catabolic process

superoxide metabolic process

nitric oxide biosynthetic process

nitric oxide biosynthetic process

nitric oxide biosynthetic process

inflammatory response

inflammatory response

nitric oxide mediated signal transduction

circadian rhythm

beta-catenin binding

cAMP-dependent protein kinase regulator activity

response to bacterium

response to hormone

FMN binding

FMN binding

negative regulation of gene expression

negative regulation of gene expression

vesicle membrane

vesicle membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

peptidyl-cysteine S-nitrosylation

protein kinase binding

heme binding

cortical cytoskeleton

positive regulation of guanylate cyclase activity

prostaglandin secretion

response to lipopolysaccharide

response to lipopolysaccharide

interleukin-6 production

interleukin-8 production

tetrahydrobiopterin binding

arginine binding

cellular response to drug

regulation of cell population proliferation

negative regulation of protein catabolic process

defense response to bacterium

defense response to bacterium

defense response to bacterium

identical protein binding

protein homodimerization activity

cadherin binding

negative regulation of blood pressure

metal ion binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

flavin adenine dinucleotide binding

flavin adenine dinucleotide binding

NADP binding

regulation of insulin secretion

nitric-oxide synthase binding

positive regulation of killing of cells of other organism

Hsp90 protein binding

cellular response to lipopolysaccharide

cellular response to cytokine stimulus

cellular response to interferon-gamma

cellular response to organic cyclic compound

regulation of cytokine production involved in inflammatory response

00330

01100

04020

04146

05140

05142

05145

05146

05200

05222

TC1800000610.mm.2 Iigp1 interferon inducible GTPase 1 18 60376028, 60373615 NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 NM_001146275, NM_021792, BC004649 44

nucleotide binding

immune system process

GTPase activity

GTPase activity

GTPase activity

protein binding

GTP binding

nucleus

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

defense response

response to bacterium

regulation of autophagy

membrane

hydrolase activity

GDP binding

cytokine-mediated signaling pathway

symbiont-containing vacuole membrane

cellular response to interferon-beta

cellular response to interferon-beta

identical protein binding

identical protein binding

defense response to protozoan

innate immune response

defense response to Gram-negative bacterium

 
TC0300001444.mm.2         NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990 NM_010259, NM_153564, BC058555, BC108990  

nucleotide binding

immune system process

GTPase activity

protein binding

GTP binding

extracellular region

cytoplasm

Golgi apparatus

Golgi apparatus

cytosol

plasma membrane

inflammatory response

response to bacterium

membrane

hydrolase activity

GMP binding

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

interleukin-1 beta production

interleukin-1 beta production

interleukin-18 production

protein localization to Golgi apparatus

cellular response to interferon-beta

identical protein binding

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

positive regulation of innate immune response

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

protein homotetramerization

defense response to virus

cellular response to interferon-gamma

cellular response to interferon-gamma

positive regulation of cytokine production involved in inflammatory response

positive regulation of NLRP3 inflammasome complex assembly

 
TC1700002781.mm.2 H2-Ab1 histocompatibility 2, class II antigen A, beta 1 17 34263226 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 NM_207105, BC008168, BC010322, BC057998 780

adaptive immune response

B cell affinity maturation

immune system process

immunoglobulin production involved in immunoglobulin-mediated immune response

humoral immune response mediated by circulating immunoglobulin

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation

positive regulation of T-helper 1 type immune response

protein binding

intracellular anatomical structure

early endosome

multivesicular body

Golgi apparatus

plasma membrane

immune response

transcription factor binding

external side of plasma membrane

cell surface

toxic substance binding

membrane

integral component of membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

ubiquitin protein ligase binding

negative regulation of T cell proliferation

peptide antigen binding

MHC class II protein complex

protein-containing complex binding

positive regulation of alpha-beta T cell activation

positive regulation of alpha-beta T cell activation

positive regulation of alpha-beta T cell activation

antigen processing and presentation of peptide antigen

T cell receptor signaling pathway

cellular response to interferon-gamma

protein antigen binding

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC1500001728.mm.2 Ly6a lymphocyte antigen 6 complex, locus A 15 -74994876 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 NM_001271416, NM_001271417, NM_001271418, NM_001271419, NM_001271446, NM_010738, BC002070 177

protein binding

intracellular anatomical structure

plasma membrane

response to bacterium

external side of plasma membrane

membrane

acetylcholine receptor inhibitor activity

anchored component of membrane

acetylcholine receptor binding

acetylcholine receptor signaling pathway

 
TC0500000283.mm.2 Il6 interleukin 6 5 30013113 NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 NM_031168, BC132458, BC138766 2037

neutrophil apoptotic process

neutrophil apoptotic process

neutrophil apoptotic process

myeloid cell homeostasis

germinal center B cell differentiation

immunoglobulin production

hepatic immune response

positive regulation of immunoglobulin production

positive regulation of acute inflammatory response

signaling receptor binding

cytokine activity

cytokine activity

interleukin-6 receptor binding

interleukin-6 receptor binding

protein binding

extracellular region

extracellular space

extracellular space

cytoplasm

interleukin-6 receptor complex

interleukin-6 receptor complex

negative regulation of protein kinase activity

acute-phase response

inflammatory response

immune response

growth factor activity

positive regulation of cell population proliferation

negative regulation of cell population proliferation

regulation of cell shape

response to wounding

external side of plasma membrane

gene expression

vascular endothelial growth factor production

regulation of vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of gene expression

positive regulation of epithelial to mesenchymal transition

positive regulation of neuron projection development

positive regulation of gliogenesis

response to activity

cytokine-mediated signaling pathway

endocrine pancreas development

neuron projection development

interleukin-21 production

negative regulation of chemokine production

negative regulation of chemokine production

positive regulation of chemokine production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-17 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

negative regulation of collagen biosynthetic process

positive regulation of peptidyl-serine phosphorylation

cellular response to hepatocyte growth factor stimulus

positive regulation of T cell proliferation

T cell activation

regulation of cell population proliferation

positive regulation of protein import into nucleus

positive regulation of tyrosine phosphorylation of STAT protein

glucose homeostasis

glucose homeostasis

glucose homeostasis

defense response to protozoan

regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of MAPK cascade

regulation of circadian sleep/wake cycle, non-REM sleep

positive regulation of nitric oxide biosynthetic process

cell redox homeostasis

positive regulation of T-helper 2 cell differentiation

positive regulation of neuron differentiation

positive regulation of osteoblast differentiation

negative regulation of gluconeogenesis

positive regulation of translation

positive regulation of DNA replication

negative regulation of bone resorption

negative regulation of bone resorption

negative regulation of membrane potential

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of receptor signaling pathway via JAK-STAT

muscle cell cellular homeostasis

negative regulation of hormone secretion

negative regulation of muscle organ development

positive regulation of smooth muscle cell proliferation

positive regulation of epithelial cell proliferation

positive regulation of epithelial cell proliferation

positive regulation of peptidyl-tyrosine phosphorylation

regulation of insulin secretion

regulation of insulin secretion

positive regulation of B cell activation

positive regulation of DNA-binding transcription factor activity

response to glucocorticoid

defense response to virus

positive regulation of protein kinase B signaling

positive regulation of transmission of nerve impulse

positive regulation of glial cell proliferation

branching involved in salivary gland morphogenesis

branching involved in salivary gland morphogenesis

epithelial cell proliferation involved in salivary gland morphogenesis

T follicular helper cell differentiation

glucagon secretion

regulation of glucagon secretion

regulation of glucagon secretion

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

cellular response to hydrogen peroxide

positive regulation of ERK1 and ERK2 cascade

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to interleukin-1

cellular response to tumor necrosis factor

positive regulation of cell proliferation in bone marrow

T-helper 17 cell lineage commitment

T-helper 17 cell lineage commitment

hepatocyte proliferation

positive regulation of extracellular matrix disassembly

liver regeneration

cellular response to virus

positive regulation of cytokine production involved in inflammatory response

negative regulation of neuron death

positive regulation of apoptotic DNA fragmentation

positive regulation of production of miRNAs involved in gene silencing by miRNA

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via STAT

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of T-helper 2 cell cytokine production

negative regulation of primary miRNA processing

negative regulation of interleukin-1-mediated signaling pathway

04060

04620

04621

04623

04630

04640

04672

05020

05142

05143

05144

05146

05200

05323

05332

05410

TC1100001223.mm.2 Ccl8 chemokine (C-C motif) ligand 8 11 82115184 NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 NM_021443, BC117101, BC117103 40

monocyte chemotaxis

cytokine activity

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

heparin binding

neutrophil chemotaxis

positive regulation of GTPase activity

positive regulation of myoblast differentiation

CCR chemokine receptor binding

eosinophil chemotaxis

lymphocyte chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

positive regulation of myoblast fusion

04060

04062

TC1900001418.mm.2 Ch25h cholesterol 25-hydroxylase 19 -34473783 NM_009890, BC039919 NM_009890, BC039919 45

C-4 methylsterol oxidase activity

cholesterol 25-hydroxylase activity

monooxygenase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

cholesterol metabolic process

cholesterol metabolic process

steroid hydroxylase activity

steroid hydroxylase activity

lipid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

B cell chemotaxis

metal ion binding

00120

TC1900000102.mm.2 Batf2 basic leucine zipper transcription factor, ATF-like 2 19 6164438 NM_028967, BC024521 NM_028967, BC024521 28

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell differentiation

defense response to protozoan

myeloid dendritic cell differentiation

 
TC0500003729.mm.2 Gbp8 guanylate-binding protein 8 5 -105014152 NM_029509, BC031475 NM_029509, BC031475 11

GTPase activity

GTP binding

cytoplasmic vesicle

defense response to protozoan

defense response to Gram-positive bacterium

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC0200002544.mm.2 Cd40 CD40 antigen 2 165055635 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 NM_011611, NM_170702, NM_170703, NM_170704, NR_027852, BC029254, CD40 573

positive regulation of protein phosphorylation

immune system process

regulation of immunoglobulin production

immune response-regulating cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway

antigen binding

antigen binding

protein binding

extracellular region

extracellular space

cytoplasm

plasma membrane

cellular calcium ion homeostasis

cellular calcium ion homeostasis

inflammatory response

inflammatory response

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

enzyme binding

protein domain specific binding

CD40 signaling pathway

CD40 signaling pathway

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of B cell proliferation

ubiquitin protein ligase binding

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

response to interferon-gamma

CD40 receptor complex

CD40 receptor complex

TRIF-dependent toll-like receptor signaling pathway

signaling receptor activity

B cell activation

B cell activation

B cell activation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

defense response to protozoan

defense response to protozoan

neuronal cell body

positive regulation of I-kappaB kinase/NF-kappaB signaling

varicosity

intracellular membrane-bounded organelle

positive regulation of MAP kinase activity

protein kinase B signaling

positive regulation of blood vessel endothelial cell migration

positive regulation of blood vessel endothelial cell migration

positive regulation of GTPase activity

positive regulation of angiogenesis

positive regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of isotype switching to IgG isotypes

positive regulation of isotype switching to IgG isotypes

regulation of immune response

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

defense response to virus

defense response to virus

cellular response to interleukin-1

cellular response to tumor necrosis factor

positive regulation of protein kinase C signaling

positive regulation of endothelial cell apoptotic process

positive regulation of endothelial cell apoptotic process

04060

04514

04620

04672

05144

05145

05310

05320

05322

05330

05340

05416

TC0800001118.mm.2 Ccl22 chemokine (C-C motif) ligand 22 8 94745683 NM_009137, BC012658 NM_009137, BC012658 54

monocyte chemotaxis

cytokine activity

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

neutrophil chemotaxis

killing of cells of other organism

positive regulation of GTPase activity

CCR chemokine receptor binding

lymphocyte chemotaxis

cell chemotaxis

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

04060

04062

TC0500001240.mm.2 Oasl1 2'-5' oligoadenylate synthetase-like 1 5 114923239 NM_145209, BC032152 NM_145209, BC032152 23

immune system process

DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

immune response

response to virus

membrane

transferase activity

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

defense response to virus

defense response to virus

regulation of ribonuclease activity

 
TC1700001596.mm.2 Mmp25 matrix metallopeptidase 25 17 -23629175 NM_001033339, BC112379 NM_001033339, BC112379 20

metalloendopeptidase activity

plasma membrane

plasma membrane

proteolysis

inflammatory response

peptidase activity

metallopeptidase activity

zinc ion binding

cell surface

membrane

integral component of membrane

peptidase activator activity

hydrolase activity

extracellular matrix organization

collagen catabolic process

extracellular matrix

anchored component of membrane

metal ion binding

hard palate development

 
TC1200002525.mm.2 Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 12 104236146, 104214453 NM_009251 30

adaptive immune response

immune system process

serine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular space

nucleus

cytoplasm

apoptotic process

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

response to cytokine

response to peptide hormone

 
TC0400002737.mm.2 Lpar1 lysophosphatidic acid receptor 1 4 -58435251, -58435251, -58435251 NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 NM_010336, NM_172989, BC025425 150

activation of MAPK activity

G-protein alpha-subunit binding

G protein-coupled receptor activity

protein binding

phospholipid binding

cytoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

activation of phospholipase C activity

activation of phospholipase C activity

regulation of cell shape

regulation of cell shape

cell surface

positive regulation of cell death

negative regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of neuron projection development

membrane

integral component of membrane

regulation of metabolic process

neurogenesis

endocytic vesicle

PDZ domain binding

bleb assembly

positive regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

lysophosphatidic acid binding

neuron projection

neuronal cell body

positive regulation of apoptotic process

dendritic spine

dendritic shaft

positive regulation of MAPK cascade

negative regulation of cAMP-mediated signaling

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

positive regulation of stress fiber assembly

cell chemotaxis

positive regulation of dendritic spine development

lysophosphatidic acid receptor activity

lysophosphatidic acid receptor activity

lysophosphatidic acid receptor activity

positive regulation of smooth muscle cell chemotaxis

cellular response to 1-oleoyl-sn-glycerol 3-phosphate

04080

04540

TC1100003396.mm.2 Ccl5 chemokine (C-C motif) ligand 5 11 -83525778 NM_013653, BC033508 NM_013653, BC033508 216

MAPK cascade

positive regulation of defense response to virus by host

monocyte chemotaxis

phosphatidylinositol phospholipase C activity

protein kinase activity

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

calcium ion transport

cellular calcium ion homeostasis

exocytosis

chemotaxis

inflammatory response

inflammatory response

inflammatory response

immune response

leukocyte cell-cell adhesion

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

cell-cell signaling

chemokine activity

chemokine activity

heparin binding

response to toxic substance

positive regulation of gene expression

positive regulation of macrophage chemotaxis

positive regulation of T cell chemotaxis

positive regulation of T cell chemotaxis

positive regulation of phosphatidylinositol 3-kinase signaling

positive regulation of smooth muscle cell migration

phospholipase activator activity

receptor signaling protein tyrosine kinase activator activity

positive regulation of cell migration

neutrophil chemotaxis

pseudopodium assembly

positive regulation of cellular biosynthetic process

activation of phospholipase D activity

positive regulation of fever generation

lipopolysaccharide-mediated signaling pathway

CCR1 chemokine receptor binding

CCR1 chemokine receptor binding

CCR5 chemokine receptor binding

positive regulation of cell-cell adhesion mediated by integrin

response to cytokine

positive regulation of homotypic cell-cell adhesion

response to interferon-gamma

response to tumor necrosis factor

T-helper 1 cell diapedesis

chemoattractant activity

positive regulation of T cell proliferation

neutrophil activation

positive regulation of phosphorylation

chemokine receptor binding

positive regulation of tyrosine phosphorylation of STAT protein

identical protein binding

protein homodimerization activity

protein kinase B signaling

positive regulation of GTPase activity

protein self-association

negative regulation by host of viral transcription

negative regulation of viral genome replication

positive regulation of neuron differentiation

positive regulation of osteoclast differentiation

negative regulation of G protein-coupled receptor signaling pathway

positive regulation of angiogenesis

positive regulation of cell adhesion

chemokine receptor antagonist activity

CCR chemokine receptor binding

eosinophil chemotaxis

lymphocyte chemotaxis

lymphocyte chemotaxis

positive regulation of smooth muscle cell proliferation

positive regulation of epithelial cell proliferation

regulation of insulin secretion

regulation of T cell activation

positive regulation of calcium ion transport

negative regulation of cell death

positive regulation of mast cell chemotaxis

chemokine-mediated signaling pathway

chemokine-mediated signaling pathway

negative regulation of T cell apoptotic process

positive regulation of T cell apoptotic process

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to organic cyclic compound

positive regulation of monocyte chemotaxis

positive regulation of monocyte chemotaxis

regulation of neuron death

negative regulation of neuron death

negative regulation of macrophage apoptotic process

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of T cell migration

positive regulation of natural killer cell chemotaxis

04060

04062

04620

04621

04623

05020

05142

05323

TC0600002641.mm.2 Mxd1 MAX dimerization protein 1 6 -86647044 NM_010751, BC034860 NM_010751, BC034860 48

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

protein binding

nucleus

nucleoplasm

mitochondrion

cytosol

regulation of transcription by RNA polymerase II

protein dimerization activity

 
TC1800001396.mm.2 Gm4841 predicted gene 4841 18 -60268300 NM_001034859, BC150900 NM_001034859, BC150900 9

GTPase activity

endoplasmic reticulum membrane

defense response

cellular response to interferon-beta

 
TC0500002896.mm.2 Gbp11 guanylate binding protein 11 5 -105323025, -105323025 NM_001039647, BC111039 NM_001039647, BC111039 3

GTPase activity

GTP binding

cytoplasmic vesicle

defense response to protozoan

defense response to Gram-positive bacterium

cellular response to interferon-gamma

 
TC0200004599.mm.2 Il1a interleukin 1 alpha 2 -129299609 NM_010554, BC003727 NM_010554, BC003727 389

fever generation

positive regulation of cytokine production

connective tissue replacement involved in inflammatory response wound healing

cytokine activity

cytokine activity

interleukin-1 receptor binding

copper ion binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

cytosol

plasma membrane

cellular sodium ion homeostasis

inflammatory response

inflammatory response

immune response

negative regulation of cell population proliferation

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of gene expression

positive regulation of steroid biosynthetic process

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

keratinization

positive regulation of prostaglandin secretion

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

regulation of actin cytoskeleton organization

positive regulation of immature T cell proliferation in thymus

cellular response to heat

ectopic germ cell programmed cell death

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of angiogenesis

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

response to copper ion

positive regulation of protein secretion

regulation of nitric-oxide synthase activity

positive regulation of cell division

regulation of sensory perception of pain

positive regulation of ERK1 and ERK2 cascade

interleukin-1-mediated signaling pathway

cellular response to lipopolysaccharide

positive regulation of monocyte chemotactic protein-1 production

extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of neutrophil migration

negative regulation of establishment of Sertoli cell barrier

positive regulation of neutrophil extravasation

04010

04060

04210

04380

04640

04940

05020

05140

05323

05332

TC0100003591.mm.2 Ifi213 interferon activated gene 213 1 -173591956, -173580356, -173573955, -173566282 NM_001177349, NM_001177350 NM_001177349, NM_001177350 10

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

cytosol

transcription factor binding

cellular response to interferon-beta

identical protein binding

 
TC1200002524.mm.2 Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F 12 104214543, 104214632 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 NM_001033335, NM_001168294, NM_001168295, BC139132, BC139133 19

serine-type endopeptidase inhibitor activity

extracellular space

response to bacterium

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

response to cytokine

response to peptide hormone

 
TC1700000835.mm.2 Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 17 43568450 NM_013737, BC010726 NM_013737, BC010726 49

1-alkyl-2-acetylglycerophosphocholine esterase activity

1-alkyl-2-acetylglycerophosphocholine esterase activity

phospholipid binding

extracellular region

extracellular space

cytoplasm

lipid metabolic process

inflammatory response

phospholipid catabolic process

lipid catabolic process

hydrolase activity

low-density lipoprotein particle

high-density lipoprotein particle

low-density lipoprotein particle remodeling

lipid oxidation

plasma lipoprotein particle oxidation

phosphatidylcholine catabolic process

platelet activating factor metabolic process

calcium-independent phospholipase A2 activity

platelet activating factor catabolic process

positive regulation of monocyte chemotaxis

00565

01100

TC0900003125.mm.2 Ccrl2 chemokine (C-C motif) receptor-like 2 9 -111054833, -111054833, -111054833 NM_017466, BC038631 NM_017466, BC038631 35

G protein-coupled receptor activity

chemokine receptor activity

cytoplasm

plasma membrane

integral component of plasma membrane

chemotaxis

inflammatory response

inflammatory response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

membrane

integral component of membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

chemokine receptor binding

chemokine receptor binding

CCR chemokine receptor binding

cell chemotaxis

 
TC0700001841.mm.2 Itgal integrin alpha L 7 127296259 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 NM_001253872, NM_001253873, NM_001253874, NM_008400, BC145094, BC145095, BC145096, BC145802 202

immunological synapse

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

plasma membrane

cell-cell junction

phagocytosis

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

cell-matrix adhesion

cell surface receptor signaling pathway

integrin-mediated signaling pathway

integrin complex

external side of plasma membrane

cell surface

membrane

integral component of membrane

regulation of cell-cell adhesion

positive regulation of cell-cell adhesion

ICAM-3 receptor activity

integrin alphaL-beta2 complex

memory T cell extravasation

positive regulation of T cell proliferation

receptor clustering

protein-containing complex binding

metal ion binding

activated T cell proliferation

cell adhesion molecule binding

positive regulation of calcium-mediated signaling

cell-cell adhesion

cell-cell adhesion

04514

04650

04670

04810

05144

05150

05323

05416

TC1100002643.mm.2         NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522 NM_001045540, NM_011579, BC022776, BC034256, BC085259, BC093522  

GTPase activity

GTPase activity

GTP binding

endoplasmic reticulum membrane

defense response

immune response

response to virus

response to bacterium

response to interferon-gamma

response to interferon-alpha

cellular response to interferon-beta

cellular response to interferon-beta

 
TC0700003517.mm.2 Slco3a1 solute carrier organic anion transporter family, member 3a1 7 -74275417, -74281915 NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 NM_001038643, NM_023908, BC025059 23

positive regulation of protein phosphorylation

transporter activity

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

ion transport

oligopeptide transport

organic anion transmembrane transporter activity

basal plasma membrane

cell surface

sodium-independent organic anion transmembrane transporter activity

organic anion transport

prostaglandin transport

prostaglandin transport

membrane

integral component of membrane

apical plasma membrane

oligopeptide transmembrane transporter activity

sodium-independent organic anion transport

positive regulation of NF-kappaB transcription factor activity

transmembrane transport

 
TC0300003133.mm.2 Ifi44 interferon-induced protein 44 3 -151730922 NM_133871, BC111882 NM_133871, BC111882 16

molecular_function

cytoplasm

immune response

response to bacterium

 
TC1300000364.mm.2 Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 13 33004540 NM_009256, BC029900 NM_009256, BC029900 40

T cell mediated cytotoxicity

protease binding

acute inflammatory response to antigenic stimulus

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

extracellular space

extracellular space

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

immune response

response to bacterium

positive regulation of gene expression

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

negative regulation by symbiont of host apoptotic process

protection from natural killer cell mediated cytotoxicity

defense response to bacterium

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

collagen-containing extracellular matrix

negative regulation of T cell apoptotic process

05146

TC0500000171.mm.2 Fgl2 fibrinogen-like protein 2 5 21372672 NM_008013, BC028893 NM_008013, BC028893 70

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

immunoglobulin production involved in immunoglobulin-mediated immune response

negative regulation of dendritic cell antigen processing and presentation

negative regulation of macrophage antigen processing and presentation

signaling receptor binding

extracellular region

extracellular space

peptidase activity

cytolysis

negative regulation of memory T cell differentiation

negative regulation of defense response to virus

collagen-containing extracellular matrix

 
TC1100002649.mm.2         NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522 NM_001145164, BC034256, BC085259, BC093522  

GTPase activity

GTPase activity

GTP binding

endoplasmic reticulum membrane

defense response

immune response

response to virus

response to bacterium

response to interferon-gamma

response to interferon-alpha

cellular response to interferon-beta

cellular response to interferon-beta

 
TC1200000837.mm.2 Jdp2 Jun dimerization protein 2 12 85599415, 85600017, 85599104 NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 NM_001205052, NM_001205053, NM_030887, BC019780 43

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of histone deacetylation

positive regulation of histone deacetylation

protein-containing complex binding

negative regulation of fat cell differentiation

sequence-specific double-stranded DNA binding

 
TC0100001338.mm.2 Ptgs2 prostaglandin-endoperoxide synthase 2 1 150100030 NM_011198, BC052900 NM_011198, BC052900 998

prostaglandin biosynthetic process

prostaglandin biosynthetic process

angiogenesis

peroxidase activity

prostaglandin-endoperoxide synthase activity

prostaglandin-endoperoxide synthase activity

protein binding

nuclear inner membrane

nuclear inner membrane

nuclear outer membrane

nuclear outer membrane

cytoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

caveola

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

inflammatory response

response to oxidative stress

embryo implantation

embryo implantation

learning

memory

regulation of blood pressure

positive regulation of cell population proliferation

negative regulation of cell population proliferation

positive regulation of vascular endothelial growth factor production

positive regulation of cell death

membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

sensory perception of pain

cyclooxygenase pathway

cyclooxygenase pathway

enzyme binding

heme binding

keratinocyte differentiation

bone mineralization

ovulation

positive regulation of prostaglandin biosynthetic process

positive regulation of fever generation

positive regulation of fever generation

positive regulation of synaptic plasticity

negative regulation of synaptic transmission, dopaminergic

response to lipopolysaccharide

protein-containing complex

positive regulation of peptidyl-serine phosphorylation

response to cytokine

maintenance of blood-brain barrier

regulation of cell population proliferation

positive regulation of protein import into nucleus

anagen

protein homodimerization activity

neuron projection

neuron projection

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

intracellular membrane-bounded organelle

positive regulation of nitric oxide biosynthetic process

negative regulation of cell cycle

positive regulation of vasoconstriction

negative regulation of smooth muscle contraction

positive regulation of smooth muscle contraction

decidualization

decidualization

metal ion binding

positive regulation of smooth muscle cell proliferation

brown fat cell differentiation

dioxygenase activity

negative regulation of calcium ion transport

positive regulation of synaptic transmission, glutamatergic

cellular response to non-ionic osmotic stress

cellular response to fluid shear stress

positive regulation of transforming growth factor beta production

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of fibroblast growth factor production

positive regulation of brown fat cell differentiation

positive regulation of platelet-derived growth factor production

regulation of neuroinflammatory response

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

00590

01100

04370

05140

05200

05222

TC0200005438.mm.2 Helz2 helicase with zinc finger 2, transcriptional coactivator 2 -181227614 NM_183162 19

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

DNA binding

RNA binding

RNA helicase activity

helicase activity

ribonuclease activity

ATP binding

nucleus

nucleoplasm

cytoplasm

hydrolase activity

nuclear receptor coactivator activity

positive regulation of transcription by RNA polymerase II

metal ion binding

 
TC0500002757.mm.2 Cxcl11 chemokine (C-X-C motif) ligand 11 5 -92359544, -92359544 NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 NM_019494, NR_038116, BC025903 38

extracellular space

inflammatory response

chemokine activity

neutrophil chemotaxis

CXCR chemokine receptor binding

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

04060

04062

04620

TC0200001854.mm.2         NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633 NM_001004174, NR_030547, BC049633  

molecular_function

cytochrome-c oxidase activity

cellular_component

nucleus

mitochondrion

mitochondrial respiratory chain complex IV

response to bacterium

BMP signaling pathway

negative regulation of inflammatory response

cellular response to lipopolysaccharide

 
TC0200000868.mm.2 Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial 2 57237677, 57238381 NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 NM_001145820, NM_010274, BC021359 55

glycerol-3-phosphate dehydrogenase [NAD+] activity

glycerol-3-phosphate dehydrogenase (quinone) activity

calcium ion binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

glycerol-3-phosphate metabolic process

glycerol-3-phosphate metabolic process

gluconeogenesis

NADH metabolic process

glycerol-3-phosphate dehydrogenase complex

membrane

oxidoreductase activity

multicellular organism growth

camera-type eye development

metal ion binding

sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

00564

TC1800000609.mm.2 F830016B08Rik RIKEN cDNA F830016B08 gene 18 60293379 NM_001101475 9

GTPase activity

endoplasmic reticulum membrane

defense response

cellular response to interferon-beta

 
TC1100000681.mm.2 Gm12250 predicted gene 12250 11 58183842 NM_001135115 9    
TC0300001447.mm.2 Gbp2 guanylate binding protein 2 3 142620662 NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 NM_010260, BC011336, BC032882 54

nucleotide binding

GTPase activity

GTPase activity

GTP binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

response to bacterium

membrane

hydrolase activity

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

protein localization to nucleus

cellular response to interferon-beta

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC0500002895.mm.2         NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768 NM_001039646, NM_194336, BC007143, BC057969, BC112328, BC114209, BC115768  

GTPase activity

GTP binding

response to bacterium

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC1800000606.mm.2 Gm4951 predicted gene 4951 18 60212076 NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 NM_001033767, BC139145, BC139147 12

GTPase activity

endoplasmic reticulum membrane

defense response

cellular response to interferon-beta

cellular response to interferon-beta

 
TC1700002352.mm.2 C3 complement component 3 17 -57203966 NM_009778, BC043338 NM_009778, BC043338 585

positive regulation of type IIa hypersensitivity

positive regulation of protein phosphorylation

positive regulation of activation of membrane attack complex

immune system process

endopeptidase inhibitor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

lipid metabolic process

fatty acid metabolic process

inflammatory response

complement activation

complement activation

complement activation

complement activation

complement activation, alternative pathway

complement activation, classical pathway

blood coagulation

lipid binding

response to bacterium

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of glucose transmembrane transport

regulation of triglyceride biosynthetic process

positive regulation of lipid storage

neuron remodeling

C5L2 anaphylatoxin chemotactic receptor binding

protein-containing complex

oviduct epithelium development

vascular associated smooth muscle cell differentiation

innate immune response

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of angiogenesis

positive regulation of receptor-mediated endocytosis

positive regulation of receptor-mediated endocytosis

positive regulation of developmental growth

positive regulation of phagocytosis

retina development in camera-type eye

positive regulation of phagocytosis, engulfment

positive regulation of phagocytosis, engulfment

positive regulation of ERK1 and ERK2 cascade

amyloid-beta clearance

amyloid-beta clearance

complement-dependent cytotoxicity

complement-mediated synapse pruning

vertebrate eye-specific patterning

cell surface receptor signaling pathway involved in cell-cell signaling

positive regulation of apoptotic cell clearance

04145

04610

05140

05142

05150

05322

TC1500001727.mm.2 Ly6i lymphocyte antigen 6 complex, locus I 15 -74979533 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 NM_020498, BC125350, BC132052, BC145087 13

plasma membrane

plasma membrane

membrane

acetylcholine receptor inhibitor activity

anchored component of membrane

acetylcholine receptor binding

acetylcholine receptor signaling pathway

 
TC0300001446.mm.2 Gbp3 guanylate binding protein 3 3 142560355, 142560043 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 NM_001289492, NM_001289493, NM_018734, BC019195 23

nucleotide binding

GTPase activity

GTPase activity

GTP binding

nucleus

cytoplasm

Golgi apparatus

cytosol

cytosol

plasma membrane

membrane

hydrolase activity

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC0500003243.mm.2 Hcar2 hydroxycarboxylic acid receptor 2 5 -123863569 NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 NM_030701, BC120715, BC125296 66

purinergic nucleotide receptor activity

neutrophil apoptotic process

G protein-coupled receptor activity

GTP binding

plasma membrane

apoptotic process

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

cell junction

positive regulation of neutrophil apoptotic process

negative regulation of lipid catabolic process

positive regulation of adiponectin secretion

nicotinic acid receptor activity

 
TC1700000077.mm.2 Tagap T cell activation Rho GTPase activating protein 17 7925999 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 NM_145968, BC030886, BC039780, BC150728 28

guanyl-nucleotide exchange factor activity

GTPase activator activity

signal transduction

defense response to virus

 
TC1100001239.mm.2 Slfn1 schlafen 1 11 83116819 NM_011407, BC052869 NM_011407, BC052869 22

negative regulation of transcription by RNA polymerase II

negative regulation of protein phosphorylation

protein binding

nucleus

cytoplasm

cell cycle arrest

negative regulation of cell population proliferation

negative regulation of T cell proliferation

negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of G1/S transition of mitotic cell cycle

 
TC0600003537.mm.2 Clec9a C-type lectin domain family 9, member a 6 129408861 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 NM_001205363, NM_001205364, NM_001205365, NM_172732, BC087955 47

positive regulation of cytokine production

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

cell surface

cell surface

cell surface

membrane

integral component of membrane

carbohydrate binding

 
TC1600000116.mm.2 Ciita class II transactivator 16 10480071, 10489780, 10488177 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 NM_001243760, NM_001243761, NM_007575, BC148699 178

negative regulation of transcription by RNA polymerase II

nucleotide binding

transcription regulatory region sequence-specific DNA binding

ATP binding

GTP binding

nucleus

nucleoplasm

cytosol

regulation of transcription, DNA-templated

inflammatory response

protein C-terminus binding

cell surface

kinase activity

phosphorylation

PML body

transferase activity

transferase activity, transferring acyl groups

activating transcription factor binding

activating transcription factor binding

response to interferon-gamma

response to interferon-gamma

protein-containing complex binding

positive regulation of MHC class I biosynthetic process

positive regulation of MHC class I biosynthetic process

positive regulation of MHC class II biosynthetic process

positive regulation of MHC class II biosynthetic process

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of viral entry into host cell

response to antibiotic

04612

05145

05340

TC1700002816.mm.2 Cfb complement factor B 17 -34856373 NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 NM_001142706, NM_008198, BC005451 166

immune system process

serine-type endopeptidase activity

extracellular region

extracellular space

proteolysis

complement activation

complement activation, alternative pathway

complement activation, alternative pathway

complement activation, alternative pathway

peptidase activity

serine-type peptidase activity

cell population proliferation

hydrolase activity

innate immune response

response to thyroid hormone

04610

05150

TC1400002162.mm.2 Phf11b PHD finger protein 11B 14 -59320963 NM_001164327 3

molecular_function

nucleus

nucleoplasm

biological_process

nuclear membrane

 
TC0700004288.mm.2 Nupr1 nuclear protein transcription regulator 1 7 -126623245 NM_019738, BC002109 NM_019738, BC002109 64

acute inflammatory response

DNA binding

chromatin binding

transcription coactivator activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

protein acetylation

negative regulation of cell population proliferation

male gonad development

response to toxic substance

negative regulation of autophagy

negative regulation of autophagy

negative regulation of cardiac muscle cell apoptotic process

acetyltransferase activator activity

positive regulation of protein modification process

protein-DNA complex

skeletal muscle cell differentiation

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

intercellular bridge

negative regulation of cell cycle

negative regulation of cell cycle

negative regulation of cell cycle

positive regulation of cell cycle

negative regulation of glycolytic process

negative regulation of fibroblast proliferation

perinuclear region of cytoplasm

negative regulation of epithelial cell proliferation

negative regulation of programmed necrotic cell death

protein-containing complex assembly

positive regulation of neuroinflammatory response

positive regulation of proteasomal protein catabolic process

negative regulation of autophagosome assembly

positive regulation of oxidative phosphorylation

negative regulation of epithelial cell apoptotic process

negative regulation of type B pancreatic cell proliferation

regulation of response to endoplasmic reticulum stress

regulation of female gonad development

positive regulation of intrinsic apoptotic signaling pathway

 
TC1800000617.mm.2         NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated) NM_001042605, NM_010545, NR_039567, BC003476, BC096435, CD74(invariant,-associated)  

activation of MAPK activity

prostaglandin biosynthetic process

amyloid-beta binding

positive regulation of protein phosphorylation

positive regulation of cytokine-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway

adaptive immune response

T cell activation involved in immune response

immune system process

positive regulation of dendritic cell antigen processing and presentation

negative regulation of peptide secretion

positive regulation of adaptive immune response

positive regulation of type 2 immune response

positive regulation of type 2 immune response

negative regulation of mature B cell apoptotic process

cytokine receptor activity

cytokine receptor activity

cytokine receptor activity

protein binding

extracellular space

nucleus

cytoplasm

cytoplasm

lysosome

endosome

late endosome

multivesicular body

vacuole

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

intracellular protein transport

intracellular protein transport

defense response

immune response

cell population proliferation

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

membrane

integral component of membrane

immunoglobulin mediated immune response

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

cytokine binding

cytokine binding

MHC class II protein complex binding

negative regulation of cell migration

positive regulation of B cell proliferation

positive regulation of prostaglandin biosynthetic process

positive regulation of chemokine production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

protein-containing complex

positive regulation of kinase activity

positive regulation of kinase activity

response to interferon-gamma

response to interferon-gamma

macrophage migration inhibitory factor signaling pathway

macrophage migration inhibitory factor receptor complex

macrophage migration inhibitory factor receptor complex

NOS2-CD74 complex

macrophage migration inhibitory factor binding

macrophage migration inhibitory factor binding

MHC class II protein binding

MHC class II protein binding

CD4 receptor binding

MHC class II protein complex

MHC class II protein complex

MHC class II protein binding, via antigen binding groove

negative regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of MAPK cascade

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of DNA damage response, signal transduction by p53 class mediator

protein folding chaperone

positive thymic T cell selection

negative thymic T cell selection

positive regulation of innate immune response

negative regulation of T cell differentiation

positive regulation of T cell differentiation

positive regulation of monocyte differentiation

positive regulation of transcription, DNA-templated

negative regulation of viral entry into host cell

positive regulation of viral entry into host cell

positive regulation of fibroblast proliferation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

protein stabilization

nitric-oxide synthase binding

chaperone cofactor-dependent protein refolding

chaperone cofactor-dependent protein refolding

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

protein-containing complex assembly

protein trimerization

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of neutrophil chemotaxis

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macrophage migration inhibitory factor signaling pathway

 
TC0200004636.mm.2 Slc4a11 solute carrier family 4, sodium bicarbonate transporter-like, member 11 2 -130684107 NM_001081162, BC111884 NM_001081162, BC111884 26

sodium channel activity

inorganic anion exchanger activity

plasma membrane

plasma membrane

ion transport

sodium ion transport

anion transport

vesicle membrane

bicarbonate transmembrane transporter activity

proton channel activity

symporter activity

anion:anion antiporter activity

bicarbonate transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

transmembrane transporter activity

cellular cation homeostasis

fluid transport

borate transport

active borate transmembrane transporter activity

protein dimerization activity

ion homeostasis

ion homeostasis

transmembrane transport

proton transmembrane transport

 
TC0300002802.mm.2 Vcam1 vascular cell adhesion molecule 1 3 -116110019 NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 NM_011693, BC011159, BC029823 334

podosome

integrin binding

integrin binding

extracellular space

early endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

integral component of plasma membrane

microvillus

cell adhesion

cell adhesion

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

cell-matrix adhesion

heart development

primary amine oxidase activity

amine metabolic process

external side of plasma membrane

cell surface

membrane

integral component of membrane

viral process

filopodium

anchored component of membrane

heterotypic cell-cell adhesion

calcium-mediated signaling using intracellular calcium source

positive regulation of T cell proliferation

sarcolemma

apical part of cell

cell adhesion molecule binding

leukocyte tethering or rolling

cell chemotaxis

innervation

embryonic placenta morphogenesis

chorio-allantoic fusion

cardiac neuron differentiation

visceral serous pericardium development

alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

cellular response to glucose stimulus

cell periphery

cell-cell adhesion

cell-cell adhesion in response to extracellular stimulus

cellular response to amyloid-beta

04514

04670

05143

05144

TC1700001905.mm.2 H2-Aa histocompatibility 2, class II antigen A, alpha 17 -34282743 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 NM_010378, BC019721, BC029620, BC031711, BC043925 115

adaptive immune response

immune system process

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

protein binding

lysosome

plasma membrane

immune response

external side of plasma membrane

membrane

integral component of membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

response to interferon-gamma

negative regulation of T cell proliferation

peptide antigen binding

MHC class II protein complex

protein-containing complex binding

positive regulation of T cell differentiation

antigen processing and presentation of peptide antigen

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC0800000482.mm.2 Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 8 40862366 NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 NM_001044740, NM_007514, BC127082 62

L-ornithine transmembrane transporter activity

L-ornithine transmembrane transporter activity

nitric oxide production involved in inflammatory response

high-affinity arginine transmembrane transporter activity

high-affinity lysine transmembrane transporter activity

plasma membrane

plasma membrane

nitric oxide biosynthetic process

amino acid transport

amino acid transmembrane transporter activity

amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

arginine transmembrane transporter activity

arginine transmembrane transporter activity

arginine transmembrane transporter activity

L-lysine transmembrane transporter activity

L-lysine transmembrane transporter activity

L-amino acid transport

arginine transport

membrane

integral component of membrane

transmembrane transporter activity

cell junction

macrophage activation

regulation of macrophage activation

regulation of inflammatory response

transmembrane transport

L-arginine transmembrane transporter activity

L-arginine transmembrane transporter activity

amino acid import across plasma membrane

low-affinity L-arginine transmembrane transporter activity

high-affinity L-ornithine transmembrane transporter activity

L-arginine import across plasma membrane

L-arginine import across plasma membrane

L-arginine import across plasma membrane

L-lysine import across plasma membrane

L-ornithine import across plasma membrane

L-arginine transport

L-alpha-amino acid transmembrane transport

L-ornithine transmembrane transport

L-ornithine transmembrane transport

 
TC1900000105.mm.2 Majin membrane anchored junction protein 19 6184344 NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 NM_001165919, BC138005, BC145092 13

chromosome, telomeric region

molecular_function

DNA binding

nucleus

integral component of nuclear inner membrane

integral component of nuclear inner membrane

chromosome

homologous chromosome pairing at meiosis

homologous chromosome pairing at meiosis

membrane

integral component of membrane

meiotic telomere clustering

meiotic cell cycle

meiotic attachment of telomere to nuclear envelope

meiotic attachment of telomere to nuclear envelope

 
TC1700002782.mm.2 H2-Eb1 histocompatibility 2, class II antigen E beta 17 34305866 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 NM_010382, BC132163, BC132165, BC172638 80

adaptive immune response

immune system process

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

protein binding

lysosomal membrane

immune response

membrane

integral component of membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

late endosome membrane

response to interferon-gamma

MHC class II protein complex

04145

04514

04612

04640

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC0500001896.mm.2 Fzd1 frizzled class receptor 1 5 -4753838 NM_021457, BC053010 NM_021457, BC053010 86

positive regulation of protein phosphorylation

membranous septum morphogenesis

muscular septum morphogenesis

outflow tract morphogenesis

transmembrane signaling receptor activity

G protein-coupled receptor activity

signaling receptor binding

frizzled binding

plasma membrane

plasma membrane

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

cell-cell signaling

cell-cell signaling

multicellular organism development

cell surface

positive regulation of neuron projection development

membrane

integral component of membrane

Wnt signaling pathway

Wnt-protein binding

Wnt-protein binding

Wnt-protein binding

PDZ domain binding

negative regulation of BMP signaling pathway

epithelial cell differentiation

epithelial cell differentiation

autocrine signaling

non-canonical Wnt signaling pathway

astrocyte-dopaminergic neuron signaling

response to drug

identical protein binding

protein homodimerization activity

Wnt-activated receptor activity

Wnt-activated receptor activity

neuron projection

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

canonical Wnt signaling pathway involved in osteoblast differentiation

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

protein heterodimerization activity

positive regulation of DNA-binding transcription factor activity

hard palate development

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

ventricular septum morphogenesis

negative regulation of canonical Wnt signaling pathway

planar cell polarity pathway involved in neural tube closure

negative regulation of oxidative stress-induced neuron death

regulation of presynapse assembly

regulation of presynapse assembly

04310

04916

05200

05217

TC0600003229.mm.2 Cd69 CD69 antigen 6 -129267323 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 NM_001033122, BC128272, BC128273, BC139135, BC139136, CD69 114

calcium ion binding

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

carbohydrate binding

protein-containing complex

cellular response to drug

identical protein binding

 
TC1400001182.mm.2 Acod1 aconitate decarboxylase 1 14 103047011 NM_008392 38

immune system process

positive regulation of antimicrobial humoral response

positive regulation of antimicrobial humoral response

mitochondrion

mitochondrion

defense response

defense response

defense response

inflammatory response

embryo implantation

response to bacterium

lyase activity

negative regulation of NF-kappaB transcription factor activity

negative regulation of type I interferon production

response to lipopolysaccharide

negative regulation of toll-like receptor 2 signaling pathway

negative regulation of toll-like receptor 4 signaling pathway

cellular response to interferon-beta

innate immune response

negative regulation of innate immune response

aconitate decarboxylase activity

aconitate decarboxylase activity

aconitate decarboxylase activity

aconitate decarboxylase activity

negative regulation of inflammatory response

defense response to virus

cellular response to molecule of bacterial origin

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to progesterone stimulus

tolerance induction to lipopolysaccharide

tolerance induction to lipopolysaccharide

positive regulation of reactive oxygen species metabolic process

 
TC1900000441.mm.2 Cd274 CD274 antigen 19 29367437 NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 NM_021893, BC066841, CD274 389

adaptive immune response

immune system process

positive regulation of tolerance induction to tumor cell

protein binding

nucleoplasm

endosome

plasma membrane

immune response

immune response

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

actin cytoskeleton

membrane

integral component of membrane

positive regulation of cell migration

T cell costimulation

T cell costimulation

early endosome membrane

negative regulation of interferon-gamma production

negative regulation of interleukin-10 production

positive regulation of interleukin-10 production

response to cytokine

positive regulation of T cell proliferation

positive regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of activated T cell proliferation

recycling endosome membrane

extracellular exosome

cellular response to lipopolysaccharide

toxin transport

negative regulation of tumor necrosis factor superfamily cytokine production

positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD8-positive, alpha-beta T cell activation

04514

TC0500002840.mm.2 Plac8 placenta-specific 8 5 -100553725, -100553725 NM_139198, BC010789 NM_139198, BC010789 35

chromatin binding

protein binding

nucleus

positive regulation of cell population proliferation

response to cold

negative regulation of multicellular organism growth

defense response to bacterium

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

brown fat cell differentiation

positive regulation of cold-induced thermogenesis

 
TC0500000466.mm.2 Bst1 bone marrow stromal cell antigen 1 5 43818892 NM_009763 37

uropod

regulation of cell-matrix adhesion

NAD+ nucleosidase activity

plasma membrane

positive regulation of cell population proliferation

membrane

transferase activity

hydrolase activity

phosphorus-oxygen lyase activity

extrinsic component of membrane

positive regulation of B cell proliferation

anchored component of membrane

regulation of actin cytoskeleton organization

NAD(P)+ nucleosidase activity

regulation of inflammatory response

regulation of peptidyl-tyrosine phosphorylation

regulation of calcium-mediated signaling

NAD+ nucleotidase, cyclic ADP-ribose generating

ADP-ribosyl cyclase activity

cyclic ADP-ribose hydrolase

regulation of neutrophil chemotaxis

00760

01100

04020

04970

04972

TC1700000618.mm.2 H2-DMa histocompatibility 2, class II, locus DMa 17 34122831, 34125517 NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 NM_010386, BC001996, BC049992 91

adaptive immune response

immune system process

peptide antigen assembly with MHC class II protein complex

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of germinal center formation

positive regulation of humoral immune response

protein binding

intracellular anatomical structure

lysosome

lysosomal membrane

lysosomal membrane

endosome

late endosome

multivesicular body

immune response

cell surface

endosome membrane

protein transport

membrane

integral component of membrane

immunoglobulin mediated immune response

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

late endosome membrane

MHC class II protein complex

intracellular membrane-bounded organelle

positive thymic T cell selection

positive regulation of T cell differentiation

inner ear development

positive regulation of immune response

chaperone cofactor-dependent protein refolding

chaperone cofactor-dependent protein refolding

protein-containing complex assembly

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC1700000846.mm.2 Clic5 chloride intracellular channel 5 17 44188571 NM_172621, BC064037 NM_172621, BC064037 31

response to dietary excess

diet induced thermogenesis

voltage-gated ion channel activity

chloride channel activity

chloride channel activity

nucleus

cytoplasm

Golgi apparatus

cytoskeleton

plasma membrane

ion transport

chloride transport

visual perception

sensory perception of sound

sensory perception of sound

sensory perception of sound

protein localization

actin cytoskeleton

membrane

integral component of membrane

stereocilium

stereocilium bundle

chloride channel complex

regulation of ion transmembrane transport

neuromuscular process controlling balance

response to stimulus

auditory receptor cell stereocilium organization

auditory receptor cell stereocilium organization

 
TC1900000141.mm.2 Plaat3 phospholipase A and acyltransferase 3 19 7557458, 7557484 NM_139269, BC024581 NM_139269, BC024581 28

phospholipase A2 activity

phospholipase A2 activity

phospholipase A2 activity

cytoplasm

cytoplasm

peroxisome

endoplasmic reticulum

plasma membrane

lipid metabolic process

triglyceride metabolic process

phospholipid metabolic process

peroxisome organization

phospholipid biosynthetic process

phospholipase A1 activity

phospholipase A1 activity

phospholipase A1 activity

response to bacterium

membrane

integral component of membrane

lipid catabolic process

N-acyltransferase activity

N-acyltransferase activity

transferase activity

hydrolase activity

negative regulation of cell cycle

ether lipid metabolic process

perinuclear region of cytoplasm

phosphatidylserine 1-acylhydrolase activity

1-acyl-2-lysophosphatidylserine acylhydrolase activity

N-acylphosphatidylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

regulation of adipose tissue development

 
TC1600002148.mm.2 Mx1 MX dynamin-like GTPase 1 16 -97447036, -97447034 NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 NM_010846, NR_003520, BC011113 108

mitochondrial fission

dynamin family protein polymerization involved in mitochondrial fission

GTPase activity

nucleus

cytoplasm

plasma membrane

microtubule binding

postsynaptic density

microtubule cytoskeleton

membrane

synaptic vesicle budding from presynaptic endocytic zone membrane

axon

cytoplasmic vesicle

receptor internalization

mitochondrial membrane

dendritic spine head

regulation of synapse structure or activity

membrane fusion

postsynaptic endocytic zone membrane

postsynaptic neurotransmitter receptor internalization

 
TC0900001339.mm.2 Tlr9 toll-like receptor 9 9 106222597 NM_031178, BC172644 NM_031178, BC172644 855

microglial cell activation

regulation of cytokine production

positive regulation of cytokine production

regulation of protein phosphorylation

activation of innate immune response

toll-like receptor signaling pathway

toll-like receptor signaling pathway

response to molecule of bacterial origin

immune system process

positive regulation of immunoglobulin production

regulation of dendritic cell cytokine production

MyD88-dependent toll-like receptor signaling pathway

transmembrane signaling receptor activity

interleukin-1 receptor binding

protein binding

cytoplasm

lysosome

endosome

endoplasmic reticulum

plasma membrane

plasma membrane

plasma membrane

plasma membrane

inflammatory response

immune response

immune response

signal transduction

I-kappaB kinase/NF-kappaB signaling

I-kappaB kinase/NF-kappaB signaling

I-kappaB phosphorylation

response to virus

positive regulation of autophagy

positive regulation of gene expression

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

maintenance of gastrointestinal epithelium

positive regulation of B cell proliferation

cytoplasmic vesicle

early phagosome

negative regulation of NF-kappaB transcription factor activity

tumor necrosis factor production

tumor necrosis factor production

negative regulation of interleukin-6 production

negative regulation of interleukin-8 production

positive regulation of chemokine production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-18 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

negative regulation of toll-like receptor signaling pathway

positive regulation of toll-like receptor signaling pathway

toll-like receptor 9 signaling pathway

regulation of toll-like receptor 9 signaling pathway

positive regulation of toll-like receptor 9 signaling pathway

siRNA binding

endolysosome

endolysosome

endolysosome

pattern recognition receptor activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of MAPK cascade

positive regulation of JUN kinase activity

innate immune response

unmethylated CpG binding

phagocytic vesicle

regulation of B cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of inflammatory response

positive regulation of inflammatory response

defense response to Gram-negative bacterium

regulation of B cell activation

positive regulation of B cell activation

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

defense response to virus

defense response to virus

defense response to virus

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of NIK/NF-kappaB signaling

negative regulation of ATPase-coupled calcium transmembrane transporter activity

cellular response to chloroquine

04620

05142

05143

05144

TC0600002425.mm.2 Il23r interleukin 23 receptor 6 -67422931 NM_144548, BC112425 NM_144548, BC112425 93

positive regulation of defense response to virus by host

immune system process

leukocyte mediated immunity

positive regulation of T-helper 1 type immune response

cytokine receptor activity

interleukin-12 receptor binding

interleukin-12 receptor binding

plasma membrane

plasma membrane

integral component of plasma membrane

inflammatory response

receptor signaling pathway via JAK-STAT

external side of plasma membrane

membrane

integral component of membrane

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

cytokine binding

response to lipopolysaccharide

negative regulation of interleukin-10 production

positive regulation of interferon-gamma production

positive regulation of interleukin-12 production

response to interferon-gamma

interleukin-23 binding

interleukin-23 binding

interleukin-23 receptor activity

receptor complex

receptor complex

innate immune response

interleukin-23 receptor complex

interleukin-23 receptor complex

04060

04630

TC0100003575.mm.2 Slamf8 SLAM family member 8 1 -172581376 NM_029084, BC024587 NM_029084, BC024587 14

leukocyte chemotaxis involved in inflammatory response

B-1 B cell lineage commitment

negative regulation of macrophage chemotaxis

membrane

integral component of membrane

regulation of NAD(P)H oxidase activity

cellular response to drug

signaling receptor activity

defense response to bacterium

identical protein binding

regulation of kinase activity

regulation of B cell differentiation

negative regulation of respiratory burst involved in inflammatory response

negative regulation of monocyte chemotaxis

phagosome acidification

negative regulation of neutrophil migration

negative regulation of dendritic cell chemotaxis

 
TC0400000458.mm.2 Glipr2 GLI pathogenesis-related 2 4 43957701 NM_027450, BC031750 NM_027450, BC031750 25

Golgi membrane

extracellular region

extracellular space

Golgi apparatus

positive regulation of epithelial cell migration

positive regulation of epithelial to mesenchymal transition

membrane

protein homodimerization activity

positive regulation of ERK1 and ERK2 cascade

 
TC1400002869.mm.2 Phf11d PHD finger protein 11D 14 -59347406 NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 NM_199015, BC030186, BC145673 18

molecular_function

nucleus

nucleoplasm

biological_process

nuclear membrane

metal ion binding

 
TC1400002161.mm.2 Phf11a PHD finger protein 11A 14 -59276912 NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 NM_172603, BC116758, BC116760 13

molecular_function

nucleus

nucleoplasm

nuclear membrane

metal ion binding

regulation of immune response

 
TC0200003355.mm.2 Traf1 TNF receptor-associated factor 1 2 -34941749 NM_009421, BC096595 NM_009421, BC096595 63

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

protein binding

cytoplasm

apoptotic process

signal transduction

zinc ion binding

cytoplasmic side of plasma membrane

ubiquitin protein ligase binding

ubiquitin protein ligase binding

thioesterase binding

tumor necrosis factor-mediated signaling pathway

identical protein binding

regulation of apoptotic process

regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of JNK cascade

positive regulation of NF-kappaB transcription factor activity

protein K63-linked ubiquitination

plasma membrane signaling receptor complex

regulation of extrinsic apoptotic signaling pathway

05200

05222

TC0700004530.mm.2 Irf7 interferon regulatory factor 7 7 -141263182 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 NM_001252600, NM_001252601, NM_016850, BC138799 230

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

immune system process

regulation of adaptive immune response

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of gene expression

immunoglobulin mediated immune response

positive regulation of type I interferon production

type I interferon production

interferon-alpha production

interferon-beta production

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

regulation of MyD88-dependent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway

innate immune response

regulation of innate immune response

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

defense response to virus

defense response to virus

type I interferon signaling pathway

positive regulation of type I interferon-mediated signaling pathway

sequence-specific double-stranded DNA binding

04620

04622

04623

05160

TC1600001198.mm.2 Socs1 suppressor of cytokine signaling 1 16 -10783808 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 NM_001271603, NM_009896, BC132366, BC132368 310

regulation of cytokine production

regulation of protein phosphorylation

insulin-like growth factor receptor binding

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

phosphatidylinositol 3-kinase complex

receptor signaling pathway via JAK-STAT

negative regulation of signal transduction

regulation of activation of Janus kinase activity

kinase inhibitor activity

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein kinase binding

cytoplasmic vesicle

intracellular signal transduction

cytoplasmic ribonucleoprotein granule

regulation of growth

regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

positive regulation of CD4-positive, alpha-beta T cell differentiation

negative regulation of CD8-positive, alpha-beta T cell differentiation

fat cell differentiation

positive regulation of regulatory T cell differentiation

regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of insulin receptor signaling pathway

phosphatidylinositol phosphorylation

1-phosphatidylinositol-3-kinase regulator activity

regulation of interferon-gamma-mediated signaling pathway

cellular response to amino acid stimulus

cellular response to cytokine stimulus

cellular response to organic cyclic compound

04120

04380

04630

04910

04930

05145

TC0700002128.mm.2 Tarm1 T cell-interacting, activating receptor on myeloid cells 1 7 -3486499, -3489068 NM_177363 10

adaptive immune response

immune system process

plasma membrane

plasma membrane

membrane

integral component of membrane

immunoglobulin receptor binding

innate immune response

positive regulation of cytokine production involved in inflammatory response

negative regulation of CD4-positive, alpha-beta T cell activation

negative regulation of CD4-positive, alpha-beta T cell proliferation

 
TC1300002013.mm.2 Nfil3 nuclear factor, interleukin 3, regulated 13 -52967208 NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 NM_017373, BC031377, BC100384 116

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

transcription, DNA-templated

regulation of transcription, DNA-templated

transcription by RNA polymerase II

immune response

circadian rhythm

positive regulation of gene expression

positive regulation of gene expression

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

rhythmic process

cellular response to interleukin-4

 
TC1700000864.mm.2 Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon 17 45555699 NM_008690, BC030923 NM_008690, BC030923 38

fibrillar center

protein binding

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

D-serine transport

negative regulation of transcription, DNA-templated

perinuclear region of cytoplasm

04660

04662

04722

04920

TC0800000770.mm.2 Il12rb1 interleukin 12 receptor, beta 1 8 70808448 NM_008353, BC057212 NM_008353, BC057212 77

positive regulation of defense response to virus by host

positive regulation of T-helper 1 type immune response

cytokine receptor activity

interleukin-12 receptor binding

interleukin-12 receptor binding

protein binding

plasma membrane

external side of plasma membrane

external side of plasma membrane

membrane

integral component of membrane

interleukin-12 receptor activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

cytokine binding

positive regulation of interferon-gamma production

interleukin-23 binding

interleukin-23 binding

interleukin-23 receptor activity

interleukin-12 receptor complex

interleukin-12 receptor complex

positive regulation of activated T cell proliferation

positive regulation of activated T cell proliferation

receptor complex

cellular response to interferon-gamma

interleukin-23 receptor complex

interleukin-23 receptor complex

interleukin-23 receptor complex

04060

04630

TC1900001123.mm.2 AW112010 expressed sequence AW112010 19 -11047611 NR_102366, NM_001177351 NR_102366, NM_001177351 10

molecular_function

cellular_component

biological_process

 
TC0500002756.mm.2 Cxcl10 chemokine (C-X-C motif) ligand 10 5 -92346638 NM_021274, BC030067 NM_021274, BC030067 278

positive regulation of leukocyte chemotaxis

cytokine activity

extracellular region

extracellular space

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

immune response

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

heparin binding

positive regulation of cell population proliferation

response to bacterium

external side of plasma membrane

T cell chemotaxis

regulation of T cell chemotaxis

negative regulation of angiogenesis

positive regulation of cell migration

neutrophil chemotaxis

killing of cells of other organism

chemoattractant activity

endothelial cell activation

regulation of cell population proliferation

regulation of apoptotic process

CXCR chemokine receptor binding

negative regulation of myoblast differentiation

CXCR3 chemokine receptor binding

positive regulation of release of sequestered calcium ion into cytosol

defense response to virus

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

positive regulation of monocyte chemotaxis

regulation of endothelial tube morphogenesis

negative regulation of myoblast fusion

positive regulation of T cell migration

04060

04062

04620

04622

04623

TC0100001634.mm.2 Ifi208 interferon activated gene 208 1 173673664, 173673664 NM_001162938 63

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

cytosol

transcription factor binding

cellular response to interferon-beta

identical protein binding

 
TC0200003560.mm.2 Nr4a2 nuclear receptor subfamily 4, group A, member 2 2 -57107225, -57107225 NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 NM_001139509, NM_013613, BC137715 310

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

response to hypoxia

neuron migration

response to amphetamine

DNA binding

DNA-binding transcription factor activity

steroid hormone receptor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

transcription, DNA-templated

transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

nervous system development

zinc ion binding

adult locomotory behavior

post-embryonic development

response to inorganic substance

gene expression

regulation of gene expression

nuclear speck

response to insecticide

central nervous system projection neuron axonogenesis

central nervous system neuron differentiation

central nervous system neuron differentiation

habenula development

neuron differentiation

cellular response to extracellular stimulus

cellular response to extracellular stimulus

cellular response to oxidative stress

glucocorticoid receptor binding

glucocorticoid receptor binding

regulation of dopamine metabolic process

dopamine biosynthetic process

dopamine metabolic process

neuron maturation

positive regulation of catalytic activity

negative regulation of neuron apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

regulation of respiratory gaseous exchange

fat cell differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

protein heterodimerization activity

general adaptation syndrome

cellular response to corticotropin-releasing hormone stimulus

cellular response to corticotropin-releasing hormone stimulus

dopaminergic neuron differentiation

dopaminergic neuron differentiation

dopaminergic neuron differentiation

sequence-specific double-stranded DNA binding

negative regulation of apoptotic signaling pathway

 
TC0600003139.mm.2 Tapbpl TAP binding protein-like 6 -125224211 NM_145391, BC017613 NM_145391, BC017613 5

immune system process

peptide antigen assembly with MHC class I protein complex

negative regulation of antigen processing and presentation of peptide antigen via MHC class I

endoplasmic reticulum

Golgi apparatus

plasma membrane

membrane

integral component of membrane

MHC class I protein complex binding

intracellular membrane-bounded organelle

 
TC0200000551.mm.2         NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556 NM_007494, NR_002687, BC002074, BC087556  

urea cycle

urea cycle

citrulline metabolic process

argininosuccinate metabolic process

argininosuccinate metabolic process

nucleotide binding

argininosuccinate synthase activity

argininosuccinate synthase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrial outer membrane

lysosome

endoplasmic reticulum

cytosol

arginine biosynthetic process

arginine biosynthetic process

aspartate metabolic process

circadian rhythm

circadian rhythm

cellular amino acid biosynthetic process

response to zinc ion

response to mycotoxin

toxic substance binding

amino acid binding

ligase activity

identical protein binding

neuron projection

neuronal cell body

perikaryon

myelin sheath

positive regulation of nitric oxide biosynthetic process

response to glucocorticoid

cell body fiber

cellular response to laminar fluid shear stress

negative regulation of leukocyte cell-cell adhesion

 
TC0600001369.mm.2 Usp18 ubiquitin specific peptidase 18 6 121245905 NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 NM_011909, BC138562, BC138577 69

cysteine-type endopeptidase activity

thiol-dependent ubiquitin-specific protease activity

protein binding

nucleus

nucleus

cytosol

cytosol

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

response to bacterium

protein deubiquitination

hydrolase activity

ISG15-specific protease activity

response to stilbenoid

intracellular membrane-bounded organelle

regulation of inflammatory response

 
TC1100004265.mm.2 Igtp interferon gamma induced GTPase 11 58199555 NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 NM_018738, BC132557, BC138607 50

GTPase activity

GTPase activity

endoplasmic reticulum membrane

cytosol

defense response

cellular response to interferon-beta

cellular response to interferon-beta

05145

TC0800001984.mm.2 Nrg1 neuregulin 1 8 -31814550, -31820775, -31814550, -31820775, -31837204, -31837204 NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344 NM_178591, BC151113, BC160344 368

MAPK cascade

cell morphogenesis

startle response

cardiac conduction system development

transcription coregulator activity

signaling receptor binding

ErbB-2 class receptor binding

ErbB-2 class receptor binding

protein binding

extracellular region

extracellular space

nucleus

cytoplasm

plasma membrane

integral component of plasma membrane

activation of transmembrane receptor protein tyrosine kinase activity

nervous system development

nervous system development

synapse assembly

synapse assembly

brain development

peripheral nervous system development

heart development

muscle organ development

locomotory behavior

axon ensheathment

external side of plasma membrane

glial cell differentiation

positive regulation of gene expression

positive regulation of phosphatidylinositol 3-kinase signaling

cell migration

glial cell fate commitment

chemorepulsion involved in interneuron migration from the subpallium to the cortex

neurogenesis

neurogenesis

myelination in peripheral nervous system

cell differentiation

protein tyrosine kinase activator activity

axon

dendrite

axolemma

receptor tyrosine kinase binding

neuromuscular junction

positive regulation of myelination

intracellular signal transduction

negative regulation of protein catabolic process

cellular protein complex disassembly

cell body

synapse

neurotransmitter receptor metabolic process

chemorepellent activity

chemorepellent activity

regulation of cell differentiation

positive regulation of axon extension

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of Ras protein signal transduction

animal organ development

neuron fate commitment

oligodendrocyte differentiation

cardiac muscle tissue development

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of striated muscle cell differentiation

positive regulation of protein kinase B signaling

cardiac muscle cell differentiation

positive regulation of dendritic spine development

positive regulation of calcineurin-NFAT signaling cascade

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

GABA-ergic synapse

postsynapse to nucleus signaling pathway

postsynapse to nucleus signaling pathway

positive regulation of protein localization to cell surface

positive regulation of cardiac muscle cell differentiation

negative regulation of neuron migration

04012

TC1400002160.mm.2 Phf11 PHD finger protein 11 14   NM_001164329 3    
TC0300001232.mm.2 Cnn3 calponin 3, acidic 3 121426540 NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 NM_028044, BC055711, BC085268 43

actin binding

protein binding

calmodulin binding

cytosol

microtubule binding

postsynaptic density

actin cytoskeleton

dendrite

actomyosin structure organization

negative regulation of ATPase activity

neuronal cell body

dendritic spine

 
TC1400001432.mm.2 Dnase1l3 deoxyribonuclease 1-like 3 14 -7965189 NM_007870, BC012671 NM_007870, BC012671 25

DNA catabolic process, endonucleolytic

DNA catabolic process, endonucleolytic

neutrophil activation involved in immune response

regulation of acute inflammatory response

DNA binding

DNA binding

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

deoxyribonuclease I activity

deoxyribonuclease activity

extracellular region

nucleus

nucleus

nucleus

endoplasmic reticulum

DNA catabolic process

apoptotic DNA fragmentation

apoptotic DNA fragmentation

apoptotic DNA fragmentation

apoptotic process

programmed cell death involved in cell development

programmed cell death involved in cell development

programmed cell death

hydrolase activity

regulation of neutrophil mediated cytotoxicity

 
TC0900003250.mm.2 Csrnp1 cysteine-serine-rich nuclear protein 1 9 -119971162, -119971162, -119971162, -119971162 NM_153287, BC050066 NM_153287, BC050066 24

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

post-embryonic development

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

platelet-derived growth factor receptor signaling pathway

skeletal system morphogenesis

roof of mouth development

face morphogenesis

 
TC0400004171.mm.2 Isg15 ISG15 ubiquitin-like modifier 4 -156199423 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 NM_015783, BC031424, BC083156, BC109346 94

integrin binding

protein binding

extracellular region

nucleus

cytoplasm

integrin-mediated signaling pathway

response to bacterium

modification-dependent protein catabolic process

modification-dependent protein catabolic process

cytosolic small ribosomal subunit

positive regulation of bone mineralization

protein tag

protein tag

negative regulation of protein ubiquitination

ubiquitin protein ligase binding

ISG15-protein conjugation

ISG15-protein conjugation

ISG15-protein conjugation

interferon-gamma production

interleukin-10 production

regulation of interferon-gamma production

response to type I interferon

defense response to bacterium

defense response to bacterium

negative regulation of viral genome replication

positive regulation of erythrocyte differentiation

defense response to virus

defense response to virus

04622

TC1300000624.mm.2 Hrh2 histamine receptor H2 13 54192128, 54192132 NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 NM_001010973, NM_008286, BC165958 62

gastric acid secretion

histamine-induced gastric acid secretion

gastrin-induced gastric acid secretion

epithelial cell morphogenesis

G protein-coupled receptor activity

histamine receptor activity

G protein-coupled serotonin receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

chemical synaptic transmission

memory

visual learning

membrane

integral component of membrane

dendrite

neurotransmitter receptor activity

positive regulation of vasoconstriction

regulation of synaptic plasticity

digestive tract development

gland development

negative regulation of arachidonic acid secretion

heterocyclic compound binding

toxin transport

04020

04080

04971

TC0200002223.mm.2 Cst7 cystatin F (leukocystatin) 2 150570414 NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 NM_009977, BC117047, BC117049 25

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

lysosome

lysosome

lysosome

endosome

late endosome

late endosome

multivesicular body

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

Golgi apparatus

negative regulation of peptidase activity

negative regulation of peptidase activity

peptidase inhibitor activity

peptidase inhibitor activity

cytoplasmic vesicle

cytoplasmic vesicle

positive regulation of myelination

positive regulation of myelination

protein homodimerization activity

inhibition of cysteine-type endopeptidase activity

inhibition of cysteine-type endopeptidase activity

negative regulation of microglial cell activation

negative regulation of microglial cell activation

 
TC0200001729.mm.2 Thbs1 thrombospondin 1 2 118111875 NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 NM_011580, BC042422, BC050917 301

activation of MAPK activity

phosphatidylserine binding

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

negative regulation of cell-matrix adhesion

fibronectin binding

sprouting angiogenesis

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of dendritic cell antigen processing and presentation

outflow tract morphogenesis

endocardial cushion development

growth plate cartilage development

growth plate cartilage development

integrin binding

extracellular matrix structural constituent

calcium ion binding

protein binding

extracellular region

fibrinogen complex

extracellular space

extracellular space

extracellular space

cytoplasm

endoplasmic reticulum

inflammatory response

inflammatory response

response to unfolded protein

cell cycle arrest

cell adhesion

heparin binding

positive regulation of cell population proliferation

response to mechanical stimulus

response to glucose

external side of plasma membrane

cell surface

positive regulation of endothelial cell migration

negative regulation of endothelial cell migration

negative regulation of long-chain fatty acid import across plasma membrane

negative regulation of nitric oxide mediated signal transduction

negative regulation of cGMP-mediated signaling

negative regulation of plasminogen activation

positive regulation of macrophage chemotaxis

positive regulation of fibroblast migration

positive regulation of cell-substrate adhesion

cell migration

negative regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of angiogenesis

sarcoplasmic reticulum

fibroblast growth factor binding

peptide cross-linking

secretory granule

low-density lipoprotein particle binding

positive regulation of blood coagulation

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

extracellular matrix

platelet alpha granule

response to magnesium ion

negative regulation of interleukin-12 production

positive regulation of tumor necrosis factor production

response to endoplasmic reticulum stress

negative regulation of fibroblast growth factor receptor signaling pathway

positive regulation of phosphorylation

positive regulation of macrophage activation

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

laminin binding

positive regulation of blood vessel endothelial cell migration

negative regulation of blood vessel endothelial cell migration

engulfment of apoptotic cell

positive regulation of translation

positive regulation of angiogenesis

behavioral response to pain

blood vessel morphogenesis

positive regulation of smooth muscle cell proliferation

transforming growth factor beta binding

extracellular matrix binding

positive regulation of chemotaxis

response to calcium ion

positive regulation of protein kinase B signaling

negative regulation of fibrinolysis

collagen-containing extracellular matrix

collagen-containing extracellular matrix

fibrinogen binding

collagen V binding

monocyte aggregation

positive regulation of transforming growth factor beta production

cellular response to nitric oxide

negative regulation of cell migration involved in sprouting angiogenesis

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of sprouting angiogenesis

positive regulation of endothelial cell apoptotic process

positive regulation of reactive oxygen species metabolic process

negative regulation of endothelial cell chemotaxis

04115

04145

04350

04510

04512

05144

05219

TC0200000933.mm.2 Gca grancalcin 2 62664326 NM_145523, BC021450 NM_145523, BC021450 17

calcium ion binding

cytoplasm

cytosol

cytosol

plasma membrane

membrane

protein homodimerization activity

metal ion binding

protein heterodimerization activity

 
TC0500000468.mm.2 Cd38 CD38 antigen 5 43868808 NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 NM_007646, BC046312, CD38 193

response to hypoxia

NAD+ nucleosidase activity

NAD+ nucleosidase activity

nucleus

plasma membrane

plasma membrane

positive regulation of cytosolic calcium ion concentration

positive regulation of cell population proliferation

response to hormone

cell surface

negative regulation of neuron projection development

artery smooth muscle contraction

membrane

integral component of membrane

basolateral plasma membrane

transferase activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds

phosphorus-oxygen lyase activity

phosphorus-oxygen lyase activity

positive regulation of cell growth

secretory granule membrane

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of insulin secretion

response to hydroperoxide

response to drug

identical protein binding

negative regulation of apoptotic process

intracellular membrane-bounded organelle

negative regulation of bone resorption

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of vasoconstriction

NAD(P)+ nucleosidase activity

B cell receptor signaling pathway

long-term synaptic depression

NAD+ nucleotidase, cyclic ADP-ribose generating

00760

01100

04020

04640

04970

04972

TC1600001580.mm.2 Cd86 CD86 antigen 16 -36603868 NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 NM_019388, BC013807, CD86 335

toll-like receptor signaling pathway

adaptive immune response

immune system process

immunoglobulin production

negative regulation of T cell anergy

signaling receptor binding

protein binding

plasma membrane

immune response

cell surface receptor signaling pathway

activation of phospholipase C activity

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

CD40 signaling pathway

T cell costimulation

toll-like receptor 3 signaling pathway

centriolar satellite

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of activated T cell proliferation

B cell activation

negative regulation of T cell proliferation

intracellular membrane-bounded organelle

defense response to virus

extracellular exosome

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

positive regulation of NIK/NF-kappaB signaling

activation of protein kinase C activity

04514

04620

04672

04940

05320

05322

05323

05330

05332

05416

TC0600000459.mm.2 Zyx zyxin 6 42349827, 42349827 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 NM_001289617, NM_001289618, NM_001289619, NM_011777, BC054775 63

stress fiber

stress fiber

protein binding

nucleus

cytoplasm

cytosol

cytoskeleton

plasma membrane

adherens junction

focal adhesion

focal adhesion

focal adhesion

cell adhesion

cell-matrix adhesion

signal transduction

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

actin cytoskeleton

cell junction

stress fiber assembly

phagocytic vesicle

metal ion binding

cellular response to interferon-gamma

04510

TC0400001047.mm.2 Pde4b phosphodiesterase 4B, cAMP specific 4 102589842, 102254938, 102254741, 102570059, 102587557, 102421554 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 NM_001177980, NM_001177981, NM_001177982, NM_001177983, NM_019840, BC071259 65

gamma-tubulin complex

neutrophil homeostasis

3',5'-cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

protein binding

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytosol

cytosol

voltage-gated calcium channel complex

signal transduction

synaptic vesicle

response to heat

postsynaptic density

membrane

Z disc

cAMP binding

neutrophil chemotaxis

positive regulation of interferon-gamma production

positive regulation of interleukin-2 production

cellular response to drug

gamma-tubulin binding

dendritic spine

ion channel binding

ion channel binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

T cell receptor signaling pathway

leukocyte migration

excitatory synapse

cellular response to lipopolysaccharide

cellular response to epinephrine stimulus

cell periphery

regulation of cardiac muscle cell contraction

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

regulation of high voltage-gated calcium channel activity

negative regulation of relaxation of cardiac muscle

00230

TC0700004287.mm.2 Il27 interleukin 27 7 -126589008 NM_145636, BC119402 NM_145636, BC119402 199

positive regulation of defense response to virus by host

positive regulation of defense response to virus by host

immune system process

signaling receptor binding

cytokine activity

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

cytosol

inflammatory response

positive regulation of interferon-gamma production

regulation of T cell proliferation

regulation of T cell proliferation

innate immune response

interleukin-27 receptor binding

interleukin-27 receptor binding

regulation of T-helper 1 cell differentiation

regulation of T-helper 1 cell differentiation

 
TC1100001222.mm.2 Ccl12 chemokine (C-C motif) ligand 12 11 82101844 NM_011331, BC027520 NM_011331, BC027520 33

MAPK cascade

angiogenesis

monocyte chemotaxis

monocyte chemotaxis

monocyte chemotaxis

positive regulation of leukocyte migration

cytokine activity

extracellular region

extracellular space

chemotaxis

inflammatory response

inflammatory response

inflammatory response

immune response

cytoskeleton organization

G protein-coupled receptor signaling pathway

chemokine activity

regulation of cell shape

cytokine-mediated signaling pathway

neutrophil chemotaxis

lipopolysaccharide-mediated signaling pathway

CCR2 chemokine receptor binding

negative regulation of glial cell apoptotic process

protein kinase B signaling

negative regulation of neuron apoptotic process

positive regulation of GTPase activity

astrocyte cell migration

CCR chemokine receptor binding

eosinophil chemotaxis

macrophage chemotaxis

lymphocyte chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

negative regulation of leukocyte proliferation

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to organic cyclic compound

positive regulation of calcium ion import

negative regulation of vascular endothelial cell proliferation

negative regulation of G1/S transition of mitotic cell cycle

positive regulation of endothelial cell apoptotic process

negative regulation of natural killer cell chemotaxis

04060

04062

TC1700001952.mm.2 Aif1 allograft inflammatory factor 1 17 -35170985 NM_019467, BC021539 NM_019467, BC021539 177

ruffle

microglial cell activation

phagocytic cup

positive regulation of protein phosphorylation

actin binding

calcium ion binding

calcium ion binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

actin filament

actin filament

actin filament

plasma membrane

phagocytosis, engulfment

positive regulation of cell population proliferation

negative regulation of gene expression

positive regulation of muscle hyperplasia

membrane

Rac protein signal transduction

lamellipodium

lamellipodium

actin filament polymerization

parallel actin filament bundle assembly

positive regulation of cell migration

ruffle membrane

ruffle membrane

ruffle membrane

positive regulation of chemokine production

positive regulation of interleukin-6 production

cellular response to oxidative stress

positive regulation of T cell proliferation

cell projection

negative regulation of apoptotic process

perikaryon

positive regulation of nitric oxide biosynthetic process

metal ion binding

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

negative regulation of smooth muscle cell proliferation

positive regulation of chemotaxis

actin filament binding

actin filament binding

actin filament binding

actin filament bundle assembly

actin filament bundle assembly

actin filament bundle assembly

actin crosslink formation

negative regulation of smooth muscle cell chemotaxis

positive regulation of smooth muscle cell chemotaxis

positive regulation of mononuclear cell migration

positive regulation of monocyte chemotaxis

positive regulation of fibroblast growth factor production

ruffle assembly

ruffle assembly

ruffle assembly

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of T cell migration

 
TC1700000621.mm.2 Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 17 34187555 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 NM_001161730, NM_013683, BC013802, BC024897 256

nucleotide binding

adaptive immune response

immune system process

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

ATP binding

mitochondrion

endoplasmic reticulum

defense response

protein transport

ABC-type peptide antigen transporter activity

ABC-type peptide antigen transporter activity

ABC-type peptide antigen transporter activity

ABC-type peptide transporter activity

peptide transport

peptide transport

membrane

integral component of membrane

integral component of membrane

ATPase activity

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I

MHC class Ib protein binding

integral component of endoplasmic reticulum membrane

phagocytic vesicle membrane

centriolar satellite

protection from natural killer cell mediated cytotoxicity

MHC protein binding

MHC class I protein binding

MHC class I protein binding

peptide antigen binding

ATPase-coupled transmembrane transporter activity

protein homodimerization activity

MHC class I peptide loading complex

MHC class I peptide loading complex

TAP complex

intracellular membrane-bounded organelle

ADP binding

protein-containing complex binding

cytosol to endoplasmic reticulum transport

TAP1 binding

TAP1 binding

TAP2 binding

tapasin binding

transmembrane transport

peptide transmembrane transporter activity

02010

04145

04612

05340

TC0400001510.mm.2 Rnf19b ring finger protein 19B 4 129058143 NM_029219 19

ubiquitin ligase complex

protein polyubiquitination

adaptive immune response

immune system process

ubiquitin-protein transferase activity

cytoplasm

endoplasmic reticulum

cytosol

ubiquitin-dependent protein catabolic process

membrane

integral component of membrane

protein ubiquitination

transferase activity

ubiquitin conjugating enzyme binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

interferon-gamma production

natural killer cell mediated cytotoxicity

ubiquitin binding

cytolytic granule

cytolytic granule

metal ion binding

protein autoubiquitination

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
TC1700002780.mm.2 H2-DMb1 histocompatibility 2, class II, locus Mb1 17 34153190 NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 NM_010387, BC002237, BC003718 23

adaptive immune response

immune system process

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

lysosome

lysosomal membrane

endosome

immune response

membrane

integral component of membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

late endosome membrane

MHC class II protein complex

intracellular membrane-bounded organelle

chaperone cofactor-dependent protein refolding

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC0500001239.mm.2 Oasl2 2'-5' oligoadenylate synthetase-like 2 5 114896933 NM_011854, BC034361 NM_011854, BC034361 21

nucleotide binding

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleoplasm

cytosol

purine nucleotide biosynthetic process

immune response

response to virus

membrane

transferase activity

nucleotidyltransferase activity

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

regulation of ribonuclease activity

 
TC0700002644.mm.2 Axl AXL receptor tyrosine kinase 7 -25756499 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 NM_001190974, NM_001190975, NM_009465, BC046618, BC050914, BC058230 152

nucleotide binding

virus receptor activity

neuron migration

neuron migration

natural killer cell differentiation

natural killer cell differentiation

phosphatidylserine binding

negative regulation of cytokine production

positive regulation of cytokine-mediated signaling pathway

blood vessel remodeling

immune system process

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

protein binding

ATP binding

extracellular space

plasma membrane

integral component of plasma membrane

protein phosphorylation

phagocytosis

phagocytosis

phagocytosis

inflammatory response

enzyme linked receptor protein signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organism development

spermatogenesis

nervous system development

cell surface

actin cytoskeleton

membrane

integral component of membrane

kinase activity

phosphorylation

cell migration

transferase activity

forebrain cell migration

cell differentiation

platelet activation

platelet activation

cellular response to extracellular stimulus

myosin heavy chain binding

negative regulation of interferon-gamma production

negative regulation of tumor necrosis factor production

positive regulation of natural killer cell differentiation

secretion by cell

positive regulation of kinase activity

erythrocyte homeostasis

erythrocyte homeostasis

substrate adhesion-dependent cell spreading

cellular response to interferon-alpha

ovulation cycle

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

receptor complex

apoptotic cell clearance

apoptotic cell clearance

protein kinase B signaling

protein kinase B signaling

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

phosphatidylinositol 3-kinase binding

innate immune response

viral entry into host cell

positive regulation of pinocytosis

negative regulation of lymphocyte activation

positive regulation of protein kinase B signaling

positive regulation of protein kinase B signaling

vagina development

cellular response to hydrogen peroxide

cellular response to lipopolysaccharide

neutrophil clearance

positive regulation of viral life cycle

negative regulation of dendritic cell apoptotic process

 
TC0300001937.mm.2 Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 3 -50364935 NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 NM_011990, BC141402, BC141408 91

amino acid transmembrane transport

rough endoplasmic reticulum

cytoskeleton

plasma membrane

plasma membrane

glutathione metabolic process

amino acid transport

brain development

visual learning

response to toxic substance

cell surface

response to organic cyclic compound

L-amino acid transmembrane transporter activity

membrane

integral component of membrane

ventricular system development

striatum development

transmembrane transporter activity

adult behavior

brush border membrane

regulation of neutrophil apoptotic process

cellular response to stress

cellular response to oxidative stress

glutathione transmembrane transport

regulation of cell population proliferation

intracellular membrane-bounded organelle

apical part of cell

regulation of melanin biosynthetic process

lung alveolus development

modulation of chemical synaptic transmission

regulation of synapse organization

regulation of protein transport

response to redox state

transmembrane transport

limb development

platelet aggregation

organic substance transport

glutamate homeostasis

glutamate homeostasis

astrocyte projection

L-glutamate import across plasma membrane

dipeptide import across plasma membrane

regulation of cellular response to oxidative stress

regulation of cysteine metabolic process

negative regulation of oxidative stress-induced neuron death

negative regulation of oxidative stress-induced neuron death

regulation of glutathione biosynthetic process

regulation of AMPA glutamate receptor clustering

regulation of glutamate metabolic process

 
TC0500003297.mm.2 Stx2 syntaxin 2 5 -128984557, -128984557 NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 NM_001286033, NM_001286034, NM_007941, BC046279 51

SNARE binding

SNARE binding

mitotic cytokinesis

structural molecule activity

SNAP receptor activity

protein binding

extracellular space

plasma membrane

plasma membrane

cell-cell junction

intracellular protein transport

exocytosis

vesicle fusion

acrosome reaction

embryo implantation

synaptic vesicle

cell surface

endomembrane system

membrane

integral component of membrane

vesicle-mediated transport

basolateral plasma membrane

lamellipodium

microvillus assembly

transport vesicle

cell differentiation

midbody

epithelial cell differentiation

SNARE complex

cytoplasmic vesicle

synaptic vesicle fusion to presynaptic active zone membrane

protein-containing complex

cellular response to oxidative stress

identical protein binding

membrane raft

synapse

vesicle docking

calcium-dependent protein binding

digestive tract morphogenesis

presynaptic active zone membrane

midbody abscission

cornified envelope assembly

04130

TC1700002823.mm.2 H2-T10 histocompatibility 2, T region locus 10 17 -36115875, -36115870 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 NM_010395, NR_046286, BC021751, BC021760 23

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

extracellular space

immune response

external side of plasma membrane

peptide antigen binding

04144

04145

04514

04612

04940

05320

05330

05332

05416

TC0300001445.mm.2 Gbp7 guanylate binding protein 7 3 142530335 NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 NM_001083312, NM_145545, BC010229 15

GTPase activity

GTP binding

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

defense response to protozoan

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC1400002744.mm.2 Gpr18 G protein-coupled receptor 18 14 -121911433 NM_182806, BC034872 NM_182806, BC034872 23

CD8-positive, alpha-beta intraepithelial T cell differentiation

CD8-positive, alpha-beta intraepithelial T cell differentiation

CD8-positive, gamma-delta intraepithelial T cell differentiation

CD8-positive, gamma-delta intraepithelial T cell differentiation

negative regulation of leukocyte chemotaxis

G protein-coupled receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

cytoplasmic vesicle

negative regulation of tumor necrosis factor production

positive regulation of Rho protein signal transduction

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

 
TC1000002794.mm.2 Tmtc2 transmembrane and tetratricopeptide repeat containing 2 10 -105187663 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 NM_177368, BC092226, BC138362, BC138363 12

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

membrane

integral component of membrane

transferase activity

protein O-linked mannosylation

calcium ion homeostasis

 
TC0600003169.mm.2 Ccnd2 cyclin D2 6 -127125708 NM_009829, BC049086 NM_009829, BC049086 357

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

chromatin

positive regulation of protein phosphorylation

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytosol

cell cycle

long-term memory

positive regulation of cell population proliferation

adult locomotory behavior

membrane

cyclin-dependent protein serine/threonine kinase regulator activity

protein kinase binding

nuclear membrane

negative regulation of apoptotic process

mitotic cell cycle phase transition

positive regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of epithelial cell proliferation

cell division

regulation of cell cycle

cellular response to X-ray

cyclin D2-CDK4 complex

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of G1/S transition of mitotic cell cycle

04110

04115

04310

04510

04630

TC1700001902.mm.2 Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 17 -34182098 NM_013585, BC116364 NM_013585, BC116364 91

proteasome complex

immune system process

endopeptidase activity

threonine-type endopeptidase activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

proteasome core complex

proteasome core complex

proteolysis

peptidase activity

response to bacterium

proteasomal ubiquitin-independent protein catabolic process

hydrolase activity

antigen processing and presentation

antigen processing and presentation

proteasome-mediated ubiquitin-dependent protein catabolic process

proteolysis involved in cellular protein catabolic process

proteasome binding

spermatoproteasome complex

regulation of cysteine-type endopeptidase activity

03050

TC1900001253.mm.2 Gda guanine deaminase 19 -21391306 NM_010266, BC076583 NM_010266, BC076583 33

protein binding

cytosol

cytosol

guanine catabolic process

zinc ion binding

guanine deaminase activity

guanine deaminase activity

guanine deaminase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

deaminase activity

positive regulation of microtubule polymerization

GMP catabolic process

dGMP catabolic process

guanine metabolic process

metal ion binding

00230

01100

TC0200000740.mm.2 Kynu kynureninase 2 43555324, 43555324, 43555324 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 NM_001289593, NM_001289594, NM_027552, BC026950, BC069848 13

catalytic activity

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

cytosol

tryptophan catabolic process

NAD biosynthetic process

hydrolase activity

pyridine nucleotide biosynthetic process

tryptophan catabolic process to kynurenine

tryptophan catabolic process to acetyl-CoA

quinolinate biosynthetic process

pyridoxal phosphate binding

kynureninase activity

kynureninase activity

response to interferon-gamma

response to vitamin B6

protein homodimerization activity

anthranilate metabolic process

anthranilate metabolic process

3-hydroxykynureninase activity

00380

01100

TC1800000924.mm.2 Crem cAMP responsive element modulator 18 -3294165, -3266353, -3266353, -3266353, -3266353, -3266353 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 NM_001110850, NM_001110851, NM_001110852, NM_001110853, NM_001110854, NM_001110855, NM_001110856, NM_001110857, NM_001110858, NM_001110859, NM_001271503, NM_001271504, NM_001271505, NM_001271506, NM_013498, NR_073193 153

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

transcription regulator complex

transcription regulator complex

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

glycosphingolipid metabolic process

spermatogenesis

spermatogenesis

circadian rhythm

circadian regulation of gene expression

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

rhythmic process

response to cAMP

ATF4-CREB1 transcription factor complex

sequence-specific double-stranded DNA binding

 
TC1900000439.mm.2 Jak2 Janus kinase 2 19 29251802 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 NM_001048177, NM_008413, BC054807, BC059834 481

nucleotide binding

activation of MAPKK activity

euchromatin

microglial cell activation

adaptive immune response

immune system process

protein kinase activity

protein kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

growth hormone receptor binding

growth hormone receptor binding

interleukin-12 receptor binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytosol

cytosol

cytoskeleton

plasma membrane

caveola

focal adhesion

chromatin organization

protein phosphorylation

activation of cysteine-type endopeptidase activity involved in apoptotic process

response to oxidative stress

signal transduction

enzyme linked receptor protein signaling pathway

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

tyrosine phosphorylation of STAT protein

tyrosine phosphorylation of STAT protein

tyrosine phosphorylation of STAT protein

tyrosine phosphorylation of STAT protein

protein C-terminus binding

positive regulation of cell population proliferation

negative regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to oxidative stress

hormone-mediated signaling pathway

negative regulation of cardiac muscle cell apoptotic process

positive regulation of cell-substrate adhesion

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein kinase binding

heme binding

negative regulation of cell-cell adhesion

myeloid cell differentiation

cell differentiation

erythrocyte differentiation

erythrocyte differentiation

positive regulation of cell migration

axon regeneration

type 1 angiotensin receptor binding

mineralocorticoid receptor signaling pathway

positive regulation of insulin secretion

response to lipopolysaccharide

positive regulation of phosphoprotein phosphatase activity

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

acetylcholine receptor binding

response to hydroperoxide

tumor necrosis factor-mediated signaling pathway

programmed cell death induced by symbiont

response to tumor necrosis factor

post-embryonic hemopoiesis

histone kinase activity (H3-Y41 specific)

histone kinase activity (H3-Y41 specific)

histone H3-Y41 phosphorylation

histone H3-Y41 phosphorylation

intracellular signal transduction

interleukin-12-mediated signaling pathway

cellular response to interleukin-3

SH2 domain binding

positive regulation of protein import into nucleus

histone binding

positive regulation of tyrosine phosphorylation of STAT protein

identical protein binding

activation of Janus kinase activity

regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of DNA binding

negative regulation of DNA binding

negative regulation of neuron apoptotic process

phosphatidylinositol 3-kinase binding

insulin receptor substrate binding

innate immune response

membrane raft

positive regulation of MHC class II biosynthetic process

regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide biosynthetic process

positive regulation of cell differentiation

negative regulation of heart contraction

positive regulation of transcription by RNA polymerase II

response to antibiotic

protein autophosphorylation

protein autophosphorylation

metal ion binding

platelet-derived growth factor receptor signaling pathway

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

modulation of chemical synaptic transmission

positive regulation of cell activation

positive regulation of DNA-binding transcription factor activity

peptide hormone receptor binding

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of nitric-oxide synthase biosynthetic process

interferon-gamma-mediated signaling pathway

positive regulation of SMAD protein signal transduction

growth hormone receptor signaling pathway

growth hormone receptor signaling pathway via JAK-STAT

growth hormone receptor signaling pathway via JAK-STAT

growth hormone receptor signaling pathway via JAK-STAT

positive regulation of growth hormone receptor signaling pathway

negative regulation of cell death

mammary gland epithelium development

response to interleukin-12

cellular response to lipopolysaccharide

cellular response to dexamethasone stimulus

response to granulocyte macrophage colony-stimulating factor

extrinsic apoptotic signaling pathway

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

postsynapse

glutamatergic synapse

postsynapse to nucleus signaling pathway

positive regulation of cold-induced thermogenesis

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

positive regulation of epithelial cell apoptotic process

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of signaling receptor activity

positive regulation of apoptotic signaling pathway

04062

04630

04920

05140

05145

TC1000001813.mm.2 Tnfaip3 tumor necrosis factor, alpha-induced protein 3 10 -19000909, -19000909 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 NM_001166402, NM_009397, BC054806, BC060221 188

B-1 B cell homeostasis

protease binding

response to molecule of bacterial origin

response to molecule of bacterial origin

marginal zone B cell differentiation

negative regulation of granuloma formation

regulation of germinal center formation

regulation of immunoglobulin production

negative regulation of chronic inflammatory response

DNA binding

catalytic activity

ubiquitin-protein transferase activity

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

lysosome

proteolysis

apoptotic process

inflammatory response

cytoskeleton organization

protein C-terminus binding

metabolic process

peptidase activity

cysteine-type peptidase activity

zinc ion binding

response to wounding

negative regulation of autophagy

cell migration

protein ubiquitination

protein deubiquitination

transferase activity

hydrolase activity

kinase binding

positive regulation of Wnt signaling pathway

negative regulation of protein ubiquitination

negative regulation of NF-kappaB transcription factor activity

response to muramyl dipeptide

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 beta production

negative regulation of interleukin-2 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

negative regulation of heterotypic cell-cell adhesion

negative regulation of toll-like receptor 3 signaling pathway

negative regulation of toll-like receptor 5 signaling pathway

protein K29-linked deubiquitination

protein K11-linked deubiquitination

identical protein binding

negative regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of I-kappaB kinase/NF-kappaB signaling

ubiquitin binding

protein self-association

regulation of innate immune response

positive regulation of protein catabolic process

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of innate immune response

metal ion binding

negative regulation of smooth muscle cell proliferation

negative regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of B cell activation

negative regulation of cell death

Lys63-specific deubiquitinase activity

cellular response to hydrogen peroxide

negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

K63-linked polyubiquitin modification-dependent protein binding

protein K63-linked deubiquitination

protein K63-linked deubiquitination

protein K48-linked ubiquitination

protein K48-linked deubiquitination

cellular response to lipopolysaccharide

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

tolerance induction to lipopolysaccharide

establishment of protein localization to vacuole

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cellular protein catabolic process

protein K33-linked deubiquitination

positive regulation of hepatocyte proliferation

negative regulation of CD40 signaling pathway

negative regulation of endothelial cell apoptotic process

04621

TC0800002330.mm.2 Tma16 translation machinery associated 16 8 -66476342 NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 NM_025465, BC016246, BC034844 15

molecular_function

nucleus

nucleoplasm

nucleolus

biological_process

 
TC0900000184.mm.2 Icam1 intercellular adhesion molecule 1 9 21015939 NM_010493, BC008626 NM_010493, BC008626 567

immunological synapse

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

acute inflammatory response to antigenic stimulus

T cell antigen processing and presentation

positive regulation of cellular extravasation

integrin binding

integrin binding

extracellular space

plasma membrane

integral component of plasma membrane

cell adhesion

cell adhesion

cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

sensory perception of sound

regulation of cell shape

external side of plasma membrane

cell surface

membrane

integral component of membrane

positive regulation of actin filament polymerization

cell adhesion mediated by integrin

positive regulation of GTPase activity

adhesion of symbiont to host

protein-containing complex binding

membrane raft

positive regulation of nitric oxide biosynthetic process

positive regulation of vasoconstriction

receptor-mediated virion attachment to host cell

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of NF-kappaB transcription factor activity

negative regulation of calcium ion transport

establishment of endothelial barrier

extracellular exosome

positive regulation of ERK1 and ERK2 cascade

cellular response to glucose stimulus

T cell extravasation

establishment of endothelial intestinal barrier

establishment of Sertoli cell barrier

cell-cell adhesion

regulation of ruffle assembly

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

cellular response to amyloid-beta

positive regulation of leukocyte adhesion to vascular endothelial cell

cellular response to leukemia inhibitory factor

negative regulation of endothelial cell apoptotic process

04514

04650

04670

05143

05144

05150

05323

05416

TC0200005290.mm.2 Zbp1 Z-DNA binding protein 1 2 -173206611, -173213735 NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 NM_001139519, NM_021394, BC020033 62

activation of innate immune response

immune system process

DNA binding

DNA binding

DNA binding

left-handed Z-DNA binding

RNA binding

double-stranded RNA binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

apoptotic process

programmed cell death

viral process

identical protein binding

positive regulation of apoptotic process

positive regulation of apoptotic process

innate immune response

regulation of inflammatory response

positive regulation of inflammatory response

defense response to virus

defense response to virus

defense response to virus

positive regulation of type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

positive regulation of necroptotic process

positive regulation of necroptotic process

positive regulation of necroptotic process

pyroptosis

regulation of interleukin-1-mediated signaling pathway

04623

TC0500000627.mm.2 Rhoh ras homolog family member H 5 65861219, 65863583 NM_001081105, BC094937 NM_001081105, BC094937 32

nucleotide binding

immunological synapse

GTPase activity

protein binding

GTP binding

GTP binding

intracellular anatomical structure

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

cell cortex

actin filament organization

establishment or maintenance of cell polarity

small GTPase mediated signal transduction

motor neuron axon guidance

regulation of cell shape

membrane

Rac protein signal transduction

kinase inhibitor activity

protein kinase binding

cell projection assembly

T cell differentiation

cortical cytoskeleton organization

cytoplasmic vesicle

regulation of actin cytoskeleton organization

cell projection

negative regulation of I-kappaB kinase/NF-kappaB signaling

intracellular membrane-bounded organelle

engulfment of apoptotic cell

mast cell activation

positive regulation of T cell differentiation

regulation of neutrophil migration

04670

TC0800001451.mm.2 Irf8 interferon regulatory factor 8 8 120736357, 120738638 NM_008320, BC005450 NM_008320, BC005450 289

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

plasmacytoid dendritic cell differentiation

immune system process

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

phagocytosis

autophagy

immune response

response to bacterium

myeloid cell differentiation

regulation of type I interferon production

positive regulation of interferon-gamma production

positive regulation of interleukin-12 production

defense response to bacterium

defense response to protozoan

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription initiation from RNA polymerase II promoter

cellular response to lipopolysaccharide

cellular response to interferon-gamma

dendritic cell differentiation

sequence-specific double-stranded DNA binding

 
TC1100002641.mm.2 Irgm1 immunity-related GTPase family M member 1 11 -48865244 NM_008326, BC145957 NM_008326, BC145957 77

autophagosome assembly

nucleotide binding

immune system process

GTPase activity

GTP binding

lysosome

endosome

late endosome

autophagosome

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

plasma membrane

autophagy

defense response

defense response

response to bacterium

membrane

hydrolase activity

cytoplasmic vesicle

cellular response to interferon-beta

cell projection

autolysosome

innate immune response

phagocytic vesicle

positive regulation of interferon-gamma-mediated signaling pathway

cellular response to interferon-gamma

positive regulation by symbiont of host autophagy

positive regulation of autophagosome maturation

 
TC0200003574.mm.2 Cytip cytohesin 1 interacting protein 2 -58129138 NM_139200, BC007144 NM_139200, BC007144 22

nucleoplasm

cytoplasm

endosome

cytosol

cell cortex

cell cortex

regulation of cell adhesion

regulation of cell adhesion

 
TC1100003097.mm.2 Cxcl16 chemokine (C-X-C motif) ligand 16 11 -70455188, -70454388 NM_023158, BC019961 NM_023158, BC019961 81

low-density lipoprotein particle receptor activity

low-density lipoprotein particle receptor activity

scavenger receptor activity

scavenger receptor activity

cytokine activity

extracellular space

extracellular space

extracellular space

extracellular space

receptor-mediated endocytosis

chemotaxis

chemokine activity

chemokine activity

chemokine activity

T cell chemotaxis

T cell chemotaxis

membrane

integral component of membrane

positive regulation of cell growth

positive regulation of cell migration

positive regulation of cell migration

response to cytokine

response to interferon-gamma

response to tumor necrosis factor

chemokine receptor binding

lymphocyte chemotaxis

cellular response to lipopolysaccharide

04060

04062

TC0700003850.mm.2 Il18bp interleukin 18 binding protein 7 -102015073 NM_010531, BC018332 NM_010531, BC018332 30

extracellular region

extracellular space

extracellular space

interleukin-18 binding

interleukin-18 binding

T-helper 1 type immune response

T-helper 1 type immune response

 
TC1100000614.mm.2 Irf1 interferon regulatory factor 1 11 53770013, 53770013, 53770472 NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 NM_001159393, NM_001159396, NM_008390, BC003821 297

chromatin

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

regulation of adaptive immune response

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleus

nucleus

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

cell cycle arrest

I-kappaB kinase/NF-kappaB signaling

negative regulation of cell population proliferation

regulation of gene expression

positive regulation of cell death

positive regulation of type I interferon production

positive regulation of interferon-beta production

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

positive regulation of natural killer cell differentiation

regulation of MyD88-dependent toll-like receptor signaling pathway

cellular response to interferon-beta

negative regulation of tyrosine phosphorylation of STAT protein

CD8-positive, alpha-beta T cell differentiation

sequence-specific DNA binding

sequence-specific DNA binding

innate immune response

regulation of innate immune response

negative regulation of regulatory T cell differentiation

positive regulation of T-helper 1 cell differentiation

negative regulation of T-helper 2 cell differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of immune response

defense response to virus

defense response to virus

interferon-gamma-mediated signaling pathway

response to growth hormone

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to peptide hormone stimulus

regulation of CD8-positive, alpha-beta T cell proliferation

05160

TC0200003209.mm.2 Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 2 -27021364, -27021366 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 NM_001177627, NM_172659, BC141168, BC165946 20

transporter activity

lysosome

lysosomal membrane

regulation of glycolytic process

regulation of glycolytic process

carbohydrate transport

membrane

integral component of membrane

transmembrane transporter activity

transmembrane transport

 
TC1500002347.mm.2 Parp10 poly (ADP-ribose) polymerase family, member 10 15 -76232994 NM_001163575, NM_001163576 NM_001163575, NM_001163576 16

transcription corepressor activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

nucleus

nucleus

nucleolus

cytoplasm

cytoplasm

Golgi apparatus

cytosol

DNA repair

protein ADP-ribosylation

cellular response to DNA damage stimulus

negative regulation of gene expression

negative regulation of gene expression

regulation of chromatin assembly

transferase activity

transferase activity, transferring glycosyl groups

translesion synthesis

negative regulation of NF-kappaB transcription factor activity

negative regulation of viral genome replication

negative regulation of fibroblast proliferation

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

protein auto-ADP-ribosylation

K63-linked polyubiquitin modification-dependent protein binding

protein mono-ADP-ribosylation

protein mono-ADP-ribosylation

negative regulation of protein K63-linked ubiquitination

protein ADP-ribosylase activity

protein ADP-ribosylase activity

 
TC0200000222.mm.2 Il15ra interleukin 15 receptor, alpha chain 2 11705711, 11705292 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 NM_001271497, NM_001271498, NM_001271499, NM_001271500, NM_001271501, NM_008358, NM_133836, NR_073191, NR_073192 143

extracellular region

nucleus

plasma membrane

plasma membrane

plasma membrane

receptor signaling pathway via JAK-STAT

cell surface

negative regulation of neuron projection development

membrane

integral component of membrane

protein kinase binding

cytoplasmic vesicle

positive regulation of natural killer cell differentiation

interleukin-15-mediated signaling pathway

interleukin-15-mediated signaling pathway

interleukin-15 receptor activity

interleukin-15 receptor activity

positive regulation of phagocytosis

04060

04630

04672

TC0800001952.mm.2 Rab11fip1 RAB11 family interacting protein 1 (class I) 8 -27138772 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 NM_001080813, NM_029423, BC125400, BC132094 17

endosome

cytosol

protein transport

membrane

small GTPase binding

cytoplasmic vesicle

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

regulated exocytosis

negative regulation of adiponectin secretion

04144

TC1700002819.mm.2 H2-T23 histocompatibility 2, T region locus 23 17 -36029976 NM_010398, BC099472 NM_010398, BC099472 74

positive regulation of antibody-dependent cellular cytotoxicity

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

adaptive immune response

immune system process

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

natural killer cell tolerance induction

positive regulation of immunoglobulin production

regulation of natural killer cell mediated immunity

positive regulation of natural killer cell mediated immunity

positive regulation of natural killer cell cytokine production

signaling receptor binding

signaling receptor binding

extracellular space

plasma membrane

immune response

external side of plasma membrane

cell surface

membrane

integral component of membrane

antibacterial humoral response

phagocytic vesicle membrane

beta-2-microglobulin binding

MHC class Ib protein complex

positive regulation of interleukin-13 production

positive regulation of interleukin-4 production

positive regulation of TRAIL production

positive regulation of tumor necrosis factor production

positive regulation of natural killer cell proliferation

CD8-positive, alpha-beta T cell activation

protection from natural killer cell mediated cytotoxicity

MHC class I protein binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

MHC class I protein complex

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

natural killer cell lectin-like receptor binding

inner ear development

defense response to Gram-positive bacterium

integral component of lumenal side of endoplasmic reticulum membrane

positive regulation of CD8-positive, alpha-beta T cell proliferation

positive regulation of CD8-positive, alpha-beta T cell activation

04144

04145

04514

04612

04650

04940

05320

05330

05332

05416

TC0700001519.mm.2 Trim6 tripartite motif-containing 6 7 104218794 NM_001013616, BC138965 NM_001013616, BC138965 25

protein polyubiquitination

protein polyubiquitination

positive regulation of defense response to virus by host

positive regulation of cytokine production involved in immune response

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

cytosol

transcription factor binding

zinc ion binding

regulation of gene expression

positive regulation of autophagy

positive regulation of gene expression

negative regulation of gene expression

positive regulation of peptidyl-threonine phosphorylation

free ubiquitin chain polymerization

protein ubiquitination

transferase activity

protein kinase binding

protein kinase binding

protein kinase binding

protein-macromolecule adaptor activity

response to lipopolysaccharide

regulation of protein localization

positive regulation of peptidyl-serine phosphorylation

cellular response to interferon-beta

identical protein binding

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

negative regulation of transcription, DNA-templated

regulation of viral entry into host cell

metal ion binding

positive regulation of NF-kappaB transcription factor activity

positive regulation of type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

ubiquitin protein ligase activity

ubiquitin protein ligase activity

cellular response to virus

protein tyrosine kinase binding

positive regulation of transcription regulatory region DNA binding

negative regulation of stem cell differentiation

 
TC0X00002999.mm.2 Armcx6 armadillo repeat containing, X-linked 6 X -134748454 NM_001007578, BC027264 NM_001007578, BC027264 14

molecular_function

mitochondrion

mitochondrial outer membrane

biological_process

membrane

integral component of membrane

 
TC0500003176.mm.2 Oas3 2'-5' oligoadenylate synthetase 3 5 -120753097 NM_145226, BC141055 NM_145226, BC141055 19

nucleotide binding

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

cytosol

plasma membrane

immune response

response to virus

membrane

transferase activity

nucleotidyltransferase activity

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

defense response to virus

regulation of ribonuclease activity

regulation of ribonuclease activity

05160

TC1700000684.mm.2 H2-Q4 histocompatibility 2, Q region locus 4 17 35379616 NM_001143689, BC010602 NM_001143689, BC010602 32

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

signaling receptor binding

extracellular space

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

plasma membrane

immune response

external side of plasma membrane

cell surface

beta-2-microglobulin binding

peptide binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD8 receptor binding

MHC class I protein complex

MHC class I peptide loading complex

protein-containing complex binding

TAP binding

TAP complex binding

endoplasmic reticulum exit site

 
TC0100001632.mm.2 Ifi209 interferon activated gene 209 1 173630858 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 NM_175026, BC096384, BC107378, BC107379 17

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

cytosol

transcription factor binding

cellular response to interferon-beta

cellular response to interferon-beta

identical protein binding

 
TC1400000071.mm.2 Flnb filamin, beta 14 7817956 NM_134080 65

stress fiber

keratinocyte development

epithelial cell morphogenesis

actin binding

protein binding

nucleus

cytoplasm

cytosol

cytoskeleton

plasma membrane

brush border

focal adhesion

skeletal muscle tissue development

actin cytoskeleton organization

cell differentiation

identical protein binding

neuron projection

neuronal cell body

phagocytic vesicle

cellular response to interferon-gamma

04010

04510

TC0200005030.mm.2 Tgm2 transglutaminase 2, C polypeptide 2 -158116404 NM_009373, BC016492 NM_009373, BC016492 250

blood vessel remodeling

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

calcium ion binding

GTP binding

GTP binding

cytoplasm

mitochondrion

mitochondrion

cytosol

cytosol

plasma membrane

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

transaminase activity

membrane

transferase activity

transferase activity, transferring acyl groups

peptide cross-linking

peptide cross-linking

peptide cross-linking

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

protein domain specific binding

extracellular matrix

intrinsic component of plasma membrane

negative regulation of endoplasmic reticulum calcium ion concentration

negative regulation of endoplasmic reticulum calcium ion concentration

identical protein binding

positive regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

apoptotic cell clearance

positive regulation of cell adhesion

metal ion binding

positive regulation of smooth muscle cell proliferation

positive regulation of inflammatory response

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

positive regulation of mitochondrial calcium ion concentration

positive regulation of mitochondrial calcium ion concentration

branching involved in salivary gland morphogenesis

salivary gland cavitation

collagen-containing extracellular matrix

05016

TC1700002822.mm.2         NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819 NM_010397, NM_010399, BC003819  

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

extracellular space

immune response

external side of plasma membrane

peptide antigen binding

 
TC1700002779.mm.2 H2-DMb2 histocompatibility 2, class II, locus Mb2 17 34145248, 34143228 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 NM_010388, BC141105, BC145385, BC145386, BC171960 23

protein binding

lysosome

lysosomal membrane

lysosomal membrane

late endosome

multivesicular body

endosome membrane

integral component of membrane

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

late endosome membrane

MHC class II protein complex

intracellular membrane-bounded organelle

chaperone cofactor-dependent protein refolding

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC0300002051.mm.2         NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558 NM_001008497, NM_001287119, NM_001287120, NM_001287121, NM_001287122, NM_001287123, NM_001287124, NM_133200, NR_045641, BC028995, BC058558  

G protein-coupled receptor activity

plasma membrane

immune response

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

G protein-coupled purinergic nucleotide receptor activity

hematopoietic stem cell homeostasis

 
TC1100000989.mm.2 Xaf1 XIAP associated factor 1 11 72301628 NM_001037713, BC153050 NM_001037713, BC153050 16

nucleus

nucleoplasm

cytoplasm

mitochondrion

apoptotic process

negative regulation of protein-containing complex assembly

response to interferon-beta

metal ion binding

 
TC0500003730.mm.2 Gbp9 guanylate-binding protein 9 5 -105076465 NM_172777, BC057170 NM_172777, BC057170 13

GTPase activity

GTP binding

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to interferon-gamma

cellular response to interferon-gamma

 
TC1900000504.mm.2 Ifit1 interferon-induced protein with tetratricopeptide repeats 1 19 34640888 NM_008331, BC003768 NM_008331, BC003768 59

immune system process

RNA binding

protein binding

cytoplasm

cytosol

response to virus

response to bacterium

cellular response to interferon-alpha

cellular response to interferon-beta

innate immune response

defense response to virus

05160

TC0400004173.mm.2 Plekhn1 pleckstrin homology domain containing, family N member 1 4 -156221455, -156221455 NM_001008233 11

response to hypoxia

response to hypoxia

phosphatidylserine binding

phosphatidylserine binding

protein binding

mitochondrion

mitochondrion

cytoskeleton

cytoskeleton

mitochondrial membrane

mitochondrial membrane

positive regulation of apoptotic process

positive regulation of apoptotic process

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

phosphatidic acid binding

phosphatidic acid binding

cardiolipin binding

cardiolipin binding

phosphatidylinositol phosphate binding

phosphatidylinositol phosphate binding

 
TC1800001181.mm.2 Sting1 stimulator of interferon response cGAMP interactor 1 18 -35733677 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 NM_001289591, NM_001289592, NM_028261, BC046640 348

autophagosome assembly

autophagosome assembly

autophagosome assembly

nucleotide binding

activation of innate immune response

activation of innate immune response

activation of innate immune response

positive regulation of defense response to virus by host

immune system process

protein binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrial outer membrane

endosome

autophagosome

autophagosome

autophagosome

peroxisome

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

cytosol

plasma membrane

autophagy

transcription factor binding

regulation of gene expression

membrane

integral component of membrane

positive regulation of macroautophagy

positive regulation of macroautophagy

positive regulation of macroautophagy

protein kinase binding

integral component of endoplasmic reticulum membrane

regulation of cellular metabolic process

cytoplasmic vesicle

ubiquitin protein ligase binding

positive regulation of protein binding

positive regulation of type I interferon production

positive regulation of type I interferon production

positive regulation of type I interferon production

interferon-beta production

interferon-beta production

cyclic-di-GMP binding

cyclic-di-GMP binding

cyclic-di-GMP binding

cellular response to interferon-beta

identical protein binding

protein homodimerization activity

innate immune response

innate immune response

innate immune response

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

perinuclear region of cytoplasm

regulation of inflammatory response

positive regulation of DNA-binding transcription factor activity

protein complex oligomerization

defense response to virus

defense response to virus

defense response to virus

cyclic-GMP-AMP binding

cyclic-GMP-AMP binding

cyclic-GMP-AMP binding

reticulophagy

reticulophagy

cellular response to exogenous dsRNA

cellular response to organic cyclic compound

cellular response to organic cyclic compound

integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

04622

04623

TC0200004602.mm.2 Il1b interleukin 1 beta 2 -129364577 NM_008361, BC011437 NM_008361, BC011437 1139

negative regulation of transcription by RNA polymerase II

MAPK cascade

activation of MAPK activity

fever generation

positive regulation of protein phosphorylation

cytokine activity

cytokine activity

interleukin-1 receptor binding

integrin binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

lysosome

inflammatory response

inflammatory response

immune response

positive regulation of cytosolic calcium ion concentration

memory

positive regulation of cell population proliferation

negative regulation of cell population proliferation

response to carbohydrate

vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of epithelial to mesenchymal transition

negative regulation of glucose transmembrane transport

positive regulation of cell death

negative regulation of glutamate secretion

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein domain specific binding

secretory granule

hyaluronan biosynthetic process

positive regulation of cell migration

neutrophil chemotaxis

sequestering of triglyceride

positive regulation of prostaglandin biosynthetic process

cytoplasmic vesicle

positive regulation of fever generation

lipopolysaccharide-mediated signaling pathway

vesicle

positive regulation of prostaglandin secretion

response to lipopolysaccharide

response to lipopolysaccharide

response to lipopolysaccharide

interleukin-1 beta production

interleukin-6 production

positive regulation of chemokine production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-gamma production

positive regulation of interleukin-2 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of stress-activated MAPK cascade

positive regulation of immature T cell proliferation in thymus

positive regulation of immature T cell proliferation in thymus

response to ATP

response to ATP

positive regulation of heterotypic cell-cell adhesion

social behavior

ectopic germ cell programmed cell death

positive regulation of myosin light chain kinase activity

cellular response to drug

positive regulation of T cell proliferation

positive regulation of apoptotic process

regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of MAP kinase activity

protein kinase B signaling

positive regulation of JUN kinase activity

positive regulation of neuron apoptotic process

positive regulation of nitric oxide biosynthetic process

negative regulation of neuron differentiation

positive regulation of glial cell differentiation

positive regulation of angiogenesis

positive regulation of angiogenesis

negative regulation of lipid metabolic process

positive regulation of mitotic nuclear division

positive regulation of transcription, DNA-templated

positive regulation of complement activation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of JNK cascade

negative regulation of insulin receptor signaling pathway

astrocyte activation

positive regulation of astrocyte differentiation

regulation of defense response to virus by host

positive regulation of inflammatory response

positive regulation of phagocytosis

regulation of neurogenesis

negative regulation of neurogenesis

regulation of insulin secretion

negative regulation of synaptic transmission

leukocyte migration

negative regulation of lipid catabolic process

positive regulation of lipid catabolic process

regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity

positive regulation of membrane protein ectodomain proteolysis

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of cell division

positive regulation of glial cell proliferation

positive regulation of calcidiol 1-monooxygenase activity

negative regulation of adiponectin secretion

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

monocyte aggregation

interleukin-1-mediated signaling pathway

response to interleukin-1

cellular response to lipopolysaccharide

cellular response to organic substance

cellular response to organic cyclic compound

positive regulation of monocyte chemotactic protein-1 production

positive regulation of neutrophil chemotaxis

extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of p38MAPK cascade

positive regulation of NIK/NF-kappaB signaling

positive regulation of RNA biosynthetic process

regulation of establishment of endothelial barrier

negative regulation of gap junction assembly

negative regulation of branching morphogenesis of a nerve

negative regulation of neural precursor cell proliferation

positive regulation of T-helper 1 cell cytokine production

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

04010

04060

04210

04380

04620

04621

04623

04640

04940

05010

05020

05140

05142

05143

05144

05146

05323

05332

TC0100000375.mm.2 Stat1 signal transducer and activator of transcription 1 1 52119437, 52119621 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 NM_001205313, NM_001205314, NM_009283, BC004808 857

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

negative regulation of endothelial cell proliferation

positive regulation of defense response to virus by host

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

tumor necrosis factor receptor binding

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytosol

cytosol

transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

activation of cysteine-type endopeptidase activity involved in apoptotic process

defense response

signal transduction

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

response to nutrient

blood circulation

positive regulation of cell population proliferation

response to mechanical stimulus

response to bacterium

macrophage derived foam cell differentiation

negative regulation of angiogenesis

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

enzyme binding

axon

dendrite

lipopolysaccharide-mediated signaling pathway

CCR5 chemokine receptor binding

response to lipopolysaccharide

positive regulation of interferon-alpha production

cellular response to insulin stimulus

protein-containing complex

tumor necrosis factor-mediated signaling pathway

response to cytokine

negative regulation of macrophage fusion

response to type I interferon

histone acetyltransferase binding

nuclear hormone receptor binding

response to interferon-beta

cellular response to interferon-beta

regulation of cell population proliferation

histone binding

response to drug

identical protein binding

protein homodimerization activity

negative regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

response to peptide hormone

response to peptide hormone

sequence-specific DNA binding

ubiquitin-like protein ligase binding

positive regulation of erythrocyte differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation by virus of viral protein levels in host cell

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

response to cAMP

defense response to virus

protein phosphatase 2A binding

positive regulation of nitric-oxide synthase biosynthetic process

interferon-gamma-mediated signaling pathway

interferon-gamma-mediated signaling pathway

type I interferon signaling pathway

type I interferon signaling pathway

type I interferon signaling pathway

renal tubule development

repressing transcription factor binding

cellular response to lipopolysaccharide

cellular response to cytokine stimulus

cellular response to interferon-gamma

cellular response to organic cyclic compound

promoter-specific chromatin binding

04062

04380

04620

04630

05140

05145

05160

05200

05212

TC0800001110.mm.2         NM_001033207, NR_106040 NM_001033207, NR_106040  

nucleotide binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

immune system process

ATP binding

nucleus

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytosol

response to bacterium

negative regulation of NF-kappaB transcription factor activity

negative regulation of NF-kappaB transcription factor activity

intracellular signal transduction

regulation of kinase activity

innate immune response

innate immune response

positive regulation of MHC class I biosynthetic process

positive regulation of MHC class I biosynthetic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of interferon-gamma-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

 
TC0700003942.mm.2         XM_485980      
TC0600002663.mm.2 Rab43 RAB43, member RAS oncogene family 6 -87788852, -87788852, -87788852, -87788852 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 NM_001039394, NM_133717, NR_104477, NR_104478, BC010248 23

autophagosome assembly

nucleotide binding

GTPase activity

GTPase activity

GTP binding

Golgi apparatus

intracellular protein transport

Golgi organization

endomembrane system

membrane

virion assembly

cytoplasmic vesicle

retrograde transport, plasma membrane to Golgi

phagocytic vesicle

phagocytic vesicle

cellular response to interferon-gamma

phagosome maturation

toxin transport

 
TC0100001190.mm.2 Nuak2 NUAK family, SNF1-like kinase, 2 1 132316124 NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 NM_001195025, NM_028778, BC033302, BC046833 30

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

protein phosphorylation

protein phosphorylation

apoptotic process

kinase activity

phosphorylation

transferase activity

actin cytoskeleton organization

intracellular signal transduction

cellular response to glucose starvation

cellular response to glucose starvation

negative regulation of apoptotic process

metal ion binding

 
TC1000002642.mm.2 Dram1 DNA-damage regulated autophagy modulator 1 10 -88322803 NM_027878, BC021433 NM_027878, BC021433 16

molecular_function

cytoplasm

lysosome

lysosome

autophagy

apoptotic process

regulation of autophagy

regulation of autophagy

membrane

integral component of membrane

 
TC1700000505.mm.2 Pim1 proviral integration site 1 17 29493084, 29490784 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 NM_008842, BC042885, BC053019, BC055316 186

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

ATP binding

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

plasma membrane

protein phosphorylation

protein phosphorylation

apoptotic process

cell cycle

transcription factor binding

membrane

kinase activity

phosphorylation

transferase activity

regulation of transmembrane transporter activity

manganese ion binding

manganese ion binding

ribosomal small subunit binding

negative regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

protein serine/threonine kinase activator activity

positive regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of transcription, DNA-templated

protein autophosphorylation

protein autophosphorylation

metal ion binding

protein stabilization

positive regulation of cardiac muscle cell proliferation

vitamin D receptor signaling pathway

positive regulation of protein serine/threonine kinase activity

positive regulation of brown fat cell differentiation

regulation of hematopoietic stem cell proliferation

positive regulation of cardioblast proliferation

cellular detoxification

04630

05221

TC1900001340.mm.2 Insl6 insulin-like 6 19 -29321353 NM_013754, BC028752 NM_013754, BC028752 19

hormone activity

extracellular region

spermatogenesis

spermatid development

male gonad development

fertilization

flagellated sperm motility

negative regulation of apoptotic process

 
TC0600002323.mm.2 Nod1 nucleotide-binding oligomerization domain containing 1 6 -54923941, -54923941 NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 NM_001171007, NM_172729, BC042670 170

nucleotide binding

pattern recognition receptor signaling pathway

immune system process

positive regulation of dendritic cell antigen processing and presentation

protein binding

ATP binding

cytoplasm

cytosol

plasma membrane

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

defense response

positive regulation of cell death

membrane

detection of bacterium

basolateral plasma membrane

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

intracellular signal transduction

intracellular signal transduction

pattern recognition receptor activity

defense response to bacterium

identical protein binding

protein homodimerization activity

regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein-containing complex binding

innate immune response

phagocytic vesicle

positive regulation of JNK cascade

anchored component of plasma membrane

CARD domain binding

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

positive regulation of nitric-oxide synthase activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of ERK1 and ERK2 cascade

cellular response to muramyl dipeptide

positive regulation of NIK/NF-kappaB signaling

positive regulation of xenophagy

04621

TC0500002945.mm.2 Mfsd7a major facilitator superfamily domain containing 7A 5 -108441053 NM_172883, BC094512 NM_172883, BC094512 13

cellular_component

membrane

integral component of membrane

transmembrane transport

 
TC1900000443.mm.2 Ric1 RAB6A GEF complex partner 1 19 29522281 NM_001081319 17

Golgi membrane

regulation of extracellular matrix constituent secretion

guanyl-nucleotide exchange factor activity

cytoplasm

cytosol

cytosol

intracellular protein transport

membrane

small GTPase binding

protein-containing complex

Ric1-Rgp1 guanyl-nucleotide exchange factor complex

Ric1-Rgp1 guanyl-nucleotide exchange factor complex

retrograde transport, endosome to Golgi

retrograde transport, endosome to Golgi

positive regulation of GTPase activity

negative regulation of cellular protein catabolic process

cranial skeletal system development

 
TC0500001355.mm.2 Hectd4 HECT domain E3 ubiquitin protein ligase 4 5 121220218 NM_181421 18

glucose metabolic process

glucose homeostasis

 
TC0700002499.mm.2 Nectin2 nectin cell adhesion molecule 2 7 -19724160, -19716643 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 NM_001159724, NM_008990, BC009088, BC046770, BC059941 73

acrosome assembly

acrosome assembly

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of immunoglobulin mediated immune response

positive regulation of immunoglobulin mediated immune response

protein binding

plasma membrane

plasma membrane

cell-cell junction

cell-cell junction

zonula adherens

cytoskeleton organization

cytoskeleton organization

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

homophilic cell adhesion via plasma membrane adhesion molecules

homophilic cell adhesion via plasma membrane adhesion molecules

spermatid development

spermatid nucleus differentiation

fertilization

cell surface

membrane

integral component of membrane

integral component of membrane

virion attachment to host cell

fusion of virus membrane with host plasma membrane

fusion of virus membrane with host plasma membrane

sperm mitochondrion organization

cell part morphogenesis

positive regulation of mast cell activation

positive regulation of mast cell activation

susceptibility to natural killer cell mediated cytotoxicity

susceptibility to natural killer cell mediated cytotoxicity

identical protein binding

identical protein binding

protein homodimerization activity

protein homodimerization activity

apical junction complex

apical junction complex

cell-cell contact zone

adhesion of symbiont to host

cilium organization

positive regulation of natural killer cell mediated cytotoxicity

regulation of viral entry into host cell

regulation of viral entry into host cell

coreceptor-mediated virion attachment to host cell

coreceptor-mediated virion attachment to host cell

cell adhesion molecule binding

cell adhesion molecule binding

cell adhesion molecule binding

positive regulation of T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

establishment of mitochondrion localization

establishment of mitochondrion localization

susceptibility to T cell mediated cytotoxicity

susceptibility to T cell mediated cytotoxicity

04514

04520

TC0100003589.mm.2         XM_136331      
TC0600000340.mm.2 Tmem140 transmembrane protein 140 6 34863145 NM_197986, BC020080, BC023802 NM_197986, BC020080, BC023802 NM_197986, BC020080, BC023802 10

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1500002183.mm.2 Rnd1 Rho family GTPase 1 15 -98669204 NM_172612, BC048531 NM_172612, BC048531 18

nucleotide binding

GTPase activity

signaling receptor binding

GTP binding

intracellular anatomical structure

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

adherens junction

cell cortex

actin filament organization

actin filament organization

negative regulation of cell adhesion

establishment or maintenance of cell polarity

small GTPase mediated signal transduction

regulation of cell shape

actin cytoskeleton

membrane

neuron remodeling

cell migration

protein kinase binding

cortical cytoskeleton organization

cytoplasmic vesicle

regulation of actin cytoskeleton organization

cell projection

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

04360

TC1200000279.mm.2 Nampt nicotinamide phosphoribosyltransferase 12 32820334 NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 NM_021524, BC004059, BC018358 155

nucleotide binding

microglial cell activation

catalytic activity

nicotinate-nucleotide diphosphorylase (carboxylating) activity

cytokine activity

extracellular region

extracellular space

nucleus

cytoplasm

cytoplasm

cytosol

plasma membrane

circadian rhythm

NAD biosynthetic process

negative regulation of autophagy

regulation of lung blood pressure

nuclear speck

transferase activity

transferase activity, transferring glycosyl groups

pyridine nucleotide biosynthetic process

cell junction

circadian regulation of gene expression

identical protein binding

identical protein binding

positive regulation of transcription by RNA polymerase II

nicotinamide phosphoribosyltransferase activity

nicotinamide phosphoribosyltransferase activity

rhythmic process

positive regulation of smooth muscle cell proliferation

positive regulation of nitric-oxide synthase biosynthetic process

negative regulation of cellular senescence

00760

TC0100001604.mm.2 Slamf6 SLAM family member 6 1 171917461, 171917461 NM_030710, BC030031 NM_030710, BC030031 44

natural killer cell differentiation

natural killer cell proliferation

adaptive immune response

immune system process

plasma membrane

integral component of plasma membrane

membrane

integral component of membrane

positive regulation of interferon-gamma production

positive regulation of interleukin-17 production

innate immune response

positive regulation of natural killer cell mediated cytotoxicity

T-helper 17 cell lineage commitment

 
TC0300002312.mm.2         NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800 NM_001163489, NM_001163490, NM_001163491, NM_013658, NR_105978, BC025800  

angiogenesis

neural crest cell migration

adaptive immune response

T cell differentiation involved in immune response

immune system process

extracellular space

plasma membrane

integral component of plasma membrane

multicellular organism development

nervous system development

axonogenesis

axon guidance

regulation of cell shape

regulation of endothelial cell migration

membrane

integral component of membrane

negative regulation of angiogenesis

cell differentiation

semaphorin receptor binding

positive regulation of cell migration

T-helper 1 cell differentiation

chemorepellent activity

negative regulation of axon extension involved in axon guidance

negative chemotaxis

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

positive regulation of excitatory synapse assembly

positive regulation of inhibitory synapse assembly

 
TC1700000214.mm.2         NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849 NM_008039, NM_008042, BC117066, BC148849  

amyloid-beta binding

amyloid-beta binding

microglial cell activation

positive regulation of protein phosphorylation

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway

complement receptor activity

G protein-coupled receptor activity

N-formyl peptide receptor activity

N-formyl peptide receptor activity

scavenger receptor binding

cytoplasm

plasma membrane

plasma membrane

receptor-mediated endocytosis

chemotaxis

chemotaxis

inflammatory response

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

integral component of membrane

calcium-mediated signaling

positive regulation of superoxide anion generation

signaling receptor activity

signaling receptor activity

cargo receptor activity

defense response to bacterium

negative regulation of neuron apoptotic process

positive regulation of innate immune response

positive regulation of G protein-coupled receptor signaling pathway

astrocyte activation

negative regulation of inflammatory response

positive regulation of phagocytosis

RAGE receptor binding

positive chemotaxis

positive regulation of protein kinase B signaling

positive regulation of 1-phosphatidylinositol-3-kinase activity

positive regulation of ERK1 and ERK2 cascade

positive regulation of monocyte chemotaxis

cellular response to amyloid-beta

cellular response to amyloid-beta

 
TC0800000538.mm.2 Acsl1 acyl-CoA synthetase long-chain family member 1 8 46490965, 46471036 NM_007981, BC056644 NM_007981, BC056644 64

very long-chain fatty acid metabolic process

very long-chain fatty acid metabolic process

nucleotide binding

long-chain fatty acid metabolic process

catalytic activity

long-chain fatty acid-CoA ligase activity

long-chain fatty acid-CoA ligase activity

ATP binding

mitochondrion

mitochondrion

mitochondrial outer membrane

peroxisome

peroxisomal membrane

endoplasmic reticulum

endoplasmic reticulum

plasma membrane

lipid metabolic process

fatty acid metabolic process

lipid biosynthetic process

lipid biosynthetic process

response to organic substance

positive regulation of long-chain fatty acid import across plasma membrane

fatty acid transport

membrane

integral component of membrane

ligase activity

triglyceride biosynthetic process

adiponectin-activated signaling pathway

long-chain fatty-acyl-CoA biosynthetic process

long-chain fatty-acyl-CoA biosynthetic process

xenobiotic catabolic process

intracellular membrane-bounded organelle

acetate-CoA ligase (ADP-forming) activity

long-chain fatty acid import into cell

arachidonate-CoA ligase activity

arachidonate-CoA ligase activity

phytanate-CoA ligase activity

positive regulation of protein serine/threonine kinase activity

oleoyl-CoA ligase activity

decanoate-CoA ligase activity

positive regulation of cold-induced thermogenesis

00071

01100

03320

04146

04920

TC1100004266.mm.2 Irgm2 immunity-related GTPase family M member 2 11 58214976 NM_019440 22

autophagosome assembly

Golgi membrane

positive regulation of protein phosphorylation

GTPase activity

GTPase activity

mitochondrion

endoplasmic reticulum membrane

Golgi apparatus

Golgi apparatus

cytosol

defense response

response to bacterium

positive regulation of autophagy

positive regulation of peptidyl-threonine phosphorylation

protein kinase binding

symbiont-containing vacuole

protein destabilization

positive regulation of peptidyl-serine phosphorylation

response to interferon-gamma

response to interferon-gamma

cellular response to interferon-beta

defense response to bacterium

defense response to bacterium

defense response to protozoan

regulation of protein-containing complex assembly

protein serine/threonine kinase activator activity

innate immune response

CARD domain binding

protein stabilization

defense response to Gram-negative bacterium

BH3 domain binding

positive regulation of interferon-gamma-mediated signaling pathway

regulation of protein complex stability

protein lipidation involved in autophagosome assembly

CAMKK-AMPK signaling cascade

nucleotide-binding oligomerization domain containing 2 signaling pathway

cellular response to lipopolysaccharide

positive regulation of protein serine/threonine kinase activity

positive regulation by symbiont of host autophagy

cellular response to virus

positive regulation of autophagosome maturation

 
TC0400003679.mm.2 Xkr8 X-linked Kx blood group related 8 4 -132724903 NM_201368, BC057035 NM_201368, BC057035 18

tolerance induction to self antigen

molecular_function

plasma membrane

plasma membrane

apoptotic process

membrane

integral component of membrane

engulfment of apoptotic cell

engulfment of apoptotic cell

establishment of localization in cell

phosphatidylserine exposure on apoptotic cell surface

phosphatidylserine exposure on apoptotic cell surface

phosphatidylserine exposure on apoptotic cell surface

apoptotic process involved in development

 
TC1700000685.mm.2 H2-Q5 histocompatibility 2, Q region locus 5 17 35394098 NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 NR_051981, BC160245, XM_003688944 29    
TC0700000693.mm.2 1600014C10Rik RIKEN cDNA 1600014C10 gene 7 38183786, 38183216 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 NM_001085385, NM_028166, BC010476, BC019834, BC085480, BC092099 15

molecular_function

cytoplasm

mitochondrion

endoplasmic reticulum

cytosol

autophagy

apoptotic process

response to oxidative stress

membrane

integral component of membrane

mitochondrial membrane

mitochondrial calcium ion homeostasis

 
TC0100000765.mm.2 Sp140 Sp140 nuclear body protein 1 85600702 NM_001013817, BC069971 NM_001013817, BC069971 5

fibrillar center

mitochondrion

 
TC1200000280.mm.2 Gdap10 ganglioside-induced differentiation-associated-protein 10 12 32824115 NR_045032, BC052902 NR_045032, BC052902 5

molecular_function

cellular_component

response to bacterium

 
TC0600003503.mm.2 Herc6 hect domain and RLD 6 6 57580991 NM_025992 17

hematopoietic progenitor cell differentiation

immune system process

ubiquitin-protein transferase activity

nucleoplasm

cytoplasm

cytosol

response to bacterium

protein ubiquitination

transferase activity

protein phosphopantetheinylation

cyclin binding

innate immune response

ubiquitin protein ligase activity

 
TC1900001019.mm.2 Prdx5 peroxiredoxin 5 19 -6906696 NM_012021, BC008174 NM_012021, BC008174 60

RNA polymerase III transcription regulatory region sequence-specific DNA binding

peroxidase activity

signaling receptor binding

signaling receptor binding

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

peroxisome

peroxisome

peroxisomal matrix

peroxisomal matrix

cytosol

response to oxidative stress

response to oxidative stress

thioredoxin peroxidase activity

thioredoxin peroxidase activity

antioxidant activity

antioxidant activity

negative regulation of transcription by RNA polymerase III

oxidoreductase activity

cytoplasmic vesicle

positive regulation of collagen biosynthetic process

cellular response to oxidative stress

cellular response to reactive oxygen species

hydrogen peroxide catabolic process

hydrogen peroxide catabolic process

hydrogen peroxide catabolic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

cell redox homeostasis

perinuclear region of cytoplasm

negative regulation of oxidoreductase activity

peroxiredoxin activity

regulation of apoptosis involved in tissue homeostasis

NADPH oxidation

peroxynitrite reductase activity

reactive nitrogen species metabolic process

04146

TC0600003329.mm.2 Plbd1 phospholipase B domain containing 1 6 -136612070 NM_025806, BC019793 NM_025806, BC019793 16

phospholipase activity

extracellular region

extracellular space

lysosome

lipid metabolic process

phospholipid catabolic process

lipid catabolic process

hydrolase activity

 
MG-1-pos-10338280_st                
TC1700001953.mm.2 Lst1 leukocyte specific transcript 1 17 -35185094 NM_010734, BC086881 NM_010734, BC086881 21

cell morphogenesis

immune system process

immune response

regulation of cell shape

membrane

integral component of membrane

dendrite development

dendrite development

 
TC0900001365.mm.2 Cish cytokine inducible SH2-containing protein 9 107296658 NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178 NM_009895, BC003783, BC022178 61

protein binding

plasma membrane

phosphatidylinositol 3-kinase complex

protein kinase C-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction

intracellular signal transduction

regulation of growth

phosphatidylinositol phosphorylation

1-phosphatidylinositol-3-kinase regulator activity

04630

TC1100000792.mm.2 Adora2b adenosine A2b receptor 11 62248983 NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416 NM_007413, BC116415, BC116416 178

G protein-coupled adenosine receptor activity

positive regulation of endothelial cell proliferation

G protein-coupled adenosine receptor signaling pathway

positive regulation of chronic inflammatory response to non-antigenic stimulus

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of cell population proliferation

negative regulation of cell population proliferation

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of endothelial cell migration

positive regulation of norepinephrine secretion

positive regulation of cGMP-mediated signaling

positive regulation of steroid biosynthetic process

regulation of glucose metabolic process

membrane

integral component of membrane

positive regulation of guanylate cyclase activity

cellular response to extracellular stimulus

positive regulation of chemokine production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

negative regulation of collagen biosynthetic process

positive regulation of catecholamine secretion

positive regulation of mast cell degranulation

positive regulation of cAMP-mediated signaling

synapse

relaxation of vascular associated smooth muscle

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

response to angiotensin

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

04020

04080

04270

TC1900000497.mm.2 Fas Fas (TNF receptor superfamily member 6) 19 34290658, 34290658 NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 NM_001146708, NM_007987, BC061160 1558

positive regulation of protein phosphorylation

protease binding

immunoglobulin production

transmembrane signaling receptor activity

tumor necrosis factor-activated receptor activity

tumor necrosis factor-activated receptor activity

protein binding

calmodulin binding

extracellular region

extracellular space

cytoplasm

cytosol

plasma membrane

apoptotic process

apoptotic process

activation-induced cell death of T cells

activation-induced cell death of T cells

activation-induced cell death of T cells

inflammatory cell apoptotic process

inflammatory cell apoptotic process

immune response

signal transduction

circadian rhythm

extrinsic apoptotic signaling pathway via death domain receptors

extrinsic apoptotic signaling pathway via death domain receptors

extrinsic apoptotic signaling pathway via death domain receptors

response to toxic substance

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

gene expression

regulation of gene expression

negative regulation of Schwann cell proliferation

positive regulation of cell death

membrane

integral component of membrane

apical plasma membrane

nuclear body

B cell mediated immunity

kinase binding

secretory granule

dendrite regeneration

death-inducing signaling complex

CD95 death-inducing signaling complex

CD95 death-inducing signaling complex

CD95 death-inducing signaling complex

positive regulation of protein-containing complex assembly

regulation of stress-activated MAPK cascade

regulation of stress-activated MAPK cascade

cellular response to amino acid starvation

Fas signaling pathway

regulation of cell population proliferation

sarcolemma

identical protein binding

identical protein binding

regulation of apoptotic process

neuron projection

neuronal cell body

T cell homeostasis

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of neuron apoptotic process

protein-containing complex binding

negative thymic T cell selection

membrane raft

membrane raft

regulation of lymphocyte differentiation

regulation of myeloid cell differentiation

perinuclear region of cytoplasm

spleen development

negative regulation of B cell activation

response to glucocorticoid

neuron apoptotic process

lymphocyte apoptotic process

cellular response to lithium ion

cellular response to hyperoxia

positive regulation of release of cytochrome c from mitochondria

motor neuron apoptotic process

motor neuron apoptotic process

apoptotic signaling pathway

apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand

hepatocyte apoptotic process

apical dendrite

necroptotic signaling pathway

necroptotic signaling pathway

necroptotic signaling pathway

negative regulation of Schwann cell migration

positive regulation of apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04010

04060

04115

04210

04650

04940

05010

05142

05143

05200

05320

05330

05332

TC1600001556.mm.2 Parp14 poly (ADP-ribose) polymerase family, member 14 16 -35832877 NM_001039530, BC138874 NM_001039530, BC138874 32

immune system process

transcription corepressor activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

plasma membrane

protein ADP-ribosylation

negative regulation of gene expression

negative regulation of gene expression

transferase activity

transferase activity, transferring glycosyl groups

enzyme binding

positive regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

innate immune response

negative regulation of interferon-gamma-mediated signaling pathway

negative regulation of interferon-gamma-mediated signaling pathway

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

NAD+ binding

protein mono-ADP-ribosylation

protein mono-ADP-ribosylation

positive regulation of interleukin-4-mediated signaling pathway

positive regulation of interleukin-4-mediated signaling pathway

protein ADP-ribosylase activity

protein ADP-ribosylase activity

 
TC1200001912.mm.2 Six1 sine oculis-related homeobox 1 12 -73041826 NM_009189, BC023304 NM_009189, BC023304 180

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription coactivator binding

DNA-binding transcription activator activity, RNA polymerase II-specific

ureteric bud development

ureteric bud development

branching involved in ureteric bud morphogenesis

organ induction

kidney development

outflow tract morphogenesis

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

nucleolus

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

multicellular organism development

pattern specification process

pattern specification process

skeletal muscle tissue development

skeletal muscle tissue development

sensory perception of sound

cell population proliferation

regulation of synaptic growth at neuromuscular junction

regulation of gene expression

regulation of skeletal muscle satellite cell proliferation

regulation of skeletal muscle cell proliferation

facial nerve morphogenesis

neurogenesis

epithelial cell differentiation

thyroid gland development

olfactory placode formation

regulation of protein localization

protein localization to nucleus

aorta morphogenesis

inner ear morphogenesis

middle ear morphogenesis

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

tongue development

regulation of neuron differentiation

regulation of neuron differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

animal organ development

thymus development

thymus development

neuron fate specification

generation of neurons

embryonic cranial skeleton morphogenesis

embryonic skeletal system morphogenesis

skeletal system morphogenesis

skeletal muscle fiber development

inner ear development

anatomical structure development

regulation of epithelial cell proliferation

myoblast migration

pharyngeal system development

pharyngeal system development

myotome development

fungiform papilla morphogenesis

trigeminal ganglion development

otic vesicle development

otic vesicle development

metanephric mesenchyme development

regulation of branch elongation involved in ureteric bud branching

positive regulation of ureteric bud formation

mesonephric tubule formation

ureter smooth muscle cell differentiation

positive regulation of secondary heart field cardioblast proliferation

cochlea morphogenesis

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of brown fat cell differentiation

cellular response to 3,3',5-triiodo-L-thyronine

sequence-specific double-stranded DNA binding

positive regulation of mesenchymal cell proliferation involved in ureter development

regulation of skeletal muscle cell differentiation

 
TC0900000032.mm.2 Casp4 caspase 4, apoptosis-related cysteine peptidase 9 5308848, 5308859 NM_007609, BC061255 NM_007609, BC061255 223

immune system process

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

extracellular region

cytoplasm

mitochondrion

endoplasmic reticulum

cytosol

plasma membrane

proteolysis

inflammatory response

actin filament organization

peptidase activity

cysteine-type peptidase activity

programmed cell death

membrane

protein autoprocessing

protein autoprocessing

hydrolase activity

positive regulation of interleukin-1 beta production

protein-containing complex

ectopic germ cell programmed cell death

ectopic germ cell programmed cell death

regulation of apoptotic process

neuron projection

neuronal cell body

innate immune response

CARD domain binding

regulation of inflammatory response

regulation of inflammatory response

regulation of inflammatory response

inflammasome complex

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

pyroptosis

pyroptosis

pyroptosis

IPAF inflammasome complex

NLRP3 inflammasome complex

scaffold protein binding

AIM2 inflammasome complex

intrinsic apoptotic signaling pathway

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of tumor necrosis factor-mediated signaling pathway

cellular response to amyloid-beta

 
TC1700000622.mm.2 Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 17 34198194 NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 NM_010724, BC013785, BC051450 114

proteasome complex

immune system process

endopeptidase activity

threonine-type endopeptidase activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

proteasome core complex

proteasome core complex

proteolysis

peptidase activity

proteasomal ubiquitin-independent protein catabolic process

hydrolase activity

antigen processing and presentation

cell differentiation

proteasome-mediated ubiquitin-dependent protein catabolic process

fat cell differentiation

fat cell differentiation

proteolysis involved in cellular protein catabolic process

regulation of endopeptidase activity

spermatoproteasome complex

03050

TC1500000565.mm.2 Gsdmd gasdermin D 15 75862338 NM_026960, BC029813 NM_026960, BC029813 94

phosphatidylserine binding

phosphatidylserine binding

immune system process

phosphatidylinositol-4,5-bisphosphate binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

extracellular space

nucleoplasm

cytoplasm

cytosol

plasma membrane

inflammatory response

lipid binding

programmed cell death

membrane

integral component of membrane

wide pore channel activity

wide pore channel activity

cellular response to extracellular stimulus

positive regulation of interleukin-1 beta production

pore formation in membrane of other organism

defense response to bacterium

innate immune response

pore complex assembly

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

protein homooligomerization

inflammasome complex

pyroptosis

pyroptosis

pyroptosis

phosphatidylinositol-4-phosphate binding

phosphatidylinositol-4-phosphate binding

phosphatidic acid binding

NLRP3 inflammasome complex

NLRP3 inflammasome complex

cardiolipin binding

 
TC0100002707.mm.2         NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247 NM_001037909, NM_175219, NM_213615, BC007193, BC107246, BC107247  

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
TC1400000574.mm.2 Pnp purine-nucleoside phosphorylase 14 50944302 NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 NM_013632, BC003788, BC052679 86

nucleoside binding

positive regulation of T cell mediated cytotoxicity

purine nucleobase binding

catalytic activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

extracellular region

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

cytoskeleton

nucleobase-containing compound metabolic process

inosine catabolic process

inosine catabolic process

inosine catabolic process

deoxyinosine catabolic process

adenosine catabolic process

adenosine catabolic process

deoxyguanosine catabolic process

GTP biosynthetic process

AMP catabolic process

AMP catabolic process

IMP catabolic process

IMP catabolic process

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic mitochondrial changes

nucleoside metabolic process

response to gamma radiation

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring pentosyl groups

urate biosynthetic process

urate biosynthetic process

positive regulation of T cell proliferation

positive regulation of T cell proliferation

purine nucleoside metabolic process

purine nucleoside metabolic process

purine nucleoside metabolic process

phosphate ion binding

identical protein binding

positive regulation of B cell differentiation

positive regulation of DNA repair

GMP catabolic process

GMP catabolic process

dGMP catabolic process

dGMP catabolic process

dAMP catabolic process

dAMP catabolic process

dGTP metabolic process

guanosine catabolic process

positive regulation of alpha-beta T cell differentiation

positive regulation of alpha-beta T cell differentiation

negative regulation of T cell apoptotic process

00230

00240

00760

01100

TC0500001546.mm.2 Castor2 cytosolic arginine sensor for mTORC1 subunit 2 5 134099747 NM_030719, BC094613 NM_030719, BC094613 14

cytoplasm

cytosol

cytosol

identical protein binding

GATOR2 complex

GATOR2 complex

regulation of intracellular signal transduction

cellular response to L-arginine

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

 
TC0500003629.mm.2 Flt1 FMS-like tyrosine kinase 1 5 -147635159, -147561603 NM_010228, BC029674 NM_010228, BC029674 432

nucleotide binding

angiogenesis

angiogenesis

branching involved in blood vessel morphogenesis

response to hypoxia

sprouting angiogenesis

hematopoietic progenitor cell differentiation

monocyte chemotaxis

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

vascular endothelial growth factor-activated receptor activity

vascular endothelial growth factor-activated receptor activity

protein binding

ATP binding

extracellular space

nucleus

endosome

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

protein phosphorylation

chemotaxis

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organism development

positive regulation of phospholipase C activity

positive regulation of phosphatidylinositol 3-kinase signaling

actin cytoskeleton

membrane

integral component of membrane

kinase activity

phosphorylation

cell migration

cell migration

cell migration

cell migration

transferase activity

peptidyl-tyrosine phosphorylation

growth factor binding

cell differentiation

positive regulation of cell migration

positive regulation of kinase activity

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor receptor-1 signaling pathway

placental growth factor-activated receptor activity

identical protein binding

receptor complex

receptor complex

positive regulation of MAP kinase activity

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase activity

positive regulation of angiogenesis

positive regulation of angiogenesis

protein autophosphorylation

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

blood vessel morphogenesis

post-embryonic camera-type eye morphogenesis

embryonic morphogenesis

positive regulation of hematopoietic progenitor cell differentiation

negative regulation of vascular endothelial cell proliferation

hyaloid vascular plexus regression

04060

04144

04510

05323

TC1500000776.mm.2 Tspo translocator protein 15 83563572 NM_009775, BC002055 NM_009775, BC002055 111

androgen binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

cytosol

steroid biosynthetic process

ion transport

chloride transport

lipid transport

glial cell migration

benzodiazepine receptor activity

negative regulation of mitochondrion organization

positive regulation of necrotic cell death

cholesterol binding

membrane

integral component of membrane

negative regulation of protein ubiquitination

negative regulation of tumor necrosis factor production

positive regulation of apoptotic process

intracellular membrane-bounded organelle

ion channel binding

negative regulation of nitric oxide biosynthetic process

behavioral response to pain

regulation of steroid biosynthetic process

positive regulation of mitochondrial depolarization

positive regulation of calcium ion transport

contact inhibition

positive regulation of glial cell proliferation

negative regulation of glial cell proliferation

establishment of protein localization to mitochondrion

maintenance of protein location in mitochondrion

negative regulation of autophagy of mitochondrion

negative regulation of ATP metabolic process

positive regulation of reactive oxygen species metabolic process

positive regulation of reactive oxygen species metabolic process

04080

TC0700004011.mm.2 Gvin3 GTPase, very large interferon inducible, family member 3 7 -106595548 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 NM_001277179, NM_001277180, NM_001277181, NM_001277182, NM_001277183, XM_001000891, XM_001478597, XM_003084724, XM_485982 8

molecular_function

cellular_component

biological_process

 
TC0200005013.mm.2 Samhd1 SAM domain and HD domain, 1 2 -157119560, -157097533 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 NM_001139520, NM_018851, BC012721, BC067198 46

nucleotide binding

double-strand break repair via homologous recombination

immune system process

nucleic acid binding

single-stranded DNA binding

RNA binding

catalytic activity

GTP binding

nucleus

nucleus

nucleoplasm

chromosome

plasma membrane

dGTP catabolic process

dGTP catabolic process

DNA replication

DNA repair

cellular response to DNA damage stimulus

metabolic process

zinc ion binding

dGTPase activity

dGTPase activity

dGTPase activity

deoxyribonucleotide catabolic process

somatic hypermutation of immunoglobulin genes

hydrolase activity

triphosphoric monoester hydrolase activity

triphosphoric monoester hydrolase activity

dGTP binding

site of double-strand break

identical protein binding

innate immune response

regulation of innate immune response

regulation of innate immune response

dATP catabolic process

dATP catabolic process

metal ion binding

protein homotetramerization

protein homotetramerization

defense response to virus

defense response to virus

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

tetraspanin-enriched microdomain

DNA strand resection involved in replication fork processing

 
MG-1-pos-10342553_st                
TC0600001258.mm.2 Irak2 interleukin-1 receptor-associated kinase 2 6 113638466 NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 NM_001113553, NM_172161, BC085324 42

nucleotide binding

regulation of cytokine-mediated signaling pathway

MyD88-dependent toll-like receptor signaling pathway

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

plasma membrane

protein phosphorylation

inflammatory response

signal transduction

I-kappaB kinase/NF-kappaB signaling

cytokine-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

intracellular signal transduction

protein homodimerization activity

regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

protein heterodimerization activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

interleukin-1-mediated signaling pathway

interleukin-1-mediated signaling pathway

response to interleukin-1

04210

04722

TC1200002359.mm.2 Wars tryptophanyl-tRNA synthetase 12 -108860029, -108860029, -108860029 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 NM_001164314, NM_001164488, NM_011710, BC003450, BC046232 35

nucleotide binding

angiogenesis

negative regulation of protein phosphorylation

aminoacyl-tRNA ligase activity

tryptophan-tRNA ligase activity

tryptophan-tRNA ligase activity

tryptophan-tRNA ligase activity

tryptophan-tRNA ligase activity

ATP binding

nucleus

cytoplasm

cytosol

translation

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation

tryptophanyl-tRNA aminoacylation

negative regulation of protein kinase activity

positive regulation of gene expression

regulation of protein ADP-ribosylation

ligase activity

kinase inhibitor activity

protein kinase binding

protein domain specific binding

positive regulation of protein-containing complex assembly

protein-containing complex

protein homodimerization activity

regulation of angiogenesis

00380

00970

TC1100000900.mm.2 Per1 period circadian clock 1 11 69100151, 69098948 NM_001159367, NM_011065, BC039768, BC091645 NM_001159367, NM_011065, BC039768, BC091645 NM_001159367, NM_011065, BC039768, BC091645 NM_001159367, NM_011065, BC039768, BC091645 344

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

transcription corepressor binding

regulation of sodium ion transport

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

circadian rhythm

circadian rhythm

circadian rhythm

transcription factor binding

response to light stimulus

posttranscriptional regulation of gene expression

kinase binding

kinase binding

chromatin DNA binding

ubiquitin protein ligase binding

circadian regulation of gene expression

circadian regulation of gene expression

circadian regulation of gene expression

circadian regulation of gene expression

regulation of hair cycle

regulation of circadian rhythm

negative regulation of I-kappaB kinase/NF-kappaB signaling

entrainment of circadian clock by photoperiod

entrainment of circadian clock by photoperiod

histone H3 acetylation

histone H3 acetylation

histone H4 acetylation

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of JNK cascade

rhythmic process

response to cAMP

E-box binding

histone H3 deacetylation

circadian regulation of translation

regulation of cytokine production involved in inflammatory response

regulation of p38MAPK cascade

negative regulation of glucocorticoid receptor signaling pathway

04710

TC1300002717.mm.2         NM_001033228, NM_134058, BC050209, BC057160, BC167237 NM_001033228, NM_134058, BC050209, BC057160, BC167237 NM_001033228, NM_134058, BC050209, BC057160, BC167237 NM_001033228, NM_134058, BC050209, BC057160, BC167237 NM_001033228, NM_134058, BC050209, BC057160, BC167237  

activation of MAPK activity

acrosomal vesicle

inner cell mass cell proliferation

nuclease activity

endonuclease activity

signaling receptor binding

protein binding

collagen binding

nucleus

cytoplasm

cytoplasm

plasma membrane

focal adhesion

cell cycle

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

endoderm development

endoderm development

negative regulation of cell population proliferation

integrin complex

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

hydrolase activity

stem cell population maintenance

protein phosphatase binding

positive regulation of BMP signaling pathway

neutrophil chemotaxis

positive regulation of phosphoprotein phosphatase activity

ribosome disassembly

integrin alpha1-beta1 complex

negative regulation of epidermal growth factor receptor signaling pathway

vasodilation

neuron projection

perikaryon

positive regulation of neuron apoptotic process

membrane raft

cellular extravasation

basal part of cell

metal ion binding

neuron projection morphogenesis

chromosome organization

cell division

mesenchymal to epithelial transition

cell chemotaxis

nuclear-transcribed mRNA catabolic process, non-stop decay

nonfunctional rRNA decay

nuclear-transcribed mRNA catabolic process, no-go decay

RNA surveillance

collagen binding involved in cell-matrix adhesion

 
TC0400003794.mm.2 C1qa complement component 1, q subcomponent, alpha polypeptide 4 -136895915 NM_007572, BC002086 NM_007572, BC002086 212

microglial cell activation

immune system process

protein binding

extracellular region

collagen trimer

extracellular space

complement activation, classical pathway

aging

aging

neuron remodeling

innate immune response

synapse

synapse

synapse

astrocyte activation

synapse organization

postsynapse

synapse pruning

complement-mediated synapse pruning

vertebrate eye-specific patterning

positive regulation of neuron death

04610

05020

05142

05150

05322

TC0100000039.mm.2 Adhfe1 alcohol dehydrogenase, iron containing, 1 1 9547947 NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 NM_175236, NR_027664, BC026584 17

alcohol dehydrogenase (NAD+) activity

mitochondrion

mitochondrion

glutamate catabolic process via 2-oxoglutarate

oxidoreductase activity

metal ion binding

hydroxyacid-oxoacid transhydrogenase activity

 
TC0100001496.mm.2 Sell selectin, lymphocyte 1 164062075 NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 NM_001164059, NM_011346, BC052681 263

protease binding

calcium ion binding

protein binding

plasma membrane

integral component of plasma membrane

cell adhesion

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

carbohydrate binding

response to ATP

regulation of apoptotic process

metal ion binding

cell adhesion molecule binding

leukocyte migration

leukocyte tethering or rolling

glycolipid binding

oligosaccharide binding

positive regulation of neutrophil chemotaxis

04514

TC1000000050.mm.2 Katna1 katanin p60 (ATPase-containing) subunit A1 10 7725999 NM_011835, BC009136 NM_011835, BC009136 33

nucleotide binding

spindle pole

microtubule bundle formation

neuron migration

protein binding

ATP binding

nucleus

nucleus

cytoplasm

lipid droplet

centrosome

spindle

cytoskeleton

microtubule

plasma membrane

cell cycle

microtubule binding

protein localization

microtubule-severing ATPase activity

microtubule-severing ATPase activity

negative regulation of neuron projection development

microtubule cytoskeleton

isomerase activity

ATPase activity

ATPase activity

axon

axon

growth cone

midbody

cytoplasmic microtubule organization

cytoplasmic microtubule organization

neuronal cell body

protein heterodimerization activity

microtubule severing

microtubule severing

microtubule severing

cell division

dynein complex binding

mitotic spindle pole

 
TC0500001043.mm.2 Lrrc8c leucine rich repeat containing 8 family, member C 5 105519470 NM_133897, BC025473, BC026572 NM_133897, BC025473, BC026572 NM_133897, BC025473, BC026572 21

volume-sensitive anion channel activity

volume-sensitive anion channel activity

cytoplasm

endoplasmic reticulum

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

ion transport

taurine transport

aspartate transmembrane transport

membrane

integral component of membrane

protein hexamerization

ion channel complex

ion channel complex

fat cell differentiation

fat cell differentiation

cellular response to osmotic stress

anion transmembrane transport

anion transmembrane transport

 
TC0600001579.mm.2 Etv6 ets variant 6 6 134035699 NM_007961, BC052163 NM_007961, BC052163 83

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleolus

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

vitellogenesis

protein domain specific binding

neurogenesis

cell differentiation

cell differentiation

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

hematopoietic stem cell proliferation

mesenchymal cell apoptotic process

04320

TSUnmapped00000047.mm.2 Cd83 CD83 antigen 13 43785111 NM_001289915 58

external side of plasma membrane

response to organic cyclic compound

membrane

integral component of membrane

negative regulation of interleukin-4 production

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

positive regulation of CD4-positive, alpha-beta T cell differentiation

 
TC0800002597.mm.2 Junb jun B proto-oncogene 8 -84976908 NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 NM_008416, BC003790, BC092302 179

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

vasculogenesis

osteoblast differentiation

in utero embryonic development

trophectodermal cell differentiation

trophectodermal cell differentiation

DNA binding

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription factor binding

cellular process

osteoclast differentiation

osteoblast proliferation

transcription factor AP-1 complex

regulation of cell population proliferation

sequence-specific DNA binding

positive regulation of cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

decidualization

regulation of cell cycle

regulation of cell cycle

embryonic process involved in female pregnancy

labyrinthine layer blood vessel development

cellular response to calcium ion

sequence-specific double-stranded DNA binding

04380

TC0400003917.mm.2 Pdpn podoplanin 4 -143267408 NM_010329, BC026551 NM_010329, BC026551 331

cell morphogenesis

cell morphogenesis

ruffle

lymphangiogenesis

signaling receptor binding

signaling receptor binding

protein binding

mitochondrion

cytosol

plasma membrane

plasma membrane

prostaglandin metabolic process

movement of cell or subcellular component

cell adhesion

signal transduction

Rho protein signal transduction

Rho protein signal transduction

multicellular organism development

cell population proliferation

negative regulation of cell population proliferation

regulation of cell shape

external side of plasma membrane

positive regulation of platelet activation

positive regulation of epithelial to mesenchymal transition

positive regulation of epithelial to mesenchymal transition

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

chemokine binding

chemokine binding

lamellipodium

lamellipodium

cell junction

regulation of cell adhesion

filopodium

filopodium

lung development

lung development

positive regulation of cell migration

positive regulation of cell migration

lamellipodium membrane

cytoplasmic vesicle

filopodium membrane

microvillus membrane

ruffle membrane

tube morphogenesis

tube morphogenesis

cell projection

negative regulation of apoptotic process

wound healing, spreading of cells

membrane raft

lung alveolus development

lymph node development

chaperone binding

chaperone binding

positive regulation of cellular component movement

response to hyperoxia

lymphatic endothelial cell fate commitment

visceral serous pericardium development

leading edge of lamellipodium

actin-mediated cell contraction

actin-mediated cell contraction

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix disassembly

tetraspanin-enriched microdomain

cell-cell adhesion

cell-cell adhesion

regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading

positive regulation of platelet aggregation

positive regulation of platelet aggregation

positive regulation of platelet aggregation

positive regulation of platelet aggregation

regulation of myofibroblast contraction

regulation of myofibroblast contraction

regulation of G1/S transition of mitotic cell cycle

regulation of lamellipodium morphogenesis

regulation of lamellipodium morphogenesis

 
TC1300000498.mm.2 Cd83 CD83 antigen 13 43785111 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 NM_009856, BC107344, BC107345, CD83 58

external side of plasma membrane

response to organic cyclic compound

membrane

integral component of membrane

negative regulation of interleukin-4 production

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

positive regulation of CD4-positive, alpha-beta T cell differentiation

 
TC1300002725.mm.2 Parp8 poly (ADP-ribose) polymerase family, member 8 13 -116850843 NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 NM_001081009, BC021315, BC021881 20

NAD+ ADP-ribosyltransferase activity

intracellular anatomical structure

protein ADP-ribosylation

transferase activity

transferase activity, transferring glycosyl groups

protein auto-ADP-ribosylation

protein mono-ADP-ribosylation

protein ADP-ribosylase activity

 
TC1800001415.mm.2 Slc26a2 solute carrier family 26 (sulfate transporter), member 2 18 -61196853 NM_007885, BC028345 NM_007885, BC028345 34

ossification

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

ion transport

secondary active sulfate transmembrane transporter activity

sulfate transport

bicarbonate transmembrane transporter activity

chloride transmembrane transporter activity

sulfate transmembrane transporter activity

sulfate transmembrane transporter activity

anion:anion antiporter activity

membrane

integral component of membrane

apical plasma membrane

oxalate transmembrane transporter activity

microvillus membrane

transmembrane transport

sulfate transmembrane transport

 
TC0700003941.mm.2 Trim30b tripartite motif-containing 30B 7 -104355397 NM_175648 14

protein polyubiquitination

nucleoplasm

cytoplasm

cytosol

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

protein kinase binding

regulation of protein localization

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

regulation of viral entry into host cell

positive regulation of NF-kappaB transcription factor activity

ubiquitin protein ligase activity

 
TC1000002374.mm.2 Gucd1 guanylyl cyclase domain containing 1 10 -75506813, -75506813 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 NM_175133, BC024851, BC043463, BC118613, BC119795 15

molecular_function

cellular_component

biological_process

 
TC0100000758.mm.2         XM_979370      
TC1900001203.mm.2 Psat1 phosphoserine aminotransferase 1 19 -15905122, -15905122 NM_001205339, NM_177420, BC004827 NM_001205339, NM_177420, BC004827 NM_001205339, NM_177420, BC004827 34

catalytic activity

O-phospho-L-serine:2-oxoglutarate aminotransferase activity

cytoplasm

cytosol

L-serine biosynthetic process

transaminase activity

cellular amino acid biosynthetic process

transferase activity

pyridoxal phosphate binding

identical protein binding

00260

00750

01100

TC0900000199.mm.2 AB124611 cDNA sequence AB124611 9 21526176 NM_001198794, NM_206536 NM_001198794, NM_206536 12

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
MG-1-pos-10339765_st                
TC0700003943.mm.2 Trim30a tripartite motif-containing 30A 7 -104409025, -104409025 NM_009099, BC005447 NM_009099, BC005447 34

protein polyubiquitination

DNA binding

ubiquitin-protein transferase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

autophagy

zinc ion binding

response to bacterium

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

protein kinase binding

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

regulation of protein localization

negative regulation of toll-like receptor signaling pathway

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

positive regulation of protein catabolic process

regulation of viral entry into host cell

positive regulation of viral entry into host cell

metal ion binding

positive regulation of NF-kappaB transcription factor activity

defense response to virus

protein autoubiquitination

ubiquitin protein ligase activity

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of reactive oxygen species metabolic process

 
MG-1-pos-10339750_st                
TC0100001765.mm.2 Dusp10 dual specificity phosphatase 10 1 184034380 NM_022019, BC025066 NM_022019, BC025066 46

inactivation of MAPK activity

inactivation of MAPK activity

regulation of adaptive immune response

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

protein dephosphorylation

protein dephosphorylation

protein dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

JUN kinase binding

negative regulation of epithelial cell migration

dephosphorylation

nuclear speck

hydrolase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

response to lipopolysaccharide

negative regulation of stress-activated MAPK cascade

MAP kinase phosphatase activity

MAP kinase phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-threonine dephosphorylation

peptidyl-threonine dephosphorylation

negative regulation of JUN kinase activity

negative regulation of JUN kinase activity

negative regulation of JUN kinase activity

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of innate immune response

positive regulation of regulatory T cell differentiation

negative regulation of JNK cascade

negative regulation of JNK cascade

mitogen-activated protein kinase p38 binding

oligodendrocyte differentiation

negative regulation of oligodendrocyte differentiation

negative regulation of epithelial cell proliferation

mitogen-activated protein kinase binding

negative regulation of respiratory burst involved in inflammatory response

negative regulation of ERK1 and ERK2 cascade

regulation of brown fat cell differentiation

negative regulation of p38MAPK cascade

negative regulation of epithelium regeneration

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

04010

TC0700001258.mm.2 Ctsc cathepsin C 7 88278084, 88278084 NM_009982, BC067063 NM_009982, BC067063 77

T cell mediated cytotoxicity

cysteine-type endopeptidase activity

serine-type endopeptidase activity

extracellular space

nucleoplasm

cytoplasm

lysosome

lysosome

endoplasmic reticulum

Golgi apparatus

centrosome

proteolysis

proteolysis

peptidase activity

cysteine-type peptidase activity

cysteine-type peptidase activity

response to organic substance

peptidase activator activity involved in apoptotic process

hydrolase activity

phosphatase binding

chloride ion binding

negative regulation of myelination

negative regulation of myelination

identical protein binding

intracellular membrane-bounded organelle

protein self-association

chaperone binding

proteolysis involved in cellular protein catabolic process

collagen-containing extracellular matrix

positive regulation of proteolysis involved in cellular protein catabolic process

positive regulation of microglial cell activation

positive regulation of apoptotic signaling pathway

04142

TC0200003278.mm.2 Ptges prostaglandin E synthase 2 -30889470 NM_022415, BC024960 NM_022415, BC024960 186

prostaglandin biosynthetic process

prostaglandin biosynthetic process

prostaglandin biosynthetic process

glutathione transferase activity

glutathione peroxidase activity

prostaglandin-D synthase activity

prostaglandin-D synthase activity

prostaglandin-D synthase activity

nuclear envelope lumen

cytoplasm

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

negative regulation of cell population proliferation

membrane

integral component of membrane

integral component of membrane

oxidoreductase activity

transferase activity

isomerase activity

sensory perception of pain

regulation of fever generation

positive regulation of prostaglandin secretion

intracellular membrane-bounded organelle

glutathione binding

perinuclear region of cytoplasm

prostaglandin-E synthase activity

prostaglandin-E synthase activity

regulation of inflammatory response

00590

01100

TC0200000486.mm.2 Ralgds ral guanine nucleotide dissociation stimulator 2 28533463, 28513166 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 NM_001145834, NM_001145835, NM_001145836, NM_009058, BC027225 32

guanyl-nucleotide exchange factor activity

protein binding

intracellular anatomical structure

nucleus

cytoplasm

cytosol

brush border

signal transduction

small GTPase mediated signal transduction

GTPase regulator activity

05200

05210

05212

TC1300000998.mm.2 Edil3 EGF-like repeats and discoidin I-like domains 3 13 88821471 NM_001037987, NM_010103, BC056386 NM_001037987, NM_010103, BC056386 NM_001037987, NM_010103, BC056386 448

integrin binding

calcium ion binding

extracellular region

cell adhesion

multicellular organism development

positive regulation of cell-substrate adhesion

metal ion binding

 
TC1000000729.mm.2 Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 10 75933129 NM_175329, BC061190 NM_175329, BC061190 28

protein binding

nucleus

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial intermembrane space

oxidative phosphorylation

mitochondrion organization

mitochondrion organization

mitochondrion organization

stabilization of membrane potential

mitochondria-nucleus signaling pathway

maintenance of protein location in nucleus

MICOS complex

protein-containing complex assembly

mitochondrial nucleoid organization

maintenance of synapse structure

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of mitochondrial transcription

positive regulation of cristae formation

 
TC1500000688.mm.2 Apobec3 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 15 79895022, 79892407 NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 NM_001160415, NM_030255, BC003314 101

P-body

hematopoietic progenitor cell differentiation

immune system process

RNA binding

catalytic activity

cytidine deaminase activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

zinc ion binding

negative regulation of transposition

negative regulation of transposition

negative regulation of transposition

cytidine to uridine editing

hydrolase activity

negative regulation of viral genome replication

innate immune response

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

metal ion binding

deoxycytidine deaminase activity

deoxycytidine deaminase activity

regulation of defense response to virus

defense response to virus

defense response to virus

DNA cytosine deamination

DNA demethylation

regulation of viral life cycle

 
TC0700003946.mm.2 Trim30d tripartite motif-containing 30D 7 -104470013 NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 NM_001167828, NM_199146, BC056631 13

protein polyubiquitination

nucleoplasm

cytoplasm

cytosol

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

protein kinase binding

regulation of protein localization

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

regulation of viral entry into host cell

positive regulation of NF-kappaB transcription factor activity

ubiquitin protein ligase activity

 
TC0700002696.mm.2 Zfp36 zinc finger protein 36 7 -28376783 NM_011756, BC021391 NM_011756, BC021391 173

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

MAPK cascade

MAPK cascade

exosome (RNase complex)

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nuclear-transcribed mRNA poly(A) tail shortening

nuclear-transcribed mRNA poly(A) tail shortening

P-body

DNA binding

mRNA binding

mRNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

regulation of transcription by RNA polymerase II

mRNA catabolic process

multicellular organism development

response to wounding

response to wounding

cytoplasmic stress granule

regulation of keratinocyte proliferation

enzyme binding

protein kinase binding

C-C chemokine binding

CCR4-NOT complex

heat shock protein binding

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

regulation of tumor necrosis factor production

negative regulation of interleukin-2 production

negative regulation of viral transcription

miRNA mediated inhibition of translation

intracellular signal transduction

mRNA 3'-UTR AU-rich region binding

mRNA 3'-UTR AU-rich region binding

p38MAPK cascade

response to starvation

regulation of mRNA stability

regulation of mRNA stability

regulation of mRNA stability

cellular response to fibroblast growth factor stimulus

cellular response to fibroblast growth factor stimulus

protein-containing complex binding

positive regulation of fat cell differentiation

regulation of keratinocyte differentiation

negative regulation of myeloid cell differentiation

negative regulation of erythrocyte differentiation

metal ion binding

negative regulation of inflammatory response

RNA destabilization

mRNA transport

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

RNA polymerase binding

RISC-loading complex

3'-UTR-mediated mRNA stabilization

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to tumor necrosis factor

cellular response to tumor necrosis factor

cellular response to epidermal growth factor stimulus

cellular response to glucocorticoid stimulus

14-3-3 protein binding

14-3-3 protein binding

cellular response to granulocyte macrophage colony-stimulating factor stimulus

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA

regulation of keratinocyte apoptotic process

negative regulation of polynucleotide adenylyltransferase activity

positive regulation of intracellular mRNA localization

ribonucleoprotein complex

ribonucleoprotein complex

positive regulation of gene silencing by miRNA

 
TC1100003779.mm.2 Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 11 -100694883 NM_030150, BC029209 NM_030150, BC029209 36

nucleotide binding

immune system process

DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

helicase activity

ATP binding

cytoplasm

cytoplasm

zinc ion binding

zinc ion binding

response to virus

response to virus

response to bacterium

hydrolase activity

negative regulation of type I interferon production

negative regulation of type I interferon production

positive regulation of type I interferon production

positive regulation of interferon-beta production

negative regulation of MDA-5 signaling pathway

negative regulation of RIG-I signaling pathway

negative regulation of RIG-I signaling pathway

innate immune response

regulation of innate immune response

negative regulation of innate immune response

negative regulation of innate immune response

metal ion binding

defense response to virus

positive regulation of MDA-5 signaling pathway

positive regulation of RIG-I signaling pathway

04622

TC0500000488.mm.2 Lap3 leucine aminopeptidase 3 5 45493373 NM_024434, BC016536 NM_024434, BC016536 31

aminopeptidase activity

intracellular anatomical structure

nucleoplasm

cytoplasm

mitochondrion

trans-Golgi network

cytosol

proteolysis

peptidase activity

metalloexopeptidase activity

hydrolase activity

protein metabolic process

manganese ion binding

midbody

metal ion binding

00330

00480

01100

TC1400000304.mm.2 Dcp1a decapping mRNA 1A 14 30479564 NM_133761, BC066173 NM_133761, BC066173 51

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

deadenylation-dependent decapping of nuclear-transcribed mRNA

P-body

P-body

mRNA binding

nucleus

transcription regulator complex

cytoplasm

cytoplasm

transforming growth factor beta receptor signaling pathway

enzyme activator activity

transcription factor binding

hydrolase activity

kinesin binding

enzyme regulator activity

deadenylation-independent decapping of nuclear-transcribed mRNA

cytoplasmic ribonucleoprotein granule

identical protein binding

positive regulation of catalytic activity

positive regulation of transcription, DNA-templated

protein localization to cytoplasmic stress granule

03018

TC1800001512.mm.2 Ptpn2 protein tyrosine phosphatase, non-receptor type 2 18 -67665500 NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269 NM_001127177, NM_008977, BC008269 111

negative regulation of transcription by RNA polymerase II

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

non-membrane spanning protein tyrosine phosphatase activity

integrin binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

cytosol

plasma membrane

protein dephosphorylation

protein dephosphorylation

protein dephosphorylation

negative regulation of cell population proliferation

insulin receptor signaling pathway

negative regulation of tumor necrosis factor-mediated signaling pathway

negative regulation of lipid storage

membrane

dephosphorylation

hydrolase activity

phosphatase activity

protein kinase binding

syntaxin binding

B cell differentiation

T cell differentiation

erythrocyte differentiation

receptor tyrosine kinase binding

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

glucose homeostasis

negative regulation of macrophage differentiation

positive regulation of gluconeogenesis

negative regulation of insulin receptor signaling pathway

negative regulation of inflammatory response

negative regulation of T cell receptor signaling pathway

negative regulation of chemotaxis

negative regulation of interferon-gamma-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

negative regulation of protein tyrosine kinase activity

negative regulation of interleukin-6-mediated signaling pathway

negative regulation of interleukin-6-mediated signaling pathway

negative regulation of ERK1 and ERK2 cascade

STAT family protein binding

regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of interleukin-2-mediated signaling pathway

negative regulation of interleukin-2-mediated signaling pathway

negative regulation of interleukin-4-mediated signaling pathway

negative regulation of interleukin-4-mediated signaling pathway

negative regulation of macrophage colony-stimulating factor signaling pathway

negative regulation of positive thymic T cell selection

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of PERK-mediated unfolded protein response

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

 
TC0100001574.mm.2 Fcgr4 Fc receptor, IgG, low affinity IV 1 171018925 NM_144559, BC027310 NM_144559, BC027310 54

transmembrane signaling receptor activity

plasma membrane

integral component of plasma membrane

cell surface receptor signaling pathway

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

IgE receptor activity

IgG receptor activity

IgE binding

IgG binding

neutrophil activation

positive regulation of bone resorption

regulation of immune response

regulation of sensory perception of pain

cellular response to lipopolysaccharide

04145

04380

04650

05140

05150

05322

MG-1-pos-10343468_st                
TC0700001793.mm.2 Il4ra interleukin 4 receptor, alpha 7 125552270 NM_001008700, BC112911 NM_001008700, BC112911 384

immune system process

production of molecular mediator involved in inflammatory response

positive regulation of immunoglobulin production

cytokine receptor activity

protein binding

extracellular region

extracellular space

nucleoplasm

plasma membrane

membrane

integral component of membrane

immunoglobulin mediated immune response

positive regulation of chemokine production

centriolar satellite

regulation of cell population proliferation

defense response to protozoan

positive regulation of macrophage activation

receptor complex

positive regulation of mast cell degranulation

negative regulation of T-helper 1 cell differentiation

positive regulation of T-helper 2 cell differentiation

positive regulation of cold-induced thermogenesis

positive regulation of myoblast fusion

04060

04630

04640

TC0500002623.mm.2 Kdr kinase insert domain protein receptor 5 -75957364, -75932826 NM_010612, BC020530 NM_010612, BC020530 1021

nucleotide binding

angiogenesis

ovarian follicle development

branching involved in blood vessel morphogenesis

vasculogenesis

response to hypoxia

positive regulation of protein phosphorylation

regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

lymph vessel development

cell migration involved in sprouting angiogenesis

positive regulation of mesenchymal cell proliferation

hematopoietic progenitor cell differentiation

endocardium development

endothelium development

endochondral bone growth

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

vascular endothelial growth factor-activated receptor activity

vascular endothelial growth factor-activated receptor activity

integrin binding

protein binding

ATP binding

extracellular region

nucleus

cytoplasm

cytoplasm

endosome

early endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

protein phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

positive regulation of cytosolic calcium ion concentration

multicellular organism development

positive regulation of cell population proliferation

regulation of cell shape

male gonad development

external side of plasma membrane

cell surface

positive regulation of endothelial cell migration

positive regulation of endothelial cell migration

negative regulation of gene expression

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

integral component of membrane

positive regulation of macroautophagy

kinase activity

phosphorylation

cell migration

cell migration

transferase activity

peptidyl-tyrosine phosphorylation

growth factor binding

growth factor binding

cell junction

hemopoiesis

cell differentiation

lung development

positive regulation of cell migration

positive regulation of BMP signaling pathway

positive regulation of vascular endothelial growth factor receptor signaling pathway

cytoplasmic vesicle

positive regulation of TOR signaling

positive regulation of kinase activity

embryonic hemopoiesis

calcium-mediated signaling using intracellular calcium source

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor receptor-2 signaling pathway

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

peptidyl-tyrosine autophosphorylation

vascular endothelial growth factor signaling pathway

vascular endothelial growth factor binding

response to drug

identical protein binding

neuron projection

neuronal cell body

negative regulation of apoptotic process

surfactant homeostasis

receptor complex

positive regulation of MAPK cascade

protein kinase B signaling

negative regulation of neuron apoptotic process

positive regulation of blood vessel endothelial cell migration

membrane raft

cell fate commitment

cadherin binding

endothelial cell differentiation

endothelial cell differentiation

endothelial cell differentiation

endothelial cell differentiation

positive regulation of angiogenesis

positive regulation of angiogenesis

positive regulation of angiogenesis

protein autophosphorylation

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

positive regulation of long-term neuronal synaptic plasticity

lung alveolus development

cell maturation

post-embryonic camera-type eye morphogenesis

branching morphogenesis of an epithelial tube

neuron projection morphogenesis

positive regulation of epithelial cell proliferation

positive regulation of calcium-mediated signaling

positive regulation of positive chemotaxis

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of focal adhesion assembly

positive regulation of mitochondrial depolarization

calcium ion homeostasis

blood vessel endothelial cell differentiation

vascular wound healing

ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

cell periphery

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of mitochondrial fission

sorting endosome

regulation of hematopoietic progenitor cell differentiation

regulation of bone development

cellular response to hydrogen sulfide

negative regulation of endothelial cell apoptotic process

positive regulation of vasculogenesis

04060

04144

04370

04510

TC0400003681.mm.2 Themis2 thymocyte selection associated family member 2 4 -132782356 NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 NM_001033308, BC151122, BC151126 18

immune system process

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

inflammatory response

T cell receptor signaling pathway

T cell receptor signaling pathway

 
TC1300000362.mm.2 Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b 13 32965260 NM_011454, BC061050 NM_011454, BC061050 18

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular space

nucleus

cytoplasm

cytoplasm

gonad development

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

05146

TC0600003231.mm.2 Klrk1 killer cell lectin-like receptor subfamily K, member 1 6 -129610322, -129610322 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 NM_001083322, NM_001286018, NM_033078, BC057147 199

stimulatory C-type lectin receptor signaling pathway

adaptive immune response

immune system process

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

protein binding

plasma membrane

plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

kinase binding

natural killer cell activation

natural killer cell activation

cell differentiation

carbohydrate binding

positive regulation of myeloid dendritic cell activation

MHC class Ib receptor activity

positive regulation of interferon-gamma production

signaling receptor activity

MHC class I protein binding

identical protein binding

positive regulation of apoptotic process

innate immune response

positive regulation of nitric oxide biosynthetic process

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

defense response to Gram-positive bacterium

cellular response to lipopolysaccharide

04650

TC0100001018.mm.2 Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 1 106171868 NM_133821, BC059254 NM_133821, BC059254 54

regulation of protein phosphorylation

regulation of T cell anergy

catalytic activity

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein serine/threonine phosphatase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

plasma membrane

protein dephosphorylation

apoptotic process

signal transduction

entrainment of circadian clock

membrane

hydrolase activity

nuclear membrane

regulation of apoptotic process

intracellular membrane-bounded organelle

regulation of MAPK cascade

regulation of JNK cascade

metal ion binding

positive regulation of protein kinase B signaling

negative regulation of protein kinase B signaling

negative regulation of ERK1 and ERK2 cascade

positive regulation of protein kinase C signaling

negative regulation of protein kinase C signaling

regulation of p38MAPK cascade

 
TC0900001858.mm.2 Tyk2 tyrosine kinase 2 9 -21104067 NM_001205312, NM_018793, BC094240 NM_001205312, NM_018793, BC094240 NM_001205312, NM_018793, BC094240 96

nucleotide binding

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

growth hormone receptor binding

ATP binding

nucleus

cytoplasm

cytosol

cytoskeleton

protein phosphorylation

membrane

kinase activity

phosphorylation

transferase activity

type 1 angiotensin receptor binding

intracellular signal transduction

04380

04630

05145

05160

TC1000001149.mm.2 Tmcc3 transmembrane and coiled coil domains 3 10 94575256, 94576262, 94550919, 94311948, 94550871, 94514856 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 NM_001168684, NM_172051, NM_177026, BC026867, BC057202, BC095951 20

endoplasmic reticulum

biological_process

endomembrane system

membrane

integral component of membrane

identical protein binding

14-3-3 protein binding

 
TC0300001578.mm.2 Ptger3 prostaglandin E receptor 3 (subtype EP3) 3 157566875 NM_011196, BC058742 NM_011196, BC058742 151

fever generation

fever generation

positive regulation of protein phosphorylation

desensitization of G protein-coupled receptor signaling pathway

G protein-coupled receptor activity

prostaglandin receptor activity

prostaglandin E receptor activity

prostaglandin E receptor activity

prostaglandin E receptor activity

prostaglandin E receptor activity

protein binding

plasma membrane

plasma membrane

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell surface

positive regulation of gene expression

negative regulation of norepinephrine secretion

regulation of circadian sleep/wake cycle, wakefulness

regulation of norepinephrine secretion

intestine smooth muscle contraction

intestine smooth muscle contraction

urinary bladder smooth muscle contraction

bicarbonate transport

membrane

integral component of membrane

brush border membrane

positive regulation of fever generation

receptor internalization

nuclear membrane

response to lipopolysaccharide

positive regulation of urine volume

neuron projection

neuronal cell body

positive regulation of cAMP-mediated signaling

positive regulation of vasoconstriction

positive regulation of circadian sleep/wake cycle, non-REM sleep

negative regulation of insulin secretion

negative regulation of gastric acid secretion

negative regulation of gastric acid secretion

negative regulation of platelet aggregation

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of potassium ion transmembrane transport

negative regulation of calcium ion transmembrane transport

negative regulation of gastrin-induced gastric acid secretion

positive regulation of smooth muscle contraction involved in micturition

cellular response to forskolin

positive regulation of inhibitory G protein-coupled receptor phosphorylation

negative regulation of circadian sleep/wake cycle, wakefulness

positive regulation of myofibroblast contraction

positive regulation of colon smooth muscle contraction

positive regulation of gastric mucosal blood circulation

prostaglandin receptor internalization

proximal neuron projection

positive regulation of neutrophil extravasation

negative regulation of forebrain neuron differentiation

04020

04080

TC0500002753.mm.2 Naaa N-acylethanolamine acid amidase 5 -92257659 NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572 NM_001163687, NM_025972, BC004572 24

cytoplasm

lysosome

lysosome

lipid metabolic process

fatty acid metabolic process

sphingosine metabolic process

transcription factor binding

membrane

lipid catabolic process

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

N-acylsphingosine amidohydrolase activity

fatty acid amide hydrolase activity

extrinsic component of membrane

N-(long-chain-acyl)ethanolamine deacylase activity

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

 
TC1400002833.mm.2 Rnf31 ring finger protein 31 14 55591741 NM_194346, BC057595 NM_194346, BC057595 49

protein polyubiquitination

ubiquitin-protein transferase activity

protein binding

cytoplasm

cytosol

cytoplasmic side of plasma membrane

protein ubiquitination

transferase activity

CD40 signaling pathway

ubiquitin protein ligase binding

CD40 receptor complex

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

ubiquitin binding

metal ion binding

T cell receptor signaling pathway

positive regulation of NF-kappaB transcription factor activity

negative regulation of necroptotic process

LUBAC complex

protein linear polyubiquitination

 
TC1900000350.mm.2 Cemip2 cell migration inducing hyaluronidase 2 19 21778339 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 NM_001033759, NM_031997, BC019745, BC076570, BC089353 25

angiogenesis

hyalurononglucosaminidase activity

calcium ion binding

plasma membrane

integral component of plasma membrane

multicellular organism development

metabolic process

membrane

integral component of membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hyaluronan catabolic process

intracellular membrane-bounded organelle

 
TC1400000745.mm.2 Mmp14 matrix metallopeptidase 14 (membrane-inserted) 14 54431597 NM_008608, BC076638 NM_008608, BC076638 211

skeletal system development

ossification

endochondral ossification

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

integrin binding

extracellular space

nucleus

cytoplasm

cytosol

plasma membrane

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

response to hormone

positive regulation of myotube differentiation

positive regulation of protein processing

membrane

integral component of membrane

cell migration

hydrolase activity

extracellular matrix organization

positive regulation of cell growth

lung development

positive regulation of cell migration

collagen catabolic process

collagen catabolic process

extracellular matrix

cytoplasmic vesicle

zymogen activation

zymogen activation

zymogen activation

chondrocyte proliferation

macropinosome

intermediate filament cytoskeleton

positive regulation of B cell differentiation

negative regulation of Notch signaling pathway

metal ion binding

embryonic cranial skeleton morphogenesis

branching morphogenesis of an epithelial tube

tissue remodeling

negative regulation of focal adhesion assembly

head development

bone development

metalloaminopeptidase activity

craniofacial suture morphogenesis

regulation of protein localization to plasma membrane

positive regulation of macrophage migration

04912

TC1600001092.mm.2 Mx2 MX dynamin-like GTPase 2 16 97536080, 97536082 NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 NM_013606, NR_003508, BC007127 25

mitochondrial fission

dynamin family protein polymerization involved in mitochondrial fission

GTPase activity

nucleus

cytoplasm

plasma membrane

microtubule binding

postsynaptic density

microtubule cytoskeleton

membrane

synaptic vesicle budding from presynaptic endocytic zone membrane

axon

cytoplasmic vesicle

receptor internalization

mitochondrial membrane

dendritic spine head

regulation of synapse structure or activity

membrane fusion

postsynaptic endocytic zone membrane

postsynaptic neurotransmitter receptor internalization

 
TC1200002440.mm.2 Gpr132 G protein-coupled receptor 132 12 -112850875 NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 NM_019925, BC120522, BC120524 46

G1/S transition of mitotic cell cycle

G1/S transition of mitotic cell cycle

G protein-coupled receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of G2/M transition of mitotic cell cycle

membrane

integral component of membrane

 
TC0200005175.mm.2 Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 2 -166566344 NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 NM_177782, BC151074, BC157940 42

guanyl-nucleotide exchange factor activity

phospholipid binding

cytoplasm

cytosol

plasma membrane

plasma membrane

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

T cell differentiation

positive regulation of cell migration

growth cone

neutrophil chemotaxis

regulation of actin filament polymerization

regulation of Rho protein signal transduction

intracellular signal transduction

dendritic shaft

positive regulation of GTPase activity

positive regulation of cell adhesion

perinuclear region of cytoplasm

regulation of dendrite development

reactive oxygen species metabolic process

positive regulation of substrate adhesion-dependent cell spreading

04062

MG-1-pos-10339726_st                
TC0500003186.mm.2 Trafd1 TRAF type zinc finger domain containing 1 5 -121371724, -121371724 NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 NM_001163470, NM_172275, BC038396 19

protein binding

zinc ion binding

negative regulation of innate immune response

metal ion binding

 
TC1900000500.mm.2 Ifit2 interferon-induced protein with tetratricopeptide repeats 2 19 34551087, 34550693 NM_008332, BC050835 NM_008332, BC050835 39

immune system process

RNA binding

cytoplasm

endoplasmic reticulum

cytosol

apoptotic process

response to virus

response to virus

negative regulation of protein binding

cellular response to interferon-alpha

positive regulation of apoptotic process

innate immune response

defense response to virus

 
TC0600000637.mm.2 Creb5 cAMP responsive element binding protein 5 6 53573373, 53287302 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 NM_172728, NR_015553, BC029022, BC098487 23

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cAMP response element binding

identical protein binding

fat cell differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

adipose tissue development

sequence-specific double-stranded DNA binding

04962

05016

05215

TC1200001729.mm.2 Gpr33 G protein-coupled receptor 33 12 -52023003 NM_008159, BC064084 NM_008159, BC064084 10

complement receptor mediated signaling pathway

complement receptor activity

G protein-coupled receptor activity

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

membrane

integral component of membrane

 
TC0900002346.mm.2 Tspan3 tetraspanin 3 9 -56135883 NM_019793, BC043072 NM_019793, BC043072 23

integral component of plasma membrane

membrane

integral component of membrane

 
TC0600000841.mm.2 St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6 72097607 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 NM_001035228, NM_011375, BC138557, BC138559 59

Golgi apparatus

protein glycosylation

sialyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

lactosylceramide alpha-2,3-sialyltransferase activity

lactosylceramide alpha-2,3-sialyltransferase activity

00604

01100

TC0400001543.mm.2 Fabp3 fatty acid binding protein 3, muscle and heart 4 130308737 NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 NM_010174, BC002082, BC089542 90

long-chain fatty acid transporter activity

fatty acid binding

extracellular space

extracellular space

cytoplasm

cytosol

cytosol

cytoskeletal protein binding

lipid binding

long-chain fatty acid transport

long-chain fatty acid transport

long-chain fatty acid transport

sarcoplasm

intracellular lipid transport

long-chain fatty acid binding

cholesterol homeostasis

regulation of fatty acid oxidation

icosatetraenoic acid binding

brown fat cell differentiation

phospholipid homeostasis

oleic acid binding

positive regulation of phospholipid biosynthetic process

positive regulation of long-chain fatty acid import into cell

positive regulation of long-chain fatty acid import into cell

regulation of phosphatidylcholine biosynthetic process

03320

TC1100000496.mm.2         NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437 NM_001271676, NM_001271677, NM_008330, NM_010999, BC001986, BC009131, BC141219, BC147437  

GTPase activity

G protein-coupled receptor activity

olfactory receptor activity

endoplasmic reticulum

endoplasmic reticulum membrane

plasma membrane

defense response

defense response

signal transduction

G protein-coupled receptor signaling pathway

sensory perception of smell

membrane

integral component of membrane

cellular response to interferon-beta

response to stimulus

 
TC1900000517.mm.2 Pcgf5 polycomb group ring finger 5 19 36409747, 36348328, 36379066 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 NM_029508, BC139258, BC139259, BC145590, BC145591 27

X chromosome

protein binding

nucleus

nucleoplasm

Golgi apparatus

centrosome

regulation of transcription by RNA polymerase II

PcG protein complex

PcG protein complex

PRC1 complex

histone H2A-K119 monoubiquitination

histone H2A-K119 monoubiquitination

positive regulation of transcription by RNA polymerase II

metal ion binding

inactivation of X chromosome by genetic imprinting

inactivation of X chromosome by genetic imprinting

 
TC0700002034.mm.2 Ifitm1 interferon induced transmembrane protein 1 7 140967428, 140968075, 140968027 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 NM_001112715, NM_026820, BC027285, BC090258, BC090972 35

ossification

somitogenesis

immune system process

molecular_function

early endosome

plasma membrane

response to virus

anterior/posterior pattern specification

membrane

integral component of membrane

protein-containing complex

response to interferon-gamma

response to interferon-alpha

response to interferon-beta

negative regulation of viral genome replication

innate immune response

negative regulation of viral entry into host cell

negative regulation of viral entry into host cell

defense response to virus

defense response to virus

type I interferon signaling pathway

04662

TC0300002659.mm.2 Mov10 Mov10 RISC complex RNA helicase 3 -104794833, -104794833 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 NM_001163440, NM_001163441, NM_008619, BC053743 39

nucleotide binding

P-body

RNA binding

RNA binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

cytosol

cytosol

cytosol

negative regulation of transposition, RNA-mediated

negative regulation of transposition, RNA-mediated

hydrolase activity

gene silencing by RNA

5'-3' RNA helicase activity

post-transcriptional gene silencing by RNA

gene silencing by miRNA

mRNA cleavage involved in gene silencing by miRNA

cytoplasmic ribonucleoprotein granule

P granule

defense response to virus

positive regulation of mRNA catabolic process

3'-UTR-mediated mRNA destabilization

regulation of neuron projection arborization

 
TC0900001155.mm.2 Ctsh cathepsin H 9 90054266 NM_007801, BC006878 NM_007801, BC006878 45

outer dense fiber

acrosomal vesicle

T cell mediated cytotoxicity

immune response-regulating signaling pathway

endopeptidase activity

endopeptidase activity

aminopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

serine-type endopeptidase activity

extracellular space

extracellular space

lysosome

lysosome

cytosol

axoneme

proteolysis

proteolysis

peptidase activity

cysteine-type peptidase activity

positive regulation of cell population proliferation

cysteine-type endopeptidase activator activity involved in apoptotic process

cysteine-type endopeptidase activator activity involved in apoptotic process

positive regulation of gene expression

positive regulation of epithelial cell migration

neuropeptide catabolic process

bradykinin catabolic process

positive regulation of peptidase activity

positive regulation of peptidase activity

peptidase activator activity involved in apoptotic process

hydrolase activity

HLA-A specific activating MHC class I receptor activity

positive regulation of cell migration

kininogen binding

zymogen activation

zymogen activation

protein destabilization

protein destabilization

response to retinoic acid

membrane protein proteolysis

membrane protein proteolysis

cytoplasmic ribonucleoprotein granule

negative regulation of apoptotic process

surfactant homeostasis

intracellular membrane-bounded organelle

protein self-association

protein-containing complex binding

positive regulation of angiogenesis

proteolysis involved in cellular protein catabolic process

dichotomous subdivision of terminal units involved in lung branching

thyroid hormone binding

ERK1 and ERK2 cascade

alveolar lamellar body

positive regulation of apoptotic signaling pathway

04142

TC0100000374.mm.2 Stat4 signal transducer and activator of transcription 4 1 51987147, 52008239 NM_011487, BC098499 NM_011487, BC098499 318

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

protein phosphorylation

defense response

signal transduction

receptor signaling pathway via JAK-STAT

cell population proliferation

positive regulation of gene expression

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

regulation of cell population proliferation

identical protein binding

response to peptide hormone

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

hematopoietic stem cell homeostasis

cellular response to organic substance

04630

TC1700001178.mm.2 Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 17 78200247 NM_015800, BC100348 NM_015800, BC100348 50

enzyme inhibitor activity

serine-type endopeptidase inhibitor activity

insulin-like growth factor binding

extracellular region

membrane

integral component of membrane

PDZ domain binding

negative regulation of BMP signaling pathway

negative regulation of osteoblast differentiation

 
TC1100004291.mm.2 Psme2b protease (prosome, macropain) activator subunit 2B 11 -48945351 NM_001281472 13

molecular_function

cellular_component

biological_process

 
TC0700002632.mm.2 Lipe lipase, hormone sensitive 7 -25379526, -25379526 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 NM_001039507, NM_010719, BC021642, XM_003688825 153

sterol esterase activity

sterol esterase activity

triglyceride lipase activity

triglyceride lipase activity

triglyceride lipase activity

protein binding

extracellular space

nucleus

cytoplasm

cytoplasm

mitochondrion

lipid droplet

cytosol

cytosol

plasma membrane

caveola

transcription initiation from RNA polymerase I promoter

termination of RNA polymerase I transcription

lipid metabolic process

steroid metabolic process

cholesterol metabolic process

membrane

lipid catabolic process

lipase activity

hydrolase activity

hydrolase activity, acting on ester bonds

serine hydrolase activity

triglyceride catabolic process

triglyceride catabolic process

triglyceride catabolic process

protein kinase binding

hormone-sensitive lipase activity

rRNA primary transcript binding

long-chain fatty acid catabolic process

diacylglycerol catabolic process

diacylglycerol catabolic process

ether lipid metabolic process

acylglycerol lipase activity

acylglycerol lipase activity

retinyl-palmitate esterase activity

retinyl-palmitate esterase activity

1,3-diacylglycerol acylhydrolase activity

1,2-diacylglycerol acylhydrolase activity

04910

TC1100003115.mm.2 Scimp SLP adaptor and CSK interacting membrane protein 11 -70790931 NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 NM_001045526, BC147177, BC147178 16

ruffle

immunological synapse

immunological synapse

cytokine production involved in immune response

positive regulation of dendritic cell cytokine production

protein binding

plasma membrane

membrane

integral component of membrane

filopodium

leading edge membrane

uropod membrane

cytoplasmic vesicle

positive regulation of lipopolysaccharide-mediated signaling pathway

positive regulation of interleukin-12 production

positive regulation of interleukin-6 production

positive regulation of stress-activated MAPK cascade

toll-like receptor 3 signaling pathway

toll-like receptor 4 signaling pathway

toll-like receptor 7 signaling pathway

toll-like receptor TLR1:TLR2 signaling pathway

cell projection

receptor complex

phagocytic vesicle

molecular adaptor activity

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

cellular response to molecule of fungal origin

tetraspanin-enriched microdomain

 
TC1000001596.mm.2 Stat2 signal transducer and activator of transcription 2 10 128270497 NM_019963, BC167243 NM_019963, BC167243 120

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

regulation of protein phosphorylation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

cytoplasm

cytosol

plasma membrane

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

defense response

signal transduction

receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

regulation of cell population proliferation

identical protein binding

response to peptide hormone

ubiquitin-like protein ligase binding

defense response to virus

type I interferon signaling pathway

type I interferon signaling pathway

type I interferon signaling pathway

regulation of mitochondrial fission

04062

04380

04630

05160

TC0600001586.mm.2 Bcl2l14 BCL2-like 14 (apoptosis facilitator) 6 134396328, 134414427 NM_025778, BC025541 NM_025778, BC025541 21

protein binding

cytoplasm

cytosol

apoptotic process

apoptotic process

protein kinase binding

regulation of apoptotic process

intracellular organelle

regulation of extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

 
TC1700002778.mm.2 Tapbp TAP binding protein 17 33919477 NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 NM_001025313, NM_009318, BC015074 69

Golgi membrane

MHC class Ib protein complex assembly

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

integral component of plasma membrane

defense response

regulation of gene expression

membrane

integral component of membrane

antigen processing and presentation of endogenous peptide antigen via MHC class I

phagocytic vesicle membrane

MHC class I peptide loading complex

TAP1 binding

TAP2 binding

peptide antigen stabilization

regulation of protein complex stability

TAP complex binding

protein-containing complex assembly

04612

TC1500000615.mm.2 1110038F14Rik RIKEN cDNA 1110038F14 gene 15 76948260 NM_054099, BC038324, BC091734 NM_054099, BC038324, BC091734 NM_054099, BC038324, BC091734 12

molecular_function

cellular_component

biological_process

 
TC1700001289.mm.2 Prkce protein kinase C, epsilon 17 86167784 NM_011104, BC165948 NM_011104, BC165948 269

Golgi membrane

nucleotide binding

macrophage activation involved in immune response

immune system process

actin monomer binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein kinase C activity

calcium-independent protein kinase C activity

signaling receptor binding

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

mitochondrion

endoplasmic reticulum

Golgi apparatus

cytosol

cytosol

cytoskeleton

plasma membrane

protein phosphorylation

protein phosphorylation

cell cycle

cell adhesion

chemosensory behavior

enzyme activator activity

positive regulation of epithelial cell migration

positive regulation of fibroblast migration

positive regulation of cell-substrate adhesion

positive regulation of cell-substrate adhesion

negative regulation of mitochondrial membrane potential

membrane

kinase activity

phosphorylation

transferase activity

SH3 domain binding

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

regulation of lipid metabolic process

enzyme binding

protein kinase binding

T-tubule

signaling receptor activator activity

positive regulation of actin filament polymerization

negative regulation of protein ubiquitination

neuromuscular junction

lipopolysaccharide-mediated signaling pathway

positive regulation of insulin secretion

positive regulation of synaptic transmission, GABAergic

positive regulation of cytokinesis

ethanol binding

intracellular signal transduction

intracellular signal transduction

locomotory exploration behavior

TRAM-dependent toll-like receptor 4 signaling pathway

cellular response to platelet-derived growth factor stimulus

negative regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

intracellular membrane-bounded organelle

response to morphine

positive regulation of MAPK cascade

positive regulation of MAPK cascade

intermediate filament cytoskeleton

metal ion binding

perinuclear region of cytoplasm

regulation of peptidyl-tyrosine phosphorylation

positive regulation of lipid catabolic process

regulation of release of sequestered calcium ion into cytosol

regulation of release of sequestered calcium ion into cytosol

negative regulation of release of sequestered calcium ion into cytosol

cell division

negative regulation of mitochondrial calcium ion concentration

regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of mucus secretion

cellular response to ethanol

cellular response to prostaglandin E stimulus

cellular response to hypoxia

14-3-3 protein binding

cell periphery

positive regulation of wound healing

glutamatergic synapse

presynaptic cytosol

regulation of synaptic vesicle exocytosis

positive regulation of cellular glucuronidation

04270

04530

04664

04666

04930

TC1700001463.mm.2 Gpr31b G protein-coupled receptor 31, D17Leh66b region 17 -13051320 NM_001013832, BC160363 NM_001013832, BC160363 11

response to molecule of bacterial origin

response to ischemia

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

response to acidic pH

membrane

integral component of membrane

bioactive lipid receptor activity

arachidonic acid binding

negative regulation of inflammatory response

positive regulation of immune response

 
TC0400001425.mm.2         NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864 NM_008385, NR_030480, BC028864  

in utero embryonic development

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

inositol-polyphosphate 5-phosphatase activity

cytoplasm

endosome

cytosol

cytosol

cytosol

signal transduction

spermatogenesis

membrane

membrane

integral component of membrane

hydrolase activity

flagellated sperm motility

cytoplasmic vesicle

inositol phosphate dephosphorylation

phosphatidylinositol dephosphorylation

phosphatidylinositol dephosphorylation

phosphatidylinositol dephosphorylation

metal ion binding

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol phosphate phosphatase activity

regulation of protein processing

 
TC1700001898.mm.2 Brd2 bromodomain containing 2 17 -34112018, -34112018, -34112018 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 NM_001204973, NM_010238, NR_037970, BC138655, BC138656 68

neural tube closure

chromatin binding

protein serine/threonine kinase activity

nucleus

nucleus

nucleoplasm

cytoplasm

chromatin organization

nucleosome assembly

regulation of transcription by RNA polymerase II

protein phosphorylation

regulation of gene expression

nuclear speck

lysine-acetylated histone binding

 
TC1900001085.mm.2 Stxbp3-ps syntaxin-binding protein 3, pseudogene 19 -9557605 NR_073559 3    
TC1600001944.mm.2 D16Ertd472e DNA segment, Chr 16, ERATO Doi 472, expressed 16 -78540335 NM_001252438, NM_001252439, NM_001252440, NM_025967, BC019957 NM_001252438, NM_001252439, NM_001252440, NM_025967, BC019957 NM_001252438, NM_001252439, NM_001252440, NM_025967, BC019957 NM_001252438, NM_001252439, NM_001252440, NM_025967, BC019957 NM_001252438, NM_001252439, NM_001252440, NM_025967, BC019957 23

protein binding

cellular_component

nervous system development

cerebral cortex neuron differentiation

cell differentiation

positive regulation of dendritic spine development

 
TC0700002705.mm.2 Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta 7 -28759037, -28758250 NM_010908, BC021938 NM_010908, BC021938 63

protein binding

nucleus

cytoplasm

cytosol

cytosol

signal transduction

signal transduction

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of NF-kappaB

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

04062

04621

04622

04623

04660

04662

04722

04920

05140

05145

TC0100003889.mm.2 Ifi211 interferon activated gene 211 1 -173896340 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 NM_001033450, BC132314, BC132316, BC145397 19

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

nucleolus

cytosol

transcription factor binding

response to bacterium

nuclear speck

positive regulation of interleukin-1 beta production

nuclear periphery

cellular response to interferon-beta

identical protein binding

 
TC1200000769.mm.2 Sipa1l1 signal-induced proliferation-associated 1 like 1 12 82170015, 82311348 NM_001167983, NM_172579, BC058681, BC095958 NM_001167983, NM_172579, BC058681, BC095958 NM_001167983, NM_172579, BC058681, BC095958 NM_001167983, NM_172579, BC058681, BC095958 42

GTPase activator activity

cytoplasm

cytoskeleton

plasma membrane

postsynaptic density

actin cytoskeleton

protein kinase binding

cell junction

actin cytoskeleton reorganization

ubiquitin protein ligase binding

protein-containing complex

neuron projection

neuronal cell body

regulation of GTPase activity

regulation of GTPase activity

dendritic spine

protein-containing complex binding

synapse

ephrin receptor binding

ephrin receptor signaling pathway

regulation of synaptic plasticity

regulation of dendrite morphogenesis

regulation of axonogenesis

actin filament binding

regulation of small GTPase mediated signal transduction

regulation of dendritic spine morphogenesis

activation of GTPase activity

activation of GTPase activity

postsynapse

postsynaptic actin cytoskeleton organization

glutamatergic synapse

regulation of postsynaptic density assembly

 
TC0900003011.mm.2 Parp3 poly (ADP-ribose) polymerase family, member 3 9 -106470321 NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 NM_145619, BC014870, BC058754 19

telomere maintenance

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

nucleus

nucleoplasm

nucleolus

cytoplasm

DNA repair

double-strand break repair

double-strand break repair

double-strand break repair

protein ADP-ribosylation

cellular response to DNA damage stimulus

nuclear body

transferase activity

transferase activity, transferring glycosyl groups

DNA ADP-ribosylation

site of double-strand break

site of double-strand break

site of double-strand break

intercellular bridge

negative regulation of isotype switching

positive regulation of DNA ligation

regulation of mitotic spindle organization

protein poly-ADP-ribosylation

protein auto-ADP-ribosylation

protein mono-ADP-ribosylation

NAD DNA ADP-ribosyltransferase activity

negative regulation of telomerase RNA reverse transcriptase activity

protein localization to site of double-strand break

protein ADP-ribosylase activity

protein ADP-ribosylase activity

positive regulation of double-strand break repair via nonhomologous end joining

03410

TC1300001395.mm.2 Pfkp phosphofructokinase, platelet 13 -6579873 NM_019703, BC006926 NM_019703, BC006926 58

nucleotide binding

catalytic activity

6-phosphofructokinase activity

6-phosphofructokinase activity

6-phosphofructokinase activity

ATP binding

ATP binding

cytoplasm

cytosol

6-phosphofructokinase complex

6-phosphofructokinase complex

fructose 6-phosphate metabolic process

fructose 6-phosphate metabolic process

glycolytic process

metabolic process

membrane

AMP binding

kinase activity

phosphorylation

transferase activity

fructose 1,6-bisphosphate metabolic process

fructose 1,6-bisphosphate metabolic process

identical protein binding

identical protein binding

protein-containing complex binding

metal ion binding

monosaccharide binding

glycolytic process through fructose-6-phosphate

canonical glycolysis

fructose-6-phosphate binding

fructose-6-phosphate binding

cellular response to leukemia inhibitory factor

00010

00030

00051

00052

01100

TC1400002091.mm.2 Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 14 -55587439, -55587439 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 NM_001029855, NM_011190, BC005680, BC057859 43

protein binding

nucleoplasm

cytoplasm

positive regulation of endopeptidase activity

antigen processing and presentation of exogenous antigen

identical protein binding

endopeptidase activator activity

regulation of proteasomal protein catabolic process

regulation of G1/S transition of mitotic cell cycle

03050

04612

TC1300002303.mm.2 Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 13 -73679744, -73679744 NM_028878, BC107411, BC107412 NM_028878, BC107411, BC107412 NM_028878, BC107411, BC107412 34

neurotransmitter:sodium symporter activity

protein binding

plasma membrane

integral component of plasma membrane

amino acid transport

neutral amino acid transmembrane transporter activity

neutral amino acid transmembrane transporter activity

symporter activity

neutral amino acid transport

neutral amino acid transport

membrane

integral component of membrane

apical plasma membrane

apical plasma membrane

brush border membrane

brush border membrane

sodium ion transmembrane transport

04974

TC1100002567.mm.2 Pttg1 pituitary tumor-transforming gene 1 11 -43420243, -43420243 NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 NM_001131054, NM_013917, BC023324 83

regulation of cell growth

cysteine-type endopeptidase inhibitor activity

nucleus

nucleus

nucleus

cytoplasm

cytosol

DNA repair

cellular response to DNA damage stimulus

cell cycle

chromosome segregation

mitotic sister chromatid cohesion

negative regulation of cell population proliferation

cellular process

SH3 domain binding

heat shock protein binding

ribosome binding

homologous chromosome segregation

homologous chromosome segregation

chromosome organization

cell division

negative regulation of mitotic sister chromatid separation

04110

04114

TC1900001018.mm.2 Ccdc88b coiled-coil domain containing 88B 19 -6844622 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 NM_001081291, BC151001, BC151009, BC157946 12

positive regulation of cytokine production

cytoplasm

endoplasmic reticulum

Golgi apparatus

centrosome

cytoskeleton

microtubule binding

membrane

cytoskeleton-dependent intracellular transport

cytoplasmic microtubule organization

positive regulation of T cell proliferation

defense response to protozoan

positive regulation of T cell activation

dynein light intermediate chain binding

 
TC1100002945.mm.2 Lrrc75a leucine rich repeat containing 75A 11 -62604883, -62604883 NM_198861, BC053455 NM_198861, BC053455 14

molecular_function

cytoplasm

biological_process

 
TC1100002091.mm.2 Inpp5j inositol polyphosphate 5-phosphatase J 11 -3494271 NM_172439, BC131634, BC131635 NM_172439, BC131634, BC131635 NM_172439, BC131634, BC131635 17

ruffle

ruffle

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

inositol-polyphosphate 5-phosphatase activity

cytoplasm

cytoplasm

plasma membrane

plasma membrane

negative regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of neuron projection development

hydrolase activity

SH3 domain binding

extrinsic component of membrane

growth cone

growth cone

negative regulation of microtubule polymerization

negative regulation of peptidyl-serine phosphorylation

negative regulation of peptidyl-serine phosphorylation

negative regulation of peptidyl-serine phosphorylation

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

dendritic shaft

inositol phosphate dephosphorylation

phosphatidylinositol dephosphorylation

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

00562

01100

04070

TC0900001722.mm.2 Birc3 baculoviral IAP repeat-containing 3 9 -7848700 NM_007464, BC011338 NM_007464, BC011338 101

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

apoptotic process

transferase activity

positive regulation of protein ubiquitination

positive regulation of protein ubiquitination

protein-containing complex

negative regulation of phosphorylation

regulation of apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

protein-containing complex binding

membrane raft

metal ion binding

regulation of cell cycle

regulation of necroptotic process

negative regulation of necroptotic process

negative regulation of necroptotic process

ubiquitin protein ligase activity

necroptotic process

cellular response to tumor necrosis factor

regulation of NIK/NF-kappaB signaling

positive regulation of protein polyubiquitination

negative regulation of reactive oxygen species metabolic process

04120

04210

04510

04621

05145

05200

05222

TC1700000362.mm.2 Clcn7 chloride channel, voltage-sensitive 7 17 25136630, 25133390 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 NM_011930, BC050907, BC053049, BC054799 53

nucleotide binding

voltage-gated chloride channel activity

protein binding

ATP binding

nucleoplasm

lysosome

ion transport

chloride transport

response to pH

chloride transmembrane transporter activity

antiporter activity

membrane

integral component of membrane

cytoplasmic vesicle

intracellular membrane-bounded organelle

transmembrane transport

 
TC0400001382.mm.2 Ppt1 palmitoyl-protein thioesterase 1 4 122836226 NM_008917, BC148714 NM_008917, BC148714 82

protein depalmitoylation

protein depalmitoylation

protein depalmitoylation

protein binding

extracellular region

extracellular space

nucleus

lysosome

lysosome

lysosome

lysosome

Golgi apparatus

receptor-mediated endocytosis

receptor-mediated endocytosis

pinocytosis

lysosome organization

lysosomal lumen acidification

neurotransmitter secretion

nervous system development

nervous system development

brain development

visual perception

grooming behavior

synaptic vesicle

associative learning

adult locomotory behavior

palmitoyl-(protein) hydrolase activity

palmitoyl-(protein) hydrolase activity

palmitoyl-(protein) hydrolase activity

palmitoyl-(protein) hydrolase activity

protein transport

lipid catabolic process

palmitoyl-CoA hydrolase activity

hydrolase activity

thiolester hydrolase activity

negative regulation of cell growth

axon

axon

dendrite

membrane raft organization

regulation of phospholipase A2 activity

lysophosphatidic acid binding

neuron projection

neuronal cell body

neuronal cell body

negative regulation of apoptotic process

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

negative regulation of neuron apoptotic process

cellular protein catabolic process

cellular macromolecule catabolic process

membrane raft

synapse

positive regulation of receptor-mediated endocytosis

positive regulation of pinocytosis

palmitoyl hydrolase activity

sulfatide binding

00062

01100

04142

TC1300001654.mm.2 Carmil1 capping protein regulator and myosin 1 linker 1 13 -24012483, -24012480, -24012480 NM_026825, BC167257 NM_026825, BC167257 23

nucleoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

membrane

cell migration

nuclear speck

lamellipodium

lamellipodium

lamellipodium assembly

positive regulation of cell migration

positive regulation of cell migration

positive regulation of actin filament polymerization

cell leading edge

ruffle organization

filamentous actin

cell projection

macropinocytosis

macropinosome

protein-containing complex binding

protein-containing complex binding

urate metabolic process

positive regulation of stress fiber assembly

positive regulation of stress fiber assembly

barbed-end actin filament uncapping

actin filament network formation

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of lamellipodium organization

positive regulation of lamellipodium organization

negative regulation of barbed-end actin filament capping

 
TC1600001742.mm.2 Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta 16 -55811376, -55811376 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 NM_001159394, NM_001159395, NM_030612, BC058188 64

protein binding

nucleus

nucleus

inflammatory response

regulation of gene expression

nuclear speck

cytoplasmic ribonucleoprotein granule

positive regulation of inflammatory response

T cell receptor signaling pathway

positive regulation of T-helper 17 cell differentiation

 
TC1700000623.mm.2 Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 17 34204478 NM_011530, BC005578, BC051257 NM_011530, BC005578, BC051257 NM_011530, BC005578, BC051257 52

nucleotide binding

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

response to molecule of bacterial origin

adaptive immune response

immune system process

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

positive regulation of antigen processing and presentation of peptide antigen via MHC class I

protein binding

ATP binding

endoplasmic reticulum

protein transport

ABC-type peptide antigen transporter activity

ABC-type peptide antigen transporter activity

ABC-type peptide transporter activity

peptide transport

peptide transport

membrane

integral component of membrane

integral component of membrane

nuclear speck

ATPase activity

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I

MHC class Ib protein binding

integral component of endoplasmic reticulum membrane

protection from natural killer cell mediated cytotoxicity

MHC protein binding

MHC class I protein binding

MHC class I protein binding

peptide antigen binding

ATPase-coupled transmembrane transporter activity

identical protein binding

protein homodimerization activity

MHC class I peptide loading complex

MHC class I peptide loading complex

TAP complex

intracellular membrane-bounded organelle

ADP binding

protein-containing complex binding

cytosol to endoplasmic reticulum transport

peptide antigen transport

TAP1 binding

TAP1 binding

TAP1 binding

TAP2 binding

tapasin binding

transmembrane transport

protein-containing complex assembly

peptide transmembrane transporter activity

02010

04145

04612

05340

TC1100002642.mm.2 Gm5431 predicted gene 5431 11 -48887421 NM_001024230 9

GTPase activity

endoplasmic reticulum membrane

defense response

cellular response to interferon-beta

 
MG-1-pos-10341395_st                
MG-1-pos-10342761_st                
TC1700001993.mm.2 H2-T24 histocompatibility 2, T region locus 24 17 -36005694 NM_008207, BC156693 NM_008207, BC156693 11

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

extracellular space

immune response

external side of plasma membrane

peptide antigen binding

04144

04145

04514

04612

04940

05320

05330

05332

05416

TC0200004251.mm.2 Prrg4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2 -104830740 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 NM_178695, BC099390, BC115470, BC151011, BC151019 13

calcium ion binding

extracellular region

plasma membrane

biological_process

membrane

integral component of membrane

WW domain binding

 
TC0700003464.mm.2 Arrdc4 arrestin domain containing 4 7 -68741592, -68736993 NM_001042592, NM_025549, BC017528 NM_001042592, NM_025549, BC017528 NM_001042592, NM_025549, BC017528 19

cytoplasm

endosome

plasma membrane

plasma membrane

plasma membrane

protein transport

protein transport

membrane

protein ubiquitination

cytoplasmic vesicle

intracellular membrane-bounded organelle

positive regulation of ubiquitin-protein transferase activity

extracellular vesicle biogenesis

extracellular vesicle

ubiquitin ligase-substrate adaptor activity

ubiquitin ligase-substrate adaptor activity

 
TC0100002725.mm.2 Sp110 Sp110 nuclear body protein 1 -85576898, -85576898 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 NM_030194, NM_175397, BC039938, BC094500 29

DNA-binding transcription factor activity, RNA polymerase II-specific

immune system process

DNA binding

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

apoptotic process

response to bacterium

response to bacterium

positive regulation of apoptotic process

innate immune response

 
TC1900000527.mm.2 Marchf5 membrane associated ring-CH-type finger 5 19 37207544, 37207544, 37207544, 37207539 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 NM_001164336, NM_001164337, NM_027314, BC064752, BC107215, BC132455, BC132457 29

protein polyubiquitination

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum membrane

zinc ion binding

membrane

integral component of membrane

transferase activity

metal ion binding

GTPase binding

protein autoubiquitination

ubiquitin protein ligase activity

protein localization to mitochondrion

regulation of mitochondrial fission

positive regulation of mitochondrial fission

negative regulation of cell aging

 
TC0700001794.mm.2 Il21r interleukin 21 receptor 7 125603428 NM_021887, BC057861 NM_021887, BC057861 141

transmembrane signaling receptor activity

cytokine receptor activity

cytokine receptor activity

membrane

integral component of membrane

04060

04630

TC1600001557.mm.2 Dtx3l deltex 3-like, E3 ubiquitin ligase 16 -35926514 NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 NM_001013371, BC085093, BC137694 18

positive regulation of defense response to virus by host

immune system process

ubiquitin-protein transferase activity

enzyme inhibitor activity

nucleus

nucleoplasm

nucleoplasm

cytoplasm

lysosome

endosome

early endosome

cytosol

DNA repair

double-strand break repair

chromatin organization

ubiquitin-dependent protein catabolic process

cellular response to DNA damage stimulus

Notch signaling pathway

enzyme activator activity

endosome to lysosome transport

histone monoubiquitination

protein transport

membrane

protein ubiquitination

transferase activity

enzyme binding

positive regulation of protein binding

protein-containing complex

histone H2A ubiquitination

histone H2B ubiquitination

positive regulation of chromatin binding

histone binding

ubiquitin-like protein ligase binding

innate immune response

positive regulation of transcription, DNA-templated

metal ion binding

negative regulation of ubiquitin-protein transferase activity

defense response to virus

protein autoubiquitination

ubiquitin protein ligase activity

protein K48-linked ubiquitination

STAT family protein binding

positive regulation of protein localization to nucleus

positive regulation of NAD+ ADP-ribosyltransferase activity

positive regulation of protein localization to early endosome

positive regulation of receptor catabolic process

positive regulation of double-strand break repair via nonhomologous end joining

04330

TC1000000171.mm.2 Sgk1 serum/glucocorticoid regulated kinase 1 10 21993889, 21992222, 21882183, 21978671, 21986103, 21994665 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 NM_001161845, NM_001161847, NM_001161848, NM_001161849, NM_001161850, NM_011361, BC005720, BC070401 198

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

endoplasmic reticulum

cytosol

cytosol

plasma membrane

protein phosphorylation

cellular sodium ion homeostasis

apoptotic process

cellular response to DNA damage stimulus

microtubule depolymerization

long-term memory

visual learning

positive regulation of sodium ion transport

potassium channel regulator activity

membrane

kinase activity

phosphorylation

nuclear speck

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

positive regulation of cell growth

negative regulation of microtubule polymerization

cellular response to insulin stimulus

regulation of protein localization

intracellular signal transduction

neuron projection

negative regulation of apoptotic process

glucocorticoid mediated signaling pathway

3-phosphoinositide-dependent protein kinase binding

tau protein binding

perinuclear region of cytoplasm

neuron projection morphogenesis

neuron projection morphogenesis

positive regulation of dendrite morphogenesis

regulation of cell cycle

cellular response to aldosterone

04960

TC0300003243.mm.2 Bcl9 B cell CLL/lymphoma 9 3 -97203661 NM_029933, BC137850 NM_029933, BC137850 39

transcription coactivator activity

nucleus

cytoplasm

Golgi apparatus

Golgi apparatus

cis-Golgi network

cis-Golgi network

beta-catenin binding

beta-catenin binding

myotube differentiation involved in skeletal muscle regeneration

Wnt signaling pathway

somatic stem cell population maintenance

skeletal muscle cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

canonical Wnt signaling pathway

canonical Wnt signaling pathway

beta-catenin-TCF complex

beta-catenin-TCF complex

 
TC1200000007.mm.2 Kif3c kinesin family member 3C 12 3365131 NM_008445, BC127063 NM_008445, BC127063 35

nucleotide binding

microtubule motor activity

protein binding

ATP binding

cytoplasm

cytosol

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule binding

microtubule binding

synaptic vesicle

positive regulation of neuron projection development

microtubule cytoskeleton

membrane

ATPase activity

kinesin binding

axon

dendrite

growth cone

microtubule plus-end

neuronal cell body

neuronal ribonucleoprotein granule

organelle transport along microtubule

 
TC1100004242.mm.2 Sectm1a secreted and transmembrane 1A 11 -121067402 NM_145373, BC010462 NM_145373, BC010462 15

cytokine activity

extracellular region

plasma membrane

immune response

membrane

integral component of membrane

integral component of membrane

 
TC1200000287.mm.2 Atxn7l1 ataxin 7-like 1 12 33147685, 33302514, 33315404, 33314296, 33146970, 33146967 NM_001033436, NM_028139, BC147479, BC147483 NM_001033436, NM_028139, BC147479, BC147483 NM_001033436, NM_028139, BC147479, BC147483 NM_001033436, NM_028139, BC147479, BC147483 16

molecular_function

cellular_component

biological_process

 
TC0500002986.mm.2 Pxmp2 peroxisomal membrane protein 2 5 -110274285 NM_008993, BC057975 NM_008993, BC057975 18

cytoplasm

cytoplasm

mitochondrion

mitochondrion

peroxisome

peroxisomal membrane

peroxisomal membrane

membrane

integral component of membrane

protein-containing complex

carboxylic acid transport

04146

MG-1-pos-10340809_st                
TC0900001445.mm.2 Map4 microtubule-associated protein 4 9 109931773, 110052020, 109931773 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 NM_001205330, NM_001205331, NM_001205332, NM_008633, BC042645, BC044654, BC050893, BC055332, BC055364 53

microtubule cytoskeleton organization

microtubule cytoskeleton organization

protein binding

cytoplasm

cytosol

cytoskeleton

microtubule

plasma membrane

axoneme

mitotic spindle organization

mitotic spindle organization

microtubule binding

microtubule binding

postsynaptic density

microtubule cytoskeleton

tubulin binding

axon

neuron projection development

neuron projection

microtubule sliding

microtubule sliding

establishment of spindle orientation

establishment of spindle orientation

cell division

mitotic spindle

negative regulation of non-motile cilium assembly

 
TC1300000113.mm.2 Inhba inhibin beta-A 13 16011850 NM_008380, BC053527 NM_008380, BC053527 200

G1/S transition of mitotic cell cycle

ovarian follicle development

mesoderm formation

hair follicle development

hematopoietic progenitor cell differentiation

hematopoietic progenitor cell differentiation

signaling receptor binding

cytokine activity

cytokine activity

hormone activity

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

regulation of transcription by RNA polymerase II

cell cycle arrest

growth factor activity

negative regulation of cell population proliferation

male gonad development

positive regulation of gene expression

positive regulation of pathway-restricted SMAD protein phosphorylation

positive regulation of pathway-restricted SMAD protein phosphorylation

peptide hormone binding

striatal medium spiny neuron differentiation

negative regulation of cell growth

positive regulation of cellular protein metabolic process

activin receptor signaling pathway

inhibin binding

endodermal cell differentiation

odontogenesis

response to drug

hemoglobin biosynthetic process

progesterone secretion

identical protein binding

activin A complex

inhibin A complex

protein-containing complex binding

positive regulation of erythrocyte differentiation

negative regulation of cell cycle

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of follicle-stimulating hormone secretion

mesodermal cell differentiation

perinuclear region of cytoplasm

negative regulation of hair follicle development

roof of mouth development

positive regulation of ovulation

SMAD protein signal transduction

eyelid development in camera-type eye

type II activin receptor binding

cellular response to follicle-stimulating hormone stimulus

cellular response to cholesterol

GABAergic neuron differentiation

extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

04060

04350

TC1700000625.mm.2 H2-Ob histocompatibility 2, O region beta locus 17 34238904 NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028 NM_010389, BC127027, BC127028 43

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

intracellular anatomical structure

lysosome

MHC class II protein complex binding

MHC class II protein complex

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC1700001954.mm.2 Tnf tumor necrosis factor 17 -35199366 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 NM_001278601, NM_013693, BC117057, BC137720 2923

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

activation of MAPKKK activity

activation of MAPK activity

transcription regulatory region sequence-specific DNA binding

microglial cell activation

microglial cell activation

cell activation

positive regulation of cytokine production

phagocytic cup

regulation of protein phosphorylation

positive regulation of protein phosphorylation

negative regulation of endothelial cell proliferation

protease binding

protease binding

negative regulation of L-glutamate import across plasma membrane

leukocyte activation involved in inflammatory response

chronic inflammatory response to antigenic stimulus

regulation of immunoglobulin production

negative regulation of cytokine production involved in immune response

positive regulation of chronic inflammatory response to antigenic stimulus

positive regulation of humoral immune response mediated by circulating immunoglobulin

negative regulation of systemic arterial blood pressure

cytokine activity

cytokine activity

cytokine activity

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

intracellular anatomical structure

cytoplasm

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

glucose metabolic process

regulation of transcription by RNA polymerase II

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

defense response

inflammatory response

inflammatory response

inflammatory response

immune response

humoral immune response

signal transduction

JNK cascade

multicellular organism development

positive regulation of cell population proliferation

negative regulation of cell population proliferation

extrinsic apoptotic signaling pathway via death domain receptors

extrinsic apoptotic signaling pathway via death domain receptors

extrinsic apoptotic signaling pathway via death domain receptors

intrinsic apoptotic signaling pathway in response to DNA damage

response to virus

animal organ morphogenesis

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

response to organic substance

negative regulation of heart rate

vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

negative regulation of alkaline phosphatase activity

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

integral component of membrane

calcium-mediated signaling

secretory granule

extracellular matrix organization

osteoclast differentiation

sequestering of triglyceride

cortical actin cytoskeleton organization

positive regulation of protein-containing complex assembly

positive regulation of fever generation

negative regulation of myelination

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

negative regulation of interleukin-6 production

positive regulation of chemokine production

positive regulation of fractalkine production

positive regulation of interferon-gamma production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-18 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of peptidyl-serine phosphorylation

tumor necrosis factor-mediated signaling pathway

tumor necrosis factor-mediated signaling pathway

tumor necrosis factor-mediated signaling pathway

positive regulation of heterotypic cell-cell adhesion

positive regulation of heterotypic cell-cell adhesion

toll-like receptor 3 signaling pathway

negative regulation of myosin-light-chain-phosphatase activity

regulation of cell population proliferation

regulation of cell population proliferation

vasodilation

positive regulation of tyrosine phosphorylation of STAT protein

defense response to bacterium

identical protein binding

neuronal cell body

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of programmed cell death

regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein-containing complex disassembly

positive regulation of protein-containing complex disassembly

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of MAP kinase activity

protein kinase B signaling

positive regulation of JUN kinase activity

positive regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

negative regulation of blood vessel endothelial cell migration

negative regulation of viral genome replication

membrane raft

membrane raft

cellular extravasation

positive regulation of nitric oxide biosynthetic process

negative regulation of fat cell differentiation

negative regulation of myoblast differentiation

negative regulation of osteoblast differentiation

regulation of osteoclast differentiation

positive regulation of osteoclast differentiation

positive regulation of protein catabolic process

positive regulation of action potential

positive regulation of cell adhesion

positive regulation of mitotic nuclear division

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

negative regulation of mitotic cell cycle

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of translational initiation by iron

negative regulation of glucose import

negative regulation of glucose import

positive regulation of JNK cascade

positive regulation of JNK cascade

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of smooth muscle cell proliferation

regulation of protein secretion

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of phagocytosis

regulation of insulin secretion

positive regulation of synaptic transmission

positive regulation of synaptic transmission

regulation of synapse organization

defense response to Gram-positive bacterium

leukocyte migration

leukocyte tethering or rolling

detection of mechanical stimulus involved in sensory perception of pain

negative regulation of lipid catabolic process

positive regulation of nitric-oxide synthase activity

positive regulation of membrane protein ectodomain proteolysis

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of nitrogen compound metabolic process

positive regulation of protein transport

response to glucocorticoid

positive regulation of hair follicle development

positive regulation of protein kinase B signaling

positive regulation of protein kinase B signaling

recycling endosome

positive regulation of glial cell proliferation

positive regulation of vitamin D biosynthetic process

positive regulation of calcidiol 1-monooxygenase activity

epithelial cell proliferation involved in salivary gland morphogenesis

regulation of branching involved in salivary gland morphogenesis

regulation of branching involved in salivary gland morphogenesis

negative regulation of vascular wound healing

negative regulation of branching involved in lung morphogenesis

positive regulation of calcineurin-NFAT signaling cascade

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to amino acid stimulus

cellular response to nicotine

cellular response to organic cyclic compound

positive regulation of podosome assembly

endothelial cell apoptotic process

protein localization to plasma membrane

negative regulation of oxidative phosphorylation

apoptotic signaling pathway

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway

necroptotic signaling pathway

necroptotic signaling pathway

negative regulation of bile acid secretion

positive regulation of interleukin-33 production

positive regulation of cytokine production involved in inflammatory response

negative regulation of amyloid-beta clearance

positive regulation of NIK/NF-kappaB signaling

positive regulation of NIK/NF-kappaB signaling

positive regulation of synoviocyte proliferation

positive regulation of superoxide dismutase activity

positive regulation of amyloid-beta formation

positive regulation of neutrophil activation

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to plasma membrane

regulation of establishment of endothelial barrier

positive regulation of oxidative stress-induced neuron death

negative regulation of bicellular tight junction assembly

positive regulation of I-kappaB phosphorylation

negative regulation of production of miRNAs involved in gene silencing by miRNA

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of leukocyte adhesion to arterial endothelial cell

positive regulation of protein localization to cell surface

negative regulation of signaling receptor activity

positive regulation of blood microparticle formation

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of hepatocyte proliferation

regulation of endothelial cell apoptotic process

regulation of reactive oxygen species metabolic process

positive regulation of DNA biosynthetic process

negative regulation of apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

04010

04060

04210

04350

04380

04612

04620

04621

04622

04640

04650

04660

04664

04920

04930

04940

05010

05014

05140

05142

05143

05144

05145

05146

05160

05310

05322

05323

05330

05332

05410

05414

TC1300000157.mm.2 Aoah acyloxyacyl hydrolase 13 20794112, 20794112 NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 NM_001281854, NM_012054, BC150767 35

calcium ion binding

calcium ion binding

calcium ion binding

extracellular region

lipid metabolic process

fatty acid metabolic process

lipopolysaccharide metabolic process

lipopolysaccharide catabolic process

lipopolysaccharide catabolic process

hydrolase activity

hydrolase activity, acting on ester bonds

cytoplasmic vesicle

intracellular membrane-bounded organelle

metal ion binding

acyloxyacyl hydrolase activity

acyloxyacyl hydrolase activity

acyloxyacyl hydrolase activity

negative regulation of inflammatory response

negative regulation of inflammatory response

 
TC1000001761.mm.2 Stx11 syntaxin 11 10 -12939982 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 NM_001163590, NM_001163591, NM_029075, BC117539, BC118516 21

SNARE binding

T cell mediated cytotoxicity

SNAP receptor activity

Golgi apparatus

plasma membrane

intracellular protein transport

exocytosis

vesicle fusion

synaptic vesicle

endomembrane system

protein transport

membrane

integral component of membrane

vesicle-mediated transport

SNARE complex

synaptic vesicle fusion to presynaptic active zone membrane

natural killer cell mediated cytotoxicity

neutrophil degranulation

cytotoxic T cell degranulation

natural killer cell degranulation

phagocytic vesicle

vesicle docking

presynaptic active zone membrane

cellular response to interferon-gamma

04130

TC1700000464.mm.2 Pacsin1 protein kinase C and casein kinase substrate in neurons 1 17 27685238, 27655590 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 NM_001286743, NM_001286744, NM_011861, NM_178365, BC014698 44

protein binding

phospholipid binding

phospholipid binding

phospholipid binding

cytoplasm

cytoplasm

cytoplasm

endosome

cytoskeleton

plasma membrane

plasma membrane

endocytosis

cytoskeleton organization

cytoskeleton organization

actin filament organization

signal transduction

cytoskeletal protein binding

lipid binding

membrane

cell junction

regulation of endocytosis

COPI-coated vesicle

cytoplasmic vesicle

ruffle membrane

identical protein binding

cell projection

neuron projection

myelin sheath

axon terminus

synapse

negative regulation of endocytosis

perinuclear region of cytoplasm

synaptic vesicle endocytosis

synaptic vesicle endocytosis

neuron development

neuron projection morphogenesis

neuron projection morphogenesis

protein localization to membrane

protein localization to plasma membrane

plasma membrane tubulation

plasma membrane tubulation

plasma membrane tubulation

photoreceptor ribbon synapse

presynaptic endocytic zone

postsynaptic density membrane

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

positive regulation of dendrite development

positive regulation of dendrite development

 
TC0400003680.mm.2 Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B 4 -132732965 NM_133888, BC009087 NM_133888, BC009087 25

immune system process

sphingomyelin phosphodiesterase activity

protein binding

extracellular region

extracellular space

plasma membrane

lipid metabolic process

sphingomyelin catabolic process

inflammatory response

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

metabolic process

zinc ion binding

membrane

lipid catabolic process

hydrolase activity

hydrolase activity, acting on glycosyl bonds

anchored component of membrane

negative regulation of toll-like receptor signaling pathway

innate immune response

negative regulation of innate immune response

membrane lipid catabolic process

metal ion binding

negative regulation of inflammatory response

 
TC1700000614.mm.2 H2-Oa histocompatibility 2, O region alpha locus 17 34092378 NM_008206, BC138996, BC138997 NM_008206, BC138996, BC138997 NM_008206, BC138996, BC138997 30

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

MHC class II protein complex

regulation of T cell differentiation

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

TC1700000148.mm.2 Sod2 superoxide dismutase 2, mitochondrial 17 13007838 NM_013671, BC010548 NM_013671, BC010548 394

response to reactive oxygen species

response to superoxide

response to superoxide

age-dependent response to oxidative stress

age-dependent response to reactive oxygen species

release of cytochrome c from mitochondria

liver development

detection of oxygen

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

DNA binding

superoxide dismutase activity

superoxide dismutase activity

superoxide dismutase activity

superoxide dismutase activity

protein binding

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

glutathione metabolic process

superoxide metabolic process

superoxide metabolic process

response to oxidative stress

response to oxidative stress

mitochondrion organization

heart development

locomotory behavior

regulation of blood pressure

negative regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic mitochondrial changes

post-embryonic development

response to gamma radiation

positive regulation of hydrogen peroxide biosynthetic process

response to activity

oxidoreductase activity

removal of superoxide radicals

removal of superoxide radicals

oxygen binding

enzyme binding

respiratory electron transport chain

hemopoiesis

manganese ion binding

manganese ion binding

positive regulation of cell migration

response to nutrient levels

oxygen homeostasis

vasodilation

response to drug

response to hydrogen peroxide

superoxide anion generation

mitochondrial nucleoid

hydrogen peroxide metabolic process

identical protein binding

negative regulation of apoptotic process

myelin sheath

negative regulation of neuron apoptotic process

positive regulation of nitric oxide biosynthetic process

negative regulation of fat cell differentiation

metal ion binding

negative regulation of fibroblast proliferation

neuron development

response to axon injury

erythrophore differentiation

hydrogen peroxide biosynthetic process

regulation of catalytic activity

protein homotetramerization

regulation of mitochondrial membrane potential

iron ion homeostasis

response to hyperoxia

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of membrane hyperpolarization

negative regulation of vascular associated smooth muscle cell proliferation

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

04146

05016

TC0300002506.mm.2 Fcgr1 Fc receptor, IgG, high affinity I 3 -96282908 NM_010186, BC160240 NM_010186, BC160240 186

antibody-dependent cellular cytotoxicity

positive regulation of type IIa hypersensitivity

positive regulation of type III hypersensitivity

immune system process

transmembrane signaling receptor activity

plasma membrane

integral component of plasma membrane

receptor-mediated endocytosis

phagocytosis, recognition

phagocytosis, engulfment

cell surface receptor signaling pathway

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

membrane

integral component of membrane

IgG receptor activity

IgG binding

IgG binding

antigen processing and presentation of exogenous antigen

leukotriene receptor binding

antigen processing and presentation of exogenous peptide antigen via MHC class I

defense response to bacterium

innate immune response

membrane raft

positive regulation of phagocytosis

regulation of immune response

regulation of immune response

positive regulation of phagocytosis, engulfment

positive regulation of protein tyrosine kinase activity

04145

04380

04640

04666

05140

05150

05322

TC0900001511.mm.2 Bcl2a1c B cell leukemia/lymphoma 2 related protein A1c 9 114330134 NM_007535, BC120720 NM_007535, BC120720 4

mitochondrial outer membrane

intrinsic apoptotic signaling pathway in response to DNA damage

protein homodimerization activity

protein heterodimerization activity

extrinsic apoptotic signaling pathway in absence of ligand

 
TC0600001193.mm.2 Itpr1 inositol 1,4,5-trisphosphate receptor 1 6 108213095 NM_010585, BC172648 NM_010585, BC172648 282

response to hypoxia

response to hypoxia

ion channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

calcium channel activity

calcium ion binding

protein binding

nuclear envelope

nuclear envelope

nuclear inner membrane

nucleolus

cytoplasm

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

plasma membrane

plasma membrane

calcineurin complex

ion transport

calcium ion transport

apoptotic process

positive regulation of cytosolic calcium ion concentration

protein C-terminus binding

post-embryonic development

positive regulation of neuron projection development

postsynaptic density

postsynaptic density

calcium-release channel activity

membrane

integral component of membrane

sarcoplasmic reticulum

sarcoplasmic reticulum

sarcoplasmic reticulum

calcium channel inhibitor activity

protein phosphatase binding

integral component of endoplasmic reticulum membrane

dendrite

cytoplasmic vesicle membrane

secretory granule membrane

secretory granule membrane

smooth endoplasmic reticulum membrane

platelet dense granule membrane

platelet dense tubular network

cytoplasmic vesicle

endoplasmic reticulum calcium ion homeostasis

protein-containing complex

protein-containing complex

phosphatidylinositol binding

phosphatidylinositol binding

epithelial fluid transport

identical protein binding

neuronal cell body

positive regulation of apoptotic process

intracellular membrane-bounded organelle

ion channel binding

protein-containing complex binding

membrane raft

perinuclear region of cytoplasm

negative regulation of calcium-mediated signaling

voluntary musculoskeletal movement

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport

transmembrane transport

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

calcium ion transmembrane transport

inositol 1,4,5 trisphosphate binding

cellular response to cAMP

synaptic membrane

liver regeneration

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

presynapse

postsynapse

GABA-ergic synapse

negative regulation of neuron death

positive regulation of hepatocyte proliferation

04020

04070

04114

04270

04540

04720

04730

04912

04970

04971

04972

05010

05016

TC1300002506.mm.2 Tmem171 transmembrane protein 171 13 -98686237, -98686237 NM_001025606, BC099490 NM_001025606, BC099490 4

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1700000600.mm.2 Daxx Fas death domain-associated protein 17 33909497, 33909600, 33909444 NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 NM_001199733, NM_007829, BC128373 100

negative regulation of transcription by RNA polymerase II

mitotic cytokinesis

chromosome, centromeric region

heterochromatin

XY body

positive regulation of protein phosphorylation

p53 binding

transcription coactivator activity

transcription coactivator activity

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

microtubule

cell cortex

chromatin organization

nucleosome assembly

nucleosome assembly

nucleosome assembly

chromatin remodeling

regulation of transcription, DNA-templated

apoptotic process

transcription factor binding

transcription factor binding

JUN kinase binding

negative regulation of myotube differentiation

nuclear body

PML body

PML body

PML body

kinesin binding

enzyme binding

protein kinase binding

protein kinase activator activity

androgen receptor signaling pathway

PML body organization

regulation of protein ubiquitination

ubiquitin protein ligase binding

positive regulation of histone phosphorylation

cellular response to heat

cellular response to unfolded protein

regulation of multicellular organism growth

histone binding

histone binding

histone binding

protein homodimerization activity

regulation of apoptotic process

neuron projection

positive regulation of apoptotic process

negative regulation of apoptotic process

cell body

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

protein N-terminus binding

androgen receptor binding

protein localization to chromatin

cellular response to cadmium ion

cellular response to copper ion

cellular response to diamide

apoptotic signaling pathway

sumo-dependent protein binding

transcription regulator inhibitor activity

positive regulation of neuron death

cellular response to sodium arsenite

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

04010

05014

TC1700000761.mm.2 Ubd ubiquitin D 17 37193891 NM_023137, BC027627, BC036383 NM_023137, BC027627, BC036383 NM_023137, BC027627, BC036383 36

fibrillar center

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

aggresome

protein ubiquitination

protein ubiquitination

protein ubiquitination

protein modification by small protein conjugation

response to interferon-gamma

response to interferon-gamma

response to tumor necrosis factor

response to tumor necrosis factor

myeloid dendritic cell differentiation

positive regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

proteasome binding

proteasome binding

aggresome assembly

regulation of mitotic cell cycle phase transition

 
TC0500000602.mm.2 Fam114a1 family with sequence similarity 114, member A1 5 64970074 NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359 NM_026667, BC027235, BC110359 17

molecular_function

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

biological_process

 
TC0100003550.mm.2 Slamf7 SLAM family member 7 1 -171632404, -171632402 NM_144539, BC011154 NM_144539, BC011154 25

adaptive immune response

immune system process

protein binding

plasma membrane

external side of plasma membrane

membrane

integral component of membrane

regulation of natural killer cell activation

identical protein binding

innate immune response

 
TC0700002414.mm.2 Selenow selenoprotein W 7 -15917207 NM_009156, BC052719 NM_009156, BC052719 32

cytoplasm

cytosol

plasma membrane

response to selenium ion

antioxidant activity

oxidoreductase activity

 
TC1900001070.mm.2 Polr2g polymerase (RNA) II (DNA directed) polypeptide G 19 -8793128 NM_026329, BC005580, BC055278 NM_026329, BC005580, BC055278 NM_026329, BC005580, BC055278 24

nuclear-transcribed mRNA catabolic process, exonucleolytic

P-body

nucleic acid binding

single-stranded DNA binding

RNA binding

single-stranded RNA binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

nucleoplasm

RNA polymerase II, core complex

RNA polymerase II, core complex

transcription, DNA-templated

transcription by RNA polymerase II

transcription by RNA polymerase II

transcription initiation from RNA polymerase II promoter

transferase activity

nucleotidyltransferase activity

translation initiation factor binding

positive regulation of translational initiation

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

00230

00240

01100

03020

05016

TC0300002760.mm.2 Fam102b family with sequence similarity 102, member B 3 -108970996 NM_001163567 11

molecular_function

cellular_component

biological_process

 
TC0700004003.mm.2         NR_040453, NR_040456 NR_040453, NR_040456      
TC0300000161.mm.2 Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 3 27317076 NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 NM_009425, BC138807, BC138808 189

cytokine activity

tumor necrosis factor receptor binding

extracellular region

extracellular space

plasma membrane

apoptotic process

immune response

zinc ion binding

membrane

integral component of membrane

tumor necrosis factor receptor superfamily binding

identical protein binding

positive regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

TRAIL binding

metal ion binding

positive regulation of release of cytochrome c from mitochondria

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

04060

04210

04650

MG-1-pos-10338116_st                
TC0600001964.mm.2 Zfp800 zinc finger protein 800 6 -28239930, -28239930 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 NM_001081678, BC119236, BC119262, BC144761 12

nucleic acid binding

DNA binding

nucleus

biological_process

metal ion binding

 
TC0100000923.mm.2 Gpr35 G protein-coupled receptor 35 1 92978902, 92973118, 92975346 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 NM_001104529, NM_001271766, NM_022320, BC027429 27

G protein-coupled receptor activity

G protein-coupled receptor activity

chemokine receptor activity

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

integral component of plasma membrane

cytoskeleton organization

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

membrane

integral component of membrane

C-X-C chemokine receptor activity

positive regulation of Rho protein signal transduction

macrophage chemotaxis

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

chemokine-mediated signaling pathway

negative regulation of voltage-gated calcium channel activity

negative regulation of neuronal action potential

04080

TC0400000529.mm.2 Nr4a3 nuclear receptor subfamily 4, group A, member 3 4 48045304, 48045304 NM_015743, BC156736 NM_015743, BC156736 115

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription coactivator binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

mesoderm formation

DNA binding

DNA-binding transcription factor activity

steroid hormone receptor activity

nuclear receptor activity

nucleus

transcription regulator complex

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

gastrulation

axon guidance

zinc ion binding

pyruvate oxidation

positive regulation of cardiac muscle hypertrophy

positive regulation of glucose transmembrane transport

protein kinase binding

hippocampus development

adult behavior

positive regulation of mast cell cytokine production

histone acetyltransferase binding

glucocorticoid receptor binding

glucocorticoid receptor binding

cAMP response element binding

common myeloid progenitor cell proliferation

positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway

inner ear morphogenesis

response to hydrogen peroxide

protein homodimerization activity

negative regulation of apoptotic process

mast cell degranulation

negative regulation of neuron apoptotic process

sequence-specific DNA binding

cellular response to leptin stimulus

cellular respiration

fat cell differentiation

positive regulation of cell cycle

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of fatty acid oxidation

metal ion binding

platelet-derived growth factor receptor signaling pathway

regulation of smooth muscle cell proliferation

positive regulation of smooth muscle cell proliferation

semicircular canal morphogenesis

positive regulation of epithelial cell proliferation

neuromuscular process controlling balance

vestibular reflex

regulation of type B pancreatic cell proliferation

cellular response to corticotropin-releasing hormone stimulus

cellular response to corticotropin-releasing hormone stimulus

cellular response to catecholamine stimulus

energy homeostasis

positive regulation of monocyte aggregation

positive regulation of monocyte aggregation

negative regulation of oxidative stress-induced neuron death

negative regulation of hydrogen peroxide-induced neuron death

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of vascular associated smooth muscle cell migration

positive regulation of leukocyte apoptotic process

positive regulation of feeding behavior

 
TC0100002204.mm.2 Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A 1 -37439339, -37439339 NM_173870, BC165942 NM_173870, BC165942 19

extracellular region

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

Golgi apparatus

Golgi stack

protein N-linked glycosylation

protein N-linked glycosylation

acetylglucosaminyltransferase activity

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

metal ion binding

00510

01100

TC0800001037.mm.2 Nod2 nucleotide-binding oligomerization domain containing 2 8 88647346 NM_145857, BC168407 NM_145857, BC168407 337

nucleotide binding

pattern recognition receptor signaling pathway

innate immune response in mucosa

activation of immune response

cytokine production involved in immune response

immune system process

immunoglobulin production involved in immunoglobulin-mediated immune response

positive regulation of dendritic cell antigen processing and presentation

negative regulation of T cell mediated immunity

positive regulation of dendritic cell cytokine production

positive regulation of type 2 immune response

negative regulation of inflammatory response to antigenic stimulus

positive regulation of humoral immune response mediated by circulating immunoglobulin

actin binding

protein binding

ATP binding

cytoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

cytosol

cytoskeleton

plasma membrane

defense response

inflammatory response

positive regulation of antibacterial peptide biosynthetic process

positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

signal transduction

positive regulation of cell population proliferation

detection of biotic stimulus

cell surface

membrane

detection of bacterium

basolateral plasma membrane

endodeoxyribonuclease activity, producing 5'-phosphomonoesters

enzyme binding

protein kinase binding

maintenance of gastrointestinal epithelium

Hsp70 protein binding

positive regulation of protein ubiquitination

vesicle

negative regulation of NF-kappaB transcription factor activity

response to peptidoglycan

response to peptidoglycan

response to muramyl dipeptide

response to muramyl dipeptide

response to muramyl dipeptide

response to muramyl dipeptide

response to lipopolysaccharide

detection of muramyl dipeptide

muramyl dipeptide binding

muramyl dipeptide binding

negative regulation of interferon-gamma production

negative regulation of interleukin-12 production

negative regulation of interleukin-12 production

negative regulation of interleukin-18 production

negative regulation of interleukin-2 production

negative regulation of tumor necrosis factor production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

positive regulation of interleukin-17 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated MAPK cascade

protein-containing complex

negative regulation of toll-like receptor 2 signaling pathway

intracellular signal transduction

intracellular signal transduction

pattern recognition receptor activity

defense response to bacterium

defense response to bacterium

peptidoglycan binding

peptidoglycan binding

regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

positive regulation of MAP kinase activity

positive regulation of MAPK cascade

positive regulation of phosphatidylinositol 3-kinase activity

protein-containing complex binding

innate immune response

positive regulation of innate immune response

positive regulation of innate immune response

phagocytic vesicle

positive regulation of Notch signaling pathway

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

positive regulation of JNK cascade

anchored component of plasma membrane

positive regulation of epithelial cell proliferation

CARD domain binding

regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of phagocytosis

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

positive regulation of B cell activation

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of oxidoreductase activity

positive regulation of nitric-oxide synthase biosynthetic process

Hsp90 protein binding

positive regulation of prostaglandin-endoperoxide synthase activity

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

nucleotide-binding oligomerization domain containing 2 signaling pathway

nucleotide-binding oligomerization domain containing 2 signaling pathway

cellular response to lipopolysaccharide

cellular response to peptidoglycan

cellular response to muramyl dipeptide

macrophage inflammatory protein-1 alpha production

positive regulation of monocyte chemotactic protein-1 production

regulation of neutrophil chemotaxis

positive regulation of cytokine production involved in inflammatory response

positive regulation of NIK/NF-kappaB signaling

positive regulation of NIK/NF-kappaB signaling

positive regulation of protein K63-linked ubiquitination

positive regulation of xenophagy

negative regulation of macrophage apoptotic process

positive regulation of prostaglandin-E synthase activity

04621

TC0300002188.mm.2 Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 3 -79062510, -79062510 NM_001099624 38

blood vessel development

neuron migration

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

GTPase activator activity

intracellular anatomical structure

cytoplasm

endosome

late endosome

cytosol

plasma membrane

bicellular tight junction

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

neuropeptide signaling pathway

small GTPase mediated signal transduction

multicellular organism development

nervous system development

negative regulation of cell population proliferation

negative regulation of cell population proliferation

positive regulation of neuron projection development

membrane

apical plasma membrane

protein kinase binding

cAMP-mediated signaling

cAMP-mediated signaling

ventricular system development

forebrain neuron development

microvillus assembly

cell junction

endocytic vesicle

cell differentiation

PDZ domain binding

neuron projection development

neuron projection development

brain-derived neurotrophic factor receptor signaling pathway

beta-1 adrenergic receptor binding

positive regulation of protein binding

Rap protein signal transduction

protein-containing complex

nerve growth factor signaling pathway

regulation of cell population proliferation

neuron projection

neuronal cell body

positive regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of cAMP-mediated signaling

synapse

positive regulation of protein kinase activity

positive regulation of protein kinase activity

negative regulation of melanin biosynthetic process

regulation of synaptic plasticity

perinuclear region of cytoplasm

WW domain binding

negative regulation of dendrite morphogenesis

negative regulation of dendrite morphogenesis

establishment of endothelial barrier

phosphatidic acid binding

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

cellular response to cAMP

cellular response to cAMP

cellular response to cAMP

cellular response to cGMP

adenylate cyclase-activating adrenergic receptor signaling pathway

protein localization to plasma membrane

establishment of endothelial intestinal barrier

regulation of cell junction assembly

cellular response to nerve growth factor stimulus

positive regulation of cAMP-dependent protein kinase activity

positive regulation of cAMP-dependent protein kinase activity

positive regulation of dendritic cell apoptotic process

positive regulation of dendritic cell apoptotic process

positive regulation of vasculogenesis

positive regulation of neuron migration

04010

TC0700003039.mm.2 Saa3 serum amyloid A 3 7 -46711997 NM_011315, BC055885 NM_011315, BC055885 76

extracellular region

extracellular space

acute-phase response

I-kappaB phosphorylation

response to bacterium

high-density lipoprotein particle

response to stilbenoid

Toll-like receptor 4 binding

chemoattractant activity

cell chemotaxis

cellular response to interleukin-1

 
TC1000001183.mm.2 Btg1 BTG anti-proliferation factor 1 10 96617000 NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 NM_007569, BC006834, BC018309 44

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

protein methylation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

enzyme binding

positive regulation of catalytic activity

positive regulation of endothelial cell differentiation

positive regulation of myoblast differentiation

positive regulation of angiogenesis

negative regulation of mitotic cell cycle

positive regulation of fibroblast apoptotic process

03018

TC0700004002.mm.2         NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717 NM_001039160, NM_001243039, NM_001243040, NM_029000, BC172717  

molecular_function

cellular_component

biological_process

 
TC1600002062.mm.2 4932438H23Rik RIKEN cDNA 4932438H23 gene 16 -91055523 NM_001163695, NM_028905, BC032975 NM_001163695, NM_028905, BC032975 NM_001163695, NM_028905, BC032975 14

molecular_function

cellular_component

biological_process

 
TC0900001018.mm.2 Lysmd2 LysM, putative peptidoglycan-binding, domain containing 2 9 75625731 NM_027309, BC048545 NM_027309, BC048545 15

molecular_function

cellular_component

biological_process

 
TC1700001699.mm.2 Dusp1 dual specificity phosphatase 1 17 -26505590 NM_013642, BC006967 NM_013642, BC006967 206

inactivation of MAPK activity

endoderm formation

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleus

cytoplasm

cytoplasm

protein dephosphorylation

protein dephosphorylation

cell cycle

negative regulation of cell adhesion

protein tyrosine/serine/threonine phosphatase activity

negative regulation of cell population proliferation

protein tyrosine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

growth factor binding

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

intracellular signal transduction

peptidyl-threonine dephosphorylation

peptidyl-threonine dephosphorylation

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of MAP kinase activity

negative regulation of MAPK cascade

mitogen-activated protein kinase binding

mitogen-activated protein kinase binding

mitogen-activated protein kinase binding

peptidyl-serine dephosphorylation

negative regulation of ERK1 and ERK2 cascade

negative regulation of monocyte chemotaxis

negative regulation of p38MAPK cascade

negative regulation of p38MAPK cascade

cellular response to chemokine

negative regulation of DNA biosynthetic process

04010

TC0900003331.mm.2         NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241 NM_007534, BC028762, BC100462, BC116241  

B cell homeostasis

negative regulation of B cell apoptotic process

protein binding

cytoplasm

mitochondrial outer membrane

apoptotic process

intrinsic apoptotic signaling pathway in response to DNA damage

protein homodimerization activity

regulation of apoptotic process

negative regulation of apoptotic process

protein-containing complex binding

protein heterodimerization activity

BH domain binding

extrinsic apoptotic signaling pathway in absence of ligand

 
TC1500001729.mm.2 Ly6c1 lymphocyte antigen 6 complex, locus C1 15 -75045472, -75045014, -75045472, -75044017 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 NM_001252055, NM_001252056, NM_001252057, NM_001252058, NM_010741, BC010764 61

plasma membrane

external side of plasma membrane

cell surface

membrane

acetylcholine receptor inhibitor activity

anchored component of membrane

acetylcholine receptor binding

acetylcholine receptor signaling pathway

 
TC0600000131.mm.2 Met met proto-oncogene 6 17463956 NM_008591 399

negative regulation of transcription by RNA polymerase II

nucleotide binding

activation of MAPK activity

neuron migration

endothelial cell morphogenesis

liver development

liver development

placenta development

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor-activated receptor activity

hepatocyte growth factor-activated receptor activity

hepatocyte growth factor-activated receptor activity

protein binding

ATP binding

extracellular space

cytoplasm

plasma membrane

integral component of plasma membrane

protein phosphorylation

phagocytosis

transmembrane receptor protein tyrosine kinase signaling pathway

chemical synaptic transmission

multicellular organism development

nervous system development

brain development

muscle organ development

muscle organ development

skeletal muscle tissue development

beta-catenin binding

basal plasma membrane

basal plasma membrane

positive regulation of gene expression

negative regulation of gene expression

positive regulation of peptidyl-threonine phosphorylation

negative regulation of peptidyl-threonine phosphorylation

positive regulation of glucose transmembrane transport

positive regulation of neuron projection development

postsynaptic density

muscle cell migration

myotube differentiation

membrane

integral component of membrane

kinase activity

phosphorylation

cell migration

transferase activity

semaphorin receptor activity

protein phosphatase binding

neuron differentiation

flagellated sperm motility

dendrite

adult behavior

pancreas development

positive regulation of microtubule polymerization

regulation of interleukin-6 production

positive regulation of peptidyl-serine phosphorylation

positive regulation of kinase activity

negative regulation of Rho protein signal transduction

sperm flagellum

glucose homeostasis

identical protein binding

neuron projection

neuronal cell body

receptor complex

phospholipase binding

phosphatidylinositol 3-kinase binding

protein-containing complex binding

postsynaptic membrane

positive regulation of DNA replication

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

protein autophosphorylation

protein autophosphorylation

hepatocyte growth factor receptor signaling pathway

branching morphogenesis of an epithelial tube

positive regulation of dendrite morphogenesis

modulation of chemical synaptic transmission

positive chemotaxis

positive chemotaxis

myoblast proliferation

negative regulation of stress fiber assembly

positive regulation of protein kinase B signaling

cardiac muscle cell development

cardiac muscle contraction

excitatory synapse

excitatory postsynaptic potential

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

establishment of skin barrier

negative regulation of thrombin-activated receptor signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

negative regulation of transforming growth factor beta production

reactive oxygen species metabolic process

regulation of cellular response to oxidative stress

positive regulation of p38MAPK cascade

negative regulation of hydrogen peroxide-mediated programmed cell death

negative regulation of guanyl-nucleotide exchange factor activity

positive regulation of endothelial cell chemotaxis

04060

04144

04360

04510

04520

05100

05144

05200

05211

05218

TC1600001400.mm.2 Bcl6 B cell leukemia/lymphoma 6 16 -23965049, -23965049 NM_009744, BC052315 NM_009744, BC052315 285

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

cell morphogenesis

cell morphogenesis

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

intronic transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

regulation of cytokine production

negative regulation of cell-matrix adhesion

immune system process

germinal center formation

regulation of immune system process

negative regulation of type 2 immune response

nucleic acid binding

DNA binding

chromatin binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

nucleolus

Golgi apparatus

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

inflammatory response

cellular response to DNA damage stimulus

Rho protein signal transduction

spermatogenesis

protein localization

negative regulation of cell population proliferation

actin cytoskeleton organization

B cell differentiation

negative regulation of cell growth

positive regulation of B cell proliferation

positive regulation of histone deacetylation

chromatin DNA binding

negative regulation of mast cell cytokine production

negative regulation of Rho protein signal transduction

type 2 immune response

type 2 immune response

regulation of cell population proliferation

regulation of cell population proliferation

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

regulation of GTPase activity

regulation of memory T cell differentiation

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of regulatory T cell differentiation

regulation of cell differentiation

negative regulation of cell differentiation

negative regulation of T-helper 2 cell differentiation

positive regulation of neuron differentiation

negative regulation of Notch signaling pathway

negative regulation of transcription, DNA-templated

metal ion binding

negative regulation of isotype switching to IgE isotypes

negative regulation of isotype switching to IgE isotypes

erythrocyte development

regulation of inflammatory response

regulation of inflammatory response

positive regulation of cellular component movement

sequence-specific double-stranded DNA binding

negative regulation of cellular senescence

 
TC0Y00000551.mm.2                
TC0Y00000552.mm.2                
TC1600000264.mm.2 B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 16 19760233 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 NM_001159407, NM_001159408, NM_054052, BC063076 22

Golgi apparatus

protein glycosylation

multicellular organism development

central nervous system development

brain development

acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity

galactosyltransferase activity

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

sphingolipid biosynthetic process

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity

00601

01100

TC1100003663.mm.2 Arl5c ADP-ribosylation factor-like 5C 11 -97989579 NM_207231, BC065791 NM_207231, BC065791 11

nucleotide binding

GTP binding

cytoplasm

trans-Golgi network

intracellular protein transport

vesicle-mediated transport

protein localization to Golgi membrane

 
TC0500003024.mm.2 Grk3 G protein-coupled receptor kinase 3 5 -112910477 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 NM_001285806, NM_177078, BC152998, NM_001035531 40

nucleotide binding

positive regulation of protein phosphorylation

desensitization of G protein-coupled receptor signaling pathway

protein kinase activity

protein serine/threonine kinase activity

G protein-coupled receptor kinase activity

G protein-coupled receptor kinase activity

ATP binding

nucleus

cytosol

cilium

protein phosphorylation

intracellular protein transport

signal transduction

membrane

kinase activity

phosphorylation

transferase activity

Z disc

axon

receptor internalization

D1 dopamine receptor binding

dendritic spine

dendritic shaft

inositol phosphate metabolic process

dendrite terminus

membrane raft

synapse

rhodopsin metabolic process

beta-adrenergic receptor kinase activity

perinuclear region of cytoplasm

sperm midpiece

04740

TC1100000984.mm.2 Txndc17 thioredoxin domain containing 17 11 72207553 NM_026559, BC030344 NM_026559, BC030344 20

peroxidase activity

cytoplasm

cytosol

cytosol

tumor necrosis factor-mediated signaling pathway

protein-disulfide reductase activity

protein-disulfide reductase activity

 
TC0200000037.mm.2 Phyh phytanoyl-CoA hydroxylase 2 4918995 NM_010726, BC002018 NM_010726, BC002018 28

fatty acid alpha-oxidation

fatty acid alpha-oxidation

fatty acid alpha-oxidation

catalytic activity

protein binding

mitochondrion

mitochondrion

peroxisome

peroxisome

peroxisomal matrix

2-oxoglutarate metabolic process

isoprenoid metabolic process

ferrous iron binding

oxidoreductase activity

2-oxobutyrate catabolic process

carboxylic acid binding

L-ascorbic acid binding

metal ion binding

phytanoyl-CoA dioxygenase activity

phytanoyl-CoA dioxygenase activity

dioxygenase activity

methyl-branched fatty acid metabolic process

9+0 non-motile cilium

04146

TC0300003067.mm.2 Lmo4 LIM domain only 4 3 -144188529, -144188529, -144188529 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 NM_001161769, NM_001161770, NM_010723, BC003488, BC010278, BC100382 153

neural tube closure

ventricular septum development

protein binding

nucleus

regulation of transcription by RNA polymerase II

transcription factor binding

ventral spinal cord interneuron differentiation

spinal cord motor neuron differentiation

spinal cord association neuron differentiation

regulation of cell migration

cell leading edge

negative regulation of protein-containing complex assembly

positive regulation of kinase activity

regulation of cell fate specification

positive regulation of transcription by RNA polymerase II

metal ion binding

thymus development

regulation of cell activation

RNA polymerase II transcription regulator complex

 
TC0800001698.mm.2 Rab20 RAB20, member RAS oncogene family 8 -11453389 NM_011227, BC089570 NM_011227, BC089570 33

nucleotide binding

GTPase activity

GTP binding

Golgi apparatus

intracellular protein transport

endomembrane system

protein transport

membrane

cytoplasmic vesicle

intracellular membrane-bounded organelle

phagocytic vesicle

phagocytic vesicle

cellular response to interferon-gamma

phagosome acidification

phagosome-lysosome fusion

 
TC0400000495.mm.2 Aldh1b1 aldehyde dehydrogenase 1 family, member B1 4 45799021 NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 NM_028270, BC020001, BC086768 32

aldehyde dehydrogenase (NAD+) activity

nucleoplasm

mitochondrion

mitochondrion

cytosol

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

intracellular membrane-bounded organelle

00010

00040

00053

00071

00280

00310

00330

00340

00380

00410

00561

00620

00640

01100

TC0100003888.mm.2 Ifi204 interferon activated gene 204 1 -173747293 NM_008329 60

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

double-stranded DNA binding

transcription coregulator activity

protein binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytosol

regulation of transcription by RNA polymerase II

multicellular organism development

transcription factor binding

response to bacterium

response to bacterium

nuclear speck

positive regulation of interleukin-1 beta production

cellular response to interferon-alpha

cellular response to interferon-beta

cellular response to interferon-beta

nuclear inclusion body

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

positive regulation of osteoblast differentiation

inner ear development

 
TC1000000529.mm.2 Sowahc sosondowah ankyrin repeat domain family member C 10 59221921 NM_172939 13

molecular_function

cellular_component

biological_process

 
TC0800000297.mm.2 Sfrp1 secreted frizzled-related protein 1 8 23411501 NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662 NM_013834, BC024495, BC094662 175

ureteric bud development

somitogenesis

somitogenesis

neural tube closure

hematopoietic progenitor cell differentiation

cysteine-type endopeptidase activity

frizzled binding

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

cytosol

plasma membrane

multicellular organism development

heparin binding

positive regulation of cell population proliferation

negative regulation of cell population proliferation

male gonad development

female gonad development

dorsal/ventral axis specification

anterior/posterior pattern specification

cell surface

regulation of cell cycle process

negative regulation of gene expression

negative regulation of gene expression

negative regulation of epithelial to mesenchymal transition

regulation of neuron projection development

neural crest cell fate commitment

response to organic cyclic compound

Wnt signaling pathway

Wnt-protein binding

Wnt-protein binding

neural tube development

actin cytoskeleton organization

hemopoiesis

cell differentiation

positive regulation of Wnt signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of Wnt signaling pathway

regulation of ossification

negative regulation of ossification

negative regulation of ossification

positive regulation of cell growth

negative regulation of cell growth

negative regulation of cell migration

negative regulation of BMP signaling pathway

negative regulation of osteoblast proliferation

negative regulation of osteoblast proliferation

substrate adhesion-dependent cell spreading

somatic stem cell population maintenance

non-canonical Wnt signaling pathway

response to drug

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of JUN kinase activity

cellular response to fibroblast growth factor stimulus

stromal-epithelial cell signaling involved in prostate gland development

negative regulation of B cell differentiation

negative regulation of B cell differentiation

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

negative regulation of osteoclast differentiation

negative regulation of osteoclast differentiation

positive regulation of smoothened signaling pathway

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

development of primary male sexual characteristics

negative regulation of insulin secretion

negative regulation of bone remodeling

negative regulation of fibroblast proliferation

digestive tract morphogenesis

positive regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

negative regulation of peptidyl-tyrosine phosphorylation

canonical Wnt signaling pathway

canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

hematopoietic stem cell differentiation

bone trabecula formation

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

regulation of branching involved in prostate gland morphogenesis

negative regulation of androgen receptor signaling pathway

collagen-containing extracellular matrix

cellular response to tumor necrosis factor

cellular response to growth factor stimulus

cellular response to estrogen stimulus

cellular response to estrogen stimulus

cellular response to X-ray

cellular response to heparin

dopaminergic neuron differentiation

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of establishment of planar polarity

planar cell polarity pathway involved in neural tube closure

Wnt signaling pathway involved in somitogenesis

convergent extension involved in somitogenesis

positive regulation of canonical Wnt signaling pathway

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of midbrain dopaminergic neuron differentiation

negative regulation of planar cell polarity pathway involved in axis elongation

positive regulation of non-canonical Wnt signaling pathway

negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

negative regulation of fibroblast apoptotic process

positive regulation of fibroblast apoptotic process

positive regulation of extrinsic apoptotic signaling pathway

04310

TC0100000919.mm.2 Dusp28 dual specificity phosphatase 28 1 92906988 NM_175118, BC119127 NM_175118, BC119127 10

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

 
TC1000000877.mm.2 Gadd45b growth arrest and DNA-damage-inducible 45 beta 10 80930090 NM_008655, BC023815 NM_008655, BC023815 88

activation of MAPKKK activity

activation of MAPKKK activity

activation of MAPKK activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

negative regulation of protein kinase activity

apoptotic process

multicellular organism development

cell differentiation

positive regulation of apoptotic process

positive regulation of JNK cascade

regulation of cell cycle

regulation of cell cycle

positive regulation of p38MAPK cascade

04010

04110

04115

TC1200001552.mm.2 Rsad2 radical S-adenosyl methionine domain containing 2 12 -26442742 NM_021384, BC057868 NM_021384, BC057868 39

ossification

fibrillar center

immune system process

catalytic activity

protein binding

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

lipid droplet

response to virus

response to virus

membrane

regulation of ossification

positive regulation of toll-like receptor 7 signaling pathway

positive regulation of toll-like receptor 9 signaling pathway

CD4-positive, alpha-beta T cell activation

CD4-positive, alpha-beta T cell differentiation

protein self-association

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

metal ion binding

negative regulation of protein secretion

positive regulation of immune response

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

4 iron, 4 sulfur cluster binding

defense response to virus

defense response to virus

defense response to virus

positive regulation of T-helper 2 cell cytokine production

 
TC0300000697.mm.2 Etv3 ets variant 3 3 87525577 NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 NM_001083318, NM_001286844, NM_012051, BC078636 36

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

negative regulation of cell population proliferation

transcription repressor complex

DEAD/H-box RNA helicase binding

cell differentiation

intracellular membrane-bounded organelle

sequence-specific DNA binding

RNA polymerase II transcription repressor complex

cellular response to granulocyte macrophage colony-stimulating factor stimulus

sequence-specific double-stranded DNA binding

 
TC1100003664.mm.2 Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 11 -98004924, -98004924, -98001507 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 NM_001159319, NM_001159320, NM_001282977, NM_001282978, NM_031173, NM_145121, BC077713 64

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

calcium channel activity

protein binding

plasma membrane

plasma membrane

voltage-gated calcium channel complex

voltage-gated calcium channel complex

protein targeting to membrane

ion transport

calcium ion transport

chemical synaptic transmission

neuromuscular junction development

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

membrane

sarcoplasmic reticulum

T-tubule

regulation of ion transmembrane transport

calcium ion transmembrane transport

presynapse

presynapse

regulation of voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

cellular response to amyloid-beta

04010

04260

05410

05412

05414

TC0100002534.mm.2 Ikzf2 IKAROS family zinc finger 2 1 -69531209 NM_011770, BC138606, BC138608 NM_011770, BC138606, BC138608 NM_011770, BC138606, BC138608 58

RNA polymerase II cis-regulatory region sequence-specific DNA binding

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

regulation of transcription by RNA polymerase II

identical protein binding

positive regulation of transcription by RNA polymerase II

metal ion binding

 
TC0200005149.mm.2 Ocstamp osteoclast stimulatory transmembrane protein 2 -165395449 NM_029021, BC020160 NM_029021, BC020160 21

molecular_function

cellular_component

membrane

integral component of membrane

cell differentiation

positive regulation of macrophage fusion

positive regulation of osteoclast differentiation

cellular response to tumor necrosis factor

cellular response to estrogen stimulus

multinuclear osteoclast differentiation

positive regulation of osteoclast proliferation

 
TC1100001236.mm.2 Slfn5 schlafen 5 11 82952101 NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 NM_183201, BC117909, BC117910 19

nucleotide binding

ATP binding

nucleus

cell differentiation

 
MG-1-pos-10343623_st                
TC1900000111.mm.2 Ehd1 EH-domain containing 1 19 6276895 NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 NM_010119, BC043332, BC054828 48

nucleotide binding

calcium ion binding

protein binding

ATP binding

GTP binding

cytoplasm

endosome

early endosome

early endosome

lipid droplet

plasma membrane

plasma membrane

cilium

intracellular protein transport

endocytosis

endocytosis

endocytosis

endosome membrane

positive regulation of cholesterol storage

positive regulation of neuron projection development

protein transport

membrane

endosomal transport

endosomal transport

ciliary pocket membrane

cell projection organization

endocytic vesicle

endocytic vesicle

platelet dense tubular network membrane

neuron projection development

small GTPase binding

cytoplasmic vesicle

early endosome membrane

endocytic recycling

endocytic recycling

low-density lipoprotein particle clearance

cholesterol homeostasis

identical protein binding

cell projection

myelin sheath

intracellular membrane-bounded organelle

metal ion binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

protein homooligomerization

recycling endosome membrane

recycling endosome membrane

cilium assembly

cilium assembly

cilium assembly

protein localization to cilium

protein localization to plasma membrane

positive regulation of myoblast fusion

cellular response to nerve growth factor stimulus

positive regulation of endocytic recycling

04144

TC0700001913.mm.2 Htra1 HtrA serine peptidase 1 7 130936202 NM_019564, BC013516 NM_019564, BC013516 71

placenta development

serine-type endopeptidase activity

protein binding

insulin-like growth factor binding

extracellular region

cytoplasm

plasma membrane

proteolysis

peptidase activity

serine-type peptidase activity

membrane

hydrolase activity

growth factor binding

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

identical protein binding

positive regulation of epithelial cell proliferation

negative regulation of defense response to virus

chorionic trophoblast cell differentiation

collagen-containing extracellular matrix

collagen-containing extracellular matrix

 
TC1_GL456212_random00000013.mm.2 Sp110 Sp110 nuclear body protein 1 -85576898, -85576898 BC039938 29

DNA-binding transcription factor activity, RNA polymerase II-specific

immune system process

DNA binding

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

apoptotic process

response to bacterium

response to bacterium

positive regulation of apoptotic process

innate immune response

 
TC1200001237.mm.2 Tnfaip2 tumor necrosis factor, alpha-induced protein 2 12 111442660 NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107 NM_009396, BC138106, BC138107 26

exocyst

SNARE binding

angiogenesis

exocytosis

multicellular organism development

cell differentiation

exocyst localization

 
TC1800000834.mm.2 Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 18 77794549 NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654 NM_013831, BC002123, BC057654 37

actin binding

protein binding

cytoplasm

cytosol

cytoskeleton

cytoskeleton

actin filament

plasma membrane

cytoskeleton organization

membrane

cell migration

actin filament polymerization

actin filament binding

 
TC1700000935.mm.2 Treml2 triggering receptor expressed on myeloid cells-like 2 17 48300037 NM_001033405, BC160362 NM_001033405, BC160362 17

plasma membrane

cell surface

cell surface

membrane

integral component of membrane

signaling receptor activity

signaling receptor activity

T cell activation

T cell activation

 
TC0700001116.mm.2 Isg20 interferon-stimulated protein 7 78913423, 78913764, 78914234 NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 NM_001113527, NM_020583, BC022751 17

3'-5'-exoribonuclease activity

DNA catabolic process, exonucleolytic

DNA catabolic process, exonucleolytic

immune system process

nucleic acid binding

RNA binding

nuclease activity

exonuclease activity

exonuclease activity

nucleus

nucleus

nucleolus

cytoplasm

rRNA processing

RNA catabolic process

RNA catabolic process

single-stranded DNA 3'-5' exodeoxyribonuclease activity

exoribonuclease II activity

response to virus

Cajal body

PML body

hydrolase activity

U1 snRNA binding

U2 snRNA binding

U3 snoRNA binding

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

defense response to virus

 
TC1300001270.mm.2 Plpp1 phospholipid phosphatase 1 13 112800776 NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 NM_008247, NM_008903, BC061161 35

diacylglycerol diphosphate phosphatase activity

diacylglycerol diphosphate phosphatase activity

diacylglycerol diphosphate phosphatase activity

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

integral component of plasma membrane

caveola

lipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

diacylglycerol biosynthetic process

sphingosine metabolic process

sphingosine metabolic process

sphingosine metabolic process

ceramide metabolic process

ceramide metabolic process

ceramide metabolic process

signal transduction

signal transduction

signal transduction

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

membrane

integral component of membrane

hydrolase activity

sphingosine-1-phosphate phosphatase activity

sphingosine-1-phosphate phosphatase activity

lipid phosphatase activity

lipid phosphatase activity

phospholipid dephosphorylation

phospholipid dephosphorylation

phospholipid dephosphorylation

phospholipid dephosphorylation

ceramide-1-phosphate phosphatase activity

ceramide-1-phosphate phosphatase activity

00561

00564

00565

00600

01100

04666

04975

TC1400000072.mm.2 Abhd6 abhydrolase domain containing 6 14 8002887, 8002965 NM_025341, BC027011 NM_025341, BC027011 31

catalytic activity

phospholipase activity

phospholipase activity

mitochondrion

mitochondrion

lysosome

lysosomal membrane

endosome

lipid metabolic process

phospholipid catabolic process

membrane

integral component of membrane

hydrolase activity

negative regulation of cell migration

late endosome membrane

AMPA glutamate receptor complex

acylglycerol catabolic process

acylglycerol catabolic process

acylglycerol catabolic process

positive regulation of lipid biosynthetic process

acylglycerol lipase activity

acylglycerol lipase activity

acylglycerol lipase activity

acylglycerol lipase activity

monoacylglycerol catabolic process

long-term synaptic depression

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

integral component of postsynaptic membrane

regulation of retrograde trans-synaptic signaling by endocanabinoid

negative regulation of cold-induced thermogenesis

regulation of endocannabinoid signaling pathway

lysobisphosphatidic acid metabolic process

 
TC0500003487.mm.2 Adap1 ArfGAP with dual PH domains 1 5 -139271875 NM_172723 19

GTPase activator activity

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

cytoplasm

cytosol

plasma membrane

plasma membrane

regulation of GTPase activity

intracellular membrane-bounded organelle

 
TC1300002001.mm.2                
TC1200000652.mm.2 Hif1a hypoxia inducible factor 1, alpha subunit 12 73907866, 73901323, 73907866 NM_010431, BC026139 NM_010431, BC026139 1372

negative regulation of transcription by RNA polymerase II

response to reactive oxygen species

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

angiogenesis

blood vessel development

response to hypoxia

response to hypoxia

response to hypoxia

response to hypoxia

neural crest cell migration

epithelial to mesenchymal transition

embryonic placenta development

embryonic placenta development

B-1 B cell homeostasis

vasculature development

heart looping

p53 binding

positive regulation of neuroblast proliferation

connective tissue replacement involved in inflammatory response wound healing

cytokine production involved in inflammatory response

outflow tract morphogenesis

cardiac ventricle morphogenesis

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

cytosol

lactate metabolic process

regulation of glycolytic process

regulation of glycolytic process

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular iron ion homeostasis

signal transduction

lactation

transcription factor binding

positive regulation of cell population proliferation

visual learning

regulation of gene expression

regulation of gene expression

positive regulation of autophagy

vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression

negative regulation of gene expression

positive regulation of epithelial cell migration

response to muscle activity

positive regulation of macroautophagy

nuclear body

nuclear speck

axonal transport of mitochondrion

enzyme binding

protein kinase binding

protein domain specific binding

neural fold elevation formation

cerebral cortex development

cell differentiation

cell differentiation

negative regulation of ossification

negative regulation of bone mineralization

positive regulation of vascular endothelial growth factor receptor signaling pathway

motile cilium

ubiquitin protein ligase binding

negative regulation of TOR signaling

oxygen homeostasis

oxygen homeostasis

regulation of transforming growth factor beta2 production

collagen metabolic process

protein-containing complex

histone acetyltransferase binding

embryonic hemopoiesis

nuclear hormone receptor binding

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cell population proliferation

hemoglobin biosynthetic process

glucose homeostasis

histone deacetylase binding

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

sequence-specific DNA binding

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

protein-containing complex binding

positive regulation of erythrocyte differentiation

positive regulation of gluconeogenesis

positive regulation of angiogenesis

positive regulation of transcription, DNA-templated

negative regulation of vasoconstriction

negative regulation of growth

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

muscle cell cellular homeostasis

positive regulation of hormone biosynthetic process

protein heterodimerization activity

protein heterodimerization activity

protein dimerization activity

blood vessel morphogenesis

digestive tract morphogenesis

camera-type eye morphogenesis

positive regulation of smooth muscle cell proliferation

regulation of catalytic activity

cartilage development

elastin metabolic process

Hsp90 protein binding

intestinal epithelial cell maturation

response to fungicide

epithelial cell differentiation involved in mammary gland alveolus development

iris morphogenesis

retina vasculature development in camera-type eye

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

positive regulation of chemokine-mediated signaling pathway

regulation of thymocyte apoptotic process

negative regulation of thymocyte apoptotic process

E-box binding

cellular response to hypoxia

cellular response to hypoxia

cellular response to hypoxia

dopaminergic neuron differentiation

dopaminergic neuron differentiation

RNA polymerase II transcription regulator complex

hypoxia-inducible factor-1alpha signaling pathway

cellular response to virus

positive regulation of pri-miRNA transcription by RNA polymerase II

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of autophagy of mitochondrion

regulation of aerobic respiration

positive regulation of signaling receptor activity

negative regulation of reactive oxygen species metabolic process

regulation of protein neddylation

negative regulation of mesenchymal cell apoptotic process

04150

05200

05211

TC0800000916.mm.2 Tbc1d9 TBC1 domain family, member 9 8 83165351 NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 NM_001111304, NM_027758, BC057027 17

GTPase activator activity

calcium ion binding

intracellular protein transport

activation of GTPase activity

 
TC0800002431.mm.2 Bst2 bone marrow stromal cell antigen 2 8 -71534255 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 NM_198095, BC027328, BC056638, BC087949 43

immune system process

cytoplasm

endosome

Golgi apparatus

plasma membrane

metalloendopeptidase inhibitor activity

response to virus

cell surface

cell surface

cell surface

membrane

integral component of membrane

apical plasma membrane

anchored component of membrane

regulation of actin cytoskeleton organization

response to interferon-gamma

response to interferon-alpha

response to interferon-beta

negative regulation of viral genome replication

innate immune response

innate immune response

defense response to virus

negative regulation of intracellular transport of viral material

negative regulation of intracellular transport of viral material

 
TC1700002789.mm.2         NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554 NM_001198560, NM_001198561, NM_001201460, NM_010394, BC120554  

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

immune system process

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

signaling receptor binding

extracellular space

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

plasma membrane

immune response

embryo implantation

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

phagocytic vesicle membrane

beta-2-microglobulin binding

MHC class Ib protein complex

positive regulation of interferon-gamma production

peptide binding

peptide antigen binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD8 receptor binding

MHC class I protein complex

MHC class I peptide loading complex

protein-containing complex binding

TAP binding

defense response to virus

TAP complex binding

endoplasmic reticulum exit site

cellular response to interferon-gamma

integral component of lumenal side of endoplasmic reticulum membrane

 
TC0400004014.mm.2 Fbxo6 F-box protein 6 4 -148145715, -148145715, -148145715 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 NM_001163704, NM_001163705, NM_001163706, NM_001163707, NM_015797, BC017512 23

protein binding

protein binding

cytoplasm

cytoplasm

DNA repair

glycoprotein catabolic process

glycoprotein catabolic process

cellular response to DNA damage stimulus

response to unfolded protein

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

carbohydrate binding

ubiquitin-dependent ERAD pathway

ubiquitin-dependent ERAD pathway

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

endoplasmic reticulum quality control compartment

endoplasmic reticulum quality control compartment

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin-dependent glycoprotein ERAD pathway

04141

TC0600001481.mm.2 Parp11 poly (ADP-ribose) polymerase family, member 11 6 127453626, 127446839 NM_181402, BC040269 NM_181402, BC040269 18

NAD+ ADP-ribosyltransferase activity

nucleus

nuclear envelope

nuclear pore

nucleoplasm

cytosol

protein ADP-ribosylation

nuclear envelope organization

spermatogenesis

protein transport

nuclear body

transferase activity

transferase activity, transferring glycosyl groups

protein phosphopantetheinylation

cell differentiation

mRNA transport

protein auto-ADP-ribosylation

protein mono-ADP-ribosylation

protein ADP-ribosylase activity

 
TC0400002251.mm.2 Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 4 -16122740 NM_138952, BC069878 NM_138952, BC069878 141

nucleotide binding

positive regulation of cytokine-mediated signaling pathway

adaptive immune response

adaptive immune response

immune system process

positive regulation of T-helper 1 type immune response

protein kinase activity

protein serine/threonine kinase activity

JUN kinase kinase kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

ATP binding

cytoplasm

cytosol

cytosol

cytoskeleton

apoptotic process

I-kappaB kinase/NF-kappaB signaling

activation of JUN kinase activity

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cell death

kinase activity

phosphorylation

transferase activity

LIM domain binding

positive regulation of protein ubiquitination

lipopolysaccharide-mediated signaling pathway

vesicle

positive regulation of protein binding

positive regulation of chemokine production

positive regulation of interferon-gamma production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-2 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

protein-containing complex

positive regulation of immature T cell proliferation

positive regulation of peptidyl-serine phosphorylation

toll-like receptor 2 signaling pathway

toll-like receptor 4 signaling pathway

T cell proliferation

identical protein binding

protein homodimerization activity

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

innate immune response

innate immune response

innate immune response

positive regulation of T-helper 1 cell differentiation

positive regulation of JNK cascade

positive regulation of alpha-beta T cell proliferation

CARD domain binding

positive regulation of peptidyl-tyrosine phosphorylation

defense response to Gram-positive bacterium

T cell receptor signaling pathway

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

nucleotide-binding oligomerization domain containing 1 signaling pathway

nucleotide-binding oligomerization domain containing 2 signaling pathway

nucleotide-binding oligomerization domain containing 2 signaling pathway

response to interleukin-1

response to interleukin-12

response to interleukin-18

cellular response to lipopolysaccharide

cellular response to lipoteichoic acid

cellular response to peptidoglycan

cellular response to muramyl dipeptide

caspase binding

activation of cysteine-type endopeptidase activity

positive regulation of xenophagy

04621

04722

TC1100004122.mm.2 Rhbdf2 rhomboid 5 homolog 2 11 -116598165, -116598165 NM_001167680, NM_172572, BC052182 NM_001167680, NM_172572, BC052182 NM_001167680, NM_172572, BC052182 63

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

plasma membrane

protein transport

membrane

integral component of membrane

regulation of epidermal growth factor receptor signaling pathway

regulation of protein secretion

negative regulation of protein secretion

 
TC0400003383.mm.2 St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 4 -117932152 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 NM_001161774, NM_001285520, NM_001285521, NM_009176, BC006710 29

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

N-acetyllactosaminide alpha-2,3-sialyltransferase activity

sialyltransferase activity

ganglioside biosynthetic process via lactosylceramide

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

00514

00533

00601

01100

TC0300000186.mm.2 Egfem1 EGF-like and EMI domain containing 1 3 29082530, 29081786 NM_001167748, NM_029412, BC117810 NM_001167748, NM_029412, BC117810 NM_001167748, NM_029412, BC117810 12

calcium ion binding

cellular_component

biological_process

 
TC1200000278.mm.2 Ccdc71l coiled-coil domain containing 71 like 12 32378788 NM_001162903 9

molecular_function

cellular_component

biological_process

 
TC1800000092.mm.2 Rbbp8 retinoblastoma binding protein 8, endonuclease 18 11657348, 11633275 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 NM_001081223, NM_001252495, NR_045526, NR_045527, BC050849 36

single-stranded DNA endodeoxyribonuclease activity

single-stranded DNA endodeoxyribonuclease activity

G1/S transition of mitotic cell cycle

Y-form DNA binding

double-strand/single-strand DNA junction binding

double-strand break repair via homologous recombination

RNA polymerase II repressing transcription factor binding

blastocyst hatching

DNA binding

damaged DNA binding

damaged DNA binding

double-stranded DNA binding

single-stranded DNA binding

transcription corepressor activity

nuclease activity

endonuclease activity

nucleus

nucleoplasm

chromosome

DNA repair

cellular response to DNA damage stimulus

cell cycle

DNA double-strand break processing involved in repair via single-strand annealing

DNA double-strand break processing involved in repair via single-strand annealing

hydrolase activity

transcription repressor complex

site of double-strand break

identical protein binding

intracellular membrane-bounded organelle

cell division

meiotic cell cycle

flap-structured DNA binding

 
TC0600003084.mm.2 Clec4e C-type lectin domain family 4, member e 6 -123281788 NM_019948, BC003218 NM_019948, BC003218 84

positive regulation of cytokine production

pattern recognition receptor signaling pathway

T cell differentiation involved in immune response

immune system process

calcium ion binding

protein binding

immune response

membrane

integral component of membrane

carbohydrate binding

signaling receptor activity

Fc-gamma receptor signaling pathway

pattern recognition receptor activity

defense response to bacterium

innate immune response

metal ion binding

 
TC0600000226.mm.2 Hilpda hypoxia inducible lipid droplet associated 6 29272487, 29272625 NM_001190461, NM_023516, BC020081, BC083056 NM_001190461, NM_023516, BC020081, BC083056 NM_001190461, NM_023516, BC020081, BC083056 NM_001190461, NM_023516, BC020081, BC083056 24

positive regulation of cytokine production

signaling receptor binding

extracellular region

extracellular space

nucleoplasm

lipid droplet

lipid droplet

positive regulation of cell population proliferation

cell surface

positive regulation of lipid storage

membrane

integral component of membrane

secretory granule

autocrine signaling

autocrine signaling

 
TC1700002820.mm.2 H2-T-ps histocompatibility 2, T region locus, pseudogene 17 -36109029 NM_001271005, XM_003688945 NM_001271005, XM_003688945 13    
TC1500001623.mm.2 Cyrib CYFIP related Rac1 interactor B 15 -63929093, -63929093, -63929093 NM_144846, BC011343 NM_144846, BC011343 30

positive regulation of T cell mediated cytotoxicity

protein binding

mitochondrion

cilium

membrane

MHC class Ib protein binding, via antigen binding groove

regulation of cell migration

negative regulation of actin filament polymerization

small GTPase binding

positive regulation of interferon-gamma production

positive regulation of T cell activation

positive regulation of T cell activation

regulation of chemotaxis

negative regulation of small GTPase mediated signal transduction

negative regulation of small GTPase mediated signal transduction

cellular response to molecule of bacterial origin

cellular response to molecule of bacterial origin

regulation of mitochondrial fission

regulation of mitochondrial fission

regulation of establishment of cell polarity

positive regulation of memory T cell activation

 
TC0800001833.mm.2 Gm15056 predicted gene 15056 8 -20900605 NM_001177471 2    
TC1700002788.mm.2         NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754 NM_023124, NM_207648, BC156754  

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

signaling receptor binding

extracellular space

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

plasma membrane

immune response

external side of plasma membrane

cell surface

phagocytic vesicle membrane

beta-2-microglobulin binding

peptide binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD8 receptor binding

MHC class I protein complex

MHC class I peptide loading complex

protein-containing complex binding

TAP binding

TAP complex binding

endoplasmic reticulum exit site

integral component of lumenal side of endoplasmic reticulum membrane

 
TC0100003890.mm.2 Mndal myeloid nuclear differentiation antigen like 1 -173857219, -173857221 NM_001170853 12

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

cytosol

transcription factor binding

response to bacterium

negative regulation of cell growth

positive regulation of interleukin-1 beta production

cellular response to interferon-beta

regulation of growth

identical protein binding

 
TC0400002808.mm.2 Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 4 -63724599 NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 NM_177371, BC096494, BC138207, BC138208 49

cytokine production

positive regulation of cytokine production

death receptor binding

cytokine activity

tumor necrosis factor receptor binding

extracellular region

extracellular space

plasma membrane

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

immune response

signal transduction

activation of NF-kappaB-inducing kinase activity

membrane

integral component of membrane

04060

TC0900003335.mm.2 Uba7 ubiquitin-like modifier activating enzyme 7 9 107975566 NM_023738, BC138843 NM_023738, BC138843 30

ubiquitin-protein transferase activity

nucleus

cytoplasm

cellular protein modification process

cellular response to DNA damage stimulus

ISG15 activating enzyme activity

ISG15 activating enzyme activity

ISG15 activating enzyme activity

modification-dependent protein catabolic process

ISG15-protein conjugation

ISG15-protein conjugation

ISG15-protein conjugation

ISG15-protein conjugation

protein modification by small protein conjugation

04120

05012

TC0800001078.mm.2 Lpcat2 lysophosphatidylcholine acyltransferase 2 8 92855332 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 NM_173014, BC144806, BC150666, BC160287 21

1-acylglycerol-3-phosphate O-acyltransferase activity

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

Golgi stack

lipid droplet

plasma membrane

lipid metabolic process

platelet activating factor biosynthetic process

phospholipid biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

phosphatidylcholine acyl-chain remodeling

metal ion binding

1-acylglycerophosphocholine O-acyltransferase activity

1-acylglycerophosphocholine O-acyltransferase activity

1-alkylglycerophosphocholine O-acetyltransferase activity

plasmalogen synthase activity

membrane organization

00564

00565

01100

TC1900000217.mm.2 Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 19 11407660 NM_029499, BC027496 NM_029499, BC027496 12

molecular_function

cellular_component

biological_process

 
TC0200003630.mm.2 Ifih1 interferon induced with helicase C domain 1 2 -62595792 NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 NM_001164477, NM_027835, BC080200 136

nucleotide binding

immune system process

DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

zinc ion binding

zinc ion binding

response to virus

response to virus

hydrolase activity

protein sumoylation

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

MDA-5 signaling pathway

identical protein binding

ribonucleoprotein complex binding

innate immune response

innate immune response

metal ion binding

defense response to virus

positive regulation of response to cytokine stimulus

cellular response to exogenous dsRNA

04622

TC0700003996.mm.2         NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717 NM_001243039, NM_001243040, NM_029000, NR_040453, NR_040456, NM_001039160, BC172717  

molecular_function

cellular_component

biological_process

 
TC0700000284.mm.2 Dmwd dystrophia myotonica-containing WD repeat motif 7 19076199 NM_010058, BC031193, BC089027 NM_010058, BC031193, BC089027 NM_010058, BC031193, BC089027 27

molecular_function

cellular_component

nucleus

cell projection

 
TC0800002542.mm.2 Il15 interleukin 15 8 -82331623 NM_001254747, NM_008357, BC023698 NM_001254747, NM_008357, BC023698 NM_001254747, NM_008357, BC023698 475

positive regulation of cytokine production

NK T cell proliferation

cytokine activity

cytokine activity

cytokine activity

cytokine receptor binding

extracellular region

extracellular region

extracellular space

extracellular space

nucleoplasm

cytoplasm

cytosol

immune response

tyrosine phosphorylation of STAT protein

positive regulation of cell population proliferation

cell surface

nuclear speck

hyaluronan metabolic process

macrophage differentiation

positive regulation of interleukin-17 production

positive regulation of natural killer cell proliferation

positive regulation of natural killer cell differentiation

positive regulation of natural killer cell differentiation

positive regulation of natural killer cell differentiation

interleukin-15-mediated signaling pathway

positive regulation of T cell proliferation

positive regulation of T cell proliferation

neutrophil activation

neutrophil activation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

extrathymic T cell selection

regulation of T cell differentiation

cell maturation

lymph node development

negative regulation of smooth muscle cell proliferation

regulation of defense response to virus by host

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of phagocytosis

positive regulation of immune response

positive regulation of immune response

negative regulation of cold-induced thermogenesis

positive regulation of protein O-linked glycosylation

04060

04630

04672

05323

TC0700004637.mm.2 Dnaaf3 dynein, axonemal assembly factor 3 7 -4522932 NM_001033548, BC150983 NM_001033548, BC150983 14

molecular_function

cellular_component

cytoplasm

determination of left/right symmetry

heart development

cell projection organization

motile cilium assembly

axonemal dynein complex assembly

 
TC0400003577.mm.2 Tlr12 toll-like receptor 12 4 -128615445 NM_205823, BC131921 NM_205823, BC131921 37

toll-like receptor signaling pathway

immune system process

integral component of plasma membrane

inflammatory response

signal transduction

membrane

integral component of membrane

hydrolase activity

signaling receptor activity

defense response to protozoan

innate immune response

NAD(P)+ nucleosidase activity

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC1600001605.mm.2 Adprh ADP-ribosylarginine hydrolase 16 -38445398 NM_007414, BC003437 NM_007414, BC003437 26

magnesium ion binding

ADP-ribosylarginine hydrolase activity

ADP-ribosylarginine hydrolase activity

extracellular space

cytosol

cellular protein modification process

cellular protein modification process

hydrolase activity

potassium ion binding

metal ion binding

protein de-ADP-ribosylation

 
TC0700004404.mm.2 Chst15 carbohydrate sulfotransferase 15 7 -132235779, -132235779 NM_029935, BC031443 NM_029935, BC031443 30

Golgi apparatus

membrane

integral component of membrane

transferase activity

hexose biosynthetic process

hexose biosynthetic process

3'-phosphoadenosine 5'-phosphosulfate binding

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

00532

TC1800000956.mm.2 Mpp7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 18 -7379648, -7347961, -7347961 NM_001081287, NM_001161620, BC117550, BC118058, XR_105925 NM_001081287, NM_001161620, BC117550, BC118058, XR_105925 NM_001081287, NM_001161620, BC117550, BC118058, XR_105925 NM_001081287, NM_001161620, BC117550, BC118058, XR_105925 NM_001081287, NM_001161620, BC117550, BC118058, XR_105925 21

nucleoplasm

cytoplasm

plasma membrane

adherens junction

bicellular tight junction

membrane

protein domain specific binding

cell junction

positive regulation of protein-containing complex assembly

molecular adaptor activity

bicellular tight junction assembly

protein localization to adherens junction

MPP7-DLG1-LIN7 complex

 
TC1100000040.mm.2 Osm oncostatin M 11 4236784 NM_001013365, BC099866 NM_001013365, BC099866 114

cytokine activity

cytokine activity

cytokine activity

oncostatin-M receptor binding

extracellular region

extracellular space

immune response

tyrosine phosphorylation of STAT protein

peripheral nervous system development

growth factor activity

positive regulation of cell population proliferation

response to heat

positive regulation of phosphatidylinositol 3-kinase signaling

positive regulation of interleukin-17 production

positive regulation of peptidyl-serine phosphorylation

oncostatin-M-mediated signaling pathway

regulation of growth

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of MAPK cascade

negative regulation of meiotic nuclear division

positive regulation of transcription by RNA polymerase II

negative regulation of hormone secretion

behavioral response to pain

positive regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of protein kinase B signaling

positive regulation of apoptotic signaling pathway

04060

04630

TC1100003382.mm.2 Slfn8 schlafen 8 11 -83002157, -83002157 NM_001167743, NM_181545 NM_001167743, NM_181545 15

tRNA binding

nucleotide binding

immune system process

nuclease activity

endonuclease activity

endoribonuclease activity

endoribonuclease activity

ATP binding

cytoplasm

zinc ion binding

rRNA catabolic process

tRNA catabolic process

hydrolase activity

metal ion binding

defense response to virus

 
TC0600001422.mm.2 C1ra complement component 1, r subcomponent A 6 124512620 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 NM_023143, BC004637, BC093528, BC172078 19

immune system process

serine-type endopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular space

extracellular space

complement activation, classical pathway

peptidase activity

serine-type peptidase activity

hydrolase activity

zymogen activation

identical protein binding

innate immune response

blood microparticle

04145

04610

05150

05322

TC1300002047.mm.2 Hk3 hexokinase 3 13 -55005984, -55005984 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 NM_001033245, NM_001206390, NM_001206391, NM_001206392, BC117860, BC117861 20

nucleotide binding

cellular glucose homeostasis

catalytic activity

glucokinase activity

glucokinase activity

hexokinase activity

ATP binding

glucose binding

mitochondrion

mitochondrion

cytosol

carbohydrate metabolic process

fructose 6-phosphate metabolic process

glycolytic process

metabolic process

fructokinase activity

fructokinase activity

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

mannokinase activity

enzyme binding

protein-containing complex

hormone binding

glucose 6-phosphate metabolic process

glucose 6-phosphate metabolic process

negative regulation of hydrogen peroxide-mediated programmed cell death

00010

00051

00052

00500

00520

00524

01100

04910

04930

04973

TC1100004159.mm.2 Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 11 -118392746 NM_011150, BC090658 NM_011150, BC090658 38

scavenger receptor activity

scavenger receptor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

cell adhesion

membrane

 
TC0600001421.mm.2 C1rl complement component 1, r subcomponent-like 6 124493112 NM_181344, BC070472 NM_181344, BC070472 14

immune system process

serine-type endopeptidase activity

extracellular region

extracellular space

extracellular space

proteolysis

complement activation, classical pathway

peptidase activity

serine-type peptidase activity

hydrolase activity

zymogen activation

innate immune response

blood microparticle

 
TC0800002947.mm.2 Mlkl mixed lineage kinase domain-like 8 -111311797 NM_029005, BC023755 NM_029005, BC023755 139

nucleotide binding

JUN kinase kinase kinase activity

protein binding

ATP binding

ATP binding

nucleus

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

cell surface receptor signaling pathway

activation of JUN kinase activity

programmed cell death

membrane

protein kinase binding

cell junction

identical protein binding

protein-containing complex binding

defense response to virus

defense response to virus

protein homotrimerization

necroptotic process

necroptotic process

necroptotic signaling pathway

necroptotic signaling pathway

execution phase of necroptosis

execution phase of necroptosis

 
TC0400001135.mm.2 Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 4 107802258, 107802884, 107802288, 107823160, 107830952 NM_001080926, NR_033496 NM_001080926, NR_033496 161

amyloid-beta binding

low-density lipoprotein particle receptor activity

calcium ion binding

protein binding

extracellular region

extracellular space

microtubule associated complex

plasma membrane

caveola

endocytosis

chemical synaptic transmission

high-density lipoprotein particle binding

cell surface

postsynaptic density

membrane

integral component of membrane

kinesin binding

ventral spinal cord development

ammon gyrus development

hippocampus development

layer formation in cerebral cortex

very-low-density lipoprotein particle receptor activity

axon

dendrite

positive regulation of CREB transcription factor activity

apolipoprotein binding

reelin receptor activity

reelin-mediated signaling pathway

regulation of apoptotic process

neuronal cell body

receptor complex

regulation of innate immune response

positive regulation of protein kinase activity

protein N-terminus binding

calcium-dependent protein binding

dendrite morphogenesis

positive regulation of peptidyl-tyrosine phosphorylation

modulation of chemical synaptic transmission

positive regulation of dendritic spine morphogenesis

positive regulation of protein tyrosine kinase activity

positive regulation of dendrite development

 
TC1800000909.mm.2 Cd226 CD226 antigen 18 89197426 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 NM_001039149, NM_178687, BC132422, BC138769, BC145410, CD226 66

cytokine production

cytokine production

positive regulation of natural killer cell cytokine production

positive regulation of natural killer cell cytokine production

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of immunoglobulin mediated immune response

positive regulation of immunoglobulin mediated immune response

integrin binding

protein binding

plasma membrane

cell adhesion

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

protein kinase binding

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of mast cell activation

positive regulation of mast cell activation

positive regulation of natural killer cell mediated cytotoxicity

cell adhesion molecule binding

positive regulation of T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

positive regulation of Fc receptor mediated stimulatory signaling pathway

positive regulation of Fc receptor mediated stimulatory signaling pathway

04514

TC0300001802.mm.2 Gnb4 guanine nucleotide binding protein (G protein), beta 4 3 -32578586, -32580331, -32580331 NM_013531, BC028753 NM_013531, BC028753 37

GTPase activity

cytoplasm

heterotrimeric G-protein complex

heterotrimeric G-protein complex

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G-protein gamma-subunit binding

myelin sheath

cell body

protein-containing complex binding

04062

TC0X00003437.mm.2 Il2rg interleukin 2 receptor, gamma chain X -101264384 NM_013563, BC014720 NM_013563, BC014720 724

cytokine receptor activity

plasma membrane

plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

regulation of gene expression

positive regulation of gene expression

membrane

integral component of membrane

cytokine-mediated signaling pathway

cytokine binding

interleukin-2 binding

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

positive regulation of T cell differentiation in thymus

interleukin-15-mediated signaling pathway

interleukin-15 receptor activity

receptor complex

positive regulation of B cell differentiation

positive regulation of lymphocyte differentiation

positive regulation of phagocytosis

04060

04144

04630

05340

TC0200004109.mm.2 Nr1h3 nuclear receptor subfamily 1, group H, member 3 2 -91184060, -91184060 NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 NM_001177730, NM_013839, BC012646 438

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

steroid hormone receptor activity

nuclear receptor activity

nuclear receptor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

fatty acid biosynthetic process

zinc ion binding

positive regulation of triglyceride biosynthetic process

positive regulation of cholesterol efflux

positive regulation of cholesterol efflux

negative regulation of cholesterol storage

negative regulation of cholesterol storage

cell differentiation

positive regulation of cellular protein metabolic process

negative regulation of lipid transport

positive regulation of cholesterol transport

response to progesterone

sterol response element binding

positive regulation of toll-like receptor 4 signaling pathway

phosphatidylcholine acyl-chain remodeling

cholesterol homeostasis

cholesterol homeostasis

cholesterol homeostasis

negative regulation of macrophage activation

receptor complex

apoptotic cell clearance

sequence-specific DNA binding

cellular lipid metabolic process

protein-containing complex binding

positive regulation of fatty acid biosynthetic process

negative regulation of proteolysis

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

retinoid X receptor binding

negative regulation of pinocytosis

negative regulation of inflammatory response

negative regulation of inflammatory response

positive regulation of lipoprotein lipase activity

lipid homeostasis

lipid homeostasis

sterol homeostasis

triglyceride homeostasis

triglyceride homeostasis

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

negative regulation of pancreatic juice secretion

negative regulation of secretion of lysosomal enzymes

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

negative regulation of cold-induced thermogenesis

negative regulation of response to endoplasmic reticulum stress

03320

05160

TC0200002961.mm.2 Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 -11471430, -11471430 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 NM_001177752, NM_001177753, NM_001177754, NM_001177755, NM_001177756, NM_001177757, NM_001177758, NM_133232, BC052400, BC057320 55

6-phosphofructo-2-kinase activity

fructose-2,6-bisphosphate 2-phosphatase activity

nucleoplasm

cytosol

fructose 2,6-bisphosphate metabolic process

fructose 2,6-bisphosphate metabolic process

00051

TC1100000039.mm.2 Castor1 cytosolic arginine sensor for mTORC1 subunit 1 11 4218224 NM_028022, BC039988 NM_028022, BC039988 13

cytoplasm

cytosol

cytosol

arginine binding

arginine binding

identical protein binding

GATOR2 complex

GATOR2 complex

regulation of intracellular signal transduction

regulation of TORC1 signaling

cellular response to L-arginine

cellular response to L-arginine

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

 
TC1100004283.mm.2 Syngr2 synaptogyrin 2 11 117809666 NM_009304, BC004829 NM_009304, BC004829 18

protein binding

protein targeting

synaptic vesicle

membrane

integral component of membrane

cell junction

synaptic vesicle membrane

synaptic vesicle membrane

cytoplasmic vesicle

neuromuscular junction

regulated exocytosis

synapse

synaptic vesicle membrane organization

 
TC1200000069.mm.2 Sdc1 syndecan 1 12 8771395 NM_011519, BC010560 NM_011519, BC010560 238

protein binding

extracellular region

extracellular region

Golgi lumen

inflammatory response

protein C-terminus binding

external side of plasma membrane

cell surface

cell surface

cell surface

membrane

integral component of membrane

cell migration

protein-containing complex

wound healing

identical protein binding

myoblast development

canonical Wnt signaling pathway

positive regulation of exosomal secretion

positive regulation of extracellular exosome assembly

04512

04514

05144

TC0100001202.mm.2 Ppp1r15b protein phosphatase 1, regulatory subunit 15B 1 133131165 NM_133819, BC156913 NM_133819, BC156913 23

protein phosphatase type 1 complex

protein phosphatase type 1 complex

protein phosphatase type 1 complex

negative regulation of protein phosphorylation

endoplasmic reticulum

regulation of translation

regulation of translational initiation

response to oxidative stress

response to oxidative stress

ER overload response

ER overload response

protein phosphatase regulator activity

protein phosphatase regulator activity

positive regulation of phosphoprotein phosphatase activity

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

response to hydrogen peroxide

peptidyl-serine dephosphorylation

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

 
TC0400002220.mm.2 Tmem67 transmembrane protein 67 4 -12039355, -12039358 NM_177861 28

kidney development

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

centrosome

cytoskeleton

plasma membrane

cilium

axoneme

determination of left/right symmetry

heart development

negative regulation of centrosome duplication

negative regulation of centrosome duplication

membrane

integral component of membrane

cell projection organization

ubiquitin-dependent ERAD pathway

cytoplasmic vesicle membrane

cytoplasmic vesicle membrane

filamin binding

photoreceptor cell outer segment organization

ciliary transition zone

ciliary transition zone

MKS complex

cell projection

branching morphogenesis of an epithelial tube

unfolded protein binding

misfolded protein binding

ciliary membrane

cilium assembly

cilium assembly

cilium assembly

head development

positive regulation of non-motile cilium assembly

positive regulation of ERAD pathway

 
TC0300000096.mm.2 Car2 carbonic anhydrase 2 3 14886268, 14886287 NM_009801, BC055291 NM_009801, BC055291 152

morphogenesis of an epithelium

arylesterase activity

carbonate dehydratase activity

carbonate dehydratase activity

carbonate dehydratase activity

carbonate dehydratase activity

extracellular space

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

microvillus

one-carbon metabolic process

regulation of pH

zinc ion binding

carbon dioxide transport

carbon dioxide transport

carbon dioxide transport

membrane

basolateral plasma membrane

lyase activity

hydro-lyase activity

axon

positive regulation of synaptic transmission, GABAergic

positive regulation of cellular pH reduction

positive regulation of cellular pH reduction

angiotensin-activated signaling pathway

myelin sheath

myelin sheath

regulation of anion transport

apical part of cell

apical part of cell

positive regulation of osteoclast differentiation

positive regulation of bone resorption

metal ion binding

secretion

regulation of intracellular pH

regulation of intracellular pH

positive regulation of dipeptide transmembrane transport

regulation of chloride transport

00910

04966

04971

04972

04976

TC0800002734.mm.2 Ciapin1 cytokine induced apoptosis inhibitor 1 8 -94819817 NM_134141, BC016261, BC021864 NM_134141, BC016261, BC021864 NM_134141, BC016261, BC021864 30

protein binding

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

apoptotic process

methyltransferase activity

iron-sulfur cluster assembly

hemopoiesis

negative regulation of apoptotic process

metal ion binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

4 iron, 4 sulfur cluster binding

 
TC0700002491.mm.2 Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 7 -19606222, -19606221 NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 NM_009046, BC019765, BC034523, BC117793 204

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

cytosol

cytosol

cytoskeleton

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

inflammatory response

I-kappaB kinase/NF-kappaB signaling

positive regulation of gene expression

transcription repressor complex

antigen processing and presentation

protein kinase binding

lymphocyte differentiation

negative regulation of interferon-beta production

circadian regulation of gene expression

protein-containing complex

cellular response to stress

response to cytokine

NIK/NF-kappaB signaling

NIK/NF-kappaB signaling

T-helper 1 type immune response

identical protein binding

myeloid dendritic cell differentiation

T-helper 1 cell differentiation

innate immune response

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

rhythmic process

cellular response to osmotic stress

04010

04380

TC1400001086.mm.2 Epsti1 epithelial stromal interaction 1 (breast) 14 77904238, 77904238 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 NM_029495, NM_178825, BC020120, BC021821 13

molecular_function

cellular_component

biological_process

 
TC0800000115.mm.2 F10 coagulation factor X 8 13037307 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 NM_001242368, NM_007972, BC003877, BC050219 49

serine-type endopeptidase activity

calcium ion binding

phospholipid binding

extracellular region

extracellular space

endoplasmic reticulum

proteolysis

blood coagulation

blood coagulation

hemostasis

peptidase activity

serine-type peptidase activity

membrane

hydrolase activity

intracellular membrane-bounded organelle

positive regulation of protein kinase B signaling

04610

TC1500001730.mm.2 Ly6c2 lymphocyte antigen 6 complex, locus C2 15 -75108160, -75108160 NM_001099217, BC092082 NM_001099217, BC092082 8

plasma membrane

cell surface

membrane

acetylcholine receptor inhibitor activity

anchored component of membrane

acetylcholine receptor binding

acetylcholine receptor signaling pathway

 
TC0100001252.mm.2 Csrp1 cysteine and glycine-rich protein 1 1 135729166, 135720062 NM_007791, BC006912 NM_007791, BC006912 46

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

structural constituent of muscle

actin cytoskeleton

Z disc

actin cytoskeleton organization

actin cytoskeleton organization

actinin binding

sarcomere organization

metal ion binding

muscle tissue development

 
TC1700000528.mm.2 Abcg1 ATP binding cassette subfamily G member 1 17 31057693 NM_009593, BC119471 NM_009593, BC119471 166

nucleotide binding

ATP binding

mitochondrion

endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

lipid transport

cholesterol metabolic process

external side of plasma membrane

external side of plasma membrane

negative regulation of macrophage derived foam cell differentiation

regulation of cholesterol esterification

positive regulation of cholesterol efflux

negative regulation of lipid storage

membrane

integral component of membrane

ATPase activity

toxin transmembrane transporter activity

cholesterol transport

intracellular cholesterol transport

cholesterol efflux

cholesterol efflux

cholesterol efflux

phospholipid efflux

response to lipid

ABC-type sterol transporter activity

ABC-type sterol transporter activity

low-density lipoprotein particle remodeling

high-density lipoprotein particle remodeling

glycoprotein transport

cholesterol homeostasis

cholesterol homeostasis

protein homodimerization activity

amyloid precursor protein catabolic process

ADP binding

reverse cholesterol transport

positive regulation of cholesterol biosynthetic process

protein heterodimerization activity

positive regulation of protein secretion

recycling endosome

transmembrane transport

phospholipid homeostasis

cellular response to high density lipoprotein particle stimulus

phosphatidylcholine floppase activity

cholesterol transfer activity

floppase activity

positive regulation of amyloid-beta formation

02010

MG-1-neg-10341222_st                
TC1_GL456211_random00000010.mm.2                
TC1200000715.mm.2 Arg2 arginase type II 12 79130787 NM_009705, BC023349 NM_009705, BC023349 105

urea cycle

ureteric bud development

adaptive immune response

immune system process

negative regulation of type 2 immune response

arginase activity

arginase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

arginine metabolic process

striated muscle contraction

regulation of L-arginine import

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

arginine catabolic process to ornithine

arginine catabolic process to ornithine

manganese ion binding

regulation of interleukin-1 beta production

negative regulation of interleukin-13 production

negative regulation of interleukin-17 production

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor production

innate immune response

negative regulation of striated muscle contraction

metal ion binding

nitric-oxide synthase binding

negative regulation of nitric-oxide synthase activity

negative regulation of macrophage inflammatory protein 1 alpha production

negative regulation of chemokine (C-C motif) ligand 4 production

negative regulation of chemokine (C-C motif) ligand 5 production

negative regulation of defense response to bacterium

regulation of reactive oxygen species biosynthetic process

negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process

negative regulation of CD4-positive, alpha-beta T cell proliferation

positive regulation of cellular senescence

00330

01100

05146

TC0900002806.mm.2 Bcl2a1d B cell leukemia/lymphoma 2 related protein A1d 9 -88723287 NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 NM_007536, BC027536, BC116240 20

mitochondrial outer membrane

intrinsic apoptotic signaling pathway in response to DNA damage

T cell differentiation

protein homodimerization activity

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein-containing complex binding

protein heterodimerization activity

T cell receptor signaling pathway

BH domain binding

extrinsic apoptotic signaling pathway in absence of ligand

 
TC0700002503.mm.2 Bcl3 B cell leukemia/lymphoma 3 7 -19808461 NM_033601, BC156806 NM_033601, BC156806 84

follicular dendritic cell differentiation

marginal zone B cell differentiation

humoral immune response mediated by circulating immunoglobulin

germinal center formation

transcription coactivator activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

plasma membrane

transcription, DNA-templated

cellular response to DNA damage stimulus

I-kappaB kinase/NF-kappaB signaling

transcription factor binding

response to virus

response to UV-C

antimicrobial humoral response

extracellular matrix organization

DNA damage response, signal transduction by p53 class mediator

midbody

negative regulation of interleukin-8 production

negative regulation of tumor necrosis factor production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

protein-containing complex

Bcl3-Bcl10 complex

Bcl3/NF-kappaB2 complex

T-helper 1 type immune response

defense response to bacterium

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

defense response to protozoan

regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

T-helper 2 cell differentiation

positive regulation of translation

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of receptor signaling pathway via JAK-STAT

spleen development

 
TC0800001896.mm.2 Ido1 indoleamine 2,3-dioxygenase 1 8 -24584132, -24584132 NM_008324, BC049931 NM_008324, BC049931 254

immune system process

cytokine production involved in inflammatory response

positive regulation of T cell tolerance induction

positive regulation of chronic inflammatory response

positive regulation of type 2 immune response

tryptophan 2,3-dioxygenase activity

tryptophan 2,3-dioxygenase activity

protein binding

cytoplasm

cytoplasm

cytosol

tryptophan catabolic process

defense response

inflammatory response

oxidoreductase activity

amino acid binding

tryptophan catabolic process to kynurenine

tryptophan catabolic process to kynurenine

tryptophan catabolic process to kynurenine

oxygen binding

heme binding

smooth muscle contractile fiber

stereocilium bundle

response to lipopolysaccharide

negative regulation of interleukin-10 production

positive regulation of interleukin-12 production

multicellular organismal response to stress

indoleamine 2,3-dioxygenase activity

indoleamine 2,3-dioxygenase activity

kynurenic acid biosynthetic process

'de novo' NAD biosynthetic process from tryptophan

swimming behavior

negative regulation of T cell proliferation

positive regulation of apoptotic process

negative regulation of activated T cell proliferation

metal ion binding

dioxygenase activity

negative regulation of T cell apoptotic process

positive regulation of T cell apoptotic process

00380

01100

05143

TC0800001132.mm.2 Usb1 U6 snRNA biogenesis 1 8 95332283 NM_133954, BC016418, U6 NM_133954, BC016418, U6 NM_133954, BC016418, U6 15

3'-5'-exoribonuclease activity

3'-5'-exoribonuclease activity

nuclease activity

nucleus

nucleus

nucleoplasm

RNA splicing

hydrolase activity

U6 snRNA 3'-end processing

U6 snRNA 3'-end processing

intercellular bridge

 
TC1400000575.mm.2 Pnp2 purine-nucleoside phosphorylase 2 14 50956140 NM_001123371 10

nucleoside binding

purine nucleobase binding

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

extracellular region

nucleus

cytoplasm

cytoplasm

cytosol

phosphate ion binding

identical protein binding

00230

00240

00760

01100

TC1100000713.mm.2         NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781 NM_031172, NM_178218, BC055112, BC058119, BC063781  

nucleosome

DNA binding

DNA binding

ubiquitin-protein transferase activity

nucleus

chromosome

cytoplasm

nucleosome disassembly

chromatin silencing

autophagy

zinc ion binding

regulation of gene expression

protein ubiquitination

transferase activity

protein-macromolecule adaptor activity

regulation of protein localization

innate immune response

metal ion binding

protein heterodimerization activity

protein autoubiquitination

ubiquitin protein ligase activity

UV-damage excision repair

 
TC1200002154.mm.2 Ston2 stonin 2 12 -91633008 NM_175367, BC132531, BC138054 NM_175367, BC132531, BC138054 NM_175367, BC132531, BC138054 27

hematopoietic progenitor cell differentiation

protein binding

nucleolus

cytoplasm

cytosol

endocytosis

chemical synaptic transmission

synaptic vesicle

synaptic vesicle

membrane

vesicle-mediated transport

cell junction

regulation of endocytosis

regulation of endocytosis

clathrin-coated vesicle

clathrin-coated vesicle

cytoplasmic vesicle

clathrin adaptor activity

synaptic vesicle recycling

neuron projection

intracellular membrane-bounded organelle

synapse

synaptic vesicle endocytosis

synaptic vesicle endocytosis

presynapse

 
TC0500003373.mm.2 Clip2 CAP-GLY domain containing linker protein 2 5 -134489382 NM_001039162, NM_009990, BC039162, BC053048 NM_001039162, NM_009990, BC039162, BC053048 NM_001039162, NM_009990, BC039162, BC053048 NM_001039162, NM_009990, BC039162, BC053048 44

protein binding

nucleus

cytoplasm

cytoskeleton

microtubule

cytoplasmic microtubule

microtubule binding

microtubule cytoskeleton

cytoplasmic microtubule organization

microtubule plus-end

microtubule plus-end

lamellar body

microtubule plus-end binding

microtubule plus-end binding

microtubule plus-end binding

dendritic microtubule

 
TC0300002050.mm.2 Gpr171 G protein-coupled receptor 171 3 -59096447 NM_173398, BC024054 NM_173398, BC024054 14

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

G protein-coupled purinergic nucleotide receptor activity

negative regulation of myeloid cell differentiation

negative regulation of myeloid cell differentiation

 
TC1500001777.mm.2 Dgat1 diacylglycerol O-acyltransferase 1 15 -76502011 NM_010046, BC003717 NM_010046, BC003717 116

2-acylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

fatty acid binding

endoplasmic reticulum

endoplasmic reticulum membrane

plasma membrane

monoacylglycerol biosynthetic process

monoacylglycerol biosynthetic process

O-acyltransferase activity

positive regulation of triglyceride biosynthetic process

membrane

integral component of membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

triglyceride biosynthetic process

triglyceride biosynthetic process

triglyceride biosynthetic process

triglyceride biosynthetic process

lipid storage

lipid storage

diacylglycerol binding

insulin secretion

very-low-density lipoprotein particle assembly

long-chain fatty-acyl-CoA metabolic process

identical protein binding

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

positive regulation of fatty acid oxidation

diacylglycerol metabolic process

diacylglycerol metabolic process

glycerolipid metabolic process

retinol O-fatty-acyltransferase activity

fatty acid homeostasis

fatty acid homeostasis

regulation of vitamin A metabolic process

ketone body metabolic process

regulation of eating behavior

regulation of intestinal lipid absorption

positive regulation of hepatic stellate cell activation

00561

00830

01100

04975

TC1200001768.mm.2 Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha 12 -55489408 NM_010907, BC046754 NM_010907, BC046754 242

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

protein import into nucleus

I-kappaB kinase/NF-kappaB signaling

cytoplasmic sequestering of NF-kappaB

nuclear localization sequence binding

regulation of gene expression

negative regulation of macrophage derived foam cell differentiation

positive regulation of cholesterol efflux

negative regulation of lipid storage

enzyme binding

heat shock protein binding

ubiquitin protein ligase binding

lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

positive regulation of cellular protein metabolic process

response to muramyl dipeptide

response to lipopolysaccharide

protein-containing complex

tumor necrosis factor-mediated signaling pathway

toll-like receptor 4 signaling pathway

response to muscle stretch

regulation of cell population proliferation

identical protein binding

cytoplasmic sequestering of transcription factor

response to exogenous dsRNA

protein-containing complex binding

negative regulation of myeloid cell differentiation

negative regulation of Notch signaling pathway

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of inflammatory response

NF-kappaB binding

nucleotide-binding oligomerization domain containing 1 signaling pathway

nucleotide-binding oligomerization domain containing 2 signaling pathway

cellular response to biotic stimulus

cellular response to cytokine stimulus

cellular response to tumor necrosis factor

cellular response to organic cyclic compound

04062

04210

04380

04620

04621

04622

04623

04660

04662

04722

04920

05140

05142

05145

05160

05200

05215

05220

05222

TC0900001978.mm.2 St14 suppression of tumorigenicity 14 (colon carcinoma) 9 -31088589 NM_011176, BC005496 NM_011176, BC005496 72

neural tube closure

serine-type endopeptidase activity

extracellular region

extracellular space

plasma membrane

integral component of plasma membrane

proteolysis

peptidase activity

serine-type peptidase activity

serine-type peptidase activity

membrane

integral component of membrane

basolateral plasma membrane

cell migration

hydrolase activity

extrinsic component of plasma membrane

extrinsic component of plasma membrane

keratinocyte differentiation

keratinocyte differentiation

epithelial cell morphogenesis involved in placental branching

 
TC1400000271.mm.2 Arhgef3 Rho guanine nucleotide exchange factor (GEF) 3 14 27238009, 27143992, 27361388, 27336036 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 NM_001289686, NM_001289687, NM_001289688, NM_027871, BC005517, BC012262 29

guanyl-nucleotide exchange factor activity

cytoplasm

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

intracellular signal transduction

 
TC1100003395.mm.2 Heatr9 HEAT repeat containing 9 11 -83511678 NM_001045543 3

hematopoietic progenitor cell differentiation

cellular_component

 
TC0600002423.mm.2 Il12rb2 interleukin 12 receptor, beta 2 6 -67292017, -67292017 NM_008354, BC137745 NM_008354, BC137745 111

cytokine receptor activity

protein binding

plasma membrane

plasma membrane

external side of plasma membrane

external side of plasma membrane

membrane

integral component of membrane

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

protein kinase binding

cytokine binding

response to lipopolysaccharide

interferon-gamma production

positive regulation of interferon-gamma production

response to cytokine

receptor complex

04060

04630

TC1100002003.mm.2         XM_001477846      
TC1800000124.mm.2 Taf4b TATA-box binding protein associated factor 4b 18 14783244 NM_001100449 40

fibrillar center

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

transcription factor TFIID complex

transcription factor TFIID complex

cytoplasm

DNA-templated transcription, initiation

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription initiation from RNA polymerase II promoter

spermatogenesis

RNA polymerase II general transcription initiation factor activity

cell differentiation

protein heterodimerization activity

oogenesis

NF-kappaB binding

positive regulation of stem cell proliferation

03022

05016

TC0900002197.mm.2 Il10ra interleukin 10 receptor, alpha 9 -45253836 NM_008348, BC146496 NM_008348, BC146496 73

cytokine receptor activity

interleukin-10 receptor activity

cytoplasm

cytosol

plasma membrane

plasma membrane

negative regulation of autophagy

membrane

integral component of membrane

cytokine-mediated signaling pathway

interleukin-10 binding

positive regulation of receptor signaling pathway via JAK-STAT

regulation of synapse organization

ubiquitin-dependent endocytosis

04060

04630

05145

TC0600002114.mm.2 Parp12 poly (ADP-ribose) polymerase family, member 12 6 -39086411 NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 NM_172893, BC120733, BC137645 25

NAD+ ADP-ribosyltransferase activity

cellular_component

nucleus

protein ADP-ribosylation

transferase activity

protein phosphopantetheinylation

metal ion binding

protein auto-ADP-ribosylation

protein mono-ADP-ribosylation

protein ADP-ribosylase activity

 
TC0100001859.mm.2 Slc30a1 solute carrier family 30 (zinc transporter), member 1 1 191906780 NM_009579, BC052166 NM_009579, BC052166 33

in utero embryonic development

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

plasma membrane

ion transport

cation transport

zinc ion transport

zinc ion transport

cellular calcium ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cation transmembrane transporter activity

detoxification of zinc ion

membrane

integral component of membrane

integral component of membrane

calcium channel inhibitor activity

calcium channel inhibitor activity

calcium channel inhibitor activity

T-tubule

nuclear membrane

negative regulation of neurotransmitter secretion

transmembrane transport

calcium ion import

cadmium ion transmembrane transport

zinc ion transmembrane transport

negative regulation of zinc ion transmembrane import

detoxification of cadmium ion

negative regulation of calcium ion import

Schaffer collateral - CA1 synapse

integral component of postsynaptic density membrane

 
TC1300001954.mm.2 Card19 caspase recruitment domain family, member 19 13 -49202950 NM_026738, BC147073, BC147074 NM_026738, BC147073, BC147074 NM_026738, BC147073, BC147074 14

molecular_function

mitochondrion

mitochondrion

endoplasmic reticulum

biological_process

membrane

integral component of membrane

regulation of apoptotic process

 
TC1700001827.mm.2 Sik1 salt inducible kinase 1 17 -31844247 NM_010831, BC146549 NM_010831, BC146549 61

negative regulation of transcription by RNA polymerase II

nucleotide binding

magnesium ion binding

regulation of sodium ion transport

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

protein phosphorylation

protein phosphorylation

protein phosphorylation

cell cycle

multicellular organism development

regulation of mitotic cell cycle

cAMP response element binding protein binding

regulation of myotube differentiation

negative regulation of triglyceride biosynthetic process

kinase activity

phosphorylation

transferase activity

protein kinase binding

protein kinase binding

cell differentiation

negative regulation of CREB transcription factor activity

negative regulation of CREB transcription factor activity

intracellular signal transduction

intracellular signal transduction

cellular response to glucose starvation

histone deacetylase binding

entrainment of circadian clock by photoperiod

anoikis

regulation of cell differentiation

negative regulation of gluconeogenesis

metal ion binding

rhythmic process

cardiac muscle cell differentiation

 
TC0500001597.mm.2         NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460 NM_001039103, NM_133914, NR_106002, BC057460  

GTPase activator activity

phospholipid binding

cytoplasm

cytosol

plasma membrane

signal transduction

membrane

negative regulation of GTPase activity

intracellular signal transduction

regulation of GTPase activity

negative regulation of Ras protein signal transduction

metal ion binding

cellular response to calcium ion

 
TC0600003307.mm.2 Dusp16 dual specificity phosphatase 16 6 -134715467 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 NM_001048054, NM_130447, BC057321, BC059232 39

inactivation of MAPK activity

inactivation of MAPK activity

phosphoprotein phosphatase activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

protein dephosphorylation

protein tyrosine/threonine phosphatase activity

dephosphorylation

phosphatase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-threonine dephosphorylation

negative regulation of MAPK cascade

mitogen-activated protein kinase binding

04010

TC0600000609.mm.2 Snx10 sorting nexin 10 6 51524259, 51545292, 51524083, 51544522, 51523902 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 NM_001127348, NM_001127349, NM_028035, BC010334 30

gastric acid secretion

1-phosphatidylinositol binding

nucleus

nucleus

cytoplasm

endosome

endoplasmic reticulum

endoplasmic reticulum

centrosome

cytoskeleton

endocytosis

endosome organization

lipid binding

protein transport

membrane

cell projection organization

secretory granule

osteoclast differentiation

extrinsic component of endosome membrane

phosphatidylinositol binding

bone mineralization involved in bone maturation

tooth eruption

bone resorption

bone remodeling

ATPase binding

calcium ion homeostasis

cilium assembly

protein localization to cilium

protein localization to centrosome

apical cytoplasm

ruffle assembly

cellular response to leukemia inhibitory factor

 
TC0200004545.mm.2 Sppl2a signal peptide peptidase like 2A 2 -126890394 NM_023220, BC026578 NM_023220, BC026578 31

aspartic-type endopeptidase activity

lysosome

lysosomal membrane

lysosomal membrane

endosome

late endosome

plasma membrane

proteolysis

membrane protein ectodomain proteolysis

peptidase activity

membrane

integral component of membrane

hydrolase activity

Golgi-associated vesicle membrane

Golgi-associated vesicle membrane

membrane protein intracellular domain proteolysis

late endosome membrane

membrane protein proteolysis

membrane protein proteolysis

aspartic endopeptidase activity, intramembrane cleaving

aspartic endopeptidase activity, intramembrane cleaving

protein homodimerization activity

intracellular membrane-bounded organelle

regulation of immune response

integral component of cytoplasmic side of endoplasmic reticulum membrane

integral component of cytoplasmic side of endoplasmic reticulum membrane

integral component of lumenal side of endoplasmic reticulum membrane

integral component of lumenal side of endoplasmic reticulum membrane

 
TC0800000800.mm.2         NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647 NM_001190830, NM_010589, NM_013564, BC049540, BC105577, BC131646, BC131647  

nucleotide binding

oocyte maturation

G protein-coupled receptor binding

G protein-coupled receptor binding

in utero embryonic development

protease binding

adaptive immune response

immune system process

negative regulation of dendritic cell cytokine production

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

hormone activity

protein binding

ATP binding

extracellular region

extracellular space

extracellular space

cytoplasm

cytosol

cytoskeleton

protein phosphorylation

enzyme linked receptor protein signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

tyrosine phosphorylation of STAT protein

positive regulation of cell population proliferation

negative regulation of cell population proliferation

male gonad development

male gonad development

positive regulation of epithelial cell migration

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein phosphatase binding

B cell differentiation

B cell differentiation

erythrocyte differentiation

negative regulation of interleukin-10 production

negative regulation of interleukin-12 production

intracellular signal transduction

interleukin-4-mediated signaling pathway

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of activated T cell proliferation

regulation of apoptotic process

T cell homeostasis

T cell homeostasis

negative regulation of apoptotic process

positive regulation of cAMP-mediated signaling

innate immune response

negative regulation of FasL production

negative regulation of T-helper 1 cell differentiation

positive regulation of transcription by RNA polymerase II

perinuclear region of cytoplasm

lymph node development

negative regulation of T cell activation

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of calcium ion transport

regulation of T cell apoptotic process

negative regulation of thymocyte apoptotic process

response to interleukin-2

response to interleukin-4

response to interleukin-4

response to interleukin-15

response to interleukin-9

cellular response to cytokine stimulus

positive regulation of wound healing

regulation of male gonad development

positive regulation of dendritic cell apoptotic process

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

 
TC1900001485.mm.2 Sorbs1 sorbin and SH3 domain containing 1 19 -40292039, -40292039, -40292039, -40292039 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 NM_001034962, NM_001034963, NM_001034964, NM_009166, NM_178362, BC012703 71

stress fiber

insulin receptor binding

insulin receptor binding

insulin receptor binding

protein binding

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytoskeleton

plasma membrane

insulin receptor complex

adherens junction

focal adhesion

transcription factor binding

insulin receptor signaling pathway

membrane

nuclear matrix

flotillin complex

protein kinase binding

cell junction

cell-substrate junction

signaling receptor complex adaptor activity

signaling receptor complex adaptor activity

ubiquitin protein ligase binding

ubiquitin protein ligase binding

cellular response to insulin stimulus

stress fiber assembly

membrane raft

synapse

positive regulation of glycogen biosynthetic process

positive regulation of glucose import

positive regulation of glucose import

positive regulation of insulin receptor signaling pathway

positive regulation of lipid biosynthetic process

focal adhesion assembly

acetylcholine receptor signaling pathway

positive regulation of protein localization to plasma membrane

regulation of skeletal muscle acetylcholine-gated channel clustering

03320

04520

04910

TC1100001386.mm.2 Trim25 tripartite motif-containing 25 11 88999402 NM_009546, BC006908, BC034276 NM_009546, BC006908, BC034276 NM_009546, BC006908, BC034276 44

immune system process

transcription coactivator activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

protein monoubiquitination

cytoplasmic stress granule

nuclear body

transferase activity

ligase activity

ubiquitin-dependent ERAD pathway

regulation of protein localization

RIG-I binding

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to estrogen

innate immune response

innate immune response

regulation of viral entry into host cell

negative regulation of viral entry into host cell

metal ion binding

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

defense response to virus

ubiquitin protein ligase activity

regulation of viral release from host cell

negative regulation of viral release from host cell

cellular response to leukemia inhibitory factor

04622

TC1200001601.mm.2 Hbp1 high mobility group box transcription factor 1 12 -31926454, -31929384 NM_153198, NM_177993, BC026853 NM_153198, NM_177993, BC026853 NM_153198, NM_177993, BC026853 40

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

RNA binding

protein binding

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

negative regulation of macrophage derived foam cell differentiation

Wnt signaling pathway

nuclear speck

negative regulation of lipid transport

positive regulation of potassium ion transport

negative regulation of reactive oxygen species biosynthetic process

 
TC1100004150.mm.2 Socs3 suppressor of cytokine signaling 3 11 -117966086 NM_007707, BC052031 NM_007707, BC052031 427

phosphotyrosine residue binding

regulation of protein phosphorylation

protein binding

cytoplasm

cytosol

phosphatidylinositol 3-kinase complex

signal transduction

receptor signaling pathway via JAK-STAT

negative regulation of signal transduction

intracellular signal transduction

regulation of growth

negative regulation of tyrosine phosphorylation of STAT protein

negative regulation of apoptotic process

regulation of cell differentiation

regulation of cell differentiation

positive regulation of cell differentiation

positive regulation of cell differentiation

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of insulin receptor signaling pathway

phosphatidylinositol phosphorylation

1-phosphatidylinositol-3-kinase regulator activity

negative regulation of inflammatory response

branching involved in labyrinthine layer morphogenesis

placenta blood vessel development

trophoblast giant cell differentiation

trophoblast giant cell differentiation

spongiotrophoblast differentiation

spongiotrophoblast differentiation

cellular response to leukemia inhibitory factor

04120

04380

04630

04910

04920

04930

05160

TC1200000359.mm.2 Dock4 dedicator of cytokinesis 4 12 40446052 NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 NM_172803, BC141138, BC172663 25

guanyl-nucleotide exchange factor activity

GTPase activator activity

nucleolus

cytoplasm

Golgi apparatus

cytosol

plasma membrane

small GTPase mediated signal transduction

membrane

SH3 domain binding

PDZ domain binding

receptor tyrosine kinase binding

small GTPase binding

stereocilium

stereocilium bundle

cell chemotaxis

negative regulation of vascular associated smooth muscle contraction

positive regulation of vascular associated smooth muscle cell migration

 
TC1700002162.mm.2 Vegfa vascular endothelial growth factor A 17 -46016992, -46016993, -46016992 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, BC061468 1580

negative regulation of transcription by RNA polymerase II

angiogenesis

angiogenesis

angiogenesis

angiogenesis

ovarian follicle development

blood vessel development

branching involved in blood vessel morphogenesis

branching involved in blood vessel morphogenesis

response to hypoxia

response to hypoxia

in utero embryonic development

kidney development

positive regulation of protein phosphorylation

positive regulation of protein phosphorylation

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

vasculature development

lymphangiogenesis

fibronectin binding

blood vessel remodeling

sprouting angiogenesis

sprouting angiogenesis

cell migration involved in sprouting angiogenesis

positive regulation of neuroblast proliferation

positive regulation of mesenchymal cell proliferation

positive regulation of receptor internalization

basophil chemotaxis

heart morphogenesis

outflow tract morphogenesis

coronary vein morphogenesis

signaling receptor binding

cytokine activity

platelet-derived growth factor receptor binding

vascular endothelial growth factor receptor binding

vascular endothelial growth factor receptor binding

protein binding

extracellular region

basement membrane

extracellular space

extracellular space

extracellular space

extracellular space

nucleus

cytoplasm

cytoplasm

plasma membrane

adherens junction

regulation of transcription by RNA polymerase II

multicellular organism development

nervous system development

mesoderm development

lactation

growth factor activity

growth factor activity

growth factor activity

heparin binding

heparin binding

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

regulation of cell shape

positive regulation of signal transduction

cell surface

positive regulation of endothelial cell migration

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

negative regulation of epithelial to mesenchymal transition

regulation of nitric oxide mediated signal transduction

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

cell migration

cell migration

growth factor binding

negative regulation of cell-cell adhesion

secretory granule

cell differentiation

monocyte differentiation

macrophage differentiation

lung development

lung development

positive regulation of cell migration

epithelial cell differentiation

post-embryonic camera-type eye development

positive regulation of protein-containing complex assembly

positive regulation of protein autophosphorylation

vesicle

activation of protein kinase activity

positive regulation of CREB transcription factor activity

positive regulation of peptidyl-serine phosphorylation

tube formation

endothelial cell chemotaxis

cellular response to vascular endothelial growth factor stimulus

cellular response to vascular endothelial growth factor stimulus

lymph vessel morphogenesis

vascular endothelial growth factor receptor-2 signaling pathway

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor signaling pathway

vascular endothelial growth factor signaling pathway

vascular endothelial growth factor signaling pathway

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

VEGF-activated neuropilin signaling pathway

VEGF-activated neuropilin signaling pathway

neuropilin binding

regulation of growth

chemoattractant activity

chemoattractant activity

chemoattractant activity

T-helper 1 type immune response

positive regulation of phosphorylation

eye photoreceptor cell development

identical protein binding

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of programmed cell death

positive regulation of vascular permeability

positive regulation of vascular permeability

surfactant homeostasis

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 2 binding

vascular endothelial growth factor receptor 2 binding

vascular endothelial growth factor receptor 2 binding

vascular endothelial growth factor receptor 2 binding

positive regulation of MAP kinase activity

positive regulation of MAPK cascade

negative regulation of neuron apoptotic process

positive regulation of blood vessel endothelial cell migration

endothelial cell migration

negative regulation of fat cell differentiation

regulation of endothelial cell differentiation

positive regulation of osteoblast differentiation

positive regulation of angiogenesis

positive regulation of angiogenesis

positive regulation of angiogenesis

negative regulation of bone resorption

positive regulation of cell adhesion

positive regulation of transcription by RNA polymerase II

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

receptor ligand activity

mRNA stabilization

lung alveolus development

cell maturation

blood vessel morphogenesis

blood vessel morphogenesis

blood vessel morphogenesis

camera-type eye morphogenesis

positive regulation of smooth muscle cell proliferation

neuron development

cardiac muscle fiber development

branching morphogenesis of an epithelial tube

positive regulation of axon extension involved in axon guidance

positive regulation of axon extension involved in axon guidance

artery morphogenesis

homeostasis of number of cells within a tissue

positive regulation of epithelial cell proliferation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

extracellular matrix binding

positive chemotaxis

positive chemotaxis

positive regulation of positive chemotaxis

induction of positive chemotaxis

induction of positive chemotaxis

positive regulation of cellular component movement

positive regulation of cell division

positive regulation of focal adhesion assembly

positive regulation of protein kinase B signaling

positive regulation of protein kinase B signaling

primitive erythrocyte differentiation

cell chemotaxis

bone trabecula formation

lung vasculature development

lung vasculature development

mammary gland alveolus development

positive regulation of mast cell chemotaxis

positive regulation of mast cell chemotaxis

cardiac vascular smooth muscle cell development

angiogenesis involved in coronary vascular morphogenesis

coronary artery morphogenesis

vascular wound healing

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

bone trabecula morphogenesis

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

cellular response to hypoxia

dopaminergic neuron differentiation

commissural neuron axon guidance

commissural neuron axon guidance

positive regulation of protein kinase C signaling

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of branching involved in ureteric bud morphogenesis

regulation of retinal ganglion cell axon guidance

regulation of retinal ganglion cell axon guidance

motor neuron migration

cellular stress response to acid chemical

positive regulation of cold-induced thermogenesis

positive regulation of peptidyl-tyrosine autophosphorylation

positive regulation of p38MAPK cascade

positive regulation of trophoblast cell migration

negative regulation of neuron death

positive regulation of lymphangiogenesis

regulation of hematopoietic progenitor cell differentiation

positive regulation of histone deacetylase activity

positive regulation of retinal ganglion cell axon guidance

positive regulation of protein localization to early endosome

negative regulation of establishment of endothelial barrier

negative regulation of adherens junction organization

positive regulation of protein kinase D signaling

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of sprouting angiogenesis

positive regulation of epithelial tube formation

negative regulation of blood-brain barrier permeability

negative regulation of cell-cell adhesion mediated by cadherin

positive regulation of DNA biosynthetic process

negative regulation of extrinsic apoptotic signaling pathway

04060

04150

04370

04510

05200

05211

05212

05219

05323

TC0800002822.mm.2 Tppp3 tubulin polymerization-promoting protein family member 3 8 -105467491 NM_026481, BC010788 NM_026481, BC010788 32

microtubule bundle formation

microtubule bundle formation

cytoplasm

cytoskeleton

microtubule

embryo implantation

tubulin binding

tubulin binding

positive regulation of protein polymerization

decidualization

microtubule polymerization

perinuclear region of cytoplasm

microtubule bundle

 
TC1400000580.mm.2 Rnase6 ribonuclease, RNase A family, 6 14 51123907, 51129036, 51129063 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 NM_030098, BC094892, BC132632, BC132634 15

nucleic acid binding

nuclease activity

endonuclease activity

ribonuclease activity

ribonuclease activity

extracellular region

extracellular space

extracellular space

extracellular space

lysosome

hydrolase activity

antibacterial humoral response

antibacterial humoral response

antibacterial humoral response

cytoplasmic vesicle

defense response to bacterium

innate immune response

innate immune response

innate immune response

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

RNA phosphodiester bond hydrolysis

 
TC0500001615.mm.2         NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734 NM_011962, NR_030483, BC043047, BC054734  

in utero embryonic development

endothelial cell morphogenesis

catalytic activity

iron ion binding

extracellular region

extracellular space

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

trans-Golgi network

protein O-linked glycosylation

protein localization

metabolic process

procollagen-lysine 5-dioxygenase activity

procollagen-lysine 5-dioxygenase activity

procollagen-lysine 5-dioxygenase activity

negative regulation of gene expression

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

transferase activity

transferase activity, transferring glycosyl groups

peptidyl-lysine hydroxylation

peptidyl-lysine hydroxylation

peptidyl-lysine hydroxylation

peptidyl-lysine hydroxylation

neural tube development

collagen fibril organization

L-ascorbic acid binding

collagen metabolic process

procollagen glucosyltransferase activity

procollagen glucosyltransferase activity

procollagen glucosyltransferase activity

vasodilation

metal ion binding

hydroxylysine biosynthetic process

epidermis morphogenesis

procollagen galactosyltransferase activity

dioxygenase activity

lung morphogenesis

collagen-containing extracellular matrix

collagen-containing extracellular matrix

basement membrane assembly

positive regulation of stem cell proliferation

 
TC1000002490.mm.2 Sbno2 strawberry notch 2 10 -80062415, -80056991, -80056991, -80080409 NM_183426, BC056369 NM_183426, BC056369 22

ossification

macrophage activation involved in immune response

macrophage activation involved in immune response

macrophage activation involved in immune response

protein binding

nucleus

regulation of transcription, DNA-templated

cell differentiation

bone mineralization

osteoclast differentiation

osteoclast differentiation

chromatin DNA binding

histone binding

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of inflammatory response

regulation of inflammatory response

regulation of inflammatory response

bone trabecula morphogenesis

cellular response to lipopolysaccharide

cellular response to interleukin-11

cellular response to interleukin-6

cellular response to interleukin-6

cellular response to interleukin-6

multinuclear osteoclast differentiation

osteoclast fusion

cellular response to leukemia inhibitory factor

 
TC0100003361.mm.2 Gpr52 G protein-coupled receptor 52 1 -160574716 NM_001146330 5

G protein-coupled receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

phototransduction

locomotory behavior

G protein-coupled photoreceptor activity

membrane

integral component of membrane

response to drug

cellular response to light stimulus

 
TC0500001098.mm.2 Dr1 down-regulator of transcription 1 5 108268896 NM_026106, BC013461 NM_026106, BC013461 30

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

core promoter sequence-specific DNA binding

DNA binding

transcription coactivator activity

transcription corepressor activity

protein binding

nucleus

nucleoplasm

Ada2/Gcn5/Ada3 transcription activator complex

Ada2/Gcn5/Ada3 transcription activator complex

Ada2/Gcn5/Ada3 transcription activator complex

chromatin remodeling

RNA polymerase II general transcription initiation factor activity

TBP-class protein binding

TBP-class protein binding

negative cofactor 2 complex

histone H3 acetylation

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

RNA polymerase II preinitiation complex assembly

RNA polymerase II transcription regulator complex

 
TC0900000705.mm.2 Cox5a cytochrome c oxidase subunit 5A 9 57521231 NM_007747, BC034302 NM_007747, BC034302 54

cytochrome-c oxidase activity

cytochrome-c oxidase activity

protein binding

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial electron transport, cytochrome c to oxygen

membrane

myelin sheath

metal ion binding

00190

01100

04260

05010

05012

05016

TC1100004299.mm.2 Mif4gd MIF4G domain containing 11 -115607918, -115607918 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 NM_001243584, NM_001243586, NM_001243587, NM_027162, BC019515, BC026740, BC055812 18

RNA binding

nucleus

nucleolus

cytoplasm

Golgi apparatus

cytosol

cytosol

regulation of translation

regulation of translational initiation

protein C-terminus binding

translation activator activity

identical protein binding

 
TC0700001448.mm.2 Pgap2 post-GPI attachment to proteins 2 7 102223027, 102210334, 102210510, 102223070, 102210172 NM_145583, BC004794 NM_145583, BC004794 23

Golgi membrane

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

GPI anchor biosynthetic process

GPI anchor biosynthetic process

membrane

integral component of membrane

protein localization to plasma membrane

 
TC0900000573.mm.2 Cadm1 cell adhesion molecule 1 9 47530351, 47530169 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 NM_001025600, NM_018770, NM_207675, NM_207676, BC057125, BC090970, BC095986 127

positive regulation of cytokine production

liver development

immune system process

signaling receptor binding

signaling receptor binding

protein binding

plasma membrane

plasma membrane

cell-cell junction

apoptotic process

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

multicellular organism development

spermatogenesis

synapse assembly

synapse assembly

synaptic vesicle

cell recognition

cell recognition

unidimensional cell growth

postsynaptic density

membrane

integral component of membrane

basolateral plasma membrane

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

cell junction

cell differentiation

PDZ domain binding

axon

dendrite

susceptibility to natural killer cell mediated cytotoxicity

susceptibility to natural killer cell mediated cytotoxicity

susceptibility to natural killer cell mediated cytotoxicity

protein homodimerization activity

neuron projection

varicosity

synapse

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

cell adhesion molecule binding

detection of stimulus

detection of stimulus

bone development

cell body fiber

lymphocyte migration into lymphoid organs

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

maintenance of postsynaptic specialization structure

maintenance of postsynaptic specialization structure

retrograde trans-synaptic signaling by trans-synaptic protein complex

retrograde trans-synaptic signaling by trans-synaptic protein complex

glutamatergic synapse

glutamatergic synapse

presynapse assembly

presynapse assembly

integral component of postsynaptic membrane

integral component of presynaptic membrane

synaptic membrane adhesion

synaptic membrane adhesion

synaptic membrane adhesion

04514

TC0800002842.mm.2 Psmb10 proteasome (prosome, macropain) subunit, beta type 10 8 -105935727 NM_013640, BC004730 NM_013640, BC004730 66

proteasome complex

cell morphogenesis

immune system process

endopeptidase activity

threonine-type endopeptidase activity

nucleus

nucleoplasm

cytoplasm

cytosol

proteasome core complex

proteasome core complex

proteolysis

peptidase activity

proteasomal ubiquitin-independent protein catabolic process

hydrolase activity

T cell proliferation

proteasome-mediated ubiquitin-dependent protein catabolic process

proteolysis involved in cellular protein catabolic process

spermatoproteasome complex

03050

TC0900001768.mm.2 Endod1 endonuclease domain containing 1 9 -14353989 NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 NM_028013, BC019813, BC096490 19

nucleic acid binding

nuclease activity

endonuclease activity

extracellular region

biological_process

hydrolase activity

metal ion binding

04210

TC1100001196.mm.2 Adap2 ArfGAP with dual PH domains 2 11 80154161 NM_172133, BC027165 NM_172133, BC027165 17

GTPase activator activity

1-phosphatidylinositol binding

phosphatidylinositol-4,5-bisphosphate binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

mitochondrial envelope

plasma membrane

plasma membrane

heart development

membrane

intracellular membrane-bounded organelle

phosphatidylinositol-3,4-bisphosphate binding

inositol 1,3,4,5 tetrakisphosphate binding

positive regulation of GTPase activity

metal ion binding

inositol lipid-mediated signaling

phosphatidylinositol bisphosphate binding

 
TC1500001812.mm.2 Apol7c apolipoprotein L 7c 15 -77524866 NM_175391, BC139148, BC139149 NM_175391, BC139148, BC139149 NM_175391, BC139148, BC139149 9

cellular_component

lipid binding

 
TC0600001203.mm.2 Bhlhe40 basic helix-loop-helix family, member e40 6 108660628 NM_011498, BC010720 NM_011498, BC010720 111

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase II activating transcription factor binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

circadian rhythm

circadian rhythm

response to light stimulus

response to light stimulus

anterior/posterior pattern specification

nuclear body

protein domain specific binding

circadian regulation of gene expression

circadian regulation of gene expression

circadian regulation of gene expression

regulation of circadian rhythm

protein homodimerization activity

entrainment of circadian clock by photoperiod

bHLH transcription factor binding

MRF binding

negative regulation of DNA-binding transcription factor activity

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

protein heterodimerization activity

protein dimerization activity

rhythmic process

regulation of neurogenesis

E-box binding

E-box binding

sequence-specific double-stranded DNA binding

04710

TC1700002071.mm.2 H2-M2 histocompatibility 2, M region locus 2 17 -37480850 NM_008204, BC150676 NM_008204, BC150676 17

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

extracellular space

immune response

external side of plasma membrane

cell surface

peptide antigen binding

04144

04145

04514

04612

04940

05320

05330

05332

05416

TC1300002392.mm.2 Vcan versican 13 -89655309, -89709947 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 NM_001081249, NM_001134474, NM_001134475, NM_019389, NM_172955 200

skeletal system development

ureteric bud development

calcium ion binding

hyaluronic acid binding

extracellular region

cell adhesion

central nervous system development

heart development

glial cell migration

cell surface

protein phosphatase binding

extracellular matrix structural constituent conferring compression resistance

carbohydrate binding

extracellular matrix

extracellular matrix

cell projection

regulation of phosphoprotein phosphatase activity

synapse

collagen-containing extracellular matrix

collagen-containing extracellular matrix

perineuronal net

04514

TC0200002410.mm.2 Src Rous sarcoma oncogene 2 157424292 NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 NM_001025395, NM_009271, BC039953 555

nucleotide binding

primary ovarian follicle growth

positive regulation of cytokine production

podosome

immune system process

protein kinase activity

protein kinase activity

protein kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein kinase C binding

signaling receptor binding

signaling receptor binding

insulin receptor binding

integrin binding

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

lysosome

late endosome

cytosol

cytosol

cytoskeleton

actin filament

plasma membrane

plasma membrane

plasma membrane

caveola

caveola

focal adhesion

protein phosphorylation

cell cycle

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

epidermal growth factor receptor signaling pathway

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

protein C-terminus binding

cell population proliferation

positive regulation of gene expression

regulation of epithelial cell migration

positive regulation of epithelial cell migration

positive regulation of glucose metabolic process

positive regulation of protein processing

postsynaptic density

positive regulation of smooth muscle cell migration

membrane

membrane

kinase activity

phosphorylation

cell migration

transferase activity

peptidyl-serine phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

enzyme binding

kinase binding

protein kinase binding

protein domain specific binding

heme binding

regulation of cell-cell adhesion

cell junction

cell differentiation

estrogen receptor binding

forebrain development

extrinsic component of cytoplasmic side of plasma membrane

negative regulation of protein-containing complex assembly

ubiquitin protein ligase binding

protein destabilization

positive regulation of protein autophosphorylation

activation of protein kinase B activity

negative regulation of telomere maintenance via telomerase

ruffle membrane

regulation of intracellular estrogen receptor signaling pathway

substrate adhesion-dependent cell spreading

cellular response to reactive oxygen species

positive regulation of dephosphorylation

intracellular signal transduction

intracellular signal transduction

osteoclast development

osteoclast development

cellular response to platelet-derived growth factor stimulus

peptidyl-tyrosine autophosphorylation

SH2 domain binding

odontogenesis

neuron projection

positive regulation of apoptotic process

negative regulation of apoptotic process

stress fiber assembly

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein binding

positive regulation of MAP kinase activity

positive regulation of phosphatidylinositol 3-kinase activity

ion channel binding

protein-containing complex binding

transcytosis

innate immune response

bone resorption

bone resorption

positive regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of Notch signaling pathway

positive regulation of Notch signaling pathway

positive regulation of cell adhesion

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of insulin receptor signaling pathway

protein autophosphorylation

ephrin receptor binding

ephrin receptor binding

neurotrophin TRK receptor signaling pathway

focal adhesion assembly

perinuclear region of cytoplasm

perinuclear region of cytoplasm

oogenesis

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

cell adhesion molecule binding

progesterone receptor signaling pathway

progesterone receptor signaling pathway

positive regulation of small GTPase mediated signal transduction

phosphoprotein binding

positive regulation of protein transport

negative regulation of focal adhesion assembly

positive regulation of protein kinase B signaling

negative regulation of mitochondrial depolarization

negative regulation of telomerase activity

uterus development

branching involved in mammary gland duct morphogenesis

regulation of cell projection assembly

intestinal epithelial cell development

intestinal epithelial cell development

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

cellular response to hydrogen peroxide

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

response to interleukin-1

BMP receptor binding

growth factor receptor binding

growth factor receptor binding

connexin binding

cellular response to peptide hormone stimulus

cellular response to progesterone stimulus

cellular response to fluid shear stress

cellular response to transforming growth factor beta stimulus

positive regulation of podosome assembly

positive regulation of podosome assembly

positive regulation of protein serine/threonine kinase activity

angiotensin-activated signaling pathway involved in heart process

positive regulation of canonical Wnt signaling pathway

scaffold protein binding

scaffold protein binding

regulation of postsynaptic neurotransmitter receptor activity

glutamatergic synapse

postsynaptic specialization, intracellular component

positive regulation of protein localization to nucleus

positive regulation of intracellular signal transduction

positive regulation of ovarian follicle development

positive regulation of lamellipodium morphogenesis

positive regulation of DNA biosynthetic process

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of early endosome to late endosome transport

negative regulation of anoikis

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway

regulation of caveolin-mediated endocytosis

04012

04144

04370

04510

04520

04530

04540

04912

05100

TC0900002922.mm.2 Armc8 armadillo repeat containing 8 9 -99478390, -99518244 NM_001166138, NM_028768, BC038866 NM_001166138, NM_028768, BC038866 NM_001166138, NM_028768, BC038866 24

ubiquitin ligase complex

molecular_function

nucleus

nucleoplasm

cytoplasm

cytosol

GID complex

proteasome-mediated ubiquitin-dependent protein catabolic process

intracellular membrane-bounded organelle

 
TC1700002790.mm.2         NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655 NM_001267808, NM_010380, BC132088, BC132655  

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

immune system process

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

signaling receptor binding

protein binding

extracellular space

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

plasma membrane

plasma membrane

defense response

immune response

external side of plasma membrane

external side of plasma membrane

cell surface

negative regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of neuron projection development

membrane

integral component of membrane

antigen processing and presentation

phagocytic vesicle membrane

beta-2-microglobulin binding

peptide binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD8 receptor binding

MHC class I protein complex

MHC class I protein complex

MHC class I peptide loading complex

protein-containing complex binding

membrane raft

TAP binding

TAP complex binding

endoplasmic reticulum exit site

integral component of lumenal side of endoplasmic reticulum membrane

 
TC0300000210.mm.2 Skil SKI-like 3 31095057 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 NM_001039090, NM_001271772, NM_011386, BC049934 57

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

acrosomal vesicle

blastocyst formation

lymphocyte homeostasis

chromatin binding

protein binding

nucleus

nucleus

nucleus

transcription regulator complex

cytoplasm

cell cycle arrest

transforming growth factor beta receptor signaling pathway

skeletal muscle tissue development

PML body

protein domain specific binding

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

protein-containing complex

identical protein binding

protein-containing complex binding

negative regulation of cell differentiation

SMAD binding

SMAD binding

positive regulation of axonogenesis

lens fiber cell differentiation

response to growth factor

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

 
TC0400003708.mm.2 Zdhhc18 zinc finger, DHHC domain containing 18 4 -133606991 NM_001017968, BC167166 NM_001017968, BC167166 17

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

protein targeting to membrane

membrane

integral component of membrane

palmitoyltransferase activity

palmitoyltransferase activity

transferase activity

transferase activity, transferring acyl groups

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

cellular protein localization

 
TC0500002315.mm.2 Fbxl5 F-box and leucine-rich repeat protein 5 5 -43757748, -43744617 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 NM_001159963, NM_178729, BC047214, BC113798 30

iron ion binding

cytoplasm

protein ubiquitination

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

metal ion binding

perinuclear region of cytoplasm

iron ion homeostasis

iron ion homeostasis

iron ion homeostasis

iron ion homeostasis

positive regulation of cellular protein catabolic process

 
TC0400000057.mm.2 Chd7 chromodomain helicase DNA binding protein 7 4 8690405, 8751323 NM_001277149, NM_001081417 NM_001277149, NM_001081417 85

nucleotide binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

skeletal system development

blood vessel development

in utero embryonic development

in utero embryonic development

blood vessel remodeling

heart morphogenesis

heart morphogenesis

ventricular trabecula myocardium morphogenesis

right ventricular compact myocardium morphogenesis

DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

chromatin organization

chromatin remodeling

rRNA processing

central nervous system development

adult heart development

sensory perception of sound

locomotory behavior

adult walking behavior

blood circulation

response to bacterium

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

hydrolase activity

hydrolase activity, acting on acid anhydrides

cranial nerve development

olfactory nerve development

olfactory bulb development

T cell differentiation

female genitalia development

embryonic hindlimb morphogenesis

aorta development

aorta morphogenesis

atrioventricular canal development

positive regulation of multicellular organism growth

olfactory behavior

ear morphogenesis

inner ear morphogenesis

inner ear morphogenesis

camera-type eye development

nose development

nose development

positive regulation of transcription by RNA polymerase II

semicircular canal morphogenesis

tissue remodeling

genitalia development

artery morphogenesis

regulation of neurogenesis

cognition

roof of mouth development

retina development in camera-type eye

regulation of growth hormone secretion

limb development

face development

innervation

cardiac septum morphogenesis

epithelium development

secondary palate development

promoter-specific chromatin binding

 
TC1900000501.mm.2 Ifit3 interferon-induced protein with tetratricopeptide repeats 3 19 34583528 NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 NM_010501, BC003804, BC089563 31

immune system process

RNA binding

protein binding

cytoplasm

mitochondrion

cytosol

cytosol

response to bacterium

cellular response to interferon-alpha

cellular response to interferon-beta

response to stilbenoid

identical protein binding

innate immune response

defense response to virus

 
TC1900000442.mm.2 Pdcd1lg2 programmed cell death 1 ligand 2 19 29410918 NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139 NM_021396, BC104138, BC104139 98

adaptive immune response

immune system process

protein binding

plasma membrane

immune response

cell surface receptor signaling pathway

external side of plasma membrane

membrane

integral component of membrane

T cell costimulation

negative regulation of interferon-gamma production

negative regulation of interleukin-10 production

positive regulation of T cell proliferation

positive regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of activated T cell proliferation

cellular response to lipopolysaccharide

04514

TC0300002752.mm.2 Stxbp3 syntaxin binding protein 3 3 -108793179 NM_011504, BC062901 NM_011504, BC062901 48

cellular glucose homeostasis

cellular glucose homeostasis

protein binding

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

plasma membrane

intracellular protein transport

exocytosis

vesicle docking involved in exocytosis

neurotransmitter secretion

brain development

protein transport

membrane

vesicle-mediated transport

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

syntaxin-1 binding

syntaxin-1 binding

syntaxin binding

syntaxin binding

syntaxin binding

syntaxin binding

protein to membrane docking

insulin secretion

secretory granule

platelet alpha granule

response to insulin

response to insulin

specific granule

protein-containing complex binding

phagocytic vesicle

negative regulation of calcium ion-dependent exocytosis

negative regulation of glucose import

negative regulation of glucose import

platelet aggregation

tertiary granule

cellular response to interferon-gamma

presynapse

 
TC0300001703.mm.2 Gyg glycogenin 3 -20122083, -20122082 NM_013755, BC029903 NM_013755, BC029903 40

glucose binding

glycogen biosynthetic process

glycogen biosynthetic process

glycogenin glucosyltransferase activity

transferase activity

transferase activity, transferring glycosyl groups

manganese ion binding

protein homodimerization activity

metal ion binding

UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity

 
TC1500000404.mm.2 Zhx2 zinc fingers and homeoboxes 2 15 57694666 NM_199449, BC059178 NM_199449, BC059178 52

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytosol

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

mRNA catabolic process

nervous system development

cell differentiation

somatic stem cell population maintenance

identical protein binding

protein homodimerization activity

negative regulation of neuron differentiation

negative regulation of transcription, DNA-templated

metal ion binding

protein heterodimerization activity

retinal bipolar neuron differentiation

 
TC1200001544.mm.2 Id2 inhibitor of DNA binding 2 12 -25093798 NM_010496, BC006921, BC053699 NM_010496, BC006921, BC053699 NM_010496, BC006921, BC053699 425

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

euchromatin

RNA polymerase II activating transcription factor binding

metanephros development

natural killer cell differentiation

natural killer cell differentiation

thigmotaxis

leukocyte differentiation

membranous septum morphogenesis

bundle of His development

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

multicellular organism development

heart development

circadian rhythm

positive regulation of cell population proliferation

adult locomotory behavior

entrainment of circadian clock

regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

oligodendrocyte development

regulation of lipid metabolic process

olfactory bulb development

cell differentiation

circadian regulation of gene expression

circadian regulation of gene expression

protein-containing complex

mammary gland epithelial cell proliferation

regulation of circadian rhythm

entrainment of circadian clock by photoperiod

enucleate erythrocyte differentiation

negative regulation of DNA binding

negative regulation of DNA-binding transcription factor activity

ion channel binding

locomotor rhythm

negative regulation of B cell differentiation

positive regulation of fat cell differentiation

positive regulation of erythrocyte differentiation

positive regulation of macrophage differentiation

regulation of neuron differentiation

negative regulation of neuron differentiation

negative regulation of osteoblast differentiation

positive regulation of blood pressure

positive regulation of cell cycle

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

protein dimerization activity

cell development

cell maturation

rhythmic process

lymph node development

Peyer's patch development

embryonic digestive tract morphogenesis

positive regulation of smooth muscle cell proliferation

neuron fate commitment

cell morphogenesis involved in neuron differentiation

positive regulation of astrocyte differentiation

negative regulation of oligodendrocyte differentiation

negative regulation of muscle cell differentiation

adipose tissue development

mammary gland alveolus development

epithelial cell differentiation involved in mammary gland alveolus development

endodermal digestive tract morphogenesis

positive regulation of cell cycle arrest

cellular response to lithium ion

cellular senescence

transcription regulator activity

transcription regulator inhibitor activity

negative regulation of core promoter binding

regulation of G1/S transition of mitotic cell cycle

regulation of neural precursor cell proliferation

04350

TC0200004423.mm.2 Rmdn3 regulator of microtubule dynamics 3 2 -119136997 NM_001033136 30

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cellular calcium ion homeostasis

apoptotic process

microtubule binding

microtubule binding

membrane

integral component of membrane

cell differentiation

organelle membrane contact site

intercellular bridge

mitotic spindle pole

mitotic spindle pole

 
MG-1-pos-10341579_st                
TC1900001541.mm.2 Got1 glutamic-oxaloacetic transaminase 1, soluble 19 -43499752 NM_010324, BC002057 NM_010324, BC002057 47

catalytic activity

L-aspartate:2-oxoglutarate aminotransferase activity

L-aspartate:2-oxoglutarate aminotransferase activity

L-aspartate:2-oxoglutarate aminotransferase activity

phosphatidylserine decarboxylase activity

nucleoplasm

cytoplasm

lysosome

cytosol

cytosol

cytosol

oxaloacetate metabolic process

oxaloacetate metabolic process

glycerol biosynthetic process

glycerol biosynthetic process

cellular amino acid metabolic process

aspartate metabolic process

aspartate biosynthetic process

aspartate biosynthetic process

aspartate catabolic process

Notch signaling pathway

transaminase activity

cellular amino acid biosynthetic process

biosynthetic process

transferase activity

glutamate catabolic process to aspartate

glutamate catabolic process to 2-oxoglutarate

glutamate catabolic process to 2-oxoglutarate

pyridoxal phosphate binding

positive regulation of transforming growth factor beta receptor signaling pathway

carboxylic acid binding

negative regulation of collagen biosynthetic process

dicarboxylic acid metabolic process

axon terminus

L-cysteine:2-oxoglutarate aminotransferase activity

negative regulation of cytosolic calcium ion concentration

negative regulation of mitochondrial depolarization

fatty acid homeostasis

transdifferentiation

cellular response to mechanical stimulus

L-phenylalanine:2-oxoglutarate aminotransferase activity

response to transition metal nanoparticle

00250

00270

00330

00350

00360

00400

01100

MG-1-neg-10341263_st                
TC0200003880.mm.2 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 -84765359 NM_009776, BC002026 NM_009776, BC002026 38

complement binding

negative regulation of complement activation, lectin pathway

immune system process

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

complement activation, classical pathway

blood coagulation

hemostasis

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of blood coagulation

peptidase inhibitor activity

fibrinolysis

innate immune response

negative regulation of complement activation

collagen-containing extracellular matrix

04610

TC0100002711.mm.2         XR_140448      
TC1100003069.mm.2 Nlgn2 neuroligin 2 11 -69823122, -69823122 NM_198862, BC156963 NM_198862, BC156963 99

thigmotaxis

regulation of respiratory gaseous exchange by nervous system process

protein binding

cytoplasm

plasma membrane

integral component of plasma membrane

cell adhesion

neuron cell-cell adhesion

neuron cell-cell adhesion

chemical synaptic transmission

synapse assembly

jump response

positive regulation of cell population proliferation

cell surface

cell surface

membrane

integral component of membrane

sensory perception of pain

cell junction

positive regulation of insulin secretion

positive regulation of synaptic transmission, GABAergic

social behavior

protein localization to synapse

locomotory exploration behavior

signaling receptor activity

neurexin family protein binding

neurexin family protein binding

identical protein binding

cell projection

dendritic shaft

synapse

synapse

postsynaptic membrane

synaptic vesicle endocytosis

modulation of chemical synaptic transmission

modulation of chemical synaptic transmission

synapse organization

cell adhesion molecule binding

neuromuscular process controlling balance

positive regulation of synapse assembly

positive regulation of synaptic transmission, glutamatergic

excitatory synapse

excitatory synapse

inhibitory synapse

inhibitory synapse

positive regulation of dendritic spine development

terminal button organization

postsynaptic membrane assembly

postsynaptic membrane assembly

presynaptic membrane assembly

presynaptic membrane assembly

presynaptic membrane assembly

presynaptic membrane assembly

gephyrin clustering involved in postsynaptic density assembly

postsynaptic density protein 95 clustering

positive regulation of inhibitory postsynaptic potential

positive regulation of inhibitory postsynaptic potential

ribbon synapse

glycinergic synapse

glycinergic synapse

glycinergic synapse

dopaminergic synapse

postsynaptic specialization assembly

postsynaptic specialization assembly

postsynaptic specialization assembly

GABA-ergic synapse

GABA-ergic synapse

GABA-ergic synapse

GABA-ergic synapse

integral component of postsynaptic membrane

integral component of postsynaptic specialization membrane

integral component of postsynaptic specialization membrane

insulin metabolic process

positive regulation of protein localization to synapse

positive regulation of t-SNARE clustering

inhibitory synapse assembly

regulation of presynapse assembly

regulation of AMPA receptor activity

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic vesicle clustering

04514

TC1100003790.mm.2 Stat3 signal transducer and activator of transcription 3 11 -100886805 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 NM_011486, NM_213659, NM_213660, BC003806, BC019168 1720

chromatin

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase II repressing transcription factor binding

DNA-binding transcription activator activity, RNA polymerase II-specific

temperature homeostasis

eye photoreceptor cell differentiation

DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

mitochondrion

mitochondrial inner membrane

cytosol

cytosol

plasma membrane

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

protein import into nucleus

defense response

acute-phase response

inflammatory response

signal transduction

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of autophagy

positive regulation of gene expression

positive regulation of gene expression

negative regulation of hydrogen peroxide biosynthetic process

postsynaptic density

phosphorylation

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

stem cell population maintenance

protein kinase binding

protein phosphatase binding

sexual reproduction

positive regulation of cell migration

intracellular receptor signaling pathway

chromatin DNA binding

CCR5 chemokine receptor binding

response to estradiol

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

cellular response to hormone stimulus

leptin-mediated signaling pathway

leptin-mediated signaling pathway

leptin-mediated signaling pathway

leptin-mediated signaling pathway

response to cytokine

glucocorticoid receptor binding

regulation of multicellular organism growth

regulation of cell population proliferation

glucose homeostasis

eating behavior

mRNA transcription by RNA polymerase II

identical protein binding

identical protein binding

protein homodimerization activity

response to peptide hormone

sequence-specific DNA binding

sequence-specific DNA binding

cellular response to leptin stimulus

response to leptin

response to leptin

response to leptin

positive regulation of erythrocyte differentiation

positive regulation of Notch signaling pathway

positive regulation of angiogenesis

negative regulation of glycolytic process

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of mitochondrial membrane permeability

protein dimerization activity

astrocyte differentiation

modulation of chemical synaptic transmission

positive regulation of NF-kappaB transcription factor activity

regulation of cell cycle

regulation of cell cycle

radial glial cell differentiation

regulation of feeding behavior

growth hormone receptor signaling pathway

growth hormone receptor signaling pathway via JAK-STAT

growth hormone receptor signaling pathway via JAK-STAT

growth hormone receptor signaling pathway via JAK-STAT

negative regulation of cell death

interleukin-6-mediated signaling pathway

primary miRNA binding

cellular response to cytokine stimulus

cellular response to organic cyclic compound

T-helper 17 type immune response

T-helper 17 cell lineage commitment

RNA polymerase II transcription regulator complex

energy homeostasis

Schaffer collateral - CA1 synapse

glutamatergic synapse

postsynapse to nucleus signaling pathway

positive regulation of cytokine production involved in inflammatory response

negative regulation of neuron death

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of metalloendopeptidase activity

positive regulation of vascular endothelial cell proliferation

positive regulation of miRNA mediated inhibition of translation

negative regulation of primary miRNA processing

positive regulation of gene silencing by miRNA

negative regulation of stem cell differentiation

positive regulation of ATP biosynthetic process

negative regulation of neuron migration

04062

04630

04920

05145

05160

05200

05212

05221

TC0400001091.mm.2 Plpp3 phospholipid phosphatase 3 4 105157346 NM_080555, BC005558 NM_080555, BC005558 46

blood vessel development

gastrulation with mouth forming second

negative regulation of protein phosphorylation

negative regulation of protein phosphorylation

integrin binding

integrin binding

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

trans-Golgi network

plasma membrane

integral component of plasma membrane

lipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

sphingosine metabolic process

ceramide metabolic process

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

cell adhesion

signal transduction

integrin-mediated signaling pathway

multicellular organism development

phosphatidate phosphatase activity

phosphatidate phosphatase activity

membrane

integral component of membrane

basolateral plasma membrane

hydrolase activity

regulation of Wnt signaling pathway

endoplasmic reticulum-Golgi intermediate compartment membrane

cell-cell adhesion mediated by integrin

homotypic cell-cell adhesion

sphingosine-1-phosphate phosphatase activity

sphingosine-1-phosphate phosphatase activity

sphingosine-1-phosphate phosphatase activity

lipid phosphatase activity

lipid phosphatase activity

canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration

canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion

canonical Wnt signaling pathway involved in positive regulation of wound healing

membrane raft

phospholipid dephosphorylation

phospholipid dephosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

protein stabilization

protein stabilization

positive regulation of DNA-binding transcription factor activity

positive regulation of DNA-binding transcription factor activity

Bergmann glial cell differentiation

canonical Wnt signaling pathway

canonical Wnt signaling pathway

endoplasmic reticulum exit site

cell-cell adhesion

ceramide-1-phosphate phosphatase activity

regulation of sphingolipid mediated signaling pathway

00561

00564

00565

00600

01100

04666

04975

TC1600000760.mm.2 Dcbld2 discoidin, CUB and LCCL domain containing 2 16 58408534 NM_028523, BC066097 NM_028523, BC066097 21

integral component of plasma membrane

cell surface

membrane

integral component of membrane

negative regulation of cell growth

wound healing

 
TC0200001222.mm.2 Ube2l6 ubiquitin-conjugating enzyme E2L 6 2 84798827 NM_019949, BC008238 NM_019949, BC008238 22

ubiquitin ligase complex

nucleotide binding

protein polyubiquitination

protein binding

ATP binding

nucleus

ubiquitin-dependent protein catabolic process

transferase activity

ubiquitin-like protein transferase activity

modification-dependent protein catabolic process

ubiquitin protein ligase binding

ISG15-protein conjugation

ISG15-protein conjugation

ISG15 transferase activity

ISG15 transferase activity

ubiquitin binding

ubiquitin conjugating enzyme activity

04120

05012

TC0600002099.mm.2 Zc3hav1 zinc finger CCCH type, antiviral 1 6 -38305285, -38315671, -38310496 NM_028421, NM_028864, BC029090 NM_028421, NM_028864, BC029090 NM_028421, NM_028864, BC029090 28

immune system process

RNA binding

NAD+ ADP-ribosyltransferase activity

nucleus

nucleus

cytoplasm

cytoplasm

lysosome

late endosome

cytosol

response to virus

DEAD/H-box RNA helicase binding

positive regulation of type I interferon production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of ATPase activity

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of viral genome replication

innate immune response

metal ion binding

regulation of defense response to virus by host

defense response to virus

positive regulation of mRNA catabolic process

cellular response to exogenous dsRNA

cellular response to virus

positive regulation of RIG-I signaling pathway

positive regulation of RIG-I signaling pathway

 
TC1400002378.mm.2 Cysltr2 cysteinyl leukotriene receptor 2 14 -73029127 NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 NM_001162412, NM_133720, BC132414, BC132418 41

cysteinyl leukotriene receptor activity

cysteinyl leukotriene receptor activity

G protein-coupled receptor activity

leukotriene receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

G protein-coupled peptide receptor activity

positive regulation of cell death

membrane

membrane

integral component of membrane

positive regulation of angiogenesis

positive regulation of ERK1 and ERK2 cascade

04020

04080

TC1100000205.mm.2 Peli1 pellino 1 11 21091323 NM_023324, BC016515 NM_023324, BC016515 62

protein polyubiquitination

protein polyubiquitination

condensed nuclear chromosome kinetochore

positive regulation of cytokine production

ubiquitin-protein transferase activity

protein binding

nucleus

Toll signaling pathway

regulation of Toll signaling pathway

transferase activity

positive regulation of B cell proliferation

positive regulation of protein ubiquitination

negative regulation of NF-kappaB transcription factor activity

response to lipopolysaccharide

response to lipopolysaccharide

positive regulation of toll-like receptor 3 signaling pathway

positive regulation of toll-like receptor 4 signaling pathway

negative regulation of T cell proliferation

positive regulation of I-kappaB kinase/NF-kappaB signaling

proteasome-mediated ubiquitin-dependent protein catabolic process

response to dsRNA

negative regulation of T cell activation

positive regulation of B cell activation

negative regulation of necroptotic process

negative regulation of necroptotic process

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

protein K63-linked ubiquitination

protein K48-linked ubiquitination

protein K48-linked ubiquitination

protein K48-linked ubiquitination

 
TC1700000881.mm.2 Gtpbp2 GTP binding protein 2 17 46161031, 46162063 NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 NM_001145979, NM_019581, BC049089, BC051958 23

nucleotide binding

translation elongation factor activity

GTPase activity

protein binding

GTP binding

translational elongation

identical protein binding

nuclear-transcribed mRNA catabolic process, no-go decay

rescue of stalled ribosome

 
TC1500000679.mm.2 Gtpbp1 GTP binding protein 1 15 79690895 NM_013818, BC046228 NM_013818, BC046228 26

nucleotide binding

cytoplasmic exosome (RNase complex)

translation elongation factor activity

GTPase activity

GTP binding

cytoplasm

cytosol

translational elongation

GTP metabolic process

positive regulation of mRNA catabolic process

 
TC0900003310.mm.2 Lztfl1 leucine zipper transcription factor-like 1 9 -123694405 NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 NM_033322, BC026840, BC098224 31

protein binding

cytoplasm

cytosol

identical protein binding

protein-containing complex binding

protein-containing complex binding

negative regulation of protein localization to cilium

negative regulation of protein localization to cilium

negative regulation of protein localization to ciliary membrane

 
TC1100001241.mm.2 Slfn4 schlafen 4 11 83175185 NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 NM_011410, BC044865, BC150770 22

molecular_function

cellular_component

response to bacterium

 
TC0100003590.mm.2 Ifi214 interferon activated gene 214 1 -173521310 NM_001024721, BC094916 NM_001024721, BC094916 12

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

cytosol

transcription factor binding

cellular response to interferon-beta

identical protein binding

 
TC0900003121.mm.2 Tdgf1 teratocarcinoma-derived growth factor 1 9 -110939607 NM_011562, BC052646 NM_011562, BC052646 158

activation of MAPK activity

blood vessel development

vasculogenesis

in utero embryonic development

morphogenesis of a branching structure

positive regulation of cell-matrix adhesion

cell migration involved in sprouting angiogenesis

signaling receptor binding

signaling receptor binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

nucleus

cytoplasm

Golgi apparatus

plasma membrane

plasma membrane

determination of left/right symmetry

gastrulation

heart development

heart development

heart development

growth factor activity

positive regulation of cell population proliferation

anterior/posterior axis specification, embryo

anterior/posterior axis specification

anterior/posterior pattern specification

regulation of signal transduction

regulation of signal transduction

cell surface

cell surface

cell surface

positive regulation of endothelial cell migration

coreceptor activity

membrane

apical plasma membrane

Wnt-protein binding

peptidyl-serine phosphorylation

extrinsic component of plasma membrane

cell differentiation

regulation of cell migration

positive regulation of cell migration

positive regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

anchored component of membrane

cellular response to hepatocyte growth factor stimulus

nodal signaling pathway

nodal signaling pathway

nodal signaling pathway

nodal binding

nodal binding

negative regulation of apoptotic process

cellular response to fibroblast growth factor stimulus

membrane raft

positive regulation of transcription by RNA polymerase II

positive regulation of fibroblast proliferation

perinuclear region of cytoplasm

anatomical structure development

positive regulation of peptidyl-tyrosine phosphorylation

cardiac muscle cell differentiation

activin receptor binding

type I activin receptor binding

cellular response to interferon-gamma

cellular response to interleukin-6

cellular response to tumor necrosis factor

cellular response to epidermal growth factor stimulus

 
TC0700003862.mm.2 Trim21 tripartite motif-containing 21 7 -102557919 NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 NM_001082552, NM_009277, BC010580 59

protein polyubiquitination

protein polyubiquitination

DNA binding

transcription coactivator activity

RNA binding

ubiquitin-protein transferase activity

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

protein monoubiquitination

cell cycle

zinc ion binding

regulation of gene expression

positive regulation of autophagy

positive regulation of autophagy

protein ubiquitination

protein ubiquitination

transferase activity

SCF ubiquitin ligase complex

protein kinase binding

cytoplasmic vesicle

protein destabilization

negative regulation of NF-kappaB transcription factor activity

positive regulation of protein binding

regulation of protein localization

negative regulation of viral transcription

response to interferon-gamma

identical protein binding

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

innate immune response

positive regulation of cell cycle

negative regulation of innate immune response

regulation of viral entry into host cell

positive regulation of viral entry into host cell

metal ion binding

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

protein autoubiquitination

ubiquitin protein ligase activity

ubiquitin protein ligase activity

protein K63-linked ubiquitination

negative regulation of protein deubiquitination

negative regulation of viral release from host cell

05322

MG-1-neg-10338367_st                
TC1600001203.mm.2 Prm1 protamine 1 16 -10796331 NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 NM_013637, BC049599, BC059733 110

nucleosome

DNA binding

nucleus

nucleus

nucleus

chromosome

nucleus organization

multicellular organism development

spermatogenesis

spermatid development

cell differentiation

chromosome condensation

 
TC1700000703.mm.2 Ier3 immediate early response 3 17 35821712 NM_133662, BC006950 NM_133662, BC006950 42

response to protozoan

negative regulation of systemic arterial blood pressure

protein binding

nucleus

nucleus

nucleus

regulation of DNA repair

mitotic G2 DNA damage checkpoint

intrinsic apoptotic signaling pathway in response to DNA damage

membrane

integral component of membrane

negative regulation of apoptotic process

positive regulation of protein catabolic process

negative regulation of glycolytic process

regulation of nucleocytoplasmic transport

negative regulation of inflammatory response

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of reactive oxygen species metabolic process

regulation of response to DNA damage stimulus

regulation of response to DNA damage stimulus

regulation of response to DNA damage stimulus

 
TC1500000580.mm.2 Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 15 76246806 NM_023168, BC010802, BC037667 NM_023168, BC010802, BC037667 NM_023168, BC010802, BC037667 20

endoplasmic reticulum

Golgi apparatus

membrane

integral component of membrane

endoplasmic reticulum calcium ion homeostasis

ion channel binding

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

 
MG-1-neg-10344254_st                
TC0200004539.mm.2 Hdc histidine decarboxylase 2 -126593659 NM_008230, BC052833 NM_008230, BC052833 188

histamine metabolic process

histamine biosynthetic process

histamine biosynthetic process

histamine biosynthetic process

catalytic activity

histidine decarboxylase activity

histidine decarboxylase activity

histidine decarboxylase activity

histidine decarboxylase activity

cytoplasm

cytosol

cellular amino acid metabolic process

histidine metabolic process

histidine catabolic process

histidine catabolic process

histidine catabolic process

histidine catabolic process

amino acid binding

lyase activity

carboxy-lyase activity

carboxylic acid metabolic process

pyridoxal phosphate binding

dendrite

catecholamine biosynthetic process

identical protein binding

neuronal cell body

00340

01100

TC0700004176.mm.2 Gde1 glycerophosphodiester phosphodiesterase 1 7 -118688557 NM_019580, BC003902 NM_019580, BC003902 24

lysophospholipase activity

plasma membrane

integral component of plasma membrane

ethanolamine metabolic process

lipid metabolic process

phospholipid metabolic process

G protein-coupled receptor signaling pathway

phosphoric diester hydrolase activity

glycerophosphodiester phosphodiesterase activity

glycerophosphodiester phosphodiesterase activity

membrane

integral component of membrane

hydrolase activity

cytoplasmic vesicle

metal ion binding

glycerophosphoinositol glycerophosphodiesterase activity

glycerophosphoinositol glycerophosphodiesterase activity

N-acylethanolamine metabolic process

N-acylethanolamine metabolic process

 
TC0400002694.mm.2 Klf4 Kruppel-like factor 4 (gut) 4 -55527136 NM_010637, BC010301 NM_010637, BC010301 370

negative regulation of transcription by RNA polymerase II

chromatin

euchromatin

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity

RNA polymerase II transcription factor binding

RNA polymerase II transcription factor binding

transcription coregulator binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

beta-catenin binding

transcription factor binding

negative regulation of cell population proliferation

epidermal cell differentiation

response to organic substance

positive regulation of gene expression

negative regulation of gene expression

negative regulation of phosphatidylinositol 3-kinase signaling

negative regulation of muscle hyperplasia

negative regulation of angiogenesis

stem cell population maintenance

cell differentiation

negative regulation of cell migration

post-embryonic camera-type eye development

negative regulation of NF-kappaB transcription factor activity

positive regulation of cellular protein metabolic process

response to retinoic acid

negative regulation of interleukin-8 production

negative regulation of heterotypic cell-cell adhesion

phosphatidylinositol 3-kinase regulator activity

post-embryonic hemopoiesis

regulation of cell population proliferation

histone deacetylase binding

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of DNA-binding transcription factor activity

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of nitric oxide biosynthetic process

fat cell differentiation

regulation of cell differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

positive regulation of hemoglobin biosynthetic process

negative regulation of smooth muscle cell proliferation

regulation of axon regeneration

regulation of axon regeneration

epidermis morphogenesis

positive regulation of protein metabolic process

negative regulation of protein kinase B signaling

positive regulation of telomerase activity

canonical Wnt signaling pathway

negative regulation of response to cytokine stimulus

negative regulation of ERK1 and ERK2 cascade

cellular response to growth factor stimulus

cellular response to laminar fluid shear stress

negative regulation of cell migration involved in sprouting angiogenesis

regulation of blastocyst development

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of sprouting angiogenesis

positive regulation of core promoter binding

negative regulation of leukocyte adhesion to arterial endothelial cell

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

promoter-specific chromatin binding

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of chemokine (C-X-C motif) ligand 2 production

 
TC0400001651.mm.2 Runx3 runt related transcription factor 3 4 135120644, 135152544 NM_019732, BC168396 NM_019732, BC168396 229

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

ossification

chondrocyte differentiation

chondrocyte differentiation

DNA binding

DNA-binding transcription factor activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

protein phosphorylation

axon guidance

core-binding factor complex

hemopoiesis

neuron differentiation

hair follicle morphogenesis

neuron projection development

interferon-gamma production

histone deacetylase binding

intracellular membrane-bounded organelle

negative regulation of CD4-positive, alpha-beta T cell differentiation

positive regulation of CD8-positive, alpha-beta T cell differentiation

regulation of cell differentiation

negative regulation of cell cycle

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

SMAD binding

cell maturation

negative regulation of epithelial cell proliferation

response to transforming growth factor beta

sequence-specific double-stranded DNA binding

positive regulation of extrinsic apoptotic signaling pathway

 
TC0200004843.mm.2 Acss1 acyl-CoA synthetase short-chain family member 1 2 -150618110 NM_080575, BC030930, BC092278 NM_080575, BC030930, BC092278 NM_080575, BC030930, BC092278 33

nucleotide binding

catalytic activity

acetate-CoA ligase activity

acetate-CoA ligase activity

ATP binding

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

acetyl-CoA biosynthetic process

acetyl-CoA biosynthetic process

AMP binding

ligase activity

acetate biosynthetic process

acetyl-CoA biosynthetic process from acetate

propionate biosynthetic process

propionate-CoA ligase activity

00010

00620

00640

01100

TC1700000948.mm.2 Mocs1 molybdenum cofactor synthesis 1 17 49428363 NM_020042, NM_028464 NM_020042, NM_028464 18

nucleotide binding

catalytic activity

GTP binding

Mo-molybdopterin cofactor biosynthetic process

lyase activity

molybdopterin synthase complex

molybdopterin cofactor biosynthetic process

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

GTP 3',8'-cyclase activity

GTP 3',8'-cyclase activity

cyclic pyranopterin monophosphate synthase activity

cyclic pyranopterin monophosphate synthase activity

04122

TC0200002588.mm.2 Rnf114 ring finger protein 114 2 167503442, 167492644 NM_030743, BC054416, BC085146 NM_030743, BC054416, BC085146 NM_030743, BC054416, BC085146 28

protein polyubiquitination

nucleic acid binding

nucleus

cytoplasm

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

multicellular organism development

spermatogenesis

transferase activity

cell differentiation

metal ion binding

ubiquitin protein ligase activity

 
TC1200002081.mm.2 Npc2 NPC intracellular cholesterol transporter 2 12 -84754558 NM_023409, BC003471, BC007190 NM_023409, BC003471, BC007190 NM_023409, BC003471, BC007190 68

extracellular region

extracellular space

extracellular space

lysosome

lysosome

lysosome

endoplasmic reticulum

lipid metabolic process

lipid transport

steroid metabolic process

cholesterol metabolic process

cholesterol binding

cholesterol binding

cholesterol binding

cholesterol binding

sterol transport

enzyme binding

cholesterol transport

cholesterol transport

cholesterol transport

intracellular sterol transport

intracellular sterol transport

intracellular cholesterol transport

intracellular cholesterol transport

intracellular cholesterol transport

sterol binding

cholesterol efflux

cholesterol efflux

cholesterol efflux

cholesterol homeostasis

cholesterol homeostasis

cholesterol transfer activity

04142

TC0300000881.mm.2 Rfx5 regulatory factor X, 5 (influences HLA class II expression) 3 94954107, 94954515 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 NM_017395, BC051965, BC118948, BC118949 32

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

04612

05340

TC0400001555.mm.2 Sdc3 syndecan 3 4 130792536 NM_011520, BC054795, BC062093 NM_011520, BC054795, BC062093 NM_011520, BC054795, BC062093 67

protein binding

Golgi lumen

plasma membrane

plasma membrane

cell adhesion

cell surface

membrane

integral component of membrane

cell migration

regulation of cell migration

axon

protein-containing complex

identical protein binding

neuron projection

microspike

04512

04514

05144

TC1600001343.mm.2 Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 16 -20400760, -20331303 NM_013790, NM_176839, BC090629 NM_013790, NM_176839, BC090629 NM_013790, NM_176839, BC090629 29

nucleotide binding

ATP binding

endosome

Golgi apparatus

plasma membrane

organic anion transmembrane transporter activity

purine nucleotide transmembrane transporter activity

efflux transmembrane transporter activity

organic anion transport

purine nucleotide transport

membrane

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

ATPase activity

glutathione transmembrane transporter activity

glutathione transmembrane transport

ATPase-coupled transmembrane transporter activity

xenobiotic transport

xenobiotic transmembrane transporter activity

perinuclear region of cytoplasm

transmembrane transport

export across plasma membrane

02010

TC1100002397.mm.2 Vrk2 vaccinia related kinase 2 11 -26471401 NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 NM_001252447, NM_027260, BC013520 27

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nuclear envelope

cytoplasm

cytoplasm

mitochondrion

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

protein phosphorylation

membrane

integral component of membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

protein kinase binding

protein domain specific binding

mitochondrial membrane

protein-containing complex

cellular response to oxidative stress

regulation of MAPK cascade

protein autophosphorylation

protein autophosphorylation

regulation of interleukin-1-mediated signaling pathway

 
TC0700003010.mm.2 Ppp1r15a protein phosphatase 1, regulatory subunit 15A 7 -45522916 NM_008654, BC138485, BC138486 NM_008654, BC138485, BC138486 NM_008654, BC138485, BC138486 90

protein phosphatase type 1 complex

protein phosphatase type 1 complex

cytoplasm

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

regulation of translation

apoptotic process

protein phosphatase 1 binding

positive regulation of gene expression

membrane

protein phosphatase regulator activity

protein phosphatase regulator activity

protein kinase binding

protein phosphatase binding

endoplasmic reticulum unfolded protein response

negative regulation of phosphoprotein phosphatase activity

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphoprotein phosphatase activity

positive regulation of peptidyl-serine phosphorylation

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

negative regulation of protein dephosphorylation

regulation of translational initiation by eIF2 alpha dephosphorylation

positive regulation of transcription by RNA polymerase I

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

peptidyl-serine dephosphorylation

protein localization to endoplasmic reticulum

positive regulation of peptidyl-serine dephosphorylation

positive regulation of peptidyl-serine dephosphorylation

negative regulation of response to endoplasmic reticulum stress

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

04141

TC0400001924.mm.2 Mthfr methylenetetrahydrofolate reductase 4 148039076, 148041188 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 NM_001161798, NM_010840, NR_027809, BC051017, BC052466 98

neural tube closure

catalytic activity

methylenetetrahydrofolate reductase (NAD(P)H) activity

methylenetetrahydrofolate reductase (NAD(P)H) activity

methylenetetrahydrofolate reductase (NAD(P)H) activity

cytosol

cytosol

methionine metabolic process

metabolic process

methionine biosynthetic process

methionine biosynthetic process

oxidoreductase activity

regulation of histone methylation

tetrahydrofolate interconversion

tetrahydrofolate interconversion

protein-containing complex binding

synapse

tetrahydrofolate metabolic process

flavin adenine dinucleotide binding

NADP binding

homocysteine metabolic process

heterochromatin maintenance

FAD binding

modified amino acid binding

00670

01100

TC0300000769.mm.2 Adar adenosine deaminase, RNA-specific 3 89715021, 89730717, 89715237 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 NM_001038587, NM_001146296, NM_019655, BC042505 115

osteoblast differentiation

in utero embryonic development

hematopoietic progenitor cell differentiation

immune system process

somatic diversification of immune receptors via somatic mutation

DNA binding

left-handed Z-DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA adenosine deaminase activity

double-stranded RNA adenosine deaminase activity

double-stranded RNA adenosine deaminase activity

adenosine deaminase activity

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

adenosine to inosine editing

adenosine to inosine editing

adenosine to inosine editing

adenosine to inosine editing

RNA processing

mRNA processing

protein import into nucleus

protein export from nucleus

tRNA-specific adenosine deaminase activity

response to virus

base conversion or substitution editing

nuclear speck

hydrolase activity

erythrocyte differentiation

gene silencing by RNA

pre-miRNA processing

production of miRNAs involved in gene silencing by miRNA

miRNA loading onto RISC involved in gene silencing by miRNA

response to interferon-alpha

negative regulation of apoptotic process

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein kinase activity by regulation of protein phosphorylation

supraspliceosomal complex

positive regulation of viral genome replication

positive regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

definitive hemopoiesis

negative regulation of type I interferon-mediated signaling pathway

hematopoietic stem cell homeostasis

cellular response to virus

negative regulation of RNA interference

04623

TC1200000614.mm.2 Daam1 dishevelled associated activator of morphogenesis 1 12 71889542, 71831067 NM_001286452, NM_026102, NM_172464, BC076585 NM_001286452, NM_026102, NM_172464, BC076585 NM_001286452, NM_026102, NM_172464, BC076585 NM_001286452, NM_026102, NM_172464, BC076585 54

stress fiber

stress fiber

stress fiber

actin binding

protein binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

cellular component organization

Wnt signaling pathway

actin cytoskeleton organization

small GTPase binding

motile cilium

ciliary basal body

identical protein binding

cell projection

04310

TC1500000960.mm.2 Pced1b PC-esterase domain containing 1B 15 97247106 NM_172293, BC038822, BC086317 NM_172293, BC038822, BC086317 NM_172293, BC038822, BC086317 13

molecular_function

cellular_component

biological_process

 
TC0600003108.mm.2 C1s1 complement component 1, s subcomponent 1 6 -124530343, -124530343 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 NM_001097617, NM_144938, BC018319, BC022123, BC111880 16

immune system process

serine-type endopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular space

proteolysis

complement activation, classical pathway

peptidase activity

serine-type peptidase activity

hydrolase activity

identical protein binding

innate immune response

metal ion binding

04610

05150

05322

TC0300000312.mm.2 Larp1b La ribonucleoprotein domain family, member 1B 3 40950649, 40950785 NM_001040399, BC025528 NM_001040399, BC025528 12

molecular_function

cellular_component

biological_process

 
TC1100003696.mm.2 Ccr7 chemokine (C-C motif) receptor 7 11 -99144198 NM_007719 354

establishment of T cell polarity

myeloid dendritic cell chemotaxis

lymphocyte chemotaxis across high endothelial venule

positive regulation of dendritic cell antigen processing and presentation

regulation of tolerance induction to self antigen

positive regulation of hypersensitivity

positive regulation of humoral immune response

G protein-coupled receptor activity

chemokine receptor activity

protein binding

mitochondrion

plasma membrane

plasma membrane

chemotaxis

inflammatory response

inflammatory response

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

activation of JUN kinase activity

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

positive regulation of macrophage chemotaxis

positive regulation of T cell chemotaxis

membrane

integral component of membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

actin cytoskeleton organization

response to lipopolysaccharide

regulation of interferon-gamma production

regulation of interleukin-1 beta production

negative regulation of interleukin-12 production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-12 production

positive regulation of tumor necrosis factor production

response to prostaglandin E

chemokine (C-C motif) ligand 19 binding

chemokine (C-C motif) ligand 19 binding

chemokine (C-C motif) ligand 21 binding

chemokine (C-C motif) ligand 21 binding

C-C motif chemokine 19 receptor activity

C-C motif chemokine 19 receptor activity

C-C motif chemokine 21 receptor activity

positive regulation of T cell proliferation

positive regulation of GTPase activity

negative thymic T cell selection

positive regulation of T-helper 1 cell differentiation

positive regulation of receptor-mediated endocytosis

lymph node development

homeostasis of number of cells

positive regulation of phagocytosis

positive regulation of T cell receptor signaling pathway

positive regulation of filopodium assembly

cell chemotaxis

cellular response to cytokine stimulus

response to nitric oxide

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil chemotaxis

lymphocyte migration into lymph node

mature conventional dendritic cell differentiation

negative regulation of leukocyte apoptotic process

positive regulation of cell motility

positive regulation of thymocyte migration

positive regulation of dendritic cell chemotaxis

positive regulation of immunological synapse formation

positive regulation of T cell costimulation

positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

regulation of dendritic cell dendrite assembly

04060

04062

TC1800000672.mm.2 Malt1 MALT1 paracaspase 18 65430989 NM_172833, BC110487, BC110488 NM_172833, BC110487, BC110488 NM_172833, BC110487, BC110488 97

fibrillar center

B-1 B cell differentiation

protease binding

polkadots

positive regulation of T cell cytokine production

cysteine-type endopeptidase activity

ubiquitin-protein transferase activity

protein binding

nucleus

cytoplasm

cytosol

cytosol

cytosol

proteolysis

proteolysis

apoptotic process

I-kappaB kinase/NF-kappaB signaling

activation of NF-kappaB-inducing kinase activity

peptidase activity

response to fungus

hydrolase activity

kinase activator activity

lipopolysaccharide-mediated signaling pathway

CBM complex

positive regulation of interleukin-1 beta production

positive regulation of interleukin-2 production

protein-containing complex

T cell proliferation

B cell activation

B cell activation

identical protein binding

regulation of apoptotic process

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein self-association

innate immune response

innate immune response

T cell receptor signaling pathway

T cell receptor signaling pathway

T cell receptor signaling pathway

regulation of T cell receptor signaling pathway

positive regulation of T cell activation

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

nuclear export

cellular response to lipopolysaccharide

positive regulation of T-helper 17 cell differentiation

04660

04662

TC0400000092.mm.2 Gem GTP binding protein (gene overexpressed in skeletal muscle) 4 11704446 NM_010276, BC029668 NM_010276, BC029668 35

nucleotide binding

mitotic cell cycle

magnesium ion binding

GTPase activity

calcium channel regulator activity

protein binding

GTP binding

GTP binding

nucleus

plasma membrane

signal transduction

cytoplasmic side of plasma membrane

membrane

GDP binding

midbody

spindle midzone

chromosome organization

metaphase plate congression

mitotic spindle

negative regulation of high voltage-gated calcium channel activity

 
TC1100003438.mm.2 Med13 mediator complex subunit 13 11 -86267032 NM_001080931 31

transcription coregulator activity

transcription coregulator activity

transcription coactivator activity

nucleus

nucleoplasm

nucleoplasm

regulation of transcription by RNA polymerase II

mediator complex

mediator complex

mediator complex

cholesterol homeostasis

negative regulation of DNA-binding transcription factor activity

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

thyroid hormone receptor binding

positive regulation of transcription initiation from RNA polymerase II promoter

triglyceride homeostasis

 
MG-1-pos-10341016_st                
TC1900000467.mm.2 Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 19 32620004, 32595714 NM_001201470, NM_011864, BC090997 NM_001201470, NM_011864, BC090997 NM_001201470, NM_011864, BC090997 59

sulfate assimilation

sulfate assimilation

nucleotide binding

catalytic activity

adenylylsulfate kinase activity

adenylylsulfate kinase activity

sulfate adenylyltransferase (ATP) activity

ATP binding

blood coagulation

metabolic process

kinase activity

transferase activity

nucleotidyltransferase activity

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

bone development

00230

00450

00920

01100

TC0700001520.mm.2         NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966 NM_001243916, NM_030684, BC165966  

protein polyubiquitination

nucleoplasm

cytoplasm

cytosol

zinc ion binding

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

protein kinase binding

regulation of protein localization

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

regulation of viral entry into host cell

metal ion binding

positive regulation of NF-kappaB transcription factor activity

defense response to virus

ubiquitin protein ligase activity

 
TC1200002269.mm.2 Ifi27l2a interferon, alpha-inducible protein 27 like 2A 12 -103433872, -103442165 NM_001281830, NM_029803, BC100588 NM_001281830, NM_029803, BC100588 NM_001281830, NM_029803, BC100588 21

molecular_function

nucleus

mitochondrion

aging

response to virus

membrane

integral component of membrane

apoptotic signaling pathway

 
TC0700002857.mm.2 Dpy19l3 dpy-19-like 3 (C. elegans) 7 -35685499 NM_178704, BC050065, BC059897 NM_178704, BC050065, BC059897 NM_178704, BC050065, BC059897 14

mannosyltransferase activity

nuclear inner membrane

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

 
TC0400002248.mm.2 Osgin2 oxidative stress induced growth inhibitor family member 2 4 -15996353, -15996353 NM_145950, BC010311 NM_145950, BC010311 13

cellular_component

growth factor activity

negative regulation of cell growth

 
TC1600001479.mm.2 Apod apolipoprotein D 16 -31296191 NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 NM_007470, BC145907, BC145909 59

response to reactive oxygen species

response to reactive oxygen species

response to reactive oxygen species

extracellular region

extracellular space

intracellular anatomical structure

cytoplasm

cytoplasm

endoplasmic reticulum

glucose metabolic process

lipid metabolic process

lipid metabolic process

lipid transport

aging

lipid binding

negative regulation of platelet-derived growth factor receptor signaling pathway

cholesterol binding

cholesterol binding

cytosolic ribosome

dendrite

negative regulation of protein import into nucleus

neuronal cell body

perinuclear region of cytoplasm

negative regulation of smooth muscle cell proliferation

negative regulation of focal adhesion assembly

negative regulation of lipoprotein lipid oxidation

negative regulation of lipoprotein lipid oxidation

negative regulation of monocyte chemotactic protein-1 production

negative regulation of cytokine production involved in inflammatory response

negative regulation of smooth muscle cell-matrix adhesion

negative regulation of T cell migration

 
TC0600003237.mm.2 Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 6 -129485247, -129485246 NM_138648 104

immune system process

low-density lipoprotein particle receptor activity

low-density lipoprotein particle receptor activity

extracellular region

nucleoplasm

plasma membrane

plasma membrane

inflammatory response

inflammatory response

cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

cell death

cell death

negative regulation of gene expression

membrane

integral component of membrane

extrinsic component of plasma membrane

carbohydrate binding

lipoprotein metabolic process

lipoprotein metabolic process

identical protein binding

intracellular membrane-bounded organelle

receptor complex

receptor complex

03320

04145

TC0900003311.mm.2 Fyco1 FYVE and coiled-coil domain containing 1 9 -123789499, -123789499 NM_001110253, NM_148925, BC157054 NM_001110253, NM_148925, BC157054 NM_001110253, NM_148925, BC157054 25

lysosome

lysosome

endosome

late endosome

late endosome

autophagosome

autophagosome

Golgi apparatus

cytoplasmic vesicle

intracellular membrane-bounded organelle

metal ion binding

plus-end-directed vesicle transport along microtubule

plus-end-directed vesicle transport along microtubule

positive regulation of autophagosome maturation

positive regulation of autophagosome maturation

 
TC0600000236.mm.2 Irf5 interferon regulatory factor 5 6 29526624, 29526624, 29529281 NM_001252382, NM_012057, BC160276 NM_001252382, NM_012057, BC160276 NM_001252382, NM_012057, BC160276 120

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

inflammatory response

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein kinase binding

protein kinase binding

positive regulation of type I interferon production

response to peptidoglycan

response to muramyl dipeptide

identical protein binding

positive regulation of apoptotic process

sequence-specific DNA binding

innate immune response

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

defense response to virus

sequence-specific double-stranded DNA binding

04620

TC0100000725.mm.2 Fbxo36 F-box protein 36 1 84839840 NM_025386, BC049581 NM_025386, BC049581 18

molecular_function

cellular_component

 
TC1300002697.mm.2 Snx18 sorting nexin 18 13 -113592178 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 NM_130796, BC063089, BC137801, BC145951 21

mitotic cell cycle

mitotic cytokinesis

protein binding

phosphatidylinositol-4,5-bisphosphate binding

endosome

plasma membrane

endocytosis

cell cycle

lipid binding

protein transport

membrane

endosomal transport

clathrin-coated vesicle

growth cone

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

phosphatidylinositol binding

cleavage furrow formation

neuronal cell body

positive regulation of GTPase activity

cell division

extracellular exosome

 
MG-1-neg-10341146_st                
TC1500001491.mm.2         NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962 NM_032000, NR_035444, BC037058, BC049857, BC099962  

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

skeletal system development

hair follicle development

chondrocyte differentiation

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transmembrane receptor protein serine/threonine kinase signaling pathway

zinc ion binding

protein domain specific binding

regulation of chondrocyte differentiation

protein-containing complex

sequence-specific DNA binding

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

metal ion binding

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

 
TC1300002011.mm.2 Auh AU RNA binding protein/enoyl-coenzyme A hydratase 13 -52835109 NM_016709, BC049597 NM_016709, BC049597 22

RNA binding

mRNA 3'-UTR binding

catalytic activity

enoyl-CoA hydratase activity

enoyl-CoA hydratase activity

enoyl-CoA hydratase activity

methylglutaconyl-CoA hydratase activity

mitochondrion

mitochondrion

mitochondrion

fatty acid beta-oxidation

branched-chain amino acid catabolic process

lyase activity

itaconyl-CoA hydratase activity

00280

01100

TC0700002507.mm.2 Pvr poliovirus receptor 7 -19903577 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 NM_027514, BC013673, BC032283, BC138219, BC138220 70

virus receptor activity

protein binding

plasma membrane

adherens junction

homophilic cell adhesion via plasma membrane adhesion molecules

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

cell surface

cell migration

dynein light chain binding

cell-cell adhesion

 
TC1900000502.mm.2 Ifit3b interferon-induced protein with tetratricopeptide repeats 3B 19 34607956 NM_001005858 10

RNA binding

cytoplasm

mitochondrion

cytosol

cytosol

identical protein binding

defense response to virus

 
MG-1-neg-10341554_st                
TC1200001041.mm.2 Serpina3i serine (or cysteine) peptidase inhibitor, clade A, member 3I 12 104263121 NM_001199940 12

serine-type endopeptidase inhibitor activity

extracellular space

negative regulation of endopeptidase activity

response to cytokine

response to peptide hormone

 
MG-1-neg-10341560_st                
TC0300000680.mm.2 Lrba LPS-responsive beige-like anchor 3 86224689, 86224689, 86224689 NM_001077687, NM_001077688, NM_030695 NM_001077687, NM_001077688, NM_030695 NM_001077687, NM_001077688, NM_030695 29

lysosome

endoplasmic reticulum

Golgi apparatus

trans-Golgi network

cytosol

plasma membrane

signal transduction

protein localization

protein localization

membrane

integral component of membrane

endosomal transport

protein kinase binding

cytoplasmic vesicle

protein kinase A binding

cellular response to leukemia inhibitory factor

 
TC0400002945.mm.2 Ttc39b tetratricopeptide repeat domain 39B 4 -83220300 NM_027238, BC151021 NM_027238, BC151021 22

molecular_function

cellular_component

lipid metabolic process

regulation of cholesterol efflux

regulation of cholesterol efflux

negative regulation of cholesterol storage

negative regulation of cholesterol storage

cholesterol homeostasis

cholesterol homeostasis

regulation of cholesterol metabolic process

regulation of cholesterol metabolic process

 
MG-1-pos-10338706_st                
TC1400002406.mm.2 Lrch1 leucine-rich repeats and calponin homology (CH) domain containing 1 14 -74754672 NM_001033439, NM_001252132 NM_001033439, NM_001252132 23

protein binding

cytoplasm

cytoplasm

negative regulation of GTPase activity

negative regulation of GTPase activity

cellular response to chemokine

cellular response to chemokine

cellular response to chemokine

negative regulation of T cell migration

negative regulation of T cell migration

negative regulation of T cell migration

 
TC1700002481.mm.2 Tgif1 TGFB-induced factor homeobox 1 17 -70844204, -70844204, -70844204, -70844204, -70844204 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 NM_001164074, NM_001164075, NM_001164076, NM_001164077, NM_009372, BC005724, BC012700 76

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

neural tube closure

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

determination of left/right symmetry

negative regulation of cell population proliferation

JUN kinase binding

dorsal/ventral pattern formation

regulation of gastrulation

negative regulation of gene expression

nodal signaling pathway

positive regulation of neuron differentiation

positive regulation of fibroblast proliferation

negative regulation of retinoic acid receptor signaling pathway

retina development in camera-type eye

co-SMAD binding

sequence-specific double-stranded DNA binding

 
TC0300000258.mm.2 Atp11b ATPase, class VI, type 11B 3 35754062 NM_029570, BC076603 NM_029570, BC076603 19

endoplasmic reticulum

endoplasmic reticulum

trans-Golgi network

plasma membrane

phospholipid translocation

recycling endosome

recycling endosome

ATPase-coupled intramembrane lipid transporter activity

 
TC0X00002637.mm.2 Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 X -93764615 NM_145630, BC008126 NM_145630, BC008126 29

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

ATP binding

nucleolus

mitochondrion

mitochondrion

mitochondrion

carbohydrate metabolic process

glucose metabolic process

protein phosphorylation

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of glucose metabolic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peroxisome proliferator activated receptor signaling pathway

cellular response to glucose stimulus

cellular response to fatty acid

hypoxia-inducible factor-1alpha signaling pathway

regulation of reactive oxygen species metabolic process

 
TC1500002318.mm.2 Itga5 integrin alpha 5 (fibronectin receptor alpha) 15 -103344285 NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 NM_010577, BC050943, BC059829 224

epidermal growth factor receptor binding

integrin binding

integrin binding

protein binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

cell-cell junction

focal adhesion

cell-substrate junction assembly

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

integrin-mediated signaling pathway

memory

integrin complex

external side of plasma membrane

cell surface

cell surface

positive regulation of cell-substrate adhesion

membrane

integral component of membrane

CD40 signaling pathway

cell junction

positive regulation of cell migration

cytoplasmic vesicle

cell-substrate adhesion

ruffle membrane

cell adhesion mediated by integrin

cell-cell adhesion mediated by integrin

heterotypic cell-cell adhesion

integrin alpha5-beta1 complex

endodermal cell differentiation

synapse

regulation of angiogenesis

metal ion binding

positive regulation of peptidyl-tyrosine phosphorylation

cell adhesion molecule binding

positive regulation of sprouting angiogenesis

negative regulation of anoikis

04145

04510

04512

04640

04810

05100

05410

05412

05414

TC1500000982.mm.2 Cacnb3 calcium channel, voltage-dependent, beta 3 subunit 15 98632327, 98634766 NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 NM_001044741, NM_001286226, NM_007581, BC160243 62

voltage-gated ion channel activity

voltage-gated calcium channel activity

calcium channel regulator activity

calcium channel activity

protein binding

cytoplasm

plasma membrane

voltage-gated calcium channel complex

voltage-gated calcium channel complex

voltage-gated calcium channel complex

ion transport

calcium ion transport

chemical synaptic transmission

neuromuscular junction development

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

membrane

apical plasma membrane

protein kinase binding

regulation of ion transmembrane transport

T cell receptor signaling pathway

detection of mechanical stimulus involved in sensory perception of pain

calcium ion transport into cytosol

calcium ion transmembrane transport via high voltage-gated calcium channel

calcium ion transmembrane transport

protein localization to plasma membrane

positive regulation of protein targeting to membrane

regulation of membrane repolarization during action potential

regulation of voltage-gated calcium channel activity

negative regulation of voltage-gated calcium channel activity

positive regulation of voltage-gated calcium channel activity

positive regulation of high voltage-gated calcium channel activity

regulation of membrane hyperpolarization

negative regulation of detection of mechanical stimulus involved in sensory perception of touch

L-type voltage-gated calcium channel complex

positive regulation of excitatory postsynaptic potential

04010

04260

05410

05412

05414

TC1000001621.mm.2 Mmp19 matrix metallopeptidase 19 10 128790909, 128790954 NM_001164197, NM_021412, BC112966 NM_001164197, NM_021412, BC112966 NM_001164197, NM_021412, BC112966 32

angiogenesis

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

extracellular region

extracellular region

extracellular space

extracellular space

plasma membrane

multicellular organism development

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

hydrolase activity

cell differentiation

extracellular matrix organization

collagen catabolic process

extracellular matrix

anchored component of membrane

metal ion binding

 
TC1200001277.mm.2 Pacs2 phosphofurin acidic cluster sorting protein 2 12 113014507 NM_001081170 24

autophagosome assembly

mitochondrion

endoplasmic reticulum

apoptotic process

endoplasmic reticulum calcium ion homeostasis

protein localization to phagophore assembly site

ion channel binding

protein localization to plasma membrane

protein localization to plasma membrane

mitochondrion-endoplasmic reticulum membrane tethering

 
TC0900002389.mm.2 Pml promyelocytic leukemia 9 -58217179 NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 NM_008884, NM_178087, BC020990 204

chromosome, telomeric region

chromatin

heterochromatin

response to hypoxia

response to hypoxia

regulation of protein phosphorylation

positive regulation of defense response to virus by host

immune system process

DNA binding

transcription coactivator activity

transcription coactivator activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

endosome

endoplasmic reticulum

cytosol

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

protein targeting

protein import into nucleus

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

cell cycle arrest

cell cycle arrest

cell cycle arrest

transforming growth factor beta receptor signaling pathway

common-partner SMAD protein phosphorylation

cell aging

zinc ion binding

negative regulation of cell population proliferation

negative regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to oxidative stress

response to UV

response to gamma radiation

regulation of calcium ion transport into cytosol

fibroblast migration

membrane

viral process

nuclear matrix

nuclear matrix

negative regulation of angiogenesis

negative regulation of angiogenesis

PML body

PML body

PML body

PML body

myeloid cell differentiation

regulation of cell adhesion

negative regulation of cell growth

PML body organization

PML body organization

PML body organization

positive regulation of histone deacetylation

ubiquitin protein ligase binding

nuclear membrane

SUMO binding

positive regulation of telomere maintenance

negative regulation of telomere maintenance via telomerase

endoplasmic reticulum calcium ion homeostasis

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production

circadian regulation of gene expression

negative regulation of translation in response to oxidative stress

response to cytokine

extrinsic component of endoplasmic reticulum membrane

regulation of circadian rhythm

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

protein homodimerization activity

entrainment of circadian clock by photoperiod

proteasome-mediated ubiquitin-dependent protein catabolic process

innate immune response

innate immune response

cell fate commitment

regulation of MHC class I biosynthetic process

positive regulation of MHC class I biosynthetic process

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

negative regulation of mitotic cell cycle

positive regulation of transcription by RNA polymerase II

SMAD binding

metal ion binding

protein heterodimerization activity

positive regulation of fibroblast proliferation

retinoic acid receptor signaling pathway

rhythmic process

protein stabilization

cobalt ion binding

maintenance of protein location in nucleus

defense response to virus

negative regulation of telomerase activity

positive regulation of apoptotic process involved in mammary gland involution

branching involved in mammary gland duct morphogenesis

protein-containing complex assembly

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to interleukin-4

intrinsic apoptotic signaling pathway by p53 class mediator

cellular senescence

extrinsic apoptotic signaling pathway

sumo-dependent protein binding

negative regulation of viral release from host cell

negative regulation of viral release from host cell

positive regulation of protein localization to chromosome, telomeric region

cellular response to leukemia inhibitory factor

negative regulation of ubiquitin-dependent protein catabolic process

regulation of double-strand break repair

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

04120

04144

05200

05221

TC1100002754.mm.2 Slc22a4 solute carrier family 22 (organic cation transporter), member 4 11 -53983114 NM_019687, BC010590 NM_019687, BC010590 43

nucleotide binding

transporter activity

ATP binding

mitochondrion

mitochondrion

mitochondrion

triglyceride metabolic process

ion transport

sodium ion transport

carnitine metabolic process

organic cation transmembrane transporter activity

amino acid transmembrane transporter activity

carnitine transmembrane transporter activity

carnitine transmembrane transporter activity

symporter activity

cation:cation antiporter activity

quaternary ammonium group transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

quaternary ammonium group transport

quaternary ammonium group transport

quaternary ammonium group transport

carnitine transport

carnitine transport

membrane

integral component of membrane

apical plasma membrane

transmembrane transporter activity

PDZ domain binding

xenobiotic transport

transmembrane transport

amino acid import across plasma membrane

 
TC1100001657.mm.2 Ifi35 interferon-induced protein 35 11 101448411 NM_027320, BC008158 NM_027320, BC008158 21

macrophage activation involved in immune response

extracellular space

extracellular space

nucleus

nucleus

cytoplasm

cytosol

negative regulation of cell population proliferation

membrane

positive regulation of toll-like receptor 4 signaling pathway

identical protein binding

positive regulation of innate immune response

positive regulation of innate immune response

positive regulation of inflammatory response

positive regulation of inflammatory response

negative regulation of NIK/NF-kappaB signaling

positive regulation of NIK/NF-kappaB signaling

 
TC0400004170.mm.2 Agrn agrin 4 -156165289, -156190167, -156165291 NM_021604, BC150703 NM_021604, BC150703 172

regulation of protein phosphorylation

positive regulation of protein phosphorylation

positive regulation of protein phosphorylation

dystroglycan binding

extracellular matrix structural constituent

calcium ion binding

protein binding

extracellular region

basement membrane

basement membrane

extracellular space

extracellular space

extracellular space

Golgi lumen

plasma membrane

plasma membrane organization

chemical synaptic transmission

chemical synaptic transmission

multicellular organism development

synapse assembly

neuromuscular junction development

neuromuscular junction development

regulation of synaptic growth at neuromuscular junction

animal organ morphogenesis

tissue development

cell surface

membrane

integral component of membrane

cell junction

cell differentiation

acetylcholine receptor regulator activity

positive regulation of protein binding

chondroitin sulfate binding

BMP binding

ATPase inhibitor activity

sarcolemma

synaptic cleft

regulation of GTPase activity

receptor clustering

receptor clustering

receptor clustering

receptor clustering

receptor clustering

heparan sulfate proteoglycan binding

positive regulation of neuron apoptotic process

positive regulation of GTPase activity

axonal growth cone

ion channel binding

synapse

synapse

synapse

neurotransmitter receptor metabolic process

positive regulation of synaptic growth at neuromuscular junction

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

transforming growth factor beta binding

positive regulation of peptidyl-tyrosine phosphorylation

regulation of synapse organization

positive regulation of filopodium assembly

regulation of cardiac muscle contraction

positive regulation of protein tyrosine kinase activity

collagen-containing extracellular matrix

collagen-containing extracellular matrix

regulation of microtubule cytoskeleton organization

skeletal muscle acetylcholine-gated channel clustering

regulation of cardiac muscle cell membrane potential

glutamatergic synapse

regulation of axon guidance

negative regulation of sodium ion export across plasma membrane

negative regulation of sodium:potassium-exchanging ATPase activity

positive regulation of protein geranylgeranylation

04512

TC1700000073.mm.2 Tcp10a t-complex protein 10a 17 7324659 NM_011553, NR_046291, BC052353 NM_011553, NR_046291, BC052353 NM_011553, NR_046291, BC052353 42

transcription corepressor activity

nucleus

centriole

biological_process

 
TC1000002916.mm.2 Rab3ip RAB3A interacting protein 10 -116905779 NM_001003950, BC080289 NM_001003950, BC080289 25

guanyl-nucleotide exchange factor activity

nucleus

cytoplasm

Golgi apparatus

centrosome

cytosol

cytoskeleton

protein targeting to membrane

exocytosis

protein transport

protein localization to organelle

identical protein binding

cell projection

perinuclear region of cytoplasm

GTPase binding

negative regulation of filopodium assembly

cilium assembly

Golgi to plasma membrane transport vesicle

proximal dendrite

 
TC0100003233.mm.2 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 1 -149829618, -149829618 NM_008869, BC003816 NM_008869, BC003816 208

Golgi membrane

prostaglandin biosynthetic process

prostaglandin biosynthetic process

ovulation from ovarian follicle

positive regulation of T-helper 1 type immune response

phospholipase activity

lysophospholipase activity

phospholipase A2 activity

phospholipase A2 activity

phospholipase A2 activity

calcium ion binding

calcium ion binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

nucleus

nucleus

nuclear envelope

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

cytosol

cytosol

glycerol metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

monoacylglycerol biosynthetic process

platelet activating factor biosynthetic process

prostaglandin metabolic process

positive regulation of cell population proliferation

lipid binding

O-acyltransferase activity

phospholipid catabolic process

response to organic substance

phosphatidylinositol-5-phosphate binding

positive regulation of platelet activation

membrane

lipid catabolic process

hydrolase activity

arachidonic acid metabolic process

leukotriene biosynthetic process

leukotriene biosynthetic process

positive regulation of vesicle fusion

positive regulation of prostaglandin biosynthetic process

phosphatidylinositol-3-phosphate binding

positive regulation of prostaglandin secretion

phosphatidylglycerol catabolic process

phosphatidylcholine catabolic process

phosphatidylcholine catabolic process

histone acetyltransferase binding

phosphatidylcholine acyl-chain remodeling

regulation of cell population proliferation

zymogen granule

positive regulation of macrophage activation

positive regulation of apoptotic process

surfactant homeostasis

intracellular membrane-bounded organelle

icosanoid biosynthetic process

glycerophospholipid catabolic process

decidualization

metal ion binding

calcium-dependent phospholipase A2 activity

calcium-dependent phospholipase A2 activity

calcium-dependent phospholipase A2 activity

calcium-independent phospholipase A2 activity

perinuclear region of cytoplasm

arachidonic acid secretion

arachidonic acid secretion

positive regulation of inflammatory response

response to calcium ion

phosphatidylinositol-4-phosphate binding

cellular response to antibiotic

ceramide 1-phosphate binding

00564

00565

00590

00591

00592

01100

04010

04270

04370

04664

04666

04730

04912

04972

04975

05145

TC0300001136.mm.2 Psma5 proteasome subunit alpha 5 3 108256925 NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 NM_011967, BC010709, BC083342, BC108368 26

proteasome complex

endopeptidase activity

threonine-type endopeptidase activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

proteasome core complex

proteasome core complex

ubiquitin-dependent protein catabolic process

proteasomal ubiquitin-independent protein catabolic process

proteasome core complex, alpha-subunit complex

proteasome core complex, alpha-subunit complex

proteasome-mediated ubiquitin-dependent protein catabolic process

proteolysis involved in cellular protein catabolic process

03050

MG-1-neg-10338071_st                
TC0500002836.mm.2 Lin54 lin-54 homolog (C. elegans) 5 -100442034, -100442034, -100442035 NM_001115010, NM_172714, BC145025 NM_001115010, NM_172714, BC145025 NM_001115010, NM_172714, BC145025 18

regulatory region nucleic acid binding

DNA binding

minor groove of adenine-thymine-rich DNA binding

nucleus

regulation of transcription, DNA-templated

cell cycle

metal ion binding

 
MG-1-neg-10343778_st                
TC0500000816.mm.2 Dck deoxycytidine kinase 5 88765012 NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 NM_007832, BC052004, BC060062 28

nucleotide binding

magnesium ion binding

deoxyadenosine kinase activity

deoxycytidine kinase activity

deoxycytidine kinase activity

deoxyguanosine kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

nucleobase-containing compound metabolic process

pyrimidine nucleotide metabolic process

drug binding

kinase activity

transferase activity

deoxynucleoside kinase activity

nucleoside kinase activity

pyrimidine deoxyribonucleoside binding

protein homodimerization activity

deoxycytidine metabolic process

nucleotide phosphorylation

00230

00240

01100

TC1300001776.mm.2 Serpinb6c serine (or cysteine) peptidase inhibitor, clade B, member 6c 13 -33879815, -33879815 NM_148942, BC062169 NM_148942, BC062169 11

serine-type endopeptidase inhibitor activity

extracellular space

cytoplasm

negative regulation of endopeptidase activity

05146

TC0600001657.mm.2 Aebp2 AE binding protein 2 6 140622662, 140626884, 140623501, 140623501, 140624908 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 NM_001005605, NM_009637, NM_178803, BC025467, BC031376, BC057681 39

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

nucleus

nucleoplasm

chromatin organization

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

ESC/E(Z) complex

ESC/E(Z) complex

ESC/E(Z) complex

metal ion binding

 
MG-1-neg-10339990_st                
TC0800002577.mm.2 Zswim4 zinc finger SWIM-type containing 4 8 -84210941 NM_172503, BC058080 NM_172503, BC058080 18

molecular_function

zinc ion binding

Cul2-RING ubiquitin ligase complex

metal ion binding

regulation of axon guidance

 
TC0400002799.mm.2 Akna AT-hook transcription factor 4 -63367122, -63367122 NM_001045514, BC092227 NM_001045514, BC092227 21

fibrillar center

epithelial to mesenchymal transition

DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

centrosome

centrosome

centriole

cytosol

cytoskeleton

microtubule

nervous system development

neuroblast division in subventricular zone

intracellular membrane-bounded organelle

positive regulation of transcription by RNA polymerase II

regulation of inflammatory response

delamination

neuroblast delamination

 
TC0100000916.mm.2 Gpc1 glypican 1 1 92831644 NM_016696, BC062902 NM_016696, BC062902 55

copper ion binding

nucleoplasm

endosome

Golgi lumen

cytosol

plasma membrane

regulation of signal transduction

cell surface

Schwann cell differentiation

membrane

cell migration

fibroblast growth factor binding

fibroblast growth factor binding

heparan sulfate proteoglycan catabolic process

extracellular matrix

anchored component of membrane

myelin assembly

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of fibroblast growth factor receptor signaling pathway

neuronal cell body

laminin binding

membrane raft

membrane raft

synapse

synapse

synapse

anchored component of plasma membrane

collagen-containing extracellular matrix

collagen V binding

regulation of protein localization to membrane

positive regulation of skeletal muscle cell differentiation

 
TC0300000309.mm.2         NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212 NM_026622, NR_038067, BC092533, BC145212  

molecular_function

cellular_component

extracellular region

biological_process

 
TC0100000743.mm.2 Gm7609 predicted pseudogene 7609 1 85199610 NM_001081746 10    
TC0700004642.mm.2 Samd4b sterile alpha motif domain containing 4B 7 -28399521 NM_175021, BC042901 NM_175021, BC042901 19

nuclear-transcribed mRNA poly(A) tail shortening

P-body

RNA binding

mRNA binding

mRNA binding

protein binding

nucleus

cytoplasm

cytosol

negative regulation of translation

translation repressor activity

regulation of mRNA stability

cerebellar neuron development

 
TC1500000641.mm.2         NM_007780, BC113202, NR_106137, NR_106138 NM_007780, BC113202, NR_106137, NR_106138 NM_007780, BC113202, NR_106137, NR_106138 NM_007780, BC113202, NR_106137, NR_106138  

regulation of cell growth

cytokine receptor activity

protein binding

membrane

integral component of membrane

cytokine-mediated signaling pathway

 
TC0100002203.mm.2 Coa5 cytochrome C oxidase assembly factor 5 1 -37417084 NM_198006, BC002137 NM_198006, BC002137 19

molecular_function

mitochondrion

mitochondrion

mitochondrial cytochrome c oxidase assembly

 
TC0200001371.mm.2 Acp2 acid phosphatase 2, lysosomal 2 91202911 NM_007387, BC023343 NM_007387, BC023343 37

skeletal system development

phosphotyrosine residue binding

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

phosphoprotein phosphatase activity

lysosome

lysosome

lysosome

lysosome

lysosome organization

lysosome organization

response to organic substance

membrane

integral component of membrane

dephosphorylation

hydrolase activity

phosphatase activity

cytoplasmic vesicle

neuron projection

autophagic cell death

00740

04142

MG-1-neg-10340905_st                
TC0X00001124.mm.2 Apool apolipoprotein O-like X 112311351 NM_026565, BC024334 NM_026565, BC024334 21

mitochondrion

mitochondrion

mitochondrial inner membrane

membrane

integral component of membrane

cristae formation

MICOS complex

MICOS complex

 
TC1100004270.mm.2 Tlcd2 TLC domain containing 2 11 75468049 NM_027249, BC021945 NM_027249, BC021945 11

molecular_function

plasma membrane

plasma membrane

plasma membrane organization

plasma membrane organization

membrane

integral component of membrane

lipid homeostasis

phospholipid homeostasis

phospholipid homeostasis

membrane assembly

membrane assembly

regulation of membrane lipid distribution

regulation of membrane lipid distribution

 
TC0600002554.mm.2 Dok1 docking protein 1 6 -83030935 NM_010070, BC013066 NM_010070, BC013066 75

protein binding

nucleus

cytoplasm

cytosol

transmembrane receptor protein tyrosine kinase signaling pathway

Ras protein signal transduction

intracellular signal transduction

macrophage colony-stimulating factor signaling pathway

negative regulation of MAPK cascade

 
TC0900001418.mm.2 Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 9 108662135 NM_020520, BC029733, BC052871 NM_020520, BC029733, BC052871 NM_020520, BC029733, BC052871 30

in utero embryonic development

mitochondrion

mitochondrion

mitochondrial inner membrane

cytosol

acyl carnitine transmembrane transporter activity

membrane

integral component of membrane

carnitine transmembrane transport

 
TC1700002418.mm.2 Twsg1 twisted gastrulation BMP signaling modulator 1 17 -65923064 NM_023053, BC004850 NM_023053, BC004850 52

ossification

mesoderm formation

negative regulation of cytokine production

protein binding

extracellular region

extracellular space

extracellular space

transforming growth factor beta receptor signaling pathway

multicellular organism development

salivary gland morphogenesis

embryo development

tissue development

positive regulation of pathway-restricted SMAD protein phosphorylation

hemopoiesis

cell differentiation

BMP signaling pathway

regulation of BMP signaling pathway

positive regulation of BMP signaling pathway

negative regulation of BMP signaling pathway

negative regulation of BMP signaling pathway

forebrain development

forebrain development

camera-type eye development

negative regulation of osteoblast differentiation

transforming growth factor beta binding

negative regulation of CD4-positive, alpha-beta T cell activation

negative regulation of CD4-positive, alpha-beta T cell proliferation

 
TC0500002526.mm.2 Bend4 BEN domain containing 4 5 -67392146 NM_001164806 9

molecular_function

cellular_component

biological_process

 
TC0100002193.mm.2 Tmem131 transmembrane protein 131 1 -36792188 NM_018872 27

molecular_function

membrane

integral component of membrane

 
TC1900000991.mm.2 Cdc42ep2 CDC42 effector protein (Rho GTPase binding) 2 19 -5917555 NM_026772, BC034884 NM_026772, BC034884 20

opioid peptide activity

GTPase activator activity

cytoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

Rho protein signal transduction

regulation of cell shape

regulation of cell shape

microtubule cytoskeleton

membrane

actin cytoskeleton organization

positive regulation of actin filament polymerization

positive regulation of actin filament polymerization

small GTPase binding

positive regulation of pseudopodium assembly

positive regulation of pseudopodium assembly

phagocytic vesicle

cellular response to interferon-gamma

 
TC1700000315.mm.2 Hcfc1r1 host cell factor C1 regulator 1 (XPO1-dependent) 17 23673607 NM_181821, BC079865 NM_181821, BC079865 13

molecular_function

nucleus

nucleoplasm

cytoplasm

biological_process

 
TC1300000365.mm.2 Serpinb9b serine (or cysteine) peptidase inhibitor, clade B, member 9b 13 33027413 NM_011452, BC064768 NM_011452, BC064768 19

T cell mediated cytotoxicity

serine-type endopeptidase inhibitor activity

protein binding

extracellular space

cytoplasm

negative regulation of endopeptidase activity

05146

TC0700000272.mm.2 Mill2 MHC I like leukocyte 2 7 18839965 NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 NM_153760, NM_153761, BC137748, BC144886 18

immune response-activating cell surface receptor signaling pathway

protein binding

extracellular space

immune response

response to oxidative stress

response to heat

external side of plasma membrane

anchored component of external side of plasma membrane

response to retinoic acid

gamma-delta T cell activation

natural killer cell lectin-like receptor binding

negative regulation of defense response to virus by host

 
TC0800000760.mm.2 Jund jun D proto-oncogene 8 70697738 NM_001286944, NM_010592, BC010572, BC094068 NM_001286944, NM_010592, BC010572, BC094068 NM_001286944, NM_010592, BC010572, BC094068 NM_001286944, NM_010592, BC010572, BC094068 109

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

osteoblast development

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription factor binding

transcription factor binding

nuclear receptor binding

enzyme binding

protein-containing complex

protein-DNA complex

transcription factor AP-1 complex

regulation of cell population proliferation

sequence-specific DNA binding

positive regulation of osteoblast differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of cell cycle

cellular response to calcium ion

sequence-specific double-stranded DNA binding

04010

04380

TC0X00000316.mm.2 Il13ra1 interleukin 13 receptor, alpha 1 X 36112107 NM_133990, BC052425, BC059939 NM_133990, BC052425, BC059939 NM_133990, BC052425, BC059939 62

cytokine receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

ciliary neurotrophic factor receptor binding

positive regulation of cell population proliferation

external side of plasma membrane

membrane

integral component of membrane

interleukin-13 receptor activity

cytokine-mediated signaling pathway

cytokine binding

receptor complex

04060

04630

TC1200000225.mm.2 Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 12 26469214 NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 NM_020557, BC027329, BC057565 17

nucleotide binding

cytidylate kinase activity

cytidylate kinase activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

thymidylate kinase activity

thymidylate kinase activity

ATP binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

nucleoside diphosphate phosphorylation

pyrimidine nucleotide biosynthetic process

dUDP biosynthetic process

dUDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTTP biosynthetic process

uridylate kinase activity

uridylate kinase activity

nucleoside triphosphate biosynthetic process

kinase activity

phosphorylation

transferase activity

UMP kinase activity

nucleoside monophosphate kinase activity

cellular response to lipopolysaccharide

00240

01100

TC0800002634.mm.2 N4bp1 NEDD4 binding protein 1 8 -86841138 NM_030563 27

RNA binding

protein binding

nucleus

nucleus

nucleolus

PML body

PML body

negative regulation of protein ubiquitination

negative regulation of protein ubiquitination

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

cellular response to UV

cellular response to UV

 
TC0300000172.mm.2 Tnik TRAF2 and NCK interacting kinase 3 28263213, 28263213 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 NM_001163007, NM_001163008, NM_001163009, NM_026910, BC137799, BC137800, BC151003, BC158011, BC158059 27

MAPK cascade

nucleotide binding

positive regulation of protein phosphorylation

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

endosome

cytosol

cytoskeleton

protein phosphorylation

cytoskeleton organization

activation of JNKK activity

nervous system development

Wnt signaling pathway

kinase activity

phosphorylation

apical plasma membrane

transferase activity

microvillus assembly

stress-activated protein kinase signaling cascade

actin cytoskeleton reorganization

activation of protein kinase activity

intracellular signal transduction

protein autophosphorylation

perinuclear region of cytoplasm

neuron projection morphogenesis

regulation of dendrite morphogenesis

recycling endosome

protein localization to plasma membrane

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

 
TC1200002220.mm.2 Nrde2 nrde-2 necessary for RNA interference, domain containing 12 -100125449, -100125449 NM_183155, BC025577 NM_183155, BC025577 23

molecular_function

nucleus

nucleoplasm

nucleolus

RNA processing

RNA interference

nuclear speck

heterochromatin assembly by small RNA

positive regulation of RNA export from nucleus

negative regulation of RNA catabolic process

 
TC0300002490.mm.2 BC028528 cDNA sequence BC028528 3 -95883944, -95883944 NM_153513, BC028528 NM_153513, BC028528 6

molecular_function

cellular_component

extracellular region

biological_process

 
TC0900001142.mm.2 Bcl2a1a B cell leukemia/lymphoma 2 related protein A1a 9 88956919 NM_009742 56

B cell homeostasis

negative regulation of B cell apoptotic process

protein binding

cytoplasm

mitochondrial outer membrane

apoptotic process

intrinsic apoptotic signaling pathway in response to DNA damage

protein homodimerization activity

regulation of apoptotic process

negative regulation of apoptotic process

protein-containing complex binding

protein heterodimerization activity

BH domain binding

extrinsic apoptotic signaling pathway in absence of ligand

 
TC1000002320.mm.2 Arid5b AT rich interactive domain 5B (MRF1-like) 10 -68095592 NM_023598, BC165988 NM_023598, BC165988 46

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

kidney development

DNA binding

transcription coactivator activity

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

nitrogen compound metabolic process

male gonad development

female gonad development

post-embryonic development

fibroblast migration

adrenal gland development

multicellular organism growth

fat cell differentiation

platelet-derived growth factor receptor signaling pathway

cell development

muscle organ morphogenesis

skeletal system morphogenesis

positive regulation of DNA-binding transcription factor activity

positive regulation of DNA-binding transcription factor activity

roof of mouth development

face morphogenesis

adipose tissue development

fat pad development

cellular response to leukemia inhibitory factor

 
TC1000003161.mm.2 Dgka diacylglycerol kinase, alpha 10 -128720135, -128720135, -128720135, -128720135 NM_016811, BC006713 NM_016811, BC006713 57

nucleotide binding

NAD+ kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

calcium ion binding

ATP binding

phospholipid binding

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

lipid metabolic process

phosphatidic acid biosynthetic process

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

lipid binding

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

diacylglycerol metabolic process

diacylglycerol metabolic process

glycerolipid metabolic process

lipid phosphorylation

lipid phosphorylation

metal ion binding

00561

00564

01100

04070

TC0600000650.mm.2 Prr15 proline rich 15 6 54326900 NM_030024, BC132416, BC138757 NM_030024, BC132416, BC138757 NM_030024, BC132416, BC138757 17

molecular_function

cellular_component

multicellular organism development

biological_process

 
TC1600002061.mm.2 Paxbp1 PAX3 and PAX7 binding protein 1 16 -91014036 NM_026110, BC014838 NM_026110, BC014838 24

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

regulation of transcription, DNA-templated

muscle organ development

transcription factor binding

regulation of skeletal muscle satellite cell proliferation

positive regulation of histone methylation

positive regulation of histone methylation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of myoblast proliferation

 
TC1900000689.mm.2 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 19 46305694, 46304736, 46305929 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 NM_001177369, NM_001177370, NM_019408, BC027423 204

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

follicular dendritic cell differentiation

germinal center formation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

signal transduction

extracellular matrix organization

Bcl3/NF-kappaB2 complex

NIK/NF-kappaB signaling

positive regulation of transcription by RNA polymerase II

rhythmic process

lymph node development

spleen development

sequence-specific double-stranded DNA binding

04010

04380

05200

TC1200000688.mm.2 Fut8 fucosyltransferase 8 12 77410140, 77388863, 77238103, 77238738 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 NM_001252614, NM_001252615, NM_001252616, NM_016893, NR_045554, BC010666 48

Golgi apparatus

protein N-linked glycosylation

N-glycan processing

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

respiratory gaseous exchange by respiratory system

glycoprotein 6-alpha-L-fucosyltransferase activity

regulation of gene expression

membrane

integral component of membrane

cell migration

transferase activity

transferase activity, transferring glycosyl groups

SH3 domain binding

protein N-linked glycosylation via asparagine

Golgi cisterna membrane

protein glycosylation in Golgi

N-glycan fucosylation

N-glycan fucosylation

receptor metabolic process

GDP-L-fucose metabolic process

alpha-(1->6)-fucosyltransferase activity

alpha-(1->6)-fucosyltransferase activity

regulation of cellular response to oxidative stress

00510

00533

01100

TC0700004538.mm.2 Slc25a22 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 7 -141429748, -141429748, -141429748 NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 NM_001177576, NM_026646, BC037949 35

L-glutamate transmembrane transporter activity

L-glutamate transmembrane transporter activity

mitochondrion

mitochondrial inner membrane

transport

L-aspartate transmembrane transporter activity

symporter activity

aspartate transmembrane transport

L-glutamate transmembrane transport

L-glutamate transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

malate-aspartate shuttle

transmembrane transport

 
TC0800002113.mm.2 Mtus1 mitochondrial tumor suppressor 1 8 -40990911, -40990911, -40990911, -40990911 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 NM_001005863, NM_001005864, NM_001005865, NM_001286413, BC041777, BC042206, BC089009 30

nucleus

nucleolus

cytoplasm

mitochondrion

Golgi apparatus

plasma membrane

cell cycle

microtubule binding

regulation of macrophage chemotaxis

regulation of macrophage chemotaxis

microtubule cytoskeleton

membrane

 
TC1000002164.mm.2 Cep85l centrosomal protein 85-like 10 -53273442 NM_001204983 10

molecular_function

centrosome

biological_process

 
TC0900002283.mm.2 Layn layilin 9 -51056779 NM_001033534, BC139816 NM_001033534, BC139816 18

hyaluronic acid binding

hyaluronic acid binding

membrane

integral component of membrane

carbohydrate binding

 
TC1700002135.mm.2 Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 17 -44096309, -44096309 NM_199016, BC027749 NM_199016, BC027749 17

catalytic activity

plasma membrane

blood coagulation

hemostasis

membrane

integral component of membrane

hydrolase activity

positive regulation of blood coagulation

purine ribonucleoside catabolic process

metal ion binding

bis(5'-adenosyl)-triphosphatase activity

 
MG-1-pos-10341289_st                
TC0200001935.mm.2 Mertk MER proto-oncogene tyrosine kinase 2 128698914 NM_008587, BC157109 NM_008587, BC157109 190

nucleotide binding

photoreceptor outer segment

natural killer cell differentiation

negative regulation of cytokine production

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ATP binding

extracellular space

cytoplasm

integral component of plasma membrane

protein phosphorylation

phagocytosis

phagocytosis

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organism development

spermatogenesis

nervous system development

membrane

integral component of membrane

rhabdomere

kinase activity

phosphorylation

cell migration

transferase activity

platelet activation

secretion by cell

positive regulation of kinase activity

substrate adhesion-dependent cell spreading

receptor complex

apoptotic cell clearance

apoptotic cell clearance

apoptotic cell clearance

protein kinase B signaling

positive regulation of phagocytosis

negative regulation of lymphocyte activation

retina development in camera-type eye

vagina development

neutrophil clearance

negative regulation of leukocyte apoptotic process

 
TC1100000015.mm.2 Selenom selenoprotein M 11 3514683 NM_053267, BC147332, BC147333 NM_053267, BC147332, BC147333 NM_053267, BC147332, BC147333 23

cytoplasm

endoplasmic reticulum

endoplasmic reticulum lumen

Golgi apparatus

response to selenium ion

oxidoreductase activity

multicellular organism growth

corticosterone secretion

hormone metabolic process

adipose tissue development

 
TC1500000235.mm.2 Laptm4b lysosomal-associated protein transmembrane 4B 15 34238025 NM_033521, BC019120 NM_033521, BC019120 22

lysosome

lysosomal membrane

lysosomal membrane

endosome

early endosome

plasma membrane

endosome organization

membrane

integral component of membrane

kinase binding

ubiquitin protein ligase binding

late endosome membrane

endosome transport via multivesicular body sorting pathway

multivesicular body membrane

negative regulation of transforming growth factor beta1 production

cell projection

ceramide binding

regulation of lysosomal membrane permeability

multivesicular body, internal vesicle

phosphatidylinositol bisphosphate binding

negative regulation of lysosomal protein catabolic process

regulation of lysosome organization

04142

TC0600003246.mm.2 Klri1 killer cell lectin-like receptor family I member 1 6 -129697217 NM_001012520 3

plasma membrane

integral component of plasma membrane

membrane

integral component of membrane

carbohydrate binding

 
TC0800001079.mm.2 Capns2 calpain, small subunit 2 8 92901394 NM_027112 8

calcium ion binding

protein binding

cytoplasm

plasma membrane

plasma membrane

membrane

metal ion binding

 
TC1000000711.mm.2 Adora2a adenosine A2a receptor 10 75316876, 75324857, 75317599 NM_009630, BC110692 NM_009630, BC110692 432

G protein-coupled adenosine receptor activity

G protein-coupled adenosine receptor activity

G protein-coupled adenosine receptor activity

synaptic transmission, dopaminergic

G protein-coupled adenosine receptor signaling pathway

G protein-coupled adenosine receptor signaling pathway

G protein-coupled adenosine receptor signaling pathway

G protein-coupled adenosine receptor signaling pathway

response to amphetamine

G protein-coupled receptor activity

protein binding

intermediate filament

plasma membrane

plasma membrane

integral component of plasma membrane

regulation of transcription, DNA-templated

negative regulation of protein kinase activity

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

protein kinase C-activating G protein-coupled receptor signaling pathway

synaptic transmission, cholinergic

locomotory behavior

locomotory behavior

negative regulation of cell population proliferation

endomembrane system

positive regulation of glutamate secretion

positive regulation of acetylcholine secretion, neurotransmission

regulation of norepinephrine secretion

postsynaptic density

membrane

membrane

integral component of membrane

enzyme binding

axon

dendrite

axolemma

response to caffeine

type 5 metabotropic glutamate receptor binding

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission, GABAergic

asymmetric synapse

synaptic transmission, glutamatergic

positive regulation of urine volume

positive regulation of renal sodium excretion

negative regulation of locomotion

vasodilation

presynaptic membrane

eating behavior

eating behavior

identical protein binding

neuronal cell body

negative regulation of vascular permeability

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

response to alkaloid

negative regulation of neuron apoptotic process

protein-containing complex binding

postsynaptic membrane

positive regulation of circadian sleep/wake cycle, sleep

negative regulation of alpha-beta T cell activation

astrocyte activation

presynaptic active zone

neuron projection morphogenesis

positive regulation of protein secretion

negative regulation of inflammatory response

alpha-actinin binding

regulation of mitochondrial membrane potential

membrane depolarization

regulation of calcium ion transport

positive regulation of synaptic transmission, glutamatergic

excitatory postsynaptic potential

inhibitory postsynaptic potential

prepulse inhibition

glutamatergic synapse

integral component of postsynaptic membrane

integral component of presynaptic membrane

positive regulation of long-term synaptic potentiation

regulation of synaptic vesicle exocytosis

positive regulation of apoptotic signaling pathway

04020

04080

04270

TC0200002594.mm.2 Cebpb CCAAT/enhancer binding protein (C/EBP), beta 2 167688914 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 NM_001287738, NM_001287739, NM_009883, BC160327 535

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

condensed chromosome, centromeric region

chromatin

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

ovarian follicle development

embryonic placenta development

granuloma formation

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription factor binding

positive regulation of gene expression

nuclear matrix

nuclear matrix

kinase binding

cell differentiation

neuron differentiation

response to lipopolysaccharide

regulation of interleukin-6 production

positive regulation of interleukin-4 production

mammary gland epithelial cell proliferation

response to endoplasmic reticulum stress

histone acetyltransferase binding

glucocorticoid receptor binding

T-helper 1 cell activation

CHOP-C/EBP complex

negative regulation of T cell proliferation

defense response to bacterium

identical protein binding

protein homodimerization activity

histone deacetylase binding

negative regulation of neuron apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

ubiquitin-like protein ligase binding

fat cell differentiation

fat cell differentiation

regulation of cell differentiation

positive regulation of fat cell differentiation

positive regulation of osteoblast differentiation

regulation of osteoclast differentiation

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

positive regulation of inflammatory response

brown fat cell differentiation

mammary gland epithelial cell differentiation

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

positive regulation of biomineral tissue development

cellular response to lipopolysaccharide

cellular response to amino acid stimulus

cellular response to interleukin-1

hepatocyte proliferation

hepatocyte proliferation

RNA polymerase II transcription regulator complex

liver regeneration

positive regulation of cold-induced thermogenesis

regulation of odontoblast differentiation

regulation of odontoblast differentiation

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

sequence-specific double-stranded DNA binding

positive regulation of sodium-dependent phosphate transport

regulation of dendritic cell differentiation

 
MG-1-neg-10339929_st                
TC0200004713.mm.2 Jag1 jagged 1 2 -137081450 NM_013822, BC058675 NM_013822, BC058675 583

negative regulation of cell-matrix adhesion

blood vessel remodeling

morphogenesis of an epithelial sheet

T cell mediated immunity

pulmonary valve morphogenesis

cardiac right ventricle morphogenesis

Notch binding

Notch binding

Notch binding

calcium ion binding

protein binding

phospholipid binding

plasma membrane

plasma membrane

plasma membrane

adherens junction

cell communication

Notch signaling pathway

Notch signaling pathway

Notch signaling pathway

Notch signaling pathway

multicellular organism development

animal organ morphogenesis

positive regulation of gene expression

membrane

integral component of membrane

apical plasma membrane

negative regulation of cell-cell adhesion

negative regulation of cell migration

response to muramyl dipeptide

aorta morphogenesis

regulation of cell population proliferation

regulation of cell population proliferation

inner ear auditory receptor cell differentiation

inner ear auditory receptor cell differentiation

camera-type eye development

apical part of cell

negative regulation of cell differentiation

negative regulation of cell differentiation

negative regulation of fat cell differentiation

negative regulation of endothelial cell differentiation

positive regulation of myeloid cell differentiation

negative regulation of neuron differentiation

positive regulation of osteoblast differentiation

positive regulation of Notch signaling pathway

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

receptor ligand activity

inner ear development

cardiac septum morphogenesis

ciliary body morphogenesis

pulmonary artery morphogenesis

cardiac neural crest cell development involved in outflow tract morphogenesis

Notch signaling involved in heart development

Notch signaling involved in heart development

endocardial cushion cell development

positive regulation of cardiac epithelial to mesenchymal transition

nephron development

glomerular visceral epithelial cell development

distal tubule development

loop of Henle development

negative regulation of stem cell differentiation

04330

TC0200003624.mm.2 Dpp4 dipeptidylpeptidase 4 2 -62330072, -62333222 NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183 NM_001159543, NM_010074, BC022183 183

virus receptor activity

behavioral fear response

response to hypoxia

protease binding

regulation of T cell mediated immunity

aminopeptidase activity

serine-type endopeptidase activity

signaling receptor binding

collagen binding

extracellular region

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

proteolysis

proteolysis

cell adhesion

peptidase activity

serine-type peptidase activity

dipeptidyl-peptidase activity

dipeptidyl-peptidase activity

positive regulation of cell population proliferation

cell surface

negative regulation of extracellular matrix disassembly

membrane

integral component of membrane

apical plasma membrane

hydrolase activity

lamellipodium

cell junction

endocytic vesicle

T cell costimulation

regulation of cell-cell adhesion mediated by integrin

locomotory exploration behavior

psychomotor behavior

T cell activation

peptide binding

identical protein binding

protein homodimerization activity

cell projection

endothelial cell migration

chemorepellent activity

intercellular canaliculus

establishment of localization

negative regulation of neutrophil chemotaxis

04974

TC1700000765.mm.2 H2-M3 histocompatibility 2, M region locus 3 17 37270233 NM_013819, BC031984 NM_013819, BC031984 41

negative regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated cytotoxicity

response to molecule of bacterial origin

alpha-beta T cell activation involved in immune response

peripheral B cell tolerance induction

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of exogenous peptide antigen via MHC class Ib

antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

positive regulation of tolerance induction

positive regulation of T cell tolerance induction

positive regulation of natural killer cell cytokine production

immune response-inhibiting cell surface receptor signaling pathway

signaling receptor binding

signaling receptor binding

extracellular space

early endosome

plasma membrane

immune response

external side of plasma membrane

external side of plasma membrane

negative regulation of angiogenesis

MHC class Ib protein complex

positive regulation of interferon-gamma production

positive regulation of interleukin-12 production

cis-Golgi network membrane

negative regulation of T cell proliferation

protection from natural killer cell mediated cytotoxicity

peptide antigen binding

peptide antigen binding

peptide antigen binding

peptide antigen binding

CD8 receptor binding

defense response to bacterium

defense response to bacterium

identical protein binding

protein homodimerization activity

positive regulation of nitric oxide biosynthetic process

positive regulation of regulatory T cell differentiation

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of protein kinase B signaling

positive regulation of macrophage cytokine production

protein homotrimerization

negative regulation of G0 to G1 transition

positive regulation of endothelial cell apoptotic process

positive regulation of cellular senescence

negative regulation of dendritic cell differentiation

04144

04145

04514

04612

04940

05320

05330

05332

05416

TC1100000850.mm.2 Sco1 SCO1 cytochrome c oxidase assembly protein 11 67052669 NM_001040026, BC139008, BC139009 NM_001040026, BC139008, BC139009 NM_001040026, BC139008, BC139009 19

molecular_function

mitochondrion

mitochondrion

mitochondrial inner membrane

cellular copper ion homeostasis

membrane

integral component of membrane

myofibril

integral component of mitochondrial inner membrane

mitochondrial cytochrome c oxidase assembly

mitochondrial cytochrome c oxidase assembly

mitochondrial cytochrome c oxidase assembly

cell redox homeostasis

metal ion binding

negative regulation of proteasomal protein catabolic process

 
TC0600002324.mm.2 Ggct gamma-glutamyl cyclotransferase 6 -54985094 NM_026637, BC080818 NM_026637, BC080818 34

release of cytochrome c from mitochondria

gamma-glutamylcyclotransferase activity

gamma-glutamylcyclotransferase activity

cytosol

lyase activity

protein homodimerization activity

00480

TC1100003418.mm.2 Dhrs11 dehydrogenase/reductase (SDR family) member 11 11 -84820727 NM_177564, BC022224 NM_177564, BC022224 14

nucleotide binding

3-keto sterol reductase activity

estradiol 17-beta-dehydrogenase activity

cellular_component

extracellular region

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

oxidoreductase activity

17-beta-ketosteroid reductase activity

17-beta-hydroxysteroid dehydrogenase (NADP+) activity

 
TC0400001392.mm.2 Nt5c1a 5'-nucleotidase, cytosolic IA 4 123201484 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 NM_001085502, BC147308, BC147309, BC147730, BC147733 9

nucleotide binding

magnesium ion binding

cytoplasm

cytosol

cytosol

5'-nucleotidase activity

5'-nucleotidase activity

nucleotide metabolic process

purine nucleoside monophosphate catabolic process

hydrolase activity

dAMP catabolic process

adenosine metabolic process

adenosine metabolic process

00230

00240

00760

01100

TC1900000797.mm.2 Casp7 caspase 7 19 56397128 NM_007611, BC005428 NM_007611, BC005428 111

aspartic-type endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteolysis

proteolysis

apoptotic process

apoptotic process

apoptotic process

heart development

peptidase activity

peptidase activity

cysteine-type peptidase activity

response to UV

protein processing

hydrolase activity

intracellular membrane-bounded organelle

neuron apoptotic process

cellular response to staurosporine

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in apoptotic process

execution phase of apoptosis

execution phase of apoptosis

cysteine-type endopeptidase activity involved in execution phase of apoptosis

cysteine-type endopeptidase activity involved in execution phase of apoptosis

04210

05010

TC0500001403.mm.2 Rnf34 ring finger protein 34 5 122850187 NM_030564, BC004042 NM_030564, BC004042 23

p53 binding

ubiquitin-protein transferase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

plasma membrane

plasma membrane

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

apoptotic process

membrane

protein ubiquitination

nuclear body

transferase activity

ubiquitin protein ligase binding

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

cellular response to cold

protein K48-linked ubiquitination

protein K48-linked ubiquitination

negative regulation of signal transduction by p53 class mediator

phosphatidylinositol phosphate binding

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of oxygen metabolic process

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

 
TC1700002766.mm.2         NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264 NM_009341, BC050771, BC141264  

transcription corepressor activity

nucleus

centriole

biological_process

 
TC0500000170.mm.2 Gsap gamma-secretase activating protein 5 21176278, 21186266, 21186266 NM_175437 14

amyloid-beta binding

Golgi apparatus

trans-Golgi network

trans-Golgi network

regulation of proteolysis

positive regulation of amyloid-beta formation

positive regulation of amyloid-beta formation

positive regulation of amyloid-beta formation

 
TC1100000684.mm.2         XM_001477470      
MG-1-neg-10341946_st                
TC0200004204.mm.2 Prr5l proline rich 5 like 2 -101714284, -101714284, -101714284 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 NM_001083810, NM_001110849, NM_175181, BC048394, BC172132 19

negative regulation of protein phosphorylation

positive regulation of protein phosphorylation

mitochondrion

negative regulation of signal transduction

regulation of fibroblast migration

regulation of fibroblast migration

positive regulation of phosphatidylinositol 3-kinase signaling

ubiquitin protein ligase binding

TORC2 complex

TORC2 complex

cellular response to oxidative stress

TORC2 signaling

TORC2 signaling

TORC2 signaling

positive regulation of mRNA catabolic process

positive regulation of intracellular protein transport

 
TC0200000833.mm.2 Fmnl2 formin-like 2 2 52857867 NM_172409, BC168411 NM_172409, BC168411 26

actin binding

cytoplasm

cytosol

cytoskeleton organization

regulation of cell shape

cellular component organization

cell migration

regulation of cell morphogenesis

actin cytoskeleton organization

cortical actin cytoskeleton organization

cortical actin cytoskeleton organization

small GTPase binding

actin filament binding

 
TC0900003312.mm.2 Xcr1 chemokine (C motif) receptor 1 9 -123852314 NM_011798, BC141368, BC141369 NM_011798, BC141368, BC141369 NM_011798, BC141368, BC141369 37

G protein-coupled receptor activity

chemokine receptor activity

plasma membrane

chemotaxis

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

membrane

integral component of membrane

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

response to cytokine

release of sequestered calcium ion into cytosol

cell chemotaxis

04060

04062

MG-1-neg-10342988_st                
TC1900000896.mm.2 Gstp1 glutathione S-transferase, pi 1 19 -4035410 NM_013541, BC002048, BC061109 NM_013541, BC002048, BC061109 NM_013541, BC002048, BC061109 95

response to reactive oxygen species

negative regulation of acute inflammatory response

glutathione transferase activity

glutathione transferase activity

glutathione transferase activity

glutathione peroxidase activity

fatty acid binding

protein binding

nucleus

cytoplasm

mitochondrion

cytosol

cytosol

plasma membrane

glutathione metabolic process

glutathione metabolic process

JUN kinase binding

transferase activity

kinase regulator activity

protein kinase binding

negative regulation of interleukin-1 beta production

negative regulation of tumor necrosis factor production

regulation of stress-activated MAPK cascade

negative regulation of stress-activated MAPK cascade

positive regulation of superoxide anion generation

protein-containing complex

common myeloid progenitor cell proliferation

S-nitrosoglutathione binding

dinitrosyl-iron complex binding

negative regulation of apoptotic process

negative regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of JUN kinase activity

negative regulation of JUN kinase activity

negative regulation of fibroblast proliferation

negative regulation of nitric-oxide synthase biosynthetic process

regulation of ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of leukocyte proliferation

cellular response to lipopolysaccharide

negative regulation of monocyte chemotactic protein-1 production

TRAF2-GSTP1 complex

negative regulation of neutrophil aggregation

negative regulation of peroxidase activity

00480

00980

00982

05215

TC0700000075.mm.2 Zfp667 zinc finger protein 667 7 6286579 NM_001024928, BC141152, BC141153 NM_001024928, BC141152, BC141153 NM_001024928, BC141152, BC141153 17

RNA polymerase II cis-regulatory region sequence-specific DNA binding

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

intracellular anatomical structure

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

metal ion binding

 
TC1500001061.mm.2 Acvrl1 activin A receptor, type II-like 1 15 101128521 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 NM_001277255, NM_001277257, NM_001277258, NM_001277259, NM_009612, BC014291, BC015083 121

nucleotide binding

angiogenesis

angiogenesis

angiogenesis

in utero embryonic development

negative regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

lymphangiogenesis

blood vessel remodeling

endocardial cushion morphogenesis

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta-activated receptor activity

transforming growth factor beta receptor activity, type I

transforming growth factor beta receptor activity, type I

protein binding

ATP binding

plasma membrane

plasma membrane

integral component of plasma membrane

regulation of transcription, DNA-templated

protein phosphorylation

protein phosphorylation

negative regulation of cell adhesion

signal transduction

transmembrane receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

heart development

blood circulation

regulation of blood pressure

negative regulation of cell population proliferation

dorsal/ventral pattern formation

cell surface

negative regulation of endothelial cell migration

negative regulation of gene expression

positive regulation of pathway-restricted SMAD protein phosphorylation

membrane

integral component of membrane

kinase activity

phosphorylation

activin receptor activity, type I

transferase activity

protein kinase binding

negative regulation of cell growth

negative regulation of cell migration

dendrite

BMP signaling pathway

BMP signaling pathway

BMP signaling pathway

positive regulation of BMP signaling pathway

positive regulation of BMP signaling pathway

wound healing, spreading of epidermal cells

dorsal aorta morphogenesis

endothelial cell activation

neuronal cell body

receptor complex

negative regulation of blood vessel endothelial cell migration

negative regulation of endothelial cell differentiation

positive regulation of endothelial cell differentiation

positive regulation of angiogenesis

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

SMAD binding

SMAD binding

metal ion binding

activin binding

blood vessel morphogenesis

transforming growth factor beta binding

negative regulation of focal adhesion assembly

lymphatic endothelial cell differentiation

lymphatic endothelial cell differentiation

artery development

venous blood vessel development

endothelial tube morphogenesis

retina vasculature development in camera-type eye

BMP receptor complex

cellular response to growth factor stimulus

cellular response to transforming growth factor beta stimulus

cellular response to transforming growth factor beta stimulus

cellular response to BMP stimulus

BMP receptor activity

negative regulation of DNA biosynthetic process

 
TC1300000476.mm.2 Hivep1 human immunodeficiency virus type I enhancer binding protein 1 13 42052020 NM_007772, BC156925 NM_007772, BC156925 28

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

mitochondrion

cytosol

regulation of transcription by RNA polymerase II

zinc ion binding

nuclear body

BMP signaling pathway

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

HMG box domain binding

sequence-specific double-stranded DNA binding

 
TC0200003313.mm.2 Stxbp1 syntaxin binding protein 1 2 -32787606, -32787606 NM_001113569, NM_009295, BC031728 NM_001113569, NM_009295, BC031728 NM_001113569, NM_009295, BC031728 128

SNARE binding

platelet degranulation

developmental process involved in reproduction

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

cytoskeleton

plasma membrane

plasma membrane

plasma membrane

plasma membrane

intracellular protein transport

exocytosis

vesicle docking involved in exocytosis

vesicle docking involved in exocytosis

neurotransmitter secretion

neurotransmitter secretion

neuromuscular synaptic transmission

axon target recognition

regulation of synaptic vesicle priming

protein transport

membrane

synaptic vesicle priming

synaptic vesicle priming

synaptic vesicle maturation

vesicle-mediated transport

syntaxin-1 binding

syntaxin-1 binding

syntaxin-1 binding

syntaxin-1 binding

protein kinase binding

protein domain specific binding

syntaxin binding

syntaxin binding

secretory granule

axon

axon

platelet alpha granule

negative regulation of protein-containing complex assembly

regulation of vesicle fusion

synaptic vesicle fusion to presynaptic active zone membrane

negative regulation of synaptic transmission, GABAergic

protein-containing complex

SNARE complex assembly

identical protein binding

myelin sheath

phospholipase binding

positive regulation of mast cell degranulation

negative regulation of neuron apoptotic process

phagocytic vesicle

positive regulation of exocytosis

positive regulation of calcium ion-dependent exocytosis

protein N-terminus binding

perinuclear region of cytoplasm

presynaptic active zone membrane

protein stabilization

long-term synaptic depression

platelet aggregation

cellular response to interferon-gamma

protein localization to plasma membrane

presynapse

postsynapse

glutamatergic synapse

glutamatergic synapse

presynaptic dense core vesicle exocytosis

positive regulation of vesicle docking

positive regulation of glutamate secretion, neurotransmission

regulation of acrosomal vesicle exocytosis

 
MG-1-neg-10343761_st                
TC0500001210.mm.2 Iscu iron-sulfur cluster assembly enzyme 5 113772800 NM_025526, BC048409, BC096049 NM_025526, BC048409, BC096049 NM_025526, BC048409, BC096049 26

iron ion binding

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

cytosol

cellular iron ion homeostasis

ferrous iron binding

iron-sulfur cluster assembly

metal ion binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

4 iron, 4 sulfur cluster binding

molecular adaptor activity

positive regulation of mitochondrial electron transport, NADH to ubiquinone

positive regulation of aconitate hydratase activity

negative regulation of iron ion import across plasma membrane

 
TC1700001395.mm.2 Tagap1 T cell activation GTPase activating protein 1 17 -6954964 NM_147155, BC165956 NM_147155, BC165956 14

GTPase activator activity

cellular_component

 
TC1400001656.mm.2 Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 14 -30039940, -30039940 NM_001083616, NM_028981, BC172729 NM_001083616, NM_028981, BC172729 NM_001083616, NM_028981, BC172729 191

ion channel activity

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

calcium channel activity

protein binding

nucleus

cytoplasm

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

voltage-gated calcium channel complex

voltage-gated calcium channel complex

ion transport

calcium ion transport

calcium ion transport

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

sensory perception of sound

sensory perception of sound

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

cell surface

membrane

integral component of membrane

apical plasma membrane

calcium-mediated signaling

metal ion transport

Z disc

PDZ domain binding

dendrite

ankyrin binding

ankyrin binding

dendrite membrane

positive regulation of CREB transcription factor activity

regulation of ion transmembrane transport

positive regulation of insulin secretion involved in cellular response to glucose stimulus

sarcolemma

neuronal cell body

positive regulation of adenylate cyclase activity

metal ion binding

alpha-actinin binding

regulation of calcium ion transport

positive regulation of calcium ion transport

transmembrane transport

regulation of atrial cardiac muscle cell membrane repolarization

calcium ion import

calcium ion import

calcium ion transmembrane transport

cardiac muscle cell action potential involved in contraction

membrane depolarization during SA node cell action potential

membrane depolarization during SA node cell action potential

voltage-gated calcium channel activity involved SA node cell action potential

voltage-gated calcium channel activity involved SA node cell action potential

regulation of heart rate by cardiac conduction

regulation of heart rate by cardiac conduction

cochlear hair cell ribbon synapse

cochlear hair cell ribbon synapse

integral component of presynaptic active zone membrane

voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

regulation of potassium ion transmembrane transporter activity

regulation of potassium ion transmembrane transport

positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

L-type voltage-gated calcium channel complex

04010

04020

04260

04270

04912

04930

04973

05010

05410

05412

05414

TC0300002959.mm.2 Sgms2 sphingomyelin synthase 2 3 -131318985, -131318985, -131318985, -131318985, -131318985, -131318985 NM_028943, BC117782 NM_028943, BC117782 62

ceramide phosphoethanolamine synthase activity

Golgi apparatus

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

integral component of plasma membrane

lipid metabolic process

sphingolipid metabolic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

membrane

integral component of membrane

kinase activity

phosphorylation

transferase activity

integral component of Golgi membrane

integral component of Golgi membrane

integral component of Golgi membrane

integral component of endoplasmic reticulum membrane

regulation of bone mineralization

sphingomyelin synthase activity

sphingomyelin synthase activity

sphingomyelin synthase activity

sphingomyelin synthase activity

ceramide biosynthetic process

ceramide biosynthetic process

ceramide cholinephosphotransferase activity

ceramide cholinephosphotransferase activity

ceramide cholinephosphotransferase activity

ceramide phosphoethanolamine biosynthetic process

00600

01100

TC1500000222.mm.2 Cpq carboxypeptidase Q 15 33083128 NM_018755, NM_176073, BC037067 NM_018755, NM_176073, BC037067 NM_018755, NM_176073, BC037067 16

carboxypeptidase activity

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

lysosome

lysosome

endoplasmic reticulum

Golgi apparatus

proteolysis

proteolysis

thyroid hormone generation

thyroid hormone generation

peptidase activity

metallopeptidase activity

hydrolase activity

protein homodimerization activity

peptide catabolic process

peptide catabolic process

intracellular membrane-bounded organelle

metal ion binding

metallodipeptidase activity

metallodipeptidase activity

 
TC0600002354.mm.2 Vopp1 vesicular, overexpressed in cancer, prosurvival protein 1 6 -57752263 NM_146168, BC024822 NM_146168, BC024822 13

endosome

membrane

integral component of membrane

cytoplasmic vesicle membrane

integral component of organelle membrane

integral component of organelle membrane

cytoplasmic vesicle

 
TC0800000659.mm.2 Ddx60 DExD/H box helicase 60 8 61928086 NM_001081215 16

double-stranded DNA binding

RNA binding

double-stranded RNA binding

single-stranded RNA binding

protein binding

cytoplasm

cytoplasm

cytosol

response to virus

intermediate filament cytoskeleton

defense response to virus

positive regulation of MDA-5 signaling pathway

positive regulation of RIG-I signaling pathway

 
TC0600003264.mm.2 Klra2 killer cell lectin-like receptor, subfamily A, member 2 6 -131219234 NM_001170851, NM_008462, BC064711 NM_001170851, NM_008462, BC064711 NM_001170851, NM_008462, BC064711 25

plasma membrane

cell adhesion

membrane

integral component of membrane

carbohydrate binding

 
TC0900001720.mm.2 Birc2 baculoviral IAP repeat-containing 2 9 -7818225, -7818225 NM_007465, BC145985 NM_007465, BC145985 90

protein polyubiquitination

response to hypoxia

XY body

placenta development

transcription coactivator activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

apoptotic process

zinc ion binding

cytoplasmic side of plasma membrane

transferase activity

positive regulation of protein ubiquitination

protein-containing complex

CD40 receptor complex

identical protein binding

regulation of apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

ubiquitin binding

proteasome-mediated ubiquitin-dependent protein catabolic process

protein-containing complex binding

membrane raft

metal ion binding

protein N-terminus binding

chaperone binding

regulation of cell cycle

regulation of cell cycle

regulation of necroptotic process

negative regulation of necroptotic process

negative regulation of necroptotic process

ubiquitin protein ligase activity

necroptotic process

cellular response to tumor necrosis factor

FBXO family protein binding

regulation of NIK/NF-kappaB signaling

negative regulation of ripoptosome assembly involved in necroptotic process

positive regulation of protein K63-linked ubiquitination

positive regulation of protein K48-linked ubiquitination

positive regulation of protein monoubiquitination

positive regulation of protein polyubiquitination

regulation of reactive oxygen species metabolic process

04120

04210

04510

04621

05145

05200

05222

TC1300002188.mm.2 Ptch1 patched 1 13 -63508327, -63508327 NM_008957, BC157045 NM_008957, BC157045 1283

negative regulation of transcription by RNA polymerase II

branching involved in ureteric bud morphogenesis

in utero embryonic development

cell fate determination

neural tube formation

neural tube closure

heart morphogenesis

patched binding

smoothened binding

smoothened binding

protein binding

extracellular region

nucleus

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

caveola

cilium

signal transduction

smoothened signaling pathway

smoothened signaling pathway

smoothened signaling pathway

smoothened signaling pathway

regulation of mitotic cell cycle

pattern specification process

brain development

hedgehog receptor activity

hedgehog receptor activity

heparin binding

zinc ion binding

negative regulation of cell population proliferation

epidermis development

animal organ morphogenesis

dorsal/ventral pattern formation

epidermal cell fate specification

response to chlorate

positive regulation of cholesterol efflux

postsynaptic density

cholesterol binding

cholesterol binding

membrane

integral component of membrane

protein processing

spinal cord motor neuron differentiation

neural tube patterning

dorsal/ventral neural tube patterning

neural plate axis specification

embryonic limb morphogenesis

embryonic limb morphogenesis

cyclin binding

cyclin binding

midbody

mammary gland development

regulation of protein localization

limb morphogenesis

hindlimb morphogenesis

regulation of growth

negative regulation of multicellular organism growth

regulation of cell population proliferation

glucose homeostasis

intracellular membrane-bounded organelle

negative regulation of DNA-binding transcription factor activity

keratinocyte proliferation

dendritic growth cone

axonal growth cone

protein-containing complex binding

apical part of cell

positive regulation of epidermal cell differentiation

negative regulation of osteoblast differentiation

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

perinuclear region of cytoplasm

embryonic organ development

negative regulation of epithelial cell proliferation

negative regulation of cell division

pharyngeal system development

mammary gland duct morphogenesis

mammary gland epithelial cell differentiation

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

cell differentiation involved in kidney development

somite development

somite development

cellular response to cholesterol

cellular response to cholesterol

commissural neuron axon guidance

cell proliferation involved in metanephros development

protein localization to plasma membrane

hedgehog family protein binding

hedgehog family protein binding

04340

05200

05217

TC0400004012.mm.2 Agtrap angiotensin II, type I receptor-associated protein 4 -148077060 NM_009642, BC046820, BC057196 NM_009642, BC046820, BC057196 NM_009642, BC046820, BC057196 98

angiotensin type II receptor activity

protein binding

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

cell cortex

regulation of blood pressure

regulation of blood pressure

membrane

integral component of membrane

cytoplasmic vesicle

angiotensin-activated signaling pathway

identical protein binding

intracellular membrane-bounded organelle

 
TC0800001323.mm.2 Cog4 component of oligomeric golgi complex 4 8 110846599, 110847023 NM_133973, BC023120 NM_133973, BC023120 19

cytoplasm

Golgi apparatus

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Golgi organization

Golgi organization

protein transport

membrane

Golgi transport complex

Golgi transport complex

identical protein binding

Golgi vesicle prefusion complex stabilization

Golgi vesicle prefusion complex stabilization

 
TC0700001174.mm.2 Whamm WAS protein homolog associated with actin, golgi membranes and microtubules 7 81571291 NM_001004185, BC042749, BC050804 NM_001004185, BC042749, BC050804 NM_001004185, BC042749, BC050804 14

Golgi membrane

actin binding

cytoplasm

Golgi apparatus

cytosol

microtubule

endoplasmic reticulum to Golgi vesicle-mediated transport

endoplasmic reticulum to Golgi vesicle-mediated transport

endoplasmic reticulum to Golgi vesicle-mediated transport

actin filament organization

cell cycle arrest

microtubule binding

membrane

lamellipodium assembly

small GTPase binding

cytoplasmic vesicle

endoplasmic reticulum-Golgi intermediate compartment membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

Arp2/3 complex-mediated actin nucleation

focal adhesion assembly

positive regulation of actin nucleation

Arp2/3 complex binding

Arp2/3 complex binding

actin filament reorganization

plasma membrane tubulation

 
TC0500001888.mm.2 Ankib1 ankyrin repeat and IBR domain containing 1 5 -3689998, -3689998 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 NM_001003909, NM_001289527, NM_001289528, NM_001289529, BC145511, BC150792 21

ubiquitin ligase complex

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

ubiquitin-dependent protein catabolic process

transferase activity

ubiquitin conjugating enzyme binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

metal ion binding

ubiquitin protein ligase activity

 
TC0800003000.mm.2 Cdyl2 chromodomain protein, Y chromosome-like 2 8 -116568723 NM_029441, BC058956 NM_029441, BC058956 19

transcription corepressor activity

catalytic activity

nucleus

nucleus

methylated histone binding

 
TC0900001675.mm.2 Ccr5 chemokine (C-C motif) receptor 5 9 124121542 NM_009917, BC103574, BC103586, BC103587, BC105643 NM_009917, BC103574, BC103586, BC103587, BC105643 NM_009917, BC103574, BC103586, BC103587, BC105643 NM_009917, BC103574, BC103586, BC103587, BC105643 NM_009917, BC103574, BC103586, BC103587, BC105643 339

actin binding

G protein-coupled receptor activity

chemokine receptor activity

cytoplasm

cytoplasm

endosome

plasma membrane

calcium ion transport

chemotaxis

defense response

inflammatory response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell-cell signaling

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

membrane

integral component of membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

protein kinase binding

C-C chemokine binding

C-C chemokine binding

C-C chemokine binding

positive regulation of cell-cell adhesion

negative regulation of cell migration

negative regulation of axon extension

positive regulation of fever generation

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

identical protein binding

positive regulation of neuron differentiation

positive regulation of inflammatory response

positive regulation of apoptotic process by virus

cell chemotaxis

response to cholesterol

neuron death

chemokine (C-C motif) ligand 5 binding

chemokine (C-C motif) ligand 5 binding

negative regulation of macrophage apoptotic process

negative regulation of neural precursor cell proliferation

04060

04062

04144

05145

TC1600000500.mm.2 Parp9 poly (ADP-ribose) polymerase family, member 9 16 35938469 NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 NM_030253, BC003281, BC070466 21

negative regulation of transcription by RNA polymerase II

positive regulation of defense response to virus by host

immune system process

transcription corepressor activity

transcription corepressor activity

NAD+ ADP-ribosyltransferase activity

enzyme inhibitor activity

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

cytosol

DNA repair

double-strand break repair

protein ADP-ribosylation

cellular response to DNA damage stimulus

posttranscriptional regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

transferase activity

enzyme binding

protein-containing complex

positive regulation of chromatin binding

histone binding

positive regulation of tyrosine phosphorylation of STAT protein

negative regulation of catalytic activity

ubiquitin-like protein ligase binding

ubiquitin-like protein ligase binding

innate immune response

positive regulation of transcription, DNA-templated

defense response to virus

regulation of response to interferon-gamma

positive regulation of interferon-gamma-mediated signaling pathway

positive regulation of interferon-gamma-mediated signaling pathway

positive regulation of interferon-gamma-mediated signaling pathway

protein poly-ADP-ribosylation

ADP-D-ribose binding

site of DNA damage

STAT family protein binding

protein mono-ADP-ribosylation

positive regulation of protein localization to nucleus

protein ADP-ribosylase activity

positive regulation of double-strand break repair via nonhomologous end joining

 
TC1700002216.mm.2 Foxp4 forkhead box P4 17 -47867132 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 NM_001110824, NM_001110825, NM_028767, BC043702, BC052407, BC057110 58

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

heart development

identical protein binding

sequence-specific DNA binding

metal ion binding

embryonic foregut morphogenesis

lung secretory cell differentiation

regulation of lung goblet cell differentiation

negative regulation of lung goblet cell differentiation

 
TC1400000314.mm.2 Stimate STIM activating enhancer 14 30825593 NM_028839, BC024583 NM_028839, BC024583 16

calcium channel regulator activity

endoplasmic reticulum

membrane

integral component of membrane

activation of store-operated calcium channel activity

cortical endoplasmic reticulum

calcium-mediated signaling using intracellular calcium source

 
MG-1-neg-10343442_st                
TC0100000736.mm.2                
TC0600001968.mm.2 Lrrc4 leucine rich repeat containing 4 6 -28828125 NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 NM_138682, BC117833, BC117834 30

protein binding

plasma membrane

membrane

integral component of membrane

cell junction

dendritic spine

neuron spine

synapse

postsynaptic membrane

modulation of chemical synaptic transmission

synapse organization

excitatory synapse

postsynaptic density protein 95 clustering

Schaffer collateral - CA1 synapse

glutamatergic synapse

glutamatergic synapse

integral component of postsynaptic density membrane

integral component of postsynaptic density membrane

synaptic membrane adhesion

excitatory synapse assembly

 
TC1900000923.mm.2 Syt12 synaptotagmin XII 19 -4445907 NM_134164, BC116846, BC116848 NM_134164, BC116846, BC116848 NM_134164, BC116846, BC116848 16

SNARE binding

phosphatidylserine binding

calcium ion binding

calcium-dependent phospholipid binding

plasma membrane

synaptic vesicle

synaptic vesicle

regulation of dopamine secretion

membrane

integral component of membrane

vesicle-mediated transport

calcium-ion regulated exocytosis

regulation of calcium ion-dependent exocytosis

syntaxin binding

cell junction

clathrin binding

cytoplasmic vesicle

synapse

regulation of neurotransmitter secretion

spontaneous exocytosis of neurotransmitter

long-term synaptic potentiation

exocytic vesicle

cellular response to calcium ion

hippocampal mossy fiber to CA3 synapse

presynapse

 
TC0300002350.mm.2 Zbtb7b zinc finger and BTB domain containing 7B 3 -89377643, -89377643, -89377643 NM_009565, BC046533, BC091651 NM_009565, BC046533, BC091651 NM_009565, BC046533, BC091651 95

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

NK T cell differentiation

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

multicellular organism development

lactation

regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

cell differentiation

positive regulation of histone deacetylation

interleukin-17 production

response to insulin

identical protein binding

protein homodimerization activity

histone deacetylase binding

regulation of CD4-positive, alpha-beta T cell differentiation

positive regulation of CD4-positive, alpha-beta T cell differentiation

regulation of CD8-positive, alpha-beta T cell differentiation

negative regulation of CD8-positive, alpha-beta T cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of insulin receptor signaling pathway

metal ion binding

negative regulation of NK T cell proliferation

positive regulation of brown fat cell differentiation

positive regulation of cold-induced thermogenesis

sequence-specific double-stranded DNA binding

adaptive thermogenesis

negative regulation of T-helper 17 cell differentiation

positive regulation of SREBP signaling pathway

 
TC1700000469.mm.2 Uhrf1bp1 UHRF1 (ICBP90) binding protein 1 17 27856506 NM_001080769 15

cellular_component

biological_process

identical protein binding

histone deacetylase binding

histone deacetylase binding

 
MG-1-neg-10338889_st                
TC0900001867.mm.2 Cdkn2d cyclin dependent kinase inhibitor 2D 9 -21288463 NM_009878, BC013898 NM_009878, BC013898 77

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

DNA synthesis involved in DNA repair

cyclin-dependent protein serine/threonine kinase inhibitor activity

nucleus

nucleoplasm

cytoplasm

cytosol

cell cycle

cell cycle arrest

sensory perception of sound

negative regulation of cell population proliferation

response to UV

protein kinase binding

protein kinase binding

negative regulation of cell growth

response to retinoic acid

response to vitamin D

negative regulation of phosphorylation

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

autophagic cell death

cyclin D2-CDK4 complex

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

negative regulation of cell cycle G1/S phase transition

04110

TC1100000585.mm.2 Cdkl3 cyclin-dependent kinase-like 3 11 52004220, 52004220, 52004220, 52004220, 52004220 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 NM_001166653, NM_001166654, NM_001166655, NM_001166656, NM_001166657, NM_153785, BC028871 21

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

cytoplasm

protein phosphorylation

kinase activity

phosphorylation

transferase activity

negative regulation of axon extension

negative regulation of axon extension

negative regulation of axon extension

positive regulation of dendrite morphogenesis

positive regulation of dendrite morphogenesis

positive regulation of dendrite morphogenesis

dendrite extension

dendrite extension

dendrite extension

 
TC1100002374.mm.2 Rel reticuloendotheliosis oncogene 11 -23736849 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 NM_009044, BC139447, BC139448, BC139770 241

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cytokine production

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

transcription regulator complex

cytoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

inflammatory response

I-kappaB kinase/NF-kappaB signaling

I-kappaB kinase/NF-kappaB signaling

negative regulation of gene expression

negative regulation of interferon-beta production

positive regulation of interleukin-12 production

cellular response to stress

response to cytokine

NIK/NF-kappaB signaling

sequence-specific DNA binding

innate immune response

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of neuron death

 
TC1600000558.mm.2 Tmem39a transmembrane protein 39a 16 38562813, 38558697 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 NM_001205286, NM_001205287, NM_026407, BC020318 17

molecular_function

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

autophagy

membrane

integral component of membrane

positive regulation of viral genome replication

negative regulation of autophagosome maturation

negative regulation of autophagosome maturation

negative regulation of autophagosome assembly

negative regulation of autophagosome assembly

 
TC0200004813.mm.2 Napb N-ethylmaleimide sensitive fusion protein attachment protein beta 2 -148694656 NM_019632, BC038362, BC049874 NM_019632, BC038362, BC049874 NM_019632, BC038362, BC049874 33

SNARE binding

regulation of receptor internalization

soluble NSF attachment protein activity

protein binding

vacuolar membrane

intracellular protein transport

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

protein transport

membrane

vesicle-mediated transport

syntaxin binding

syntaxin binding

syntaxin binding

SNARE complex

protein-containing complex disassembly

synaptic transmission, glutamatergic

synaptic transmission, glutamatergic

SNARE complex disassembly

SNARE complex disassembly

myelin sheath

regulation of ATPase activity

synaptic vesicle endocytosis

synaptobrevin 2-SNAP-25-syntaxin-1a complex

synaptobrevin 2-SNAP-25-syntaxin-1a complex

presynapse

postsynapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

 
TC1700002791.mm.2 H2-Q1 histocompatibility 2, Q region locus 1 17 35320546 NM_010390, BC080812 NM_010390, BC080812 46

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

signaling receptor binding

extracellular space

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

plasma membrane

immune response

external side of plasma membrane

cell surface

antigen processing and presentation

beta-2-microglobulin binding

peptide binding

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD8 receptor binding

MHC class I protein complex

MHC class I peptide loading complex

protein-containing complex binding

TAP binding

TAP complex binding

endoplasmic reticulum exit site

04144

04145

04514

04612

04940

05320

05330

05332

05416

MG-1-neg-10340298_st                
TC1900000027.mm.2 Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 19 4099997, 4100621 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 NM_008851, NR_075078, BC044893, BC048150, NM_001136078 33

calcium ion binding

phospholipid binding

phospholipid transporter activity

intracellular anatomical structure

cytoplasm

endoplasmic reticulum

Golgi apparatus

lipid droplet

cytosol

phosphatidylcholine transporter activity

phosphatidylinositol transfer activity

phosphatidylinositol transfer activity

protein transport

phospholipid transport

membrane

receptor tyrosine kinase binding

phosphatidylcholine binding

phosphatidylcholine binding

phosphatidylinositol binding

phosphatidylinositol binding

intracellular membrane-bounded organelle

cell body

metal ion binding

phosphatidic acid binding

 
TC1400001741.mm.2 Ccser2 coiled-coil serine rich 2 14 -36874935, -36874935, -36874935, -36874935 NM_027045, NM_028407, BC139090 NM_027045, NM_028407, BC139090 NM_027045, NM_028407, BC139090 21

microtubule bundle formation

cytoplasm

cytoskeleton

microtubule binding

microtubule cytoskeleton

 
MG-1-neg-10340353_st                
TC0600000240.mm.2 Tspan33 tetraspanin 33 6 29694213 NM_146173, BC024685 NM_146173, BC024685 18

cytoplasm

plasma membrane

integral component of plasma membrane

cell surface

membrane

integral component of membrane

enzyme binding

enzyme binding

cell junction

pore complex

pore complex

pore complex assembly

pore complex assembly

protein maturation

protein maturation

protein maturation

protein localization to plasma membrane

protein localization to plasma membrane

protein localization to plasma membrane

tetraspanin-enriched microdomain

 
TC1300002534.mm.2 Naip1 NLR family, apoptosis inhibitory protein 1 13 -100407769 NM_008670, BC132413 NM_008670, BC132413 46

nucleotide binding

cysteine-type endopeptidase inhibitor activity

ATP binding

cytoplasm

cytoplasm

apoptotic process

inflammatory response

negative regulation of peptidase activity

detection of bacterium

basolateral plasma membrane

peptidase inhibitor activity

defense response to bacterium

neuron projection

neuronal cell body

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

perikaryon

metal ion binding

pyroptosis

cellular response to estrogen stimulus

IPAF inflammasome complex

04621

TC0300000631.mm.2 Pdgfc platelet-derived growth factor, C polypeptide 3 81036415 NM_019971, BC037696 NM_019971, BC037696 85

platelet-derived growth factor receptor binding

platelet-derived growth factor receptor binding

platelet-derived growth factor receptor binding

extracellular region

extracellular space

extracellular space

nucleus

cytoplasm

cytosol

plasma membrane

activation of transmembrane receptor protein tyrosine kinase activity

multicellular organism development

growth factor activity

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

animal organ morphogenesis

animal organ morphogenesis

cell surface

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

positive regulation of cell migration

positive regulation of protein autophosphorylation

protein homodimerization activity

positive regulation of MAP kinase activity

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

positive regulation of fibroblast proliferation

digestive tract development

embryonic organ development

regulation of peptidyl-tyrosine phosphorylation

positive regulation of cell division

bone development

positive regulation of ERK1 and ERK2 cascade

growth factor receptor binding

cellular response to amino acid stimulus

positive regulation of cold-induced thermogenesis

04060

04510

04540

04810

05215

05218

TC0300000305.mm.2 Intu inturned planar cell polarity protein 3 40540766 NM_175515, BC125523, BC132387 NM_175515, BC125523, BC132387 NM_175515, BC125523, BC132387 18

establishment of planar polarity

protein binding

cytoplasm

cytoskeleton

multicellular organism development

nervous system development

regulation of smoothened signaling pathway

negative regulation of keratinocyte proliferation

spinal cord dorsal/ventral patterning

neural tube development

cell projection organization

keratinocyte differentiation

regulation of ossification

hair follicle morphogenesis

motile cilium

ciliary basal body

embryonic digit morphogenesis

embryonic digit morphogenesis

cell projection

tongue morphogenesis

motile cilium assembly

positive regulation of smoothened signaling pathway

negative regulation of cell division

roof of mouth development

limb development

cilium assembly

non-motile cilium assembly

 
TC0800003224.mm.2 Zdhhc2 zinc finger, DHHC domain containing 2 8 40423814 NM_178395, BC127156 NM_178395, BC127156 32

endosome

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

Golgi apparatus

plasma membrane

integral component of plasma membrane

protein targeting to membrane

postsynaptic density

membrane

integral component of membrane

synaptic vesicle maturation

palmitoyltransferase activity

palmitoyltransferase activity

transferase activity

transferase activity, transferring acyl groups

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein palmitoylation

protein-cysteine S-myristoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

regulation of cell-cell adhesion

cell junction

regulation of protein catabolic process

protein homodimerization activity

synapse

regulation of neuronal synaptic plasticity

recycling endosome membrane

protein localization to plasma membrane

protein localization to plasma membrane

postsynaptic recycling endosome

protein-cysteine S-stearoyltransferase activity

positive regulation of long-term synaptic potentiation

regulation of protein localization to plasma membrane

protein localization to postsynaptic membrane

positive regulation of AMPA glutamate receptor clustering

positive regulation of endosome to plasma membrane protein transport

 
TC0100002602.mm.2 Atg9a autophagy related 9A 1 -75180860 NM_001003917, NM_001288612, NM_001288613, NR_109938, BC079884 NM_001003917, NM_001288612, NM_001288613, NR_109938, BC079884 NM_001003917, NM_001288612, NM_001288613, NR_109938, BC079884 NM_001003917, NM_001288612, NM_001288613, NR_109938, BC079884 NM_001003917, NM_001288612, NM_001288613, NR_109938, BC079884 40

autophagosome assembly

autophagosome assembly

phagophore assembly site

phagophore assembly site

autophagy of mitochondrion

molecular_function

cytoplasm

endosome

late endosome

autophagosome

autophagosome

Golgi apparatus

trans-Golgi network

autophagy

synaptic vesicle

protein transport

membrane

integral component of membrane

cytoplasmic vesicle

negative regulation of interferon-beta production

protein localization to Golgi apparatus

protein localization to phagophore assembly site

intracellular membrane-bounded organelle

late nucleophagy

innate immune response

recycling endosome

 
MG-1-neg-10342467_st                
TC0200000525.mm.2 Tbc1d13 TBC1 domain family, member 13 2 30133745 NM_146252, BC025586 NM_146252, BC025586 21

GTPase activator activity

GTPase activator activity

protein binding

cytoplasm

cytosol

intracellular protein transport

intracellular protein transport

membrane

small GTPase binding

activation of GTPase activity

 
TC0100001468.mm.2 Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 1 161395437 NM_009452, BC153120 NM_009452, BC153120 112

blood vessel development

negative regulation of cytokine production

positive regulation of cytokine production

defense response to nematode

acute inflammatory response

positive regulation of immunoglobulin production

positive regulation of immune effector process

positive regulation of T cell cytokine production

regulation of adaptive immune response

positive regulation of type 2 immune response

positive regulation of type 2 immune response

positive regulation of immunoglobulin mediated immune response

cytokine activity

tumor necrosis factor receptor binding

protein binding

extracellular space

extracellular space

inflammatory response

inflammatory response

immune response

cholesterol metabolic process

response to virus

cell surface

membrane

integral component of membrane

negative regulation of interferon-gamma production

negative regulation of interleukin-17 production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-13 production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

positive regulation of interleukin-4 production

positive regulation of interleukin-4 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

tumor necrosis factor receptor superfamily binding

tumor necrosis factor receptor superfamily binding

tumor necrosis factor receptor superfamily binding

memory T cell activation

T-helper 2 cell activation

response to nitrogen dioxide

cellular response to nitrogen dioxide

CD4-positive, alpha-beta T cell costimulation

T cell proliferation

positive regulation of T cell proliferation

positive regulation of activated T cell proliferation

positive regulation of CD4-positive, alpha-beta T cell differentiation

positive regulation of memory T cell differentiation

negative regulation of DNA-binding transcription factor activity

innate immune response

negative regulation of regulatory T cell differentiation

negative regulation of T-helper 1 cell differentiation

positive regulation of T-helper 2 cell differentiation

negative regulation of transcription, DNA-templated

positive regulation of alpha-beta T cell proliferation

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of B cell activation

negative regulation of T cell apoptotic process

negative regulation of activation-induced cell death of T cells

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to prostaglandin E stimulus

chemokine (C-C motif) ligand 11 production

positive regulation of CD4-positive, alpha-beta T cell costimulation

positive regulation of T cell migration

positive regulation of T cell costimulation

positive regulation of memory T cell activation

positive regulation of T-helper 2 cell activation

positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

negative regulation of extrinsic apoptotic signaling pathway

04060

MG-1-neg-10338492_st                
TC1600000346.mm.2 Rtp4 receptor transporter protein 4 16 23609918 NM_023386, BC024872 NM_023386, BC024872 15

detection of chemical stimulus involved in sensory perception of bitter taste

detection of chemical stimulus involved in sensory perception of bitter taste

protein binding

cytoplasm

cytoplasm

protein targeting to membrane

protein targeting to membrane

membrane

integral component of membrane

olfactory receptor binding

protein insertion into membrane

defense response to virus

 
TC0700003938.mm.2 Trim12a tripartite motif-containing 12A 7 -104299896, -104303594 NM_023835, BC094899 NM_023835, BC094899 20

protein polyubiquitination

ubiquitin-protein transferase activity

nucleoplasm

cytoplasm

cytoplasm

cytosol

autophagy

zinc ion binding

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

protein kinase binding

regulation of protein localization

protein homodimerization activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

regulation of viral entry into host cell

metal ion binding

positive regulation of NF-kappaB transcription factor activity

defense response to virus

ubiquitin protein ligase activity

 
TC1200000878.mm.2 Slirp SRA stem-loop interacting RNA binding protein 12 87443895 NM_026958, BC116739, BC116741 NM_026958, BC116739, BC116741 NM_026958, BC116739, BC116741 25

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial RNA catabolic process

acrosomal vesicle

nucleic acid binding

RNA binding

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

spermatid development

single fertilization

flagellated sperm motility

sperm flagellum

perinuclear region of cytoplasm

mitochondrion morphogenesis

mitochondrion morphogenesis

ribonucleoprotein complex

 
TC0300000092.mm.2 Car13 carbonic anhydrase 13 3 14641726 NM_024495, BC064050 NM_024495, BC064050 21

carbonate dehydratase activity

carbonate dehydratase activity

cytoplasm

cytosol

cytosol

one-carbon metabolic process

zinc ion binding

lyase activity

hydro-lyase activity

myelin sheath

intracellular membrane-bounded organelle

metal ion binding

00910

TC1100002574.mm.2 Ttc1 tetratricopeptide repeat domain 1 11 -43730005 NM_133795, BC010236 NM_133795, BC010236 20

molecular_function

cytosol

biological_process

 
TC1400000833.mm.2 Rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 14 59201227, 59201227 NM_027764, BC067005 NM_027764, BC067005 22

nucleus

cytoplasm

chromatin organization

cell cycle

 
TC0600000135.mm.2 St7 suppression of tumorigenicity 7 6 17749169, 17743591, 17693993 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 NM_001083315, NM_001289624, NM_001289625, NM_001289626, NM_001289627, NM_001289629, NM_022332, BC024652, BC108418 21

membrane

integral component of membrane

 
TC1000002645.mm.2 Chpt1 choline phosphotransferase 1 10 -88472812, -88473475 NM_001146690, NM_144807, NR_027477, BC016251, BC031435 NM_001146690, NM_144807, NR_027477, BC016251, BC031435 NM_001146690, NM_144807, NR_027477, BC016251, BC031435 NM_001146690, NM_144807, NR_027477, BC016251, BC031435 NM_001146690, NM_144807, NR_027477, BC016251, BC031435 20

diacylglycerol cholinephosphotransferase activity

diacylglycerol cholinephosphotransferase activity

endoplasmic reticulum membrane

Golgi apparatus

Golgi apparatus

lipid metabolic process

phosphatidylcholine biosynthetic process

phosphatidylcholine biosynthetic process

platelet activating factor biosynthetic process

phospholipid biosynthetic process

membrane

integral component of membrane

transferase activity

phosphotransferase activity, for other substituted phosphate groups

metal ion binding

00564

00565

01100

MG-1-neg-10344031_st                
TC1400002310.mm.2 Slc25a37 solute carrier family 25, member 37 14 -69241850 NM_026331, BC040399 NM_026331, BC040399 35

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

iron import into the mitochondrion

iron import into the mitochondrion

 
TC0700003998.mm.2         NR_030719, NR_030720 NR_030719, NR_030720      
TC0700004007.mm.2 Gvin-ps5 GTPase, very large interferon inducible, pseudogene 5 7 -106322395, -106075731 NR_030720 7    
TC0800000483.mm.2 Pdgfrl platelet-derived growth factor receptor-like 8 40926232 NM_026840, BC058275 NM_026840, BC058275 14

molecular_function

cellular_component

extracellular region

biological_process

 
TC0800002178.mm.2 Ing2 inhibitor of growth family, member 2 8 -47667177 NM_023503, BC096433, BC138229 NM_023503, BC096433, BC138229 NM_023503, BC096433, BC138229 28

DNA binding

chromatin binding

nucleus

nucleus

nucleoplasm

plasma membrane

chromatin organization

regulation of transcription, DNA-templated

male meiosis I

spermatogenesis

spermatid development

negative regulation of cell population proliferation

Sin3 complex

CCAAT-binding factor complex

flagellated sperm motility

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of histone deacetylation

methylated histone binding

methylated histone binding

phosphatidylinositol binding

regulation of growth

regulation of apoptotic process

protein-containing complex binding

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

metal ion binding

male germ-line stem cell asymmetric division

seminiferous tubule development

regulation of cellular senescence

negative regulation of apoptotic signaling pathway

 
TC1100001722.mm.2 Arf2 ADP-ribosylation factor 2 11 103966870, 103966724 NM_007477, BC010487 NM_007477, BC010487 22

nucleotide binding

GTP binding

GTP binding

cytoplasm

Golgi apparatus

plasma membrane

intracellular protein transport

protein transport

vesicle-mediated transport

 
TC0200003670.mm.2 Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 2 -66082765 NM_015736, BC043331 NM_015736, BC043331 39

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

Golgi apparatus

Golgi apparatus

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

protein O-linked glycosylation via threonine

manganese ion binding

carbohydrate binding

metal ion binding

perinuclear region of cytoplasm

00512

01100

TC1700002308.mm.2 Stap2 signal transducing adaptor family member 2 17 -55997075, -55997078 NM_145934, NR_102313, BC026642 NM_145934, NR_102313, BC026642 NM_145934, NR_102313, BC026642 30

protein binding

cytoplasm

plasma membrane

membrane

signaling adaptor activity

 
TC1300001430.mm.2 Chrm3 cholinergic receptor, muscarinic 3, cardiac 13 -9876612 NM_033269, BC129892, BC129893 NM_033269, BC129892, BC129893 NM_033269, BC129892, BC129893 164

regulation of vascular associated smooth muscle contraction

negative regulation of heart rate by acetylcholine

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

protein binding

endoplasmic reticulum

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

smooth muscle contraction

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

chemical synaptic transmission

synaptic transmission, cholinergic

basal plasma membrane

membrane

integral component of membrane

G protein-coupled acetylcholine receptor activity

G protein-coupled acetylcholine receptor activity

calcium-mediated signaling

cell junction

dendrite

dendrite

neurotransmitter receptor activity

asymmetric synapse

regulation of ion transmembrane transporter activity

acetylcholine binding

axon terminus

synapse

postsynaptic membrane

positive regulation of vasoconstriction

positive regulation of smooth muscle contraction

saliva secretion

acetylcholine receptor signaling pathway

glutamatergic synapse

integral component of presynaptic membrane

integral component of postsynaptic density membrane

positive regulation of vascular associated smooth muscle contraction

04020

04080

04810

04970

04971

04972

MG-1-neg-10338281_st                
TC0100001600.mm.2 Slamf1 signaling lymphocytic activation molecule family member 1 1 171767131, 171767131 NM_013730, BC117095, BC117099 NM_013730, BC117095, BC117099 NM_013730, BC117095, BC117099 74

natural killer cell differentiation

natural killer cell proliferation

leukocyte chemotaxis involved in inflammatory response

adaptive immune response

myeloid dendritic cell activation involved in immune response

immune system process

negative regulation of T cell cytokine production

protein binding

plasma membrane

phagocytosis

cell adhesion

external side of plasma membrane

cell surface

positive regulation of macrophage chemotaxis

membrane

integral component of membrane

regulation of vesicle fusion

negative regulation of interferon-gamma production

negative regulation of interleukin-12 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of interferon-gamma production

T-helper 1 cell cytokine production

signaling receptor activity

positive regulation of activated T cell proliferation

SH2 domain binding

identical protein binding

identical protein binding

innate immune response

phagocytic vesicle

positive regulation of JNK cascade

lymphocyte activation

regulation of catalytic activity

positive regulation of ERK1 and ERK2 cascade

negative regulation of CD40 signaling pathway

positive regulation of dendritic cell chemotaxis

 
MG-1-pos-10338817_st                
TC1400000843.mm.2 Mtmr6 myotubularin related protein 6 14 60265204 NM_144843, BC020019 NM_144843, BC020019 19

phosphatidylinositol-3-phosphatase activity

phosphatidylinositol-3-phosphatase activity

protein tyrosine phosphatase activity

nuclear envelope

nuclear envelope

cytoplasm

cytoplasm

endoplasmic reticulum

plasma membrane

lipid metabolic process

endocytosis

membrane

dephosphorylation

hydrolase activity

cell projection

phosphatidylinositol dephosphorylation

phosphatidylinositol dephosphorylation

phosphatidylinositol phosphate phosphatase activity

phosphatidylinositol-3,5-bisphosphate phosphatase activity

phosphatidylinositol-3,5-bisphosphate phosphatase activity

00051

TC1200001763.mm.2 Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma 12 -55280855 NM_021529, BC024754, BC138295, BC138296 NM_021529, BC024754, BC138295, BC138296 NM_021529, BC024754, BC138295, BC138296 NM_021529, BC024754, BC138295, BC138296 25

microtubule cytoskeleton organization

B cell homeostasis

B cell homeostasis

regulation of antimicrobial humoral response

protein binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

centrosome

centrosome

spindle

cytosol

cortical cytoskeleton organization

activation of protein kinase activity

regulation of dephosphorylation

T cell homeostasis

T cell homeostasis

positive regulation of B cell differentiation

positive regulation of B cell differentiation

metal ion binding

spleen development

regulation of B cell activation

regulation of mitochondrial depolarization

03015

TC0600000007.mm.2 Gng11 guanine nucleotide binding protein (G protein), gamma 11 6 4003986 NM_025331, BC039062, BC040065 NM_025331, BC039062, BC040065 NM_025331, BC039062, BC040065 17

GTPase activity

heterotrimeric G-protein complex

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

G-protein beta/gamma-subunit complex

G-protein beta-subunit binding

04062

TC0700001876.mm.2 Itgax integrin alpha X 7 128129549, 128129549 NM_021334, BC167225 NM_021334, BC167225 159

cell adhesion

integrin-mediated signaling pathway

positive regulation of cell population proliferation

integrin complex

external side of plasma membrane

cell surface

positive regulation of gene expression

positive regulation of gene expression

membrane

integral component of membrane

positive regulation of cell migration

receptor tyrosine kinase binding

positive regulation of myelination

heterotypic cell-cell adhesion

positive regulation of angiogenesis

metal ion binding

defense response to virus

positive regulation of endothelial tube morphogenesis

04810

TC0300000307.mm.2 Hspa4l heat shock protein 4 like 3 40745612 NM_011020, BC012712, BC057002, BC110662 NM_011020, BC012712, BC057002, BC110662 NM_011020, BC012712, BC057002, BC110662 NM_011020, BC012712, BC057002, BC110662 40

nucleotide binding

protein binding

ATP binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

protein folding

response to unfolded protein

04141

TC0500000738.mm.2 Rest RE1-silencing transcription factor 5 77265493 NM_011263, BC127065 NM_011263, BC127065 200

negative regulation of transcription by RNA polymerase II

regulation of alternative mRNA splicing, via spliceosome

chromatin

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

response to hypoxia

hematopoietic progenitor cell differentiation

response to ischemia

nucleic acid binding

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription factor binding

negative regulation of cell population proliferation

regulation of gene expression

regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

transcription repressor complex

transcription repressor complex

transcription repressor complex

negative regulation of aldosterone biosynthetic process

protein-containing complex

cellular response to stress

somatic stem cell population maintenance

cellular response to drug

identical protein binding

positive regulation of apoptotic process

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation by host of viral transcription

protein-containing complex binding

negative regulation of neuron differentiation

negative regulation of neuron differentiation

negative regulation of neuron differentiation

negative regulation of neuron differentiation

positive regulation of neuron differentiation

regulation of osteoblast differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of calcium ion-dependent exocytosis

negative regulation of insulin secretion

metal ion binding

negative regulation of neurogenesis

neuromuscular process controlling balance

detection of mechanical stimulus involved in sensory perception of sound

auditory receptor cell stereocilium organization

cardiac muscle cell myoblast differentiation

histone H4 deacetylation

cellular response to electrical stimulus

cellular response to glucocorticoid stimulus

neuronal stem cell population maintenance

modification of synaptic structure

positive regulation of stem cell population maintenance

regulation of oxidative stress-induced neuron death

negative regulation of oxidative stress-induced neuron death

positive regulation of oxidative stress-induced neuron death

negative regulation of cortisol biosynthetic process

negative regulation of transcription regulatory region DNA binding

negative regulation of dense core granule biogenesis

negative regulation of mesenchymal stem cell differentiation

negative regulation of amniotic stem cell differentiation

05016

MG-1-neg-10340782_st                
TC1200000530.mm.2 Wdr20rt WD repeat domain 20, retrogene 12 65225516 NM_027614, BC050778 NM_027614, BC050778 11

molecular_function

cellular_component

 
TC0200001036.mm.2 Hat1 histone aminotransferase 1 2 71389259 NM_026115, BC055460 NM_026115, BC055460 36

chromatin

histone acetyltransferase activity

nucleus

nucleoplasm

chromatin organization

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

chromatin silencing at telomere

H4 histone acetyltransferase activity

H4 histone acetyltransferase activity

histone acetylation

transferase activity

transferase activity, transferring acyl groups

protein-containing complex

histone binding

histone H4 acetylation

histone H4 acetylation

 
TC1800000105.mm.2 Ttc39c tetratricopeptide repeat domain 39C 18 12643532 NM_028341, BC020021 NM_028341, BC020021 17

molecular_function

cellular_component

otolith morphogenesis

cilium assembly

 
TC1100002755.mm.2 Pdlim4 PDZ and LIM domain 4 11 -54054927 NM_019417, BC030068 NM_019417, BC030068 36

stress fiber

stress fiber

actin binding

protein binding

nucleus

cytoplasm

endosome

cytoskeleton

adherens junction

heart development

actin cytoskeleton

membrane

protein phosphatase binding

protein phosphatase binding

Z disc

lamellipodium

actin cytoskeleton organization

actin cytoskeleton organization

cell junction

actin cytoskeleton reorganization

early endosome lumen

filamentous actin

filamentous actin

recycling endosome lumen

protein homodimerization activity

actinin binding

cell projection

neuron projection

dendritic spine

synapse

postsynaptic membrane

metal ion binding

perinuclear region of cytoplasm

muscle alpha-actinin binding

alpha-actinin binding

positive regulation of stress fiber assembly

muscle structure development

excitatory chemical synaptic transmission

 
TC0200003601.mm.2 Ly75 lymphocyte antigen 75 2 -60292102 NM_013825, BC150734 NM_013825, BC150734 67

endocytosis

external side of plasma membrane

external side of plasma membrane

membrane

integral component of membrane

carbohydrate binding

signaling receptor activity

 
TC0100000292.mm.2 Il1r2 interleukin 1 receptor, type II 1 40084713, 40086092 NM_010555, BC032962 NM_010555, BC032962 52

interleukin-1 receptor activity

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

extracellular region

cytoplasm

plasma membrane

negative regulation of protein processing

membrane

integral component of membrane

interleukin-1 binding

interleukin-1 binding

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of interleukin-1-mediated signaling pathway

04010

04060

04640

05146

MG-1-neg-10340391_st                
MG-1-pos-10340242_st                
TC0600003482.mm.2 Amn1 antagonist of mitotic exit network 1 6 -149157576, -149157580 NM_001113424 18

protein binding

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

 
MG-1-neg-10340044_st                
TC1300001526.mm.2 Gpr141 G protein-coupled receptor 141 13 -19749681 NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 NM_181754, BC125585, BC125587 13

G protein-coupled receptor activity

cellular_component

plasma membrane

signal transduction

membrane

integral component of membrane

 
TC1000002664.mm.2 Apaf1 apoptotic peptidase activating factor 1 10 -90989310 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 NM_001042558, NM_001282947, NM_009684, BC131683, BC131684 151

nucleotide binding

neural tube closure

ATP binding

nucleus

cytoplasm

cytosol

cytosol

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

multicellular organism development

brain development

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

cysteine-type endopeptidase activator activity involved in apoptotic process

cardiac muscle cell apoptotic process

forebrain development

heat shock protein binding

protein-containing complex

identical protein binding

identical protein binding

regulation of apoptotic process

apoptosome

ADP binding

neuron apoptotic process

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to transforming growth factor beta stimulus

apoptotic signaling pathway

regulation of apoptotic DNA fragmentation

positive regulation of apoptotic signaling pathway

04115

04210

05010

05012

05014

05016

05222

MG-1-neg-10338225_st                
TC1300000514.mm.2 Jarid2 jumonji, AT rich interactive domain 2 13 44730773, 44731270 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 NM_001205043, NM_001205044, NM_021878, BC052444, BC060695 106

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

liver development

DNA binding

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

mitochondrion

chromatin organization

chromatin remodeling

multicellular organism development

transcription factor binding

negative regulation of cell population proliferation

negative regulation of cardiac muscle hypertrophy

cell differentiation

negative regulation of histone methylation

histone methyltransferase complex

ESC/E(Z) complex

ESC/E(Z) complex

regulation of cell population proliferation

negative regulation of transcription, DNA-templated

spleen development

thymus development

stem cell differentiation

positive regulation of histone H3-K9 methylation

negative regulation of cardiac muscle cell proliferation

cellular response to leukemia inhibitory factor

 
TC0100003891.mm.2 Ifi203 interferon activated gene 203 1 -173920400, -173920400 BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 BC008167, NM_001045481, NM_008328 26

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

cytosol

transcription factor binding

cellular response to interferon-beta

cellular response to interferon-beta

identical protein binding

 
MG-1-neg-10341133_st                
TC0200001535.mm.2 Abtb2 ankyrin repeat and BTB (POZ) domain containing 2 2 103566309 NM_178890, BC054399 NM_178890, BC054399 25

protein heterodimerization activity

cellular response to toxic substance

 
TC1000001743.mm.2 Adgb androglobin 10 -10335702 NM_001127353, BC153036 NM_001127353, BC153036 11

calcium-dependent cysteine-type endopeptidase activity

intracellular anatomical structure

proteolysis

oxygen binding

heme binding

 
TC1800000006.mm.2 Cul2 cullin 2 18 3383224, 3382969 NM_029402, BC026779, BC027428 NM_029402, BC026779, BC027428 NM_029402, BC026779, BC027428 35

ubiquitin-protein transferase activity

protein binding

nucleoplasm

nucleolus

ubiquitin-dependent protein catabolic process

protein ubiquitination

SCF ubiquitin ligase complex

protein catabolic process

VCB complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

cullin-RING ubiquitin ligase complex

Cul2-RING ubiquitin ligase complex

Cul2-RING ubiquitin ligase complex

Cul2-RING ubiquitin ligase complex

ubiquitin protein ligase binding

ubiquitin protein ligase binding

protein-containing complex binding

04120

05200

05211

TC1700000117.mm.2 Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) 17 12119283 NM_026644, BC047281 NM_026644, BC047281 28

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

lipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

phospholipid biosynthetic process

endomembrane system

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

lysophosphatidic acid acyltransferase activity

00561

00564

01100

TC1100003638.mm.2 Tbkbp1 TBK1 binding protein 1 11 -97136172, -97136172, -97136172 NM_198100, BC057590 NM_198100, BC057590 20

immune system process

protein binding

cytoplasm

I-kappaB kinase/NF-kappaB signaling

innate immune response

metal ion binding

04622

TC1000001962.mm.2 Rnf217 ring finger protein 217 10 -31501886 NM_001146349 7

ubiquitin ligase complex

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

ubiquitin-dependent protein catabolic process

membrane

integral component of membrane

protein ubiquitination

transferase activity

ubiquitin conjugating enzyme binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

metal ion binding

ubiquitin protein ligase activity

 
TC1400002454.mm.2 Lacc1 laccase domain containing 1 14 -77024200 NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 NM_172488, BC116748, BC119140 18

pattern recognition receptor signaling pathway

cytokine production involved in immune response

immune system process

adenosine deaminase activity

purine-nucleoside phosphorylase activity

copper ion binding

nucleus

cytoplasm

peroxisome

endoplasmic reticulum

inflammatory response

transferase activity

hydrolase activity

S-methyl-5-thioadenosine phosphorylase activity

regulation of cellular pH

innate immune response

metal ion binding

guanosine phosphorylase activity

regulation of inflammatory response

nucleotide-binding oligomerization domain containing 2 signaling pathway

regulation of purine nucleotide metabolic process

 
TC0600001595.mm.2 Cdkn1b cyclin-dependent kinase inhibitor 1B 6 134920400 NM_009875, BC014296 NM_009875, BC014296 921

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

G1/S transition of mitotic cell cycle

G1/S transition of mitotic cell cycle

placenta development

protein kinase inhibitor activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

endosome

cytosol

cytosol

potassium ion transport

cell cycle

cell cycle arrest

cell cycle arrest

cell cycle arrest

regulation of exit from mitosis

Notch signaling pathway

heart development

sensory perception of sound

cell death

positive regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

positive regulation of cell death

protein kinase binding

protein phosphatase binding

negative regulation of cell growth

cyclin binding

cyclin binding

Hsp70 protein binding

positive regulation of microtubule polymerization

protein-containing complex

negative regulation of kinase activity

regulation of cell population proliferation

negative regulation of phosphorylation

negative regulation of apoptotic process

intracellular membrane-bounded organelle

protein-containing complex binding

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cell cycle

negative regulation of transcription, DNA-templated

negative regulation of mitotic cell cycle

negative regulation of mitotic cell cycle

autophagic cell death

inner ear development

negative regulation of epithelial cell proliferation

chaperone binding

chaperone binding

negative regulation of cellular component movement

negative regulation of epithelial cell proliferation involved in prostate gland development

cellular response to antibiotic

cellular response to lithium ion

cellular response to organic cyclic compound

mitotic cell cycle arrest

mitotic cell cycle arrest

regulation of lens fiber cell differentiation

regulation of cell cycle G1/S phase transition

negative regulation of cyclin-dependent protein kinase activity

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cardiac muscle tissue regeneration

04012

04110

05200

05215

05220

05222

TC0700001262.mm.2 Rab38 RAB38, member RAS oncogene family 7 88430272 NM_028238, BC089578 NM_028238, BC089578 39

nucleotide binding

GTPase activity

protein binding

GTP binding

cytoplasm

mitochondrion

lysosome

early endosome

endoplasmic reticulum

Golgi apparatus

trans-Golgi network

cytosol

plasma membrane

intracellular protein transport

mitochondrion organization

endomembrane system

protein transport

membrane

vesicle-mediated transport

GTP-dependent protein binding

cytoplasmic vesicle

vesicle

melanosome organization

melanosome membrane

endosome to melanosome transport

AP-1 adaptor complex binding

AP-3 adaptor complex binding

BLOC-2 complex binding

melanosome

melanosome

melanosome

mitochondria-associated endoplasmic reticulum membrane

phagocytic vesicle

platelet dense granule organization

protein localization to membrane

phagosome acidification

melanosome assembly

positive regulation of phosphatidylcholine biosynthetic process

 
TC0300000139.mm.2 Hltf helicase-like transcription factor 3 20058290, 20057810 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 NM_009210, NR_105046, NR_105047, BC057116, BC059240, NM_144959 33

nucleotide binding

nucleic acid binding

DNA binding

catalytic activity

helicase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

chromatin organization

DNA-dependent ATPase activity

metabolic process

zinc ion binding

protein ubiquitination

transferase activity

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

protein phosphopantetheinylation

ubiquitin protein ligase binding

positive regulation of transcription by RNA polymerase II

metal ion binding

ubiquitin protein ligase activity

 
TC0700003763.mm.2 Usp35 ubiquitin specific peptidase 35 7 -97309405 NM_001177412 4

cysteine-type endopeptidase activity

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

nucleus

cytosol

protein deubiquitination

protein deubiquitination

 
TC0200003532.mm.2 Arl5a ADP-ribosylation factor-like 5A 2 -52397950 NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307 NM_182994, BC048170, BC100307 16

nucleotide binding

GTP binding

cytoplasm

trans-Golgi network

intracellular protein transport

vesicle-mediated transport

protein localization to Golgi membrane

protein localization to Golgi membrane

 
TC1100002746.mm.2                
TC0100002552.mm.2 Mreg melanoregulin 1 -72159232, -72159232 NM_001005423, BC068125 NM_001005423, BC068125 33

protein binding

lysosome

plasma membrane

lipid binding

membrane

melanocyte differentiation

melanocyte differentiation

cytoplasmic vesicle membrane

intrinsic component of organelle membrane

cytoplasmic vesicle

late endosome membrane

melanosome localization

melanosome transport

melanosome transport

protein-containing complex

melanosome membrane

phosphatidylinositol binding

melanosome

melanosome

anagen

pigmentation

developmental pigmentation

minus-end-directed organelle transport along microtubule

phagosome maturation

 
TC1200000432.mm.2 Akap6 A kinase (PRKA) anchor protein 6 12 52699382 NM_198111, BC057114 NM_198111, BC057114 27

positive regulation of protein phosphorylation

protein binding

nucleus

nuclear envelope

cytoplasm

caveola

negative regulation of adenylate cyclase activity

adenylate cyclase binding

adenylate cyclase binding

regulation of protein kinase A signaling

junctional sarcoplasmic reticulum membrane

intercalated disc

sarcoplasmic reticulum

sarcoplasmic reticulum

enzyme binding

positive regulation of cell growth

T-tubule

nuclear membrane

nuclear membrane

protein-containing complex

protein kinase A regulatory subunit binding

cellular protein-containing complex localization

calcium channel complex

sarcolemma

protein-membrane adaptor activity

ion channel binding

ion channel binding

positive regulation of translation

perinuclear region of cytoplasm

perinuclear region of cytoplasm

perinuclear region of cytoplasm

protein kinase A binding

protein kinase A binding

positive regulation of release of sequestered calcium ion into cytosol

protein phosphatase 2A binding

molecular adaptor activity

regulation of membrane repolarization

positive regulation of ryanodine-sensitive calcium-release channel activity

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of calcineurin-NFAT signaling cascade

cellular response to cAMP

cellular response to cytokine stimulus

cellular response to epinephrine stimulus

regulation of cardiac muscle cell contraction

positive regulation of potassium ion transmembrane transport

regulation of relaxation of cardiac muscle

positive regulation of delayed rectifier potassium channel activity

positive regulation of cAMP-dependent protein kinase activity

 
MG-1-neg-10340949_st                
TC0400003581.mm.2 Azin2 antizyme inhibitor 2 4 -128930232, -128932016 NM_172875, BC138973, BC138974 NM_172875, BC138973, BC138974 NM_172875, BC138973, BC138974 29

catalytic activity

protein binding

nucleus

cytoplasm

mitochondrion

Golgi apparatus

cis-Golgi network

trans-Golgi network

cytosol

ornithine metabolic process

polyamine biosynthetic process

membrane

transport vesicle

axon

dendrite

cytoplasmic vesicle

endoplasmic reticulum-Golgi intermediate compartment membrane

putrescine biosynthetic process from ornithine

negative regulation of protein catabolic process

negative regulation of protein catabolic process

ornithine decarboxylase activator activity

ornithine decarboxylase activator activity

ornithine decarboxylase activator activity

ornithine decarboxylase activator activity

cell projection

positive regulation of catalytic activity

positive regulation of catalytic activity

perikaryon

perinuclear region of cytoplasm

trans-Golgi network membrane organization

positive regulation of polyamine transmembrane transport

positive regulation of polyamine transmembrane transport

granular vesicle

00330

01100

MG-1-neg-10342058_st                
TC0200005181.mm.2 Znfx1 zinc finger, NFX1-type containing 1 2 -167035795, -167035796 NM_001033196 24

DNA-binding transcription factor activity

RNA binding

nucleus

regulation of transcription, DNA-templated

zinc ion binding

heterochromatin assembly by small RNA

nuclear RNA-directed RNA polymerase complex

metal ion binding

 
TC0900000599.mm.2 Il18 interleukin 18 9 50554699 NM_008360, BC024384 NM_008360, BC024384 586

MAPK cascade

angiogenesis

angiogenesis

response to hypoxia

cytokine activity

cytokine activity

cytokine activity

extracellular region

extracellular space

extracellular space

cytoplasm

inflammatory response

inflammatory response

immune response

cell population proliferation

cell population proliferation

extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of gene expression

positive regulation of macrophage derived foam cell differentiation

positive regulation of phosphatidylinositol 3-kinase signaling

positive regulation of smooth muscle cell migration

apical plasma membrane

natural killer cell activation

regulation of cell adhesion

regulation of cell adhesion

sleep

sleep

lipopolysaccharide-mediated signaling pathway

activation of protein kinase B activity

interferon-gamma production

interleukin-13 production

interleukin-6 production

positive regulation of chemokine production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interleukin-17 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of natural killer cell proliferation

positive regulation of superoxide anion generation

positive regulation of collagen biosynthetic process

negative regulation of neutrophil apoptotic process

interleukin-18-mediated signaling pathway

interleukin-18-mediated signaling pathway

T-helper 1 cell cytokine production

T-helper 1 cell cytokine production

T-helper 1 type immune response

T-helper 1 type immune response

positive regulation of activated T cell proliferation

positive regulation of activated T cell proliferation

neutrophil activation

natural killer cell mediated cytotoxicity

positive regulation of tyrosine phosphorylation of STAT protein

cholesterol homeostasis

positive regulation of apoptotic process

positive regulation of vascular permeability

positive regulation of neuron apoptotic process

interleukin-18 receptor binding

positive regulation of T-helper 2 cell differentiation

negative regulation of myoblast differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of smooth muscle cell proliferation

negative regulation of peptidyl-tyrosine phosphorylation

detection of mechanical stimulus involved in sensory perception of pain

positive regulation of NF-kappaB transcription factor activity

positive regulation of NK T cell proliferation

positive regulation of protein kinase B signaling

triglyceride homeostasis

cellular response to peptide hormone stimulus

cellular response to organic cyclic compound

positive regulation of cold-induced thermogenesis

positive regulation of NIK/NF-kappaB signaling

positive regulation of male germ cell proliferation

positive regulation of hepatocyte proliferation

positive regulation of blood vessel remodeling

positive regulation of T-helper 1 cell cytokine production

04060

04621

04623

05143

05144

05323

TC0X00001557.mm.2 Klf8 Kruppel-like factor 8 X 153359612, 153237747 NM_173780, BC070442 NM_173780, BC070442 31

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

nucleus

nucleoplasm

cytosol

regulation of transcription by RNA polymerase II

aggresome

metal ion binding

 
TC0800000541.mm.2 Casp3 caspase 3 8 46617290 NM_001284409, NM_009810, BC038825 NM_001284409, NM_009810, BC038825 NM_001284409, NM_009810, BC038825 2354

B cell homeostasis

protease binding

aspartic-type endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

death receptor binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

cytosol

proteolysis

proteolysis

apoptotic process

apoptotic process

apoptotic process

apoptotic process

cellular response to DNA damage stimulus

axonal fasciculation

heart development

sensory perception of sound

learning or memory

peptidase activity

peptidase activity

peptidase activity

peptidase activity

cysteine-type peptidase activity

cysteine-type peptidase activity

intrinsic apoptotic signaling pathway in response to osmotic stress

response to UV

response to UV

response to wounding

response to glucose

response to organic substance

phospholipase A2 activator activity

protein processing

hydrolase activity

neuron differentiation

keratinocyte differentiation

keratinocyte differentiation

erythrocyte differentiation

erythrocyte differentiation

negative regulation of B cell proliferation

death-inducing signaling complex

regulation of protein stability

glial cell apoptotic process

intracellular signal transduction

response to hydrogen peroxide

neuronal cell body

T cell homeostasis

positive regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of neuron apoptotic process

protein-containing complex binding

membrane raft

cell fate commitment

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cell cycle

negative regulation of activated T cell proliferation

neurotrophin TRK receptor signaling pathway

neuron apoptotic process

neuron apoptotic process

neuron apoptotic process

anterior neural tube closure

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to organic substance

cellular response to staurosporine

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in apoptotic process

execution phase of apoptosis

execution phase of apoptosis

execution phase of apoptosis

execution phase of apoptosis

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

cysteine-type endopeptidase activity involved in execution phase of apoptosis

cysteine-type endopeptidase activity involved in execution phase of apoptosis

positive regulation of amyloid-beta formation

04010

04115

04210

04650

05010

05012

05014

05016

05145

05146

05200

05210

05416

MG-1-neg-10342216_st                
TC0600002351.mm.2 Ppm1k protein phosphatase 1K (PP2C domain containing) 6 -57506501 NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 NM_175523, BC092238, BC138473, BC138474 30

catalytic activity

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

mitochondrion

mitochondrion

protein dephosphorylation

hydrolase activity

cation binding

metal ion binding

 
TC1800001397.mm.2 Smim3 small integral membrane protein 3 18 -60474190 NM_134133, BC012898 NM_134133, BC012898 17

cellular_component

biological_process

membrane

integral component of membrane

identical protein binding

 
TC0200001396.mm.2 Phf21a PHD finger protein 21A 2 92185482, 92184181, 92221471 NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 NM_001109690, NM_001109691, NM_138755, BC019181 38

histone deacetylase complex

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

suckling behavior

DNA binding

chromatin binding

chromatin binding

chromatin binding

nucleus

nucleus

chromatin organization

metal ion binding

DNA repair complex

 
TC0400001525.mm.2 Marcksl1 MARCKS-like 1 4 129513580 NM_010807, BC006757 NM_010807, BC006757 47

actin binding

calmodulin binding

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

actin filament organization

central nervous system development

synaptic vesicle

positive regulation of cell population proliferation

membrane

actin filament binding

anchored component of presynaptic membrane

presynaptic cytosol

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

04666

05140

TC1600001439.mm.2 Mb21d2 Mab-21 domain containing 2 16 -28826175 NM_177718, BC085092 NM_177718, BC085092 19

protein-containing complex binding

 
TC0100001620.mm.2 Cfap45 cilia and flagella associated protein 45 1 172521129 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 NM_027972, BC150929, BC151048, BC151055 13

molecular_function

nucleoplasm

biological_process

 
TC1100000436.mm.2 Il12b interleukin 12b 11 44400062 BC103608, BC103609, BC103610, BC103614, NM_008352 BC103608, BC103609, BC103610, BC103614, NM_008352 BC103608, BC103609, BC103610, BC103614, NM_008352 BC103608, BC103609, BC103610, BC103614, NM_008352 BC103608, BC103609, BC103610, BC103614, NM_008352 654

positive regulation of T cell mediated cytotoxicity

positive regulation of defense response to virus by host

positive regulation of defense response to virus by host

natural killer cell activation involved in immune response

positive regulation of T-helper 1 type immune response

positive regulation of T-helper 1 type immune response

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

negative regulation of inflammatory response to antigenic stimulus

cytokine receptor activity

cytokine activity

cytokine activity

cytokine receptor binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

cytoplasm

endoplasmic reticulum lumen

Golgi lumen

cell cycle arrest

cell surface receptor signaling pathway

growth factor activity

cell population proliferation

cell population proliferation

external side of plasma membrane

cell surface

response to organic substance

response to UV-B

positive regulation of activation of Janus kinase activity

membrane

cell migration

cytokine-mediated signaling pathway

sensory perception of pain

cytokine binding

natural killer cell activation

endosome lumen

negative regulation of interleukin-10 production

negative regulation of interleukin-17 production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-17 production

positive regulation of tumor necrosis factor production

positive regulation of natural killer cell activation

positive regulation of natural killer cell proliferation

positive regulation of mononuclear cell proliferation

positive regulation of smooth muscle cell apoptotic process

T-helper 1 cell cytokine production

T-helper cell differentiation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of activated T cell proliferation

interleukin-12 alpha subunit binding

interleukin-12 alpha subunit binding

interleukin-12 alpha subunit binding

regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

identical protein binding

identical protein binding

defense response to protozoan

defense response to protozoan

defense response to protozoan

receptor complex

interleukin-12 complex

interleukin-12 complex

interleukin-12 complex

interleukin-12 complex

protein-containing complex binding

interleukin-23 receptor binding

positive regulation of osteoclast differentiation

positive regulation of cell adhesion

protein heterodimerization activity

negative regulation of smooth muscle cell proliferation

positive regulation of lymphocyte proliferation

negative regulation of protein secretion

defense response to Gram-negative bacterium

positive regulation of NK T cell activation

positive regulation of NK T cell proliferation

defense response to virus

interleukin-23 complex

interleukin-23 complex

interleukin-23 complex

cellular response to lipopolysaccharide

cellular response to interferon-gamma

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

04060

04620

04622

04630

04940

05140

05142

05143

05145

05146

05330

TC1000000100.mm.2 Hivep2 human immunodeficiency virus type I enhancer binding protein 2 10 13966378, 13966074 NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340 NM_010437, BC150704, XR_105340 44

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

nucleus

nucleoplasm

transcription regulator complex

transcription, DNA-templated

regulation of transcription by RNA polymerase II

signal transduction

positive regulation of transcription by RNA polymerase II

metal ion binding

 
TC1200002024.mm.2 Adam21 a disintegrin and metallopeptidase domain 21 12 -81558574 NM_020330, BC132152, BC132344 NM_020330, BC132152, BC132344 NM_020330, BC132152, BC132344 16

metalloendopeptidase activity

plasma membrane

proteolysis

peptidase activity

metallopeptidase activity

male gonad development

external side of plasma membrane

membrane

integral component of membrane

hydrolase activity

axon

neuron projection

neuronal cell body

metal ion binding

sperm head plasma membrane

 
TC0400002434.mm.2 Ddx58 DEAD/H box helicase 58 4 -40203776 NM_172689, BC167209 NM_172689, BC167209 157

nucleotide binding

positive regulation of defense response to virus by host

immune system process

positive regulation of myeloid dendritic cell cytokine production

DNA binding

double-stranded DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

helicase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytosol

cytosol

cytoskeleton

plasma membrane

bicellular tight junction

zinc ion binding

zinc ion binding

detection of virus

response to virus

response to virus

positive regulation of gene expression

actin cytoskeleton

membrane

hydrolase activity

cell junction

regulation of cell migration

ubiquitin protein ligase binding

ruffle membrane

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

RIG-I signaling pathway

identical protein binding

cell projection

response to exogenous dsRNA

innate immune response

innate immune response

innate immune response

positive regulation of transcription by RNA polymerase II

metal ion binding

positive regulation of DNA-binding transcription factor activity

defense response to virus

positive regulation of response to cytokine stimulus

cellular response to exogenous dsRNA

antiviral innate immune response

ribonucleoprotein complex

04622

04623

05160

MG-1-neg-10340317_st                
TC0200004651.mm.2 Rnf24 ring finger protein 24 2 -131298487 NM_178607, BC096529 NM_178607, BC096529 22

Golgi apparatus

Golgi apparatus

zinc ion binding

endomembrane system

membrane

integral component of membrane

metal ion binding

ubiquitin protein ligase activity

 
MG-1-neg-10340975_st                
TC0900001905.mm.2 Zfp810 zinc finger protein 810 9 -22276747 NM_145612, BC005471 NM_145612, BC005471 16

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

regulation of transcription by RNA polymerase II

 
TC0100001465.mm.2 Cenpl centromere protein L 1 161070766 NM_001159930, BC116944, BC116970, NM_027429 NM_001159930, BC116944, BC116970, NM_027429 NM_001159930, BC116944, BC116970, NM_027429 NM_001159930, BC116944, BC116970, NM_027429 15

chromosome, centromeric region

molecular_function

cellular_component

nucleus

chromosome

biological_process

 
TC0200001411.mm.2 Pex16 peroxisomal biogenesis factor 16 2 92374675, 92375238 NM_145122, NR_028114, BC010822 NM_145122, NR_028114, BC010822 NM_145122, NR_028114, BC010822 20

peroxisome

peroxisomal membrane

peroxisomal membrane

peroxisomal membrane

integral component of peroxisomal membrane

endoplasmic reticulum

endoplasmic reticulum membrane

protein targeting to peroxisome

peroxisome organization

peroxisome organization

protein C-terminus binding

membrane

integral component of membrane

peroxisome membrane biogenesis

protein import into peroxisome matrix

protein to membrane docking

ER-dependent peroxisome organization

protein import into peroxisome membrane

ER-dependent peroxisome localization

04146

TC0200005112.mm.2         NM_011414, NR_106143, BC028509 NM_011414, NR_106143, BC028509 NM_011414, NR_106143, BC028509  

immune system process

DNA binding

mRNA binding

endopeptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

Golgi apparatus

immune response

negative regulation of peptidase activity

antibacterial humoral response

antibacterial humoral response

antibacterial humoral response

enzyme binding

peptidase inhibitor activity

negative regulation of protein binding

response to lipopolysaccharide

modulation of process of other organism

defense response to bacterium

negative regulation of viral genome replication

innate immune response

innate immune response

 
MG-1-neg-10342169_st                
TC1700002004.mm.2 Gm8909 predicted gene 8909 17 -36164443 NM_001081032 2

positive regulation of T cell mediated cytotoxicity

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

signaling receptor binding

extracellular space

immune response

external side of plasma membrane

peptide antigen binding

 
MG-1-neg-10342007_st                
TC0600001424.mm.2 C1rb complement component 1, r subcomponent B 6 124570429 NM_001113356 4

immune system process

serine-type endopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular space

extracellular space

proteolysis

complement activation, classical pathway

peptidase activity

serine-type peptidase activity

hydrolase activity

zymogen activation

identical protein binding

innate immune response

blood microparticle

 
TC0400001726.mm.2 Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 4 138434671 NM_026689, BC019516 NM_026689, BC019516 25

protein polyubiquitination

mitochondrial fission

p53 binding

ubiquitin-protein transferase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

peroxisome

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

organelle organization

activation of JUN kinase activity

negative regulation of mitochondrial fusion

regulation of mitochondrion organization

membrane

integral component of membrane

protein ubiquitination

protein ubiquitination

transferase activity

SUMO transferase activity

negative regulation of cell growth

axon

integral component of mitochondrial outer membrane

ubiquitin protein ligase binding

regulation of protein stability

protein destabilization

positive regulation of protein sumoylation

identical protein binding

neuronal cell body

negative regulation of innate immune response

metal ion binding

negative regulation of defense response to virus by host

protein stabilization

mitochondrion localization

regulation of mitochondrial membrane potential

negative regulation of protein kinase B signaling

negative regulation of type I interferon-mediated signaling pathway

ubiquitin protein ligase activity

cellular response to exogenous dsRNA

negative regulation of chemokine (C-C motif) ligand 5 production

positive regulation of mitochondrial fission

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of dendrite extension

positive regulation of dendrite extension

positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization

 
MG-1-neg-10341905_st                
TC1100000106.mm.2 Ramp3 receptor (calcitonin) activity modifying protein 3 11 6658532 NM_019511, BC024765 NM_019511, BC024765 34

angiogenesis

adrenomedullin receptor activity

positive regulation of receptor recycling

lysosome

plasma membrane

plasma membrane

calcium ion transport

calcium ion transport

intracellular protein transport

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway

cell surface

cell surface

positive regulation of gene expression

positive regulation of protein kinase A signaling

positive regulation of cell death

coreceptor activity

coreceptor activity

coreceptor activity

protein transport

protein transport

membrane

integral component of membrane

receptor internalization

receptor internalization

cellular response to hormone stimulus

positive regulation of peptidyl-serine phosphorylation

cross-receptor inhibition within G protein-coupled receptor heterodimer

receptor complex

receptor complex

positive regulation of protein kinase B signaling

positive regulation of ERK1 and ERK2 cascade

cellular response to estradiol stimulus

protein localization to plasma membrane

protein localization to plasma membrane

G protein-coupled receptor signaling pathway involved in heart process

amylin receptor activity

amylin receptor signaling pathway

amylin receptor complex 3

positive regulation of protein localization to plasma membrane

adrenomedullin receptor complex

response to amyloid-beta

positive regulation of calcium ion import across plasma membrane

adrenomedullin receptor signaling pathway

04270

TC0400000659.mm.2 Hsdl2 hydroxysteroid dehydrogenase like 2 4 59581562 NM_024255, BC002211 NM_024255, BC002211 20

molecular_function

mitochondrion

mitochondrion

peroxisome

biological_process

oxidoreductase activity

 
TC1500001144.mm.2 Fbxo4 F-box protein 4 15 -3963563 NM_134099, BC040086 NM_134099, BC040086 24

ubiquitin ligase complex

protein polyubiquitination

telomere maintenance

ubiquitin-protein transferase activity

protein binding

cytoplasm

ubiquitin-dependent protein catabolic process

aging

posttranscriptional regulation of gene expression

protein ubiquitination

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

cellular homeostasis

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein ubiquitination

regulation of protein stability

protein destabilization

positive regulation of telomere maintenance via telomerase

common myeloid progenitor cell proliferation

protein homodimerization activity

negative regulation of fibroblast proliferation

ubiquitin protein ligase activity

cellular response to ionizing radiation

negative regulation of protein localization to nucleus

positive regulation of protein polyubiquitination

regulation of DNA damage checkpoint

04120

TC0800002012.mm.2 Rbpms RNA binding protein gene with multiple splicing 8 -33782643, -33803939 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 NM_001042674, NM_001042675, NM_001286168, NM_019733, BC030397 48

nucleic acid binding

transcription coactivator activity

RNA binding

mRNA binding

nucleus

nucleoplasm

cytoplasm

cytosol

response to oxidative stress

poly(A) binding

cytoplasmic stress granule

positive regulation of pathway-restricted SMAD protein phosphorylation

protein homodimerization activity

positive regulation of SMAD protein signal transduction

 
TC1000000493.mm.2 Gja1 gap junction protein, alpha 1 10 56377299 NM_010288, BC006894, BC055375 NM_010288, BC006894, BC055375 NM_010288, BC006894, BC055375 967

establishment of mitotic spindle orientation

osteoblast differentiation

in utero embryonic development

neuron migration

negative regulation of endothelial cell proliferation

heart looping

epithelial cell maturation

lens development in camera-type eye

chronic inflammatory response

positive regulation of glomerular filtration

atrial ventricular junction remodeling

epicardial cell to mesenchymal cell transition

signaling receptor binding

gap junction channel activity

gap junction channel activity

gap junction channel activity

gap junction channel activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrial outer membrane

lysosome

endosome

early endosome

late endosome

multivesicular body

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

intermediate filament

plasma membrane

plasma membrane

cell-cell junction

fascia adherens

fascia adherens

gap junction

gap junction

connexin complex

connexin complex

apoptotic process

cell communication

signal transduction

positive regulation of cytosolic calcium ion concentration

cell-cell signaling

cell-cell signaling

cell-cell signaling

spermatogenesis

heart development

adult heart development

beta-catenin binding

regulation of heart contraction

negative regulation of cell population proliferation

male gonad development

response to pH

vascular transport

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

cell communication by chemical coupling

cell communication by electrical coupling

cell communication by electrical coupling

regulation of cell communication by electrical coupling

positive regulation of cell communication by chemical coupling

glutamate secretion

intercalated disc

intercalated disc

ion transmembrane transporter activity

efflux transmembrane transporter activity

tubulin binding

ATP transport

membrane

membrane

integral component of membrane

apical plasma membrane

lateral plasma membrane

SH3 domain binding

protein domain specific binding

transmembrane transporter activity

regulation of transmembrane transporter activity

cell junction

cell junction

PDZ domain binding

negative regulation of cell growth

negative regulation of cell growth

regulation of bone mineralization

positive regulation of insulin secretion

negative regulation of gonadotropin secretion

protein-containing complex

ion transmembrane transport

cellular protein localization

glutathione transmembrane transporter activity

embryonic heart tube development

maintenance of protein localization in endoplasmic reticulum

T cell proliferation

T cell activation

embryonic digit morphogenesis

xenobiotic transport

regulation of apoptotic process

alpha-tubulin binding

intracellular membrane-bounded organelle

contractile fiber

skeletal muscle tissue regeneration

cell-cell contact zone

membrane raft

cell-cell junction organization

positive regulation of protein catabolic process

positive regulation of striated muscle tissue development

positive regulation of vasoconstriction

bone remodeling

regulation of bone remodeling

beta-tubulin binding

blood vessel morphogenesis

neuron projection morphogenesis

regulation of calcium ion transport

gap junction hemi-channel activity

transmembrane transport

negative regulation of cardiac muscle cell proliferation

milk ejection reflex

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of blood vessel remodeling

bone development

regulation of atrial cardiac muscle cell membrane depolarization

regulation of ventricular cardiac muscle cell membrane depolarization

regulation of ventricular cardiac muscle cell membrane depolarization

negative regulation of wound healing

cardiac conduction

tight junction

connexin binding

cellular response to pH

gap junction channel activity involved in cardiac conduction electrical coupling

establishment of epithelial cell polarity

scaffold protein binding

disordered domain specific binding

microtubule-based transport

positive regulation of cold-induced thermogenesis

export across plasma membrane

negative regulation of trophoblast cell migration

gap junction channel activity involved in cell communication by electrical coupling

cellular response to amyloid-beta

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of morphogenesis of an epithelium

positive regulation of mesodermal cell differentiation

protein tyrosine kinase binding

negative regulation of DNA biosynthetic process

positive regulation of stem cell proliferation

regulation of bicellular tight junction assembly

positive regulation of behavioral fear response

04540

05412

TC1000001988.mm.2 Zup1 zinc finger containing ubiquitin peptidase 1 10 -33919141, -33925133 NM_028287, BC089514 NM_028287, BC089514 18

nucleic acid binding

thiol-dependent ubiquitin-specific protease activity

nucleus

cytoplasm

regulation of gene expression

hydrolase activity

metal ion binding

 
TC0100003487.mm.2 Pbx1 pre B cell leukemia homeobox 1 1 -168153526, -168119363 NM_008783, NM_183355, BC002244, BC058390 NM_008783, NM_183355, BC002244, BC058390 NM_008783, NM_183355, BC002244, BC058390 NM_008783, NM_183355, BC002244, BC058390 208

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

eye development

urogenital system development

branching involved in ureteric bud morphogenesis

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

steroid biosynthetic process

multicellular organism development

brain development

sex differentiation

transcription factor binding

positive regulation of cell population proliferation

animal organ morphogenesis

animal organ morphogenesis

anterior/posterior pattern specification

proximal/distal pattern formation

proximal/distal pattern formation

positive regulation of G2/M transition of mitotic cell cycle

cell differentiation

regulation of ossification

adrenal gland development

embryonic limb morphogenesis

embryonic hemopoiesis

regulation of cell population proliferation

negative regulation of DNA-binding transcription factor activity

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation of neuron differentiation

positive regulation of transcription by RNA polymerase II

spleen development

spleen development

thymus development

embryonic organ development

embryonic organ development

neuron development

embryonic skeletal system development

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

 
TC1700001578.mm.2 Zfp945 zinc finger protein 945 17 -22846696 NM_001110254, NM_177358, BC078460 NM_001110254, NM_177358, BC078460 NM_001110254, NM_177358, BC078460 12

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
TC0400003249.mm.2 Prpf38a PRP38 pre-mRNA processing factor 38 (yeast) domain containing A 4 -108564866 NM_172697, BC139277, BC139305 NM_172697, BC139277, BC139305 NM_172697, BC139277, BC139305 16

mRNA splicing, via spliceosome

nucleus

nucleoplasm

spliceosomal complex

mRNA processing

RNA splicing

U2-type precatalytic spliceosome

precatalytic spliceosome

precatalytic spliceosome

03040

TC1100000856.mm.2 Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal 11 67277123 NM_177369, BC150737 NM_177369, BC150737 55

microfilament motor activity

nucleotide binding

skeletal muscle contraction

motor activity

actin binding

protein binding

ATP binding

cytoplasm

myosin complex

ATPase activity

muscle filament sliding

myosin filament

ATP metabolic process

actin filament binding

04530

05416

839 Genes